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| 1 | 【特刊综述】性腺功能低下在克氏综合征中的角色显示文摘克氏综合症(47,XXY)(KS)是最常见的性染色体异常,也是男性不育和性腺功能低下的常见原因。大部分KS患者终其一生都不知道自己患有这个疾病,只有25%的患者得到诊断,而在青春期前被诊断的更是少数。除了性腺功能低下和无精子症,大多数KS患者都有一定程度的学习障碍,并且可能有多种精神问题。长期性腺功能低下的影响可能使其难以与额外的x染色体引起的基因剂量效应相辨别。不管是什么原因,KS患者常出现身体成分的改变,包括脂肪增加、肌肉减少和骨矿物质流失,同时发生代谢障碍的风险也增加,例如患2型糖尿病和代谢综合征。这些发现应该引起我们的重视,因为他们不仅仅是简单的化验结果,流行病学调查表明KS患者因不同的疾病住院和死亡的风险均增加。KS患者应该在青春期早期就被给予睾丸激素治疗,尽管目前证据不足,因为至今仍未有随机对照试验的文章发表过。在这篇文章里,我们回顾了近期关于KS患者性腺功能低下症的研究进展和睾丸激素治疗的合理性,希望能为这个常见但往往被忽视的综合征提出我们的最佳建议。 | Christian Host Anne Skakkeb k Kristian A Groth Anders Bojesen | 2014 | Asian Journal of Andrology2014，16，2： | 3 |
| 2 | Prospective evaluation of the short access cholangioscopy for stone clearance and evaluation of indeterminate strictures显示文摘BACKGROUND: Peroral cholangioscopy facilitates diagnosis and therapy of biliary disorders. This study prospectively evaluated a new short access cholangioscopy. METHODS: Consecutive patients were included as follows: difficult stones(group 1) underwent cholangioscopy with electrohydraulic lithotripsy and indeterminate biliary strictures(group 2) were evaluated with macroscopic assessment and cholangioscopy guided biopsy sampling. We evaluated the complete stone clearance rate(group 1) and diagnostic accuracy(group 2). Follow-up was performed over a median of 13 and 16 months, respectively.RESULTS: Group 1(n=21): complete stone clearance defined as lack of stones in cholangiography and stone removal during cholangioscopy was achieved in 15(71.4%) patients. Clinical stone clearance defined as lack of symptoms, laboratory abnormalities and hospital visits during follow-up, irrespective of stone clearance was evident in 17(81.0%) patients. One serious adverse event occurred(bile duct perforation). Group 2(n=28): malignancy was confirmed in 15 patients. Sensitivity, specificity and diagnostic accuracy of cholangioscopy were 85.7%, 75.0% and 80.7%, respectively. Sensitivity, specificity and diagnostic accuracy of biopsies were 54.5%, 100.0% and 72.2%, respectively. No serious adverse events occurred, and one patient was lost to follow-up.CONCLUSIONS: The novel system enabled complex stone treatment and biliary stricture diagnosis. Cholangioscopy outperformed direct biopsy regarding characterization of indeterminate strictures. | Athanasios D Sioulas Muhammad A El-Masry Stefan Groth Guido Schachschal Mario Anders Thomas Rosch Ulrike Denzer | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，1： | 2 |
| 3 | Transconjunctival Lower Eyelid Blepharoplasty: Technique and Complications显示文摘 | Baylis H I Long J A Groth M J | 1989 | Ophthaimology1989，96，： | 1 |
| 4 | MF59-adjuvanted influenza vaccine(FLUAD)in children:safety and immunogenicity following a second year seasonal vaccination显示文摘 | Vesikari T Groth N Karvonen A Borkowski A Pellegrini M | | 0，，45： | 1 |
| 5 | Chemotherapy in advanced gastric cancer: asystematic review and meta-analysis basedon aggregate data显示文摘 | WAGNER A D GROTHE W HAERTING J | 2006 | J Clin Oncol2006，24，18： | 1 |
| 6 | Raman microspectroscopy of soot and related carbonaceous materials: Spec-tral analysis and structural information 显示文摘 | Sadezky A Muckenhuber H Grothe H | 2005 | Carbon2005，43，8： | 1 |
| 7 | Cervimycin A-D: Apolykefide glycoside complex from a cave bacterium can defeat vancomycin resistance显示文摘 | Herold K Gollmick F A Groth I | 2005 | Chem Eur2005，11，： | 1 |
| 8 | Chemotherapy in advanced gastric cancer: a systematic review and meta-analysis based on aggregate data 显示文摘 | Wagner A D Grothe W Haerting J | 2006 | J Clin Onco2006，24，18： | 1 |
| 9 | Assessment of myocardial viability in ischemic heart disease by cardiac magnetic resonance imaging显示文摘 | Muellerleile K Barmeyer A Groth M Lund G K | 2008 | Minerva Cardioangiol2008，56，： | 1 |
| 10 | Percutaneous radiofrequency ablation(RFA)or robotic radiosurgery(RRS)for salvage treatment of colorectal liver metastases显示文摘 | Stintzing S Grothe A Hendrich S | 2013 | Acta Oncol2013，14，： | 1 |
| 11 | Treatment-dependent and treat- ment-independent risk factors associated with the risk of diabetes-re- lated events: a retrospective analysis based on 229,042 patients with type 2 diabetes mellitus显示文摘 | Wilke T Mueller S Groth A | 2015 | Cardiovasc Diabetol2015，14，： | 1 |
| 12 | Inflammatory cytokines pul- monary hypertension显示文摘 | Groth A Vruqt B Brock M | 2014 | Respir Res2014，15，： | 1 |
| 13 | Chemotherapy in advanced gastric cancer: a systematic review and meta analysis based on aggregate data显示文摘 | WAGNER A D GROTHE W HAERTING J | 2006 | J Clin Oncol2006，24，： | 1 |
| 14 | Mammalian genomes contain active recombinase recognition sites 显示文摘 | Thyagarajan B Guimaraes A C Groth M P | 2000 | Gene2000，244，12： | 1 |
| 15 | Endoscopic ultrasound staging in gastric cancer:Does it help management decisions in the era of neoadjuvant treatment显示文摘 | Kutup A Vashist YK Groth S | | 0，，06： | 1 |
| 16 | Chemotherapy in advanced gastric cancer: A systematic review and meta analysis based on aggregate data显示文摘 | Wagner A D Grothe W Haerting J | 2006 | Journal of Clinical Oncology2006，24，18： | 1 |
| 17 | Raman microspectroscopy of soot and related carbonaceous materials : Spec-tral analysis and structural information显示文摘 | Sadezky A Muckenhuber H Grothe H | 2005 | Carbon2005，43，8： | 1 |
| 18 | New linked macrocyclic systems derived from selectively protected S2 N2 macrocycles 显示文摘 | GROTH A M LINDOY L F MEEHAN G V | 1996 | J Chem Soc Perkin Trans1996，1，13： | 1 |
| 19 | Surgery for early-stage non-small cell lung cancer:a systematic review of the video-assisted thoracoscopic surgery versus thoracotomy approaches to lobectomy显示文摘 | Whitson B A Groth S S Duval S J | 2008 | Ann Thorac Surg2008，86，6： | 1 |
| 20 | New gene-immunotherapy combining TRAIL-lymphocytes and EpCAMxCD3 Bispecific antibody for tumor targeting显示文摘 | GROTH A SALNIKOV A V OTTINGER S | | 0，，04： | 1 |
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