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| 1 | HPV阴性胃型子宫颈原位腺癌:一种具有胃和肠分化的罕见病变谱系显示文摘作者报道9例罕见的具有胃和肠分化且与人类乳头瘤病毒(HPV)感染无关的子宫颈原位腺癌(AIS)。患者年龄25~73岁(平均51岁),所有病例均位于子宫颈鳞一柱交界区(或邻近),其中有3例延伸子宫下段,2例累及子宫内膜。所有病例均大部分保留正常子宫颈腺体结构,其中5例有轻度腺体复杂性增生。腺上皮从几乎为纯胃型(4例)至混合不同比例杯状细胞的胃肠型(5例)。与正常的子宫颈腺体嗜碱性细胞质不同,胃型上皮通常由明显嗜酸性或浅粉色胞质的细胞组成,但在某些病例中胞质呈明显的泡沫状或透明胞质。所有病例均有核非典型性, | Talia K L Stewart C J R Howitt B E 黄爱清(摘译) 余英豪(审校) | 2017 | 临床与实验病理学杂志2017，33，11： | 19 |
| 2 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 3 | Premotor biomarkers for Parkinson's disease-a promising direction of research显示文摘The second most serious neurodegenerative disease is Parkinson’s disease(PD).Over the past several decades,a strong body of evidence suggests that PD can begin years before the hallmark clinical motor symptoms appear.Biomarkers for PD are urgently needed to differentiate between neurodegenerative disorders,screen novel therapeutics,and predict eventual clinical PD before the onset of symptoms.Some clinical evaluations and neuroimaging techniques have been developed in the last several years with some success in this area.Moreover,other strategies have been utilized to identify biochemical and genetic markers associated with PD leading to the examination of PD progression and pathogenesis in cerebrospinal fluid,blood,or saliva.Finally,interesting results are surfacing from preliminary studies using known PD-associated genetic mutations to assess potential premotor PD biomarkers.The current review highlights recent advances and underscores areas of potential advancement. | Brian R Haas Tessandra H Stewart Jing Zhang | 2012 | Translational Neurodegeneration2012，1，1： | 5 |
| 4 | Continuous wound infusion of local anaesthetic agents following colorectal surgery:Systematic review and meta-analysis显示文摘AIM:To provide a specifi c review and meta-analysis of the available evidence for continuous wound infusion of local anaesthetic agents following midline laparoto-my for major colorectal surgery. METHODS: Medline, Embase, trial registries, conference proceedings and article reference lists were searched to identify randomised, controlled trials of continuous wound infusion of local anaesthetic agents following colorectal surgery. The primary outcomes were opioid consumption, pain visual analogue scores (VASs), return to bowel function and length of hospital stay. Weighted mean difference were calculated for continuous outcomes. RESULTS: Five trials containing 542 laparotomy wounds were eligible for inclusion. There was a sig- nificant decrease in post-operative pain VAS at rest on day 3 (weighted mean difference: -0.43; 95% CI: -0.81 to -0.04; P = 0.03) but not on post-operative day 1 and 2. Local anaesthetic infusion was associated with a signifi cant reduction in pain VAS on movement on all three post-operative days (day 1 weighted mean difference: -1.14; 95% CI: -2.24 to -0.041; P = 0.04, day 2 weighted mean difference: -0.97, 95% CI: -1.91to -0.029; P = 0.04, day 3 weighted mean difference: -0.61; 95% CI: 1.01 to -0.20; P = 0.0038). Local an- aesthetic wound infusion was associated with a signifi - cant decrease in total opioid consumption (weighted mean difference: -40.13; 95% CI: -76.74 to -3.53; P = 0.03). There was no signifi cant decrease in length of stay (weighted mean difference: -20.87; 95% CI: -46.96 to 5.21; P = 0.12) or return of bowel function (weighted mean difference: -9.40; 95% CI: -33.98 to 15.17; P = 0.45). CONCLUSION: The results of this systematic re- view and meta-analysis suggest that local anaesthetic wound infusion following laparotomy for major color- ectal surgery is a promising technique but do not pro- vide conclusive evidence of benefi t. Further research is required including cost-effectiveness analysis. | Alan Karthikesalingam Stewart R Walsh Sheraz R Markar Umar Sadat Tjun Y Tang Charles M Malata | 2008 | World Journal of Gastroenterology2008，14，34： | 4 |
| 5 | Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Joseph P Costantino Takamaru Ashikaga Donald L Weaver Eleftherios P Mamounas Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Norman Wolmark | 2010 | Lancet Oncology2010，，10： | 3 |
| 6 | Gynecologic oncologists involvement on ovarian cancer standard of care receipt and survival显示文摘AIM:To examine the influence of gynecologic oncolo-gists(GO) in the United States on surgical/chemotherapeutic standard of care(SOC), and how this translates into improved survival among women with ovarian cancer(OC).METHODS: Surveillance, Epidemiology, and End Result(SEER)-Medicare data were used to identify 11688 OC patients(1992-2006). Only Medicare recipients with an initial surgical procedure code(n = 6714) were included. Physician specialty was identified by linking SEER-Medicare to the American Medical Association Masterfile. SOC was defined by a panel of GOs. Multivariate logistic regression was used to determine predictors of receiving surgical/chemotherapeutic SOCand proportional hazards modeling to estimate the effect of SOC treatment and physician specialty on survival. RESULTS: About 34% received surgery from a GO and 25% received the overall SOC. One-third of women had a GO involved sometime during their care. Women receiving surgery from a GO vs non-GO had 2.35 times the odds of receiving the surgical SOC and 1.25 times the odds of receiving chemotherapeutic SOC(P < 0.01). Risk of mortality was greater among women not receiving surgical SOC compared to those who did [hazard ratio = 1.22(95%CI: 1.12-1.33), P < 0.01], and also was higher among women seen by non-GOs vs GOs(for surgical treatment) after adjusting for covariates. Median survival time was 14 mo longer for women receiving combined SOC. CONCLUSION: A survival advantage associated with receiving surgical SOC and overall treatment by a GO is supported. Persistent survival differences, particularly among those not receiving the SOC, require further investigation. | Sun Hee Rim Shawn Hirsch Cheryll C Thomas Wendy R Brewster Darryl Cooney Trevor D Thompson Sherri L Stewart | 2016 | World Journal of Obstetrics and Gynecology2016，5，2： | 3 |
| 7 | 子宫炎性肌纤维母细胞肿瘤通常存在ALK与IGFBP5和THBS1基因的融合显示文摘炎性肌纤维母细胞肿瘤能够发生在包括子宫在内的多个解剖部位。子宫炎性肌纤维母细胞肿瘤与发生在软组织的炎性肌纤维母细胞肿瘤相似,也通常表达ALK,并存在ALK基因重排。该文着重分析子宫炎性肌纤维母细胞肿瘤的基因融合特征。 | Haimes J D Stewart C J R Kudlow B A 赵芳 魏建国 | 2018 | 临床与实验病理学杂志2018，34，1： | 2 |
| 8 | Migraine prevalence, disease burden, and the need for preventive therapy显示文摘 | R B. Lipton M E. Bigal M Diamond F Freitag M L. Reed W F. Stewart | 2007 | Neurology2007，，5： | 2 |
| 9 | Towards a new tuberculosis drug: pyridomycin – nature’s isoniazid显示文摘 | Ruben C. Hartkoorn Claudia Sala Jo?o Neres Florence Pojer Sophie Magnet Raju Mukherjee Swapna Uplekar Stefanie Boy‐R?ttger Karl‐Heinz Altmann Stewart T. Cole | 2012 | EMBO Mol Med2012，，： | 2 |
| 10 | SCTP:New Transport Protocol for TCP/IP 显示文摘 | Stewart R Metz C | 2001 | IEEE Internet Computing2001，，6： | 2 |
| 11 | Manipulation of human embryonal carcinoma stem cells and the development of neural subtypes显示文摘 | Stewart R Christie VB Przyborski SA | 2003 | Stem Cells2003，21，： | 2 |
| 12 | Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase III trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Takamaru Ashikaga Donald L Weaver Barbara J Miller Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Denise M Mammolito David R McCready Eleftherios P Mamo | 2007 | Lancet Oncology2007，，10： | 2 |
| 13 | Scientific charge-coupled devices显示文摘 | JANESICK J R TOM E STEWART C | 1987 | Optical Engineering1987，26，8： | 2 |
| 14 | The essential nature of the ubiquitous 26-kilobase circular replicon of Borreliaburgdorferi显示文摘 | Byram R Stewart PE Rosa P | 2004 | J Bacteriol2004，186，： | 1 |
| 15 | Lipid peroxidation associated with accelerated aging of soybean axes 显示文摘 | Stewart R R C Bewley J D | 1980 | Plant Physiology1980，65，2： | 1 |
| 16 | Lactate dehydrogenase A as a highly abundant eye lens protein in platypus (Ornithorhynchus anatinus): Upsilon (t)-Crystallin 显示文摘 | Rheede TV Amons R Stewart N | 2003 | Mol Biol Evol2003，20，： | 1 |
| 17 | Determination of total and speciated arsenic in rice by ion chromatography and inductively coupled plasma mass spectrometry 显示文摘 | HEITKEMPER D T VELA N P STEWART K R | 2001 | J Anal Atom Spectrom2001，16，： | 1 |
| 18 | Epidemiology of constipation study in the United States: relation of clinical subtypes to sociodemographicfeatures 显示文摘 | Stewart WF Lieberman JN Sandler R | 1999 | Am J Gastroenterology1999，94，12： | 1 |
| 19 | Interactions between life stressors and susceptibility genes (5-HTTLPR and BDNF) on depression in Korean elders显示文摘 | Kim J M Stewart R Kim S W | 2007 | Biol Psychiatry2007，62，5： | 1 |
| 20 | Expression and activity of the CDK inhibitor p57 Kip2 in chondrocytes undergoing hypertrophic differentiation 显示文摘 | Stewart M C Kadlcek R M Robbins P D | 2004 | J Bone Miner Res2004，19，1： | 1 |
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