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| 1 | HPV阴性胃型子宫颈原位腺癌:一种具有胃和肠分化的罕见病变谱系显示文摘作者报道9例罕见的具有胃和肠分化且与人类乳头瘤病毒(HPV)感染无关的子宫颈原位腺癌(AIS)。患者年龄25~73岁(平均51岁),所有病例均位于子宫颈鳞一柱交界区(或邻近),其中有3例延伸子宫下段,2例累及子宫内膜。所有病例均大部分保留正常子宫颈腺体结构,其中5例有轻度腺体复杂性增生。腺上皮从几乎为纯胃型(4例)至混合不同比例杯状细胞的胃肠型(5例)。与正常的子宫颈腺体嗜碱性细胞质不同,胃型上皮通常由明显嗜酸性或浅粉色胞质的细胞组成,但在某些病例中胞质呈明显的泡沫状或透明胞质。所有病例均有核非典型性, | Talia K L Stewart C J R Howitt B E 黄爱清(摘译) 余英豪(审校) | 2017 | 临床与实验病理学杂志2017，33，11： | 19 |
| 2 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 3 | Determination of total and speciated arsenic in rice by ion chromatography and inductively coupled plasma mass spectrometry 显示文摘 | HEITKEMPER D T VELA N P STEWART K R | 2001 | J Anal Atom Spectrom2001，16，： | 1 |
| 4 | Reduction of chromium (VI) at sub-μg 1-1 levels by fulvic acid 显示文摘 | ECKERT J M STEWART J J WAITE T D SZYMCZAK R WILLIAMS K L | 1990 | Analytica Chimica Acta1990，236，： | 1 |
| 5 | The Role of Climate for Innovation in En- hancing Business Performance: The Case of Design Firms显示文摘 | PANUWATWANICH K STEWART R A MO- HAMED S | 2008 | Engineering Construction and Architectur- al Management2008，15，5： | 1 |
| 6 | Mapping copynumber variation by population-scale genome sequen-cing显示文摘 | Mills R E Walter K Stewart C | 2011 | Nature2011，470，： | 1 |
| 7 | Relating Member Ability and Personality to Work-team Process and Team Effectiveness 显示文摘 | Barrick M R Stewart G L Neubert M J Mount M K | 1998 | Journal of Applied Psychology1998，83，3： | 1 |
| 8 | Resilience and mentalhealth显示文摘 | Davydov D M Stewart R Ritchie K | 2010 | Clin Psychol Rev2010，30，5： | 1 |
| 9 | Evidence suggesting that a chronic disease self-management pro- gram can improve health status while reducing hospitali- zation: a randomized trial显示文摘 | Lorig K R Sobel D S Stewart A L | 1999 | Med Care1999，37，1： | 1 |
| 10 | Automated multiple flow injection analysis for flame atomic absorption spectrometry显示文摘 | WOLF W R STEWART K K | 1979 | Anal Chem1979，51，8： | 1 |
| 11 | Estimating historical heating and cooling need: per capita degreeday显示文摘 | Downton M W Stewart T R Miller K A | 1988 | Journal of Applied Meteorology1988，27，1： | 1 |
| 12 | Chronic disease self-management program: 2-year health status and health care utilization outcomes显示文摘 | Lorig K R Ritter P Stewart A L | 2001 | Med Care2001，39，11： | 1 |
| 13 | Localization and characterization of peroxidases in the mitochondria of chilling-acclimated maize seedlings显示文摘 | Prasad T K Anderson M D Stewart C R | 1995 | Plant Physiology1995，108，4： | 1 |
| 14 | Evaluation of a communi- ty pharmary - based intervention for improving adherence to antihy - pertensive: A randomized controlled trial显示文摘 | Lau R Stewart K McNamara KP | 2010 | BMC Health Serv Res2010，10，： | 1 |
| 15 | Endothelial cell proliferation activity in BPH and prostate cancer: an in vitro model for assessment 显示文摘 | Weingartner K Ben Sasson SA Stewart R | 1998 | J Urol1998，159，2： | 1 |
| 16 | Scaling of Terahertz Radiation via Optical Rectification in Electro-optic Crystals显示文摘 | Carrig T J Rodriguez G Stewart K R | 1995 | Appl Phys Lett1995，66，： | 1 |
| 17 | Arsenic extraction and speciation in carrots using accelerated solvent extraction, liquid chromatography and plasma mass spectrometry显示文摘 | VELA N P HEITKEMPER D T STEWART K R | 2001 | Analyst2001，126，7： | 1 |
| 18 | Humanglutathione S-transferase P1 polymorphisms: relationship to lung tissue enzyme activity and population frequency distribution显示文摘 | Watson M A Stewart R K Smith G B | 1998 | Carci nogenesis1998，19，2： | 1 |
| 19 | Moisture transport and other hydrometererelogyical features associated with the severe 2000/01 drought over the weatem central Canadian Prairies 显示文摘 | Liu J L Stewart R E Szeto K K | 2004 | Journal of Climate2004，17，： | 1 |
| 20 | Soil carbon satura- tion: implications for measurable carbon pool dynamics in long - term incubations 显示文摘 | Stewart C E Paustian K Conant R T | 2009 | Soil Biology & Biochemistry2009，41，： | 1 |
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