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| 1 | Metastatic colorectal cancer-past,progress and future显示文摘The clinical management of metastatic (stage Ⅳ) colorectal cancer (CRC) is a common challenge faced by surgeons and physicians. The last decade has seen exciting developments in the management of CRC, with significant improvements in prognosis for patients diagnosed with stage Ⅳ disease. Treatment options have expanded from 5-fluorouracil alone to a range of pharmaceutical and interventional therapies, improving survival, and providing a cure in selected cases. Enhanced understanding of the biologic pathways most important in colorectal carcinogenesis has led to a new generation of drugs showing promise in advanced disease. It is hoped that in the near future the treatment paradigm of metastatic CRC will be analogous to that of a chronic illness, rather than a rapidly terminal condition. This overview discusses the epidemiology of advanced CRC and currently available therapeutic options including medical, surgical, ablative and novel modalities in the management of metastatic colorectal cancer. | Kathryn Field Lara Lipton | 2007 | World Journal of Gastroenterology2007，13，28： | 8 |
| 2 | Adjuvant therapies for colorectal cancer显示文摘The management of colon and rectal cancer has changed dramatically over the last 25 years. The use of adjuvant therapies has become standard practice in locally advanced (stage Ⅲ and selected stage Ⅱ) colorectal cancer. Improved surgical techniques, chemotherapeutics and radiotherapy are resulting in higher cure rates and the development of agents targeting proliferative and angiogenic pathways offer further promise. Here we explore risk factors for local and distant recurrence after resection of colon and rectal cancer, and the role of adjuvant treatments. Discussion will focus on the evidence base for adjuvant therapies utilised in colorectal cancer, and the treatment of sub-groups such as the elderly and stage Ⅱ disease. The role of adjuvant radiotherapy in rectal cancer in reduction of recurrence will be explored and the role and optimal methods for surveillance post-curative resection with or without adjuvant therapy will also be addressed. | Suzanne Kosmider Lara Lipton | 2007 | World Journal of Gastroenterology2007，13，28： | 7 |
| 3 | Small molecules enable OCT4-mediated direct reprogramming into expandable human neural stem cells显示文摘 | Saiyong Zhu Raiesh Ambasudhan Woong Sun Hyun Jung Kim Maria Talantova Xiaojing Wang Mingliang Zhang Yu Zhang Timothy Laurent James Parker Han-Seop Kim Jeffrey D Zaremba Sofiyan Saleem Sara Sanz-Blasco Eliezer Masliah Scott R McKercher Yee Sook Cho Stuart A Lipton Janghwan Kim Sheng Ding | 2014 | Cell Research2014，24，1： | 6 |
| 4 | 中国:如何维持平衡的增长显示文摘 | Richard Hausmann Michael Lipton 楼继伟 余永定 | 2006 | 国际经济评论2006，，4： | 4 |
| 5 | Nutrient dynamics in the Sundarbans mangrove estuarine system of Bangladesh under different weather and tidal cycles显示文摘Introduction:Seasonal and tidal variations in nutrient concentration and water quality were investigated in the western Sundarbans of Bangladesh during the post-monsoon,winter and monsoon seasons during 2010–2011.Methods:Water collected from the surface,middle and bottom layers at six locations of the Kholpetua-Arpangashia river system during high and low tides was analyzed for temperature,salinity,pH,dissolved oxygen(DO),total dissolved solids(TDS),electrical conductivity(EC)and dissolved nutrients(NO3–N,PO4–P,SO4 and NH3–N).Results:The study revealed that nutrient concentrations were influenced by seasonal changes.Mean nutrient levels during post-monsoon,winter and monsoon seasons,respectively,were in the following ranges:nitrate(0.06–0.40,0.06–0.46 and 0.08–0.46 mg/L);phosphate(0.09–0.18,0.05–0.42 and 0.10–0.16 mg/L);sulphate(58.71–86.14,68.68–119.01 and 78.15–136.47 mg/L)and ammonia(0.02–0.08,0.02–0.04 and 0.26–0.38 mg/L).Increased levels of PO4–P,SO4 and NH3–N and lower DO and salinity were recorded during the monsoon period.Most of the experimental sites showed higher NO3–N content during monsoon,whereas few elevated concentrations were observed during post-monsoon and winter periods.High and low tidal waters contained mean nutrient levels in the following ranges:nitrate(0.05–0.46 and 0.04–0.40 mg/L);phosphate(0.05–0.42 and 0.07–0.18 mg/L);sulphate(63.63–125.36 and 58.71–136.47 mg/L)and ammonia(0.02–0.38 and 0.02–0.37 mg/L)without following any distinct fluctuation patterns.The western part of the Sundarbans receives less freshwater input during the monsoon season than other areas of the ecosystem,which reduces the variability of nutrient levels and water quality components.Conclusions:This study provides considerable advances in understanding the seasonality of nutrient distribution with possible tidal influence.The data generated from this study will guide continuing efforts to support a sound management for coastal mangrove ecosystems. | Shak Md Bazlur Rahaman Lipton Sarder Md Sayadur Rahaman Alokesh Kumar Ghosh Sudhin Kumar Biswas SM Shahjahan Siraj Khandaker Anisul Huq Abul Farah Md Hasanuzzaman Shikder Saiful Islam | 2013 | Ecological Processes2013，2，1： | 2 |
| 6 | Epidemiology of constipation (EPOC) study in the United States: relation of clinical subtypes to sociodemographic features显示文摘 | Walter F Stewart Joshua N Liberman Robert S Sandler Michael S Woods Annette Stemhagen Elsbeth Chee Richard B Lipton Christina E Farup | 1999 | The American Journal of Gastroenterology1999，，12： | 2 |
| 7 | Migraine prevalence, disease burden, and the need for preventive therapy显示文摘 | R B. Lipton M E. Bigal M Diamond F Freitag M L. Reed W F. Stewart | 2007 | Neurology2007，，5： | 2 |
| 8 | 输血相关的急性肺损伤显示文摘TRALI是美国目前最常见的输血引起死亡的原因,超过ABO不相容和细菌污染。虽然仍不知道美国TRALI的实际发生率,但随着认识的提高,文献中TRALI病例报告数量自1985年以来显著增加。但对输血引起的许多类似的临床并发症仍然缺乏了解。2004年4月,在加拿大的多伦多召开了一次题为“关于TRALI的认识”的交流讨论会议。由加拿大血液机构和Hma-Qubec发起会议,得到了国际输血协会下属的BEST(Biomedical Excellence for Safer Transfusion)委员会的支持。许多专家提供了资料,大约240人出席了会议,包括会议专业组的11名成员。他们广泛代表了内科和其他学科的专家,如输血医学、流行病学、免疫学、麻醉学、急救医学、伦理学以及定期捐血者和长期受血者。完整的会议记录已经发表。 | Mintz PD Lipton KS 赵国胜(节译) 贾苍松(校) | 2007 | 国际输血及血液学杂志2007，30，2： | 2 |
| 9 | 山地坡度与坡向对卫星地面温度反演及中尺度分析的影响显示文摘在山区一个卫星视场内温度差异可能很大,这使得山区地面温度反演变得更加复杂,温度与山坡相对于太阳的朝向有关,它在很短的距离内可以相差很大。由卫星测得的地面温度偏向于直接面向卫星的亚视场地面元的温度。本文对科罗拉多中部卫星对地观测的星视几何状况对地面温度反演的影响进行了数值模拟。用一个中尺度模式计算了地面温度,对坡向与坡度角的次网格变化进行了参数化。模拟表明,在科罗拉多山区秋季坡度坡向的影响可以导致局地地面温度变化达30℃。在实际卫星观测条件下反演的地面温度偏差达3℃。不同视角的两颗卫星得出的相对温度偏差可以超过6℃,这还会导致在合并多个数据集时发生混乱。这种偏差的计算受到现有地形高度资料分辨率(约90米)的限制。结果表明如果资料分辨率精细足以表示科罗拉多的详细地形状况或者在陡坡所占比例大于科罗拉多落基山脉的山岳地区做反演,那末偏差会非常大。按照模拟计算出的科罗拉多地区的偏差梯度还未大到足以显著改变周日上坡-下坡环流的强迫作用,模拟中考虑了视角偏差的地面温度反演值被同化到在时间上连续的分析中。由于这种视角偏差引起的误差是系统性的,反演的视角偏差对依赖于遥感资料的气候分析就可能密切有关了。 | Alan E. Lipton 陆文杰 | 1993 | 气象科技1993，21，3： | 2 |
| 10 | The medical management of migraine显示文摘 | Bigal ME Lipton RB Krymchantowski AV | 2004 | Am J Ther2004，11，： | 1 |
| 11 | Transplantation-associated thrombotic microangiopathy: twenty-two years later 显示文摘 | Daly AS Xenocostas A Lipton JH | 2002 | Bone Marrow Transplant2002，30，11： | 1 |
| 12 | Denosumab compared with zoledronic acid for the treatment of bone metastases in pa tients with advanced breast cancer: a randomized, double-blind study显示文摘 | Stopeck A T Lipton A Body J J | 2010 | J Clin Oncol2010，28，35： | 1 |
| 13 | Impact of skeletal complications on patients' quality of life, mobility, and functional independence显示文摘 | Costa L Badia X Chow E Lipton A Wardley A | 2008 | Support Care Cancer2008，16，8： | 1 |
| 14 | Tumor necrosis factoralpha is toxic to embryonic mesencephalic dopamine neurons显示文摘 | McGuire SO Ling ZD Lipton JW | 2001 | Exp Neurol2001，169，2： | 1 |
| 15 | Suppression of neuron apoptosis by S nitroslation of caspases显示文摘 | TENNETI L D'EMILIA DM LIPTON SA | 1997 | Neurosci Lett1997，236，3： | 1 |
| 16 | Isohemic cell death in brain neurous显示文摘 | Lipton P | 1999 | Physiol Rev1999，79，： | 1 |
| 17 | Nerve growth factor prevents toxic neuropathy in mice 显示文摘 | APFEL SC LIPTON RB AREZZO JC | 1991 | Ann Neurol1991，29，1： | 1 |
| 18 | Surgical treatment of seoliosis in Marfan syndrome:guidelines for a suecessful outcome显示文摘 | Lipton GE Guille JT Kumar SJ | 2002 | J Pediatr Orthop2002，22，3： | 1 |
| 19 | Selection and characterization of a BHK-21 cell line resistant to infection by Theiler's murine encephalomyelitis virus due to a block in virus attachment and entry显示文摘 | Hertzler S Trottier M Lipton HL | 2000 | J Gen Virol2000，81，： | 1 |
| 20 | Premonitory symptoms in migraine : an electronic diary study显示文摘 | Giffin NJ Ruggiero L Lipton RB | 2003 | Neu- rology2003，60，： | 1 |
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