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| 1 | HPV阴性胃型子宫颈原位腺癌:一种具有胃和肠分化的罕见病变谱系显示文摘作者报道9例罕见的具有胃和肠分化且与人类乳头瘤病毒(HPV)感染无关的子宫颈原位腺癌(AIS)。患者年龄25~73岁(平均51岁),所有病例均位于子宫颈鳞一柱交界区(或邻近),其中有3例延伸子宫下段,2例累及子宫内膜。所有病例均大部分保留正常子宫颈腺体结构,其中5例有轻度腺体复杂性增生。腺上皮从几乎为纯胃型(4例)至混合不同比例杯状细胞的胃肠型(5例)。与正常的子宫颈腺体嗜碱性细胞质不同,胃型上皮通常由明显嗜酸性或浅粉色胞质的细胞组成,但在某些病例中胞质呈明显的泡沫状或透明胞质。所有病例均有核非典型性, | Talia K L Stewart C J R Howitt B E 黄爱清(摘译) 余英豪(审校) | 2017 | 临床与实验病理学杂志2017，33，11： | 19 |
| 2 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 3 | Gynecologic oncologists involvement on ovarian cancer standard of care receipt and survival显示文摘AIM:To examine the influence of gynecologic oncolo-gists(GO) in the United States on surgical/chemotherapeutic standard of care(SOC), and how this translates into improved survival among women with ovarian cancer(OC).METHODS: Surveillance, Epidemiology, and End Result(SEER)-Medicare data were used to identify 11688 OC patients(1992-2006). Only Medicare recipients with an initial surgical procedure code(n = 6714) were included. Physician specialty was identified by linking SEER-Medicare to the American Medical Association Masterfile. SOC was defined by a panel of GOs. Multivariate logistic regression was used to determine predictors of receiving surgical/chemotherapeutic SOCand proportional hazards modeling to estimate the effect of SOC treatment and physician specialty on survival. RESULTS: About 34% received surgery from a GO and 25% received the overall SOC. One-third of women had a GO involved sometime during their care. Women receiving surgery from a GO vs non-GO had 2.35 times the odds of receiving the surgical SOC and 1.25 times the odds of receiving chemotherapeutic SOC(P < 0.01). Risk of mortality was greater among women not receiving surgical SOC compared to those who did [hazard ratio = 1.22(95%CI: 1.12-1.33), P < 0.01], and also was higher among women seen by non-GOs vs GOs(for surgical treatment) after adjusting for covariates. Median survival time was 14 mo longer for women receiving combined SOC. CONCLUSION: A survival advantage associated with receiving surgical SOC and overall treatment by a GO is supported. Persistent survival differences, particularly among those not receiving the SOC, require further investigation. | Sun Hee Rim Shawn Hirsch Cheryll C Thomas Wendy R Brewster Darryl Cooney Trevor D Thompson Sherri L Stewart | 2016 | World Journal of Obstetrics and Gynecology2016，5，2： | 3 |
| 4 | 子宫炎性肌纤维母细胞肿瘤通常存在ALK与IGFBP5和THBS1基因的融合显示文摘炎性肌纤维母细胞肿瘤能够发生在包括子宫在内的多个解剖部位。子宫炎性肌纤维母细胞肿瘤与发生在软组织的炎性肌纤维母细胞肿瘤相似,也通常表达ALK,并存在ALK基因重排。该文着重分析子宫炎性肌纤维母细胞肿瘤的基因融合特征。 | Haimes J D Stewart C J R Kudlow B A 赵芳 魏建国 | 2018 | 临床与实验病理学杂志2018，34，1： | 2 |
| 5 | SCTP:New Transport Protocol for TCP/IP 显示文摘 | Stewart R Metz C | 2001 | IEEE Internet Computing2001，，6： | 2 |
| 6 | Scientific charge-coupled devices显示文摘 | JANESICK J R TOM E STEWART C | 1987 | Optical Engineering1987，26，8： | 2 |
| 7 | Computationally Attractive Real Gabor Transforms 显示文摘 | Stewart D F Potter L C Ahalt S C | 1995 | IEEE Transactions on Signal Processing1995，43，1： | 1 |
| 8 | Extensive butyltin contamination in southwestern coastal British Columbia显示文摘 | Stewart C Thompson J A J | 1994 | Marine Pollution Bulletin1994，28，： | 1 |
| 9 | Lipid peroxidation associated with accelerated aging of soybean axes 显示文摘 | Stewart R R C Bewley J D | 1980 | Plant Physiology1980，65，2： | 1 |
| 10 | Inhalation of ultrafine particles alters blood leukocyte expression of adhesion molecules in humans 显示文摘 | FRAMPTON M W STEWART J C OBERDORSTER G | 2006 | Environ Health Perspect2006，114，1： | 1 |
| 11 | New approaches to the synthesis of functionalized fluorine -containing polymers显示文摘 | GRAINGER D W STEWART C W | 2001 | ACS Symposium Series2001，17，： | 1 |
| 12 | Spatial variability of evaporation derived from aircraft and ground-based data显示文摘 | HOLWILL C J STEWART J B | 1992 | J Geophys Res1992，97，18： | 1 |
| 13 | Self- confidence of young girl in physical activity and sport显示文摘 | Stewart N J Corbin C B | 1989 | Runner1989，4，： | 1 |
| 14 | Consensus guidelines for the management of women with cervical intraepithelial neoplasia 显示文摘 | Thomas CW Thomas C Stewart M | 2003 | Am J Obstet Gynecol2003，189，： | 1 |
| 15 | CD147 (EMMPRIN) and matrix metallopro- teinase-2 expression in uterine endometrioid adenocarcinoma 显示文摘 | Stewart C J Crook ML | 2011 | Pathol Res Pract2011，207，1： | 1 |
| 16 | Expression and activity of the CDK inhibitor p57 Kip2 in chondrocytes undergoing hypertrophic differentiation 显示文摘 | Stewart M C Kadlcek R M Robbins P D | 2004 | J Bone Miner Res2004，19，1： | 1 |
| 17 | An integrated mental health clinical rotation显示文摘 | Roberts KT Robinson KM Stewart C | 2009 | J Nurs Educ2009，48，8： | 1 |
| 18 | Microdosimetric properties of ionizing electrons in water显示文摘 | STEWART R D WILSON W E MCDONALD J C | 2002 | Phys Med Biol2002，47，1： | 1 |
| 19 | Fusobacterium necrophorum leukotoxin indnces activation and apopotosis of bovine leukocytes显示文摘 | NARAYANAN S K STEWART G C CHENGAPPA M M | 2002 | Infect Immun2002，70，： | 1 |
| 20 | Removal and inactivation of Staphylococcus epidermidis biofilms by electrolysis显示文摘 | Rabinovitch C Stewart PS | 2006 | Appl Environ Microbiol2006，72，9： | 1 |
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