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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Studies on flaovr volatiles of some sweet corn products显示文摘 | Buttery R G Stern D J Ling L C | 1982 | Journal of Agricultural and Food Chemistry1982，30，： | 1 |
| 3 | Nanostructured hydrotreating catalysts for electrochemical hydrogen evolution显示文摘 | Morales-Guio C G Stern L-A Hu X L | 2014 | Chemical Society Reviews2014，43，18： | 1 |
| 4 | Catalytic dehydrogenation (DH) of light paraffins combined with selective hydrogen combustion (SHC) : I DH-SHC-DH catalysts in series (co-fed process mode) 显示文摘 | GRASSELLI R K STERN D L TSIKOYIANNIS J G | 1999 | Appl Catal A1999，189，1： | 1 |
| 5 | Catalytic dehydrogenation (DH) of light paraffins combined with selective hydrogen combustion (SHC) : II DH+SHC catalysts physically mixed (redox process mode) 显示文摘 | GRASSELLI R K STERN D L TSIKOYIANNIS J G | 1999 | Appl Catal A1999，189，1： | 1 |
| 6 | PAHs, PCBs,PCNs, organochlorine pesticides, synthetic musks, and polychlorinated n-alkanes in UK sewage sludge: survey results and implications 显示文摘 | Stevens J L Northeott G L Stern G A | 2003 | Environmental Science & Technology2003，37，46： | 1 |
| 7 | Hyaluronic acid: a natural biopolymer with a broad range of biomedical and industrial applications显示文摘 | Kogan G Solt6s L Stern R | 2007 | Biotechnol Lett2007，29，1： | 1 |
| 8 | A value-belief-norm theory of support for social movements:The case of environmentalism显示文摘 | Stern P C Dietz T Abel T D Guagnano G A Kalof L (1999) | 1999 | Human Ecology Review1999，6，2： | 1 |
| 9 | Hyaluronic acid: a natural biopolymer with a broad range of biomed- ical and industrial applications 显示文摘 | KOGAN G SOLTES L STERN R | 2007 | Biotechnology Let- ters2007，29，1： | 1 |
| 10 | A Kazal prolyl endopeptidase inhibitor isolated from the skin of Phyllomedusa sauvagii 显示文摘 | Gebhard L G Carrizo F U Stern A L | 2004 | Eur J Siochem2004，271，11： | 1 |
| 11 | 查看详情显示文摘 | Woo J H Treu T Barth A J Wright S A Walsh J L Bentz M C Martini P Bennert A N Canalizo G Filippenko A V Gates E Greene J Malkan M A Stern D Minezaki T | | 0，，： | 1 |
| 12 | Multiple neuro- logic, psychiatric, and endocrine complaints in a young woman: a case discussion and review of the clinical fea- tures and management of mitochondrial myopathy, en- cephalopathy, lactic acidosis, and stroke显示文摘 | Bhuvaneswar C G Coetz J L Stern T A | 2008 | Prim Care Companion J Clin Psychiatry2008，10，23： | 1 |
| 13 | Hyaluronic acid : a natural biopolymer with a broad range of biomed- ical and industrial applications 显示文摘 | KOGAN G OLTES L STERN R | 2007 | Biotechnology let-ters2007，29，1： | 1 |
| 14 | Golgi biogenesis in Toxoplasma gondii显示文摘 | Pelletier L Stern CA Pypaert M Sheff D Ngo HM Roper N He CY Hu K Toomre D Coppens I Roos DS Joiner KA Warren G | 2002 | Nature2002，418，6897： | 1 |
| 15 | Epithermal and por-phyry deposits:The adakite connection显示文摘 | Thieblemont D Stern G Lescuyer J L | 1997 | Earth and Plane-tary Science Letters1997，325，： | 1 |
| 16 | Anonlin- eardosimetric model for hemoglobin adduct formation by the neu- rotoxic agent acrylamide and its genotoxic metabolite glycidamide 显示文摘 | CALLEMAN C J BERGMARK E STERN L G | 1993 | Environmental Health Perspectives1993，99，： | 1 |
| 17 | The first Australian experience of heterotopic grafting of cryopreserved ovarian tissue:Evidence of establishment of normal ovarian function显示文摘 | Stern C J Toledo M G Hale L G | 2011 | Aust N Z J Obstet Gynaecol2011，51，3： | 1 |
| 18 | Partial depletion of sarcoplasmic reticulum calcium does not prevent calcium sparks in rat ventricular myocytes显示文摘 | Stern M D Lakatta E G | 1997 | Physiol1997，505，3： | 1 |
| 19 | PAHs, PCBs, PCNs, organochlorine pesticides, synthetic musks, and polychlorinated n-alkanes in UK sewage sludge: survey results and implications 显示文摘 | STEVENS J L NORTHCOTT G L STERN G A | 2003 | Environ Sci Technol2003，37，： | 1 |
| 20 | PAHs, PCBs, PCNs, organochlorine pesticides, synthetic musks, and polychlorinated n- alkanes in UK sewage sludge: Survey results and implications 显示文摘 | Stevens J L Northcott G L Stern G A | 2003 | Environ Sci Technol2003，37，3： | 1 |
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