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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease显示文摘 | TANG M X JACOBS D STERN Y | 1996 | Lancet1996，348，9025： | 1 |
| 3 | Timing of initiation ofantiretroviral therapy in AIDS-free HIV-1-infected patients: acol-iaborative analysis of 18 HIV cohort studies 显示文摘 | Sterne JA May M Costagliola D | 2009 | Lancet2009，373，9672： | 1 |
| 4 | High incidence of cardiovascular events in a rheumatoid arthritis cohort not explained by traditional cardiac risk factors显示文摘 | RINCON I D WILLIAMS K STERN M P | 2001 | Arthritis Rheum2001，44，12： | 1 |
| 5 | MDS clinical diagnostic criteria for Parkinson's disease显示文摘 | Postuma RB Berg D Stern M | 2015 | Mov Disord2015，30，12： | 1 |
| 6 | On the drag and virtual mass coefficients in Biot's equations显示文摘 | Bedford A Costley R D Stern M | 1984 | J Acoust Soc Am1984，76，6： | 1 |
| 7 | Effects of different levels of methionine and ruminally undegradable protein on the amino acid profile of effluent from continuous culture fermenters 显示文摘 | Bach A Stern M D | 1999 | J Anim Sci1999，77，： | 1 |
| 8 | XPD codon 751 polymorphism,metabolism genes,smoking,and bladder cancer risk显示文摘 | STERN M C JOHNSON L R BELL D A | 2002 | Cancer Epidemiol Biomarkers Prev2002，11，101： | 1 |
| 9 | Economic Growth and Environment Degradation: A Critique of the Environmental Kuznets Curve显示文摘 | Stern D I Common M S Barbier E B | 1996 | Word Development1996，7，： | 1 |
| 10 | Evaluation of a mathematical model of rnmen digestion and an in vitro simulation of rumen proteolysis to estimate the rumen- undegraded nitrogen content of feedstuffs显示文摘 | Krishnamoorthy U Sniffen C J Stern M D | 1983 | Brit J Nutr1983，50，3： | 1 |
| 11 | A Three-Step In VitroProcedure for Esti- mating Iniestinal Digestion of Protein in Ruminants 显示文摘 | Calsamiglia S Stern M D | 1995 | J Anim Sci1995，73，： | 1 |
| 12 | Role of the JAK/STAT signaling pathway in diabetic nephropathy显示文摘 | Marrero M B Banes-Berceli A K Stern D M Eaton D C | 2006 | Am J Physiol2006，290，4： | 1 |
| 13 | Effects of soybean hulls and lignosulfonate- treated soybean meal on ruminal fermentation in lactating dairy cows 显示文摘 | Mansfield H R Stern M D | 1994 | J Dairy Sci1994，77，： | 1 |
| 14 | Genetics and genomics of chloroplast biogenesis: maize as a model system 显示文摘 | Stern D B Hanson M R Barkan A | 2004 | Trends in plant science2004，9，6： | 1 |
| 15 | Is There An Environmental KuznetsCurve forSulfur- 显示文摘 | Stern D I Common M S | 1998 | Journal of Environmental Economicsand Management1998，41，2： | 1 |
| 16 | Effects of protein source on nitrogen metabolism in continuous culture and intestinal digestion in vitro显示文摘 | Calsamiglia S Stern M D Firkins J L | 2005 | J Anita Sci2005，73，： | 1 |
| 17 | Evaluation of mathraatical of digestion and in vitro simulation of rumen proteolysis to estimate the rumen undegxaded nitrogen content of feedstuffs显示文摘 | Krishnamoorthy U C Siffen C J Stern M D | 1983 | British Journal of Nutrition1983，50，55： | 1 |
| 18 | MDS clinical diagnostic criteria for Parkinson's disease 显示文摘 | Postuma RB Berg D Stern M Poewe W Olanow CW Oertel W Obeso J Marek K Litvan I Lang AE Halliday G Goetz CG Gasser T Dubois B Chan P Bloem BR Adler CH Deuschl G | 2015 | Mov Disord2015，30，12： | 1 |
| 19 | Theory of excitation-contraction coupling in cardiac muscle显示文摘 | Stern M D | 1992 | Biophys J1992，63，2： | 1 |
| 20 | Influence of branched-chain volatile fatty acids on fiber digestion in continuous culture of rumen contents显示文摘 | Stern M D | 1985 | Sci1985，59，： | 1 |
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