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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | 踝关节创伤后关节炎的相关危险因素:一项随访18年的回顾性研究显示文摘踝关节创伤后关节炎十分常见,其发生率比髋膝关节高得多,而目前对其危险因素评估的长期随访研究报道很少。作者对1988年1月-1997年12月的373例进行切开复位内固定的踝关节骨折进行了回顾性研究,并进行统计学分析。Pilon骨折、距骨骨折及年龄〈18岁者未纳入研究。 | Lübbeke A Salvo D Stern R Hoffmeyer P Holzer N Assal M. 于涛 俞光荣 | 2012 | 中国矫形外科杂志2012，20，18： | 14 |
| 3 | 从微孔洞起始的热冲击裂纹的数值研究——Ⅰ:热应力分析显示文摘陶瓷材料在热冲击荷载作用下的典型破坏模式是裂纹的起始和扩展。当高温的材料或构件突然处于低温环境时 ,裂纹将由材料或构件的表面开始产生和发展。因此 ,材料表面及其表面附近的材料微结构对裂纹的起始有着非常重要的影响。实验表明 :某些具有微孔洞结构的陶瓷材料比相应的密实材料的抗热冲击性能有所提高 ,但相关的机制目前还没有得到定量的解释。本文作者利用商业有限元软件 ABAQUS,分析了受热冲击表面上的开口微孔洞、处于表面附近的闭口微孔洞周围的热应力场 ,以及微孔洞的大小、微孔洞与表面的距离对热应力场的影响 ,其目的是为进一步分析裂纹的起始和扩展做准备。数值结果表明 :一般情况下 ,闭口微孔洞引起的应力集中比开口微孔洞引起的应力集中更为严重 ,特别当闭口微孔洞与表面之间的距离很小时 ,和没有微孔洞情况相比 ,闭口微孔洞引起的最大的应力集中系数超过 | 贺鹏飞 李京剑 Yuan C Stern R Clegg W J | 2002 | 复合材料学报2002，19，5： | 5 |
| 4 | 金刚石中硫同位素组成揭示大陆形成过程的差异性显示文摘厚的岩石圈地幔的出现使得地球古老大陆变得稳定,然而关于这些古老大陆岩石圈地幔的形成却存在不同的成因解释。一些学者认为古老的大陆岩石圈地幔可通过俯冲洋壳平流增厚或堆叠等水平构造过程形成,而其他学者则认为地幔柱增生、海洋高原基底的熔融或地幔柱熔融残留物的底辟作用等垂向构造过程,在古老大陆岩石群地幔的形成过程中扮演了重要角色。目前,关于最早岩石圈的形成是通过水平还是垂向增生方式完成依然存在很大的争议,而不同的增生模式对于理解地球早期演化和板块作用的起始时限具有完全不同的意义。 | Smit K V Shirey S B Hauri E H Stern R A 袁超 | 2019 | 矿物岩石地球化学通报2019，38，5： | 5 |
| 5 | Correlation of endoscopic disease severity with pediatric ulcerative colitis activity index score in children and young adults with ulcerative colitis显示文摘AIM To investigate of pediatric ulcerative colitis activity index(PUCAI) in ulcerative colitis correlate with mucosal inflammation and endoscopic assessment of disease activity(Mayo endoscopic score).METHODS We reviewed charts from ulcerative colitis patients who had undergone both colonoscopy over 3 years. Clinical assessment of disease severity within 35 d(either before or after) the colonoscopy were included. Patients were excluded if they had significant therapeutic interventions(such as the start of corticosteroids or immunosuppressive agents) between the colonoscopy and the clinical assessment. Mayoendoscopic score of the rectum and sigmoid were done by two gastroenterologists. Inter-observer variability in Mayo score was assessed.RESULTS We identified 99 patients(53% female, 74% pancolitis) that met inclusion criteria. The indications for colonoscopy included ongoing disease activity(62%), consideration of medication change(10%), assessment of medication efficacy(14%), and cancer screening(14%). Based on PUCAI scores, 33% of patients were in remission, 39% had mild disease, 23% had moderate disease, and 4% had severe disease. There was 'moderate-substantial' agreement between the two reviewers in assessing rectal Mayo scores(kappa = 0.54, 95%CI: 0.41-0.68). CONCLUSION Endoscopic disease severity(Mayo score) assessed by reviewing photographs of pediatric colonoscopy has moderate inter-rater reliability, and agreement was less robust in assessing patients with mild disease activity. Endoscopic disease severity generally correlates with clinical disease severity as measured by PUCAI score. However, children with inflamed colons can have significant variation in their reported clinical symptoms. Thus, assessment of both clinical symptoms and endoscopic disease severity may be required in future clinical studies. | Basavaraj Kerur Heather J Litman Julia Bender Stern Sarah Weber Jenifer R Lightdale Paul A Rufo Athos Bousvaros | 2017 | World Journal of Gastroenterology2017，23，18： | 5 |
| 6 | 从微孔洞起始的热冲击裂纹的数值研究——Ⅱ:能量释放率分析显示文摘利用商业的有限元软件 ABAQU S,分析了具有微孔洞结构氧化铝陶瓷材料在受到热冲击作用下 ,从处于材料表面上的开口微孔洞以及临近材料表面的闭口微孔洞的底部起始的裂纹扩展。结果表明 :对于从开口微孔洞和闭口微孔洞底部起始的裂纹 ,其能量释放率随冷却时间的变化规律类似 ,即随冷却时间 t由零开始增加 ,能量释放率也由零开始快速增大 ,在冷却时间大约为 t=0 .1s时 ,达到其最大值 ,随后开始降低。另外对于从开口微孔洞底部起始的裂纹 ,结果发现裂纹的能量释放率随裂纹长度的增加、微孔洞半径的增加而增加 ,而对于从闭口微孔洞底部起始的裂纹 ,其能量释放率随裂纹长度的增加、微孔洞半径的增加、以及微孔洞与材料受热冲击面距离的增加而增加。以开口微孔洞底部起始的裂纹为例 ,研究了裂纹与临近微孔洞之间的作用 ,发现临近微孔洞的存在可以明显减小裂纹的能量释放率。 | 贺鹏飞 李京剑 Yuan C Stern R Clegg W J | 2002 | 复合材料学报2002，19，5： | 2 |
| 7 | Assessing Reseller Performance from the Perspective of the Supplier显示文摘 | KUMAR N STERN L W ACHROL R S | 1992 | Journal of Marketing Research1992，29，5： | 1 |
| 8 | SFBs of Japanese plum(Prunussalicina):Cloning seven alleles and determining their linkage to the S-RNase gene显示文摘 | SAPIR G STERN R A GOLDWAY M | 2007 | Hortscience2007，42，7： | 1 |
| 9 | Dimethylni trosamine induced liver injury in rats:the early deposition of collagen显示文摘 | George J Rao KR Stern R | 2001 | Toxicology2001，，156： | 1 |
| 10 | A new Lagrangian model of Arctic sea ice显示文摘 | LINDSAY R W STERN H L | 2004 | Journal of Physical Oceanography2004，34，： | 1 |
| 11 | Enriched back-arc basin basalts from the northern Mariana Trough:Implications for the magmatic evolution of back-arc basins显示文摘 | STERN R J LIN P MORRIS J D | 1990 | Earth and Planetary Science Letters1990，100，： | 1 |
| 12 | The Palomo procedure in thetreatment of boys with varicocele : a retrospective study of testieu-lar growth and fertility显示文摘 | Stern R Kistler W Seharli AF | 1998 | Pediatr Surg Int1998，14，12： | 1 |
| 13 | Bilateral intralobar pulmonary sequestration in a newborn, case report and review of the literature on bilateral pulmonary sequestrations显示文摘 | Stern R Berger S Casauha C | 2007 | J Pediatr Surg2007，42，4： | 1 |
| 14 | Indefinite trust region subproblems and nonsymmetric eigenvalue perturbatious显示文摘 | Stern R Wolkewiez H | 1995 | SIAM J Optim1995，5，2： | 1 |
| 15 | Mushrooms,Tumors, and Irnmunily 显示文摘 | Borchers A T Stern J S Hanckman R M | 1999 | Proceedings of the Society for Experimental Biology and Medicine1999，221，： | 1 |
| 16 | Mapping Gossans inArid Regions with Landsat TM and SIR-C Images:the BeddahoAlteration Zone in Northern Eritrea显示文摘 | Abdelsalam M G Stern R J Berhane W G | 2000 | Journal of African EarthSciences2000，30，4： | 1 |
| 17 | Research on teachers' pedagogical thoughts, judgments, decisions, and behavior显示文摘 | Shavelson R J and Stern P | 1981 | Review of Educational Reaearch1981，1981，51： | 1 |
| 18 | Structure/permeability relationships of siliconcontaining polyimides显示文摘 | Stern S A Vaidyanathan R | 1990 | Journal of Membrane Science1990，49，1： | 1 |
| 19 | Mauritius' lychee fruitdevelopment and reduced abscission after treatment with the auxin2,4,5-TP显示文摘 | Stern R A Kigel J Tomer E | 1995 | JAmer Soc Hort Sci1995，120，1： | 1 |
| 20 | Are there advances in the treatment of extracapsular hip fractures in the elderly 显示文摘 | Stern R | 2007 | Injury2007，39，1： | 1 |
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