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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | SFBs of Japanese plum(Prunussalicina):Cloning seven alleles and determining their linkage to the S-RNase gene显示文摘 | SAPIR G STERN R A GOLDWAY M | 2007 | Hortscience2007，42，7： | 1 |
| 3 | Corticotropin-releasing factor and urocortin 1 activate CREB through functionally selective G/ signalling in hippocampal pyramidal neurons显示文摘 | Stern C M Meitzen J Mermelstein P G | 2011 | Eur J Neurosci2011，34，5： | 1 |
| 4 | Subthalamic GAD gene transfer in Parkinson disease patients who are candidates for deep brain stimulation显示文摘 | During M J Kaplitt M G Stern M B | 2001 | Hum Gene Ther2001，12，12： | 1 |
| 5 | Akinetic freezing and trick move- ments in Parkinson's disease 显示文摘 | Stern G Lander C Lees A | 1980 | J Neural Transm Suppl1980，，16： | 1 |
| 6 | Mapping Gossans inArid Regions with Landsat TM and SIR-C Images:the BeddahoAlteration Zone in Northern Eritrea显示文摘 | Abdelsalam M G Stern R J Berhane W G | 2000 | Journal of African EarthSciences2000，30，4： | 1 |
| 7 | Compound specific δ13C analyses of leaf lipids from plants with differing carbon dioxide metabolisms显示文摘 | Collister J W Rieley G Stern B | 1994 | Organic Geochemistry1994，21，： | 1 |
| 8 | The polyester polyurethanase gene (pue A) from Pseudomonas chlororaphis encodes a lipase 显示文摘 | STERN R V HOWARD G T | 2000 | FEMS Microbiol Lett2000，185，： | 1 |
| 9 | Stability measurements of 1 -stage implants in the edentulous mandi- ble by means of resonance frequency analysis 显示文摘 | Kessler- Liechti G Zix J Mericske- Stern R | 2008 | Int J Oral Maxillofac Implants2008，23，2： | 1 |
| 10 | Processing and degradation of chloroplast mRNA 显示文摘 | MONDE R A SCHUSTER G STERN D B | 2000 | Biochimie2000，82，67： | 1 |
| 11 | Adipose tissue renin-angiotensin-aldoste-rone system(RAAS) and progression of insulin resistance显示文摘 | Marcus Y Shefer G Stern N | | 0，，： | 1 |
| 12 | Myth and reality in the American college显示文摘 | Stern G G | | 0，，： | 1 |
| 13 | Influences on attitude- behavior relationships: A natural experiment with curbside recy- cling 显示文摘 | GUAGNANO G A STERN P C DIETZ T | 1995 | Environment and Behavior1995，27，5： | 1 |
| 14 | Influences on attitude-behavior relationships: A natural experiment with curbside recycling 显示文摘 | Guagnano G A Stern P C Dietz T | 1995 | Environment and Behavior1995，27，5： | 1 |
| 15 | A New Technique for Shaped Beam Syntbesis of Equi-spaced Atrays显示文摘 | Stern G J | 1984 | IEEE Trans1984，，： | 1 |
| 16 | Trace metal profiles in the varved sediment of an Arctic lake显示文摘 | Outridge P M Stern G A Hamilton P B | 2005 | Geochim Cosmochim Acta2005，69，20： | 1 |
| 17 | Geochemistry, geochronology and petrology of Monte Mucrone: An example of Eo-alpine eclogitization of Permian granitoids in the Sesia-Lanzo zone, western Alps, Italy显示文摘 | Hunziker J C Martinotti G,Stern W B | 1985 | Chemical Geology1985，52，： | 1 |
| 18 | Studies on flaovr volatiles of some sweet corn products显示文摘 | Buttery R G Stern D J Ling L C | 1982 | Journal of Agricultural and Food Chemistry1982，30，： | 1 |
| 19 | Compound-specific δ13C analyses of leaf lipids from plants with differing carbon dioxide metabolisms显示文摘 | Collister J W Rieley G Stern B | 1994 | Org Geochem1994，21，： | 1 |
| 20 | Transarterial emboliza- tion for acute head and neck bleeding: eight-year experi- ence with emphasis on rebleeding risk in cancer patients 显示文摘 | Bachar G Esmat N Stern S | 2013 | Laryngoscope2013，123，5： | 1 |
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