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| 1 | Management of occult hepatitis B virus infection:An update for the clinician显示文摘Occult hepatitis B virus(HBV) infection(OBI) is defined by the presence of HBV DNA in the liver tissue of individuals who test negative for hepatitis B surface antigen(HBsAg).Patients who have recovered from acute hepatitis B can carry HBV genomes for a long time and show histological patterns of mild necro-inflammation,even fibrosis,years after the resolution of acute hepatitis,without showing any clinical or biochemical evidence of liver disease.At least in conditions of immunocompetence,OBI is inoffensive itself,but when other relevant causes of liver damage are present it might make the course of the liver disease worse.The risk of HBV transmission through transfusion is related to blood donations negative for HBsAg that have been collected during the pre-seroconversion period or during chronic OBI.Use of HBV nucleic acid amplification testing and multivalent anti-HBs antibodies in the HBsAg assays is recommended for detection of true and false OBI,respectively.It is not known if prior hepatitis B immunization with an optimal anti-HBs response in cases of HBV transmission through organ transplantation can effectively modulate or abort the infection.Use of anti-viral agents as prophylaxis in patients with serological evidence of past HBV infection prevents reactivation of OBI after transplantation in most cases.Reactivation of OBI has been observed in other conditions that cause immunosuppression,in which antiviral therapy could be delayed until the HBV DNA or HBsAg becomes detectable.OBI might contribute to the progression of liver fibrosis and hepatocellular carcinoma development in patients with chronic liver disease. | JoséLuis Lledó Conrado Fernández María Luisa Gutiérrez Sara Ocaa | 2011 | World Journal of Gastroenterology2011，17，12： | 9 |
| 2 | Optimal management of a patient with recurrent nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma is rare in western countries, accounting for less than 1% of all malignancies. Despite prognosis is satisfactory for newly diagnosed, non-metastatic disease, management of recurrent disease is challenging, with a survival expectancy of approximately 6 mo with the use of chemotherapy as the sole salvage treatment. We report a case of recurrent nasopharyngeal carcinoma treated with a combination of chemotherapy, radiotherapy and surgery in the context of a multidisciplinary approach. A durable complete response was achieved. | Francesco Perri Italo Dell’Oca Paolo Muto Concetta Schiavone Corrado Aversa Franco Fulciniti Raffaele Solla Giuseppina Della Vittoria Scarpati Carlo Buonerba Giuseppe Di Lorenzo Francesco Caponigro | 2014 | World Journal of Clinical Cases2014，2，7： | 8 |
| 3 | Accelerating phase-field-based microstructure evolution predictions via surrogate models trained by machine learning methods显示文摘The phase-field method is a powerful and versatile computational approach for modeling the evolution of microstructures and associated properties for a wide variety of physical,chemical,and biological systems.However,existing high-fidelity phase-field models are inherently computa fonally expensive,requiring high-performance computing resources and sophisticated numefical integration schemes to achieve a useful degree of accuracy.In this paper,we present a computationally inexpensive,accurate,data-driven surmogate model that directly learns the microstructural evolution of targeted systems by combining phase-field and history-dependent machine-learning techniques.We integrate a statisti cally representative,low-dimensianal description of the micrastructure,obtained direcdy from phase-field simulations,with either a time-series multivariate adaptive regression splines autoregressive al garithm or a lang short-term memory neural network.The neural-network-trained surrogate model shows the bestperformance and accurately predicts the nanlinear microstructure evolutian of a two-phase mixture during spinodal decomposition in seconds,without the need for'on-the-fly'solutions of the phase-field equations of motion.We also show that the predictions from our machine learned surrogate model can be fed directly as an input into a classical high-fideli ty phase-field model in order to accelerate the high-fidelity phase field simulations by leaping in time.Such machine-learned phase-field framework opens a promising path forward to use accelerated phase field simulations for discovering,understanding,and predicting processing-microstructure-performance relationships. | David Montes de Oca Zapiain James A.Stewart Rémi Dingreville | 2021 | npj Computational Materials2021，，1： | 4 |
| 4 | 低剂量左旋布比卡因3mg复合芬太尼10μg脊髓麻醉在妇科门诊腹腔镜手术中的应用显示文摘背景对于妇科门诊腹腔镜这种短时手术来说,选择利多卡因进行脊髓麻醉是十分有效的。本研究中,我们对比了利多卡因.芬太尼与左旋布比卡因-芬太尼脊髓麻醉在短时妇科腹腔镜手术中的麻醉效果、麻醉恢复时间和患者满意度。方法在这项双盲研究中,52例拟行输卵管绝育术的健康妇女被随机分为组Ⅰ(椎管内注射2%利多卡因10mg加芬太尼10μg)和组Ⅱ(椎管内注射0.5%左旋布比卡因3mg加芬太尼10μg),每组药物用灭菌水稀释至3ml。术中需要监测以下指标:麻醉起效时间、是否需要补充麻醉一镇痛药物、镇静深度、手术条件以及血流动力学方面的事件。术后,通过测试运动阻滞情况、本体感觉、振动觉、轻触觉和进行Romberg试验来评估患者是否可以不去麻醉恢复室并独立行走。麻醉给药后5、10、15分钟测试感觉阻滞平面,之后每15分钟测试一次直至感觉完全恢复。感觉阻滞恢复时间的差异达25分钟被认为在临床上是有意义的。结果两组的麻醉起效时间和术中条件相同。没有患者需要全身麻醉来完成手术。所有两组患者都不需要去麻醉恢复室。组Ⅰ患者在27分钟(18-45分钟)后可行走,组Ⅱ30分钟(18。56分钟)后可行走(P=0.24)。脊髓麻醉完全恢复组Ⅰ需要93分钟(65-120分钟),组Ⅱ需要105分钟(78-150分钟)(P=0.019);然而,出院时间两组没有区别,组Ⅰ为185分钟(150-300分钟),组Ⅱ为188分钟(125-300分钟)(P=0.62)。两组患者的总体满意度也相似。结论左旋布比卡因3mg复合芬太尼10μg可以替代利多卡因10mg复合芬太尼10μg用于短时手术的脊髓麻醉。前者在临床中可以达到与后者相当的感觉阻滞恢复时间、术中条件和患者满意度。 | Jesus de Santiago, DESA, MD Javier Santos,Yglesias, MD Jorge Giron, MD Frandsco Montes de Oca, MD Alejandro Jimenez, PhDl Pilar Diaz, PhD | 2012 | 麻醉与镇痛2012，8，1： | 3 |
| 5 | New genes emerging for colorectal cancer predisposition显示文摘Colorectal cancer(CRC)is one of the most frequent neoplasms and an important cause of mortality in the developed world.This cancer is caused by both genetic and environmental factors although 35%of the variation in CRC susceptibility involves inherited genetic differences.Mendelian syndromes account for about5%of the total burden of CRC,with Lynch syndrome and familial adenomatous polyposis the most common forms.Excluding hereditary forms,there is an important fraction of CRC cases that present familial aggregation for the disease with an unknown germline genetic cause.CRC can be also considered as a complex disease taking into account the common diseasecommom variant hypothesis with a polygenic model of inheritance where the genetic components of common complex diseases correspond mostly to variants of low/moderate effect.So far,30 common,low-penetrance susceptibility variants have been identified for CRC.Recently,new sequencing technologies including exomeand whole-genome sequencing have permitted to add a new approach to facilitate the identification of new genes responsible for human disease predisposition.By using whole-genome sequencing,germline mutations in the POLE and POLD1 genes have been found to be responsible for a new form of CRC genetic predisposition called polymerase proofreading-associated polyposis. | Clara Esteban-Jurado Pilar Garre Maria Vila Juan José Lozano Anna Pristoupilova Sergi Beltrán Anna Abulí Jenifer Muoz Francesc Balaguer Teresa Ocaa Antoni Castells Josep M Piqué Angel Carracedo Clara Ruiz-Ponte Xavier Bessa Montserrat Andreu Luis Bujanda Trinidad Caldés Sergi Castellví-Bel | 2014 | World Journal of Gastroenterology2014，20，8： | 3 |
| 6 | Identification of Lynch syndrome: How should we proceed in the 21^(st) century?显示文摘Lynch syndrome, also known as hereditary non-polyposis colorectal cancer (HNPCC), is the most common form of hereditary colorectal cancer. Although great advances in the understanding of its molecular basis have taken place in the last decade, optimal selection of individuals for HNPCC genetic testing remains controversial. This is especially relevant since colonoscopy has been proven effective for reducing colorectal cancer incidence and mortality in individuals at-risk for this disorder. In this manuscript, we summarize the most significant contributions to this important issue that have appearedin the last few years. | Antoni Castells Francesc Balaguer Sergi Castellví-Bel Victòria Gonzalo Teresa Ocaa | 2007 | World Journal of Gastroenterology2007，13，33： | 3 |
| 7 | Generalizable occupant-driven optimization model fordomestic hot water production in NZEB显示文摘The primary objective of this paper is to demonstrate improved energy efficiency for domestic hot water(DHW)production in residential buildings.This is done by deriving data-driven optimal heating schedules(used interchangeably with policies)automatically.The optimization leverages actively learnt occupant behaviour and models for thermodynamics of the storage vessel to operate the heating mechanism-an air-source heat pump(ASHP)in this case-at the highest possible efficiency.The proposed algorithm,while tested on an ASHP,is essentially decoupled from the heating mechanism making it sufficiently robust to generalize to other types of heating mechanisms as well.Simulation results for this optimization based on data from 46 Net-Zero Energy Buildings(NZEB)in the Netherlands are presented.These show a reduction of energy consumption for DHW by 20%using a computationally inexpensive heuristic approach,and 27%when using a more intensive hybrid ant colony optimization based method.The energy savings are strongly dependent on occupant comfort level.This is demonstrated in real-world settings for a low-consumption house where active control was performed using heuristics for 3.5months and resulted in energy savings of 27%(61 kW h).It is straightforward to extend the same models to perform automatic demand side management(ADSM)by treating the DHW vessel as a flexibility bearing device. | H.Kaz-mi S.D'Oca C.Delmastro S.Lodeweyckx S.P.Corgnati 侯恩哲 | 2016 | 建筑节能2016，44，8： | 2 |
| 8 | Extinction in nonautonomous competitive Lokta-Volterra system 显示文摘 | Montes de Oca F Zeeman M L | 1996 | Proc Amer Math Soc1996，124，： | 2 |
| 9 | Respiratory muscle and cardiopulmonary function during exercise in very severe COPD显示文摘 | Montes de Oca M Rassulo J Celli BR | 1996 | Am J Respir Crit Care Med1996，154，： | 1 |
| 10 | Extinction in nonautonomous competitive Lotka-volterra system显示文摘 | Montes de Oca F Zeeman M L | 1996 | Proc Am Math Soc1996，124，： | 1 |
| 11 | Internal femoral osteosynthesis after external fixation in multiple-trauma patients显示文摘 | Lavini F Carita E Dall'oca C | 2007 | Strategies Trauma Limb Reconstr2007，2，1： | 1 |
| 12 | Antimicrobial peptide elicitors: New hope for the post-antibiotic era显示文摘 | Prado Montes de Oca E | 2013 | Innate Immunity2013，19，3： | 1 |
| 13 | Extinction in nonautonomous T-periodic competitive Lotka-volterra system显示文摘 | Ahmad S Montes de Oca F | 1998 | Appl Math Comput1998，90，： | 1 |
| 14 | Lactate de- hydrogenase isozymes in skeletal muscle of patients with chronic obstructive pulmonary disease显示文摘 | Torres SH Montes De Oca M Loeb E | 2009 | Archivos de Bronconeumologia ( English Edition)2009，45，2： | 1 |
| 15 | A Unified Ant Colony Optimization Algorithm for Continuous Optimiza- tion 显示文摘 | LIAO T STUTZLE T de Oca M A M | 2014 | European Journal of Operational Research2014，234，3： | 1 |
| 16 | Determination of extended spectrumβ-lactamases/AmpCβ-lactamases and plasmid-mediated quinolone resistance in Escherichia coli isolates obtained from bovine carcasses in Mexico显示文摘 | Aguilar-Montes de Oca S Talavera-Rojas M Soriano-Vargas E | 2015 | Trop Anim Health Prod2015，47，5： | 1 |
| 17 | Static and rotational intensity modulated techniques for head-neck cancer radiotherapy: A planning comparison显示文摘 | Sara Broggi Lucia Perna Francesco Bonsignore Giuseppe Rinaldin Claudio Fiorino Anna Chiara Cristina Frigerio Ivana Butti Giulia Sangalli Italo Dell’Oca Nadia Di Muzio Giovanni Mauro Cattaneo Fausto Declich | 2014 | Physica Medica2014，，： | 1 |
| 18 | Adherence to NICE guidance on glucagon-like peptide-1 receptor agonists among patients with type 2 diabetes mellitus:an evaluation using the Clinical Practice Research Datalink显示文摘 | Jameson K D'Oca K Leigh P | 2016 | Curr Med Res Opin2016，32，1： | 1 |
| 19 | The body-mass index,airflow obstruction,dyspnea,and exercise capacity index in chronic obstructive pulmonary disease显示文摘 | Celli BR Cote CG Marin JM Casanova C Montes de Oca M Mendez RA Pinto Plata V Cabral HJ | 2004 | N Engl J Med2004，350，10： | 1 |
| 20 | Supercritical fluid extraction and fractionation of different preprocessed rosemary plants显示文摘 | Ibanez E Oca A Murga G De | 1999 | J Agric Food Chem1999，47，： | 1 |
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