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| 1 | High fat diet dysregulates microRNA-17-5p and triggers retinal inflammation:Role of endoplasmic-reticulum-stress显示文摘AIM To elucidate how high diet-induced endoplasmic reticulum-stress upregulates thioredoxin interacting protein expression in Müller cells leading to retinal inflammation. METHODS Male C57Bl/J mice were fed either normal diet or 60% high fat diet for 4-8 wk. During the 4 wk study, mice received phenyl-butyric acid(PBA); endoplasmic reticulum-stress inhibitor; for 2 wk. Insulin resistance was assessed by oral glucose tolerance. Effects of palmitate-bovine serum albumin(BSA)(400 μmol/L) were examined in retinal Müller glial cell line and primary Müller cells isolated from wild type and thioredoxin interacting protein knock-out mice. Expression of thioredoxin interacting protein, endoplasmic reticulum-stress markers, mi R-17-5p m RNA, as well as nucleotide-binding oligomerization domain-like receptor protein(NLRP3) and IL1β protein was determined.RESULTS High fat diet for 8 wk induced obesity and insulin resistance evident by increases in body weight and impaired glucose tolerance. By performing quantitative real-time polymerase chain reaction, we found that high fat diet triggered the expression of retinal endoplasmic reticulum-stress markers(P < 0.05). These effects were associated with increased thioredoxin interacting protein and decreased mi R-17-5p expression, whichwere restored by inhibiting endoplasmic reticulumstress with PBA(P < 0.05). In vitro, palmitate-BSA triggered endoplasmic reticulum-stress markers, which was accompanied with reduced mi R-17-5p and induced thioredoxin interacting protein m RNA in retinal Müller glial cell line(P < 0.05). Palmitate upregulated NLRP3 and IL1β expression in primary Müller cells isolated from wild type. However, using primary Müller cells isolated from thioredoxin interacting protein knock-out mice abolished palmitate-mediated increase in NLRP3 and IL1β.CONCLUSION Our work suggests that targeting endoplasmic reticulumstress or thioredoxin interacting protein are potential therapeutic strategies for early intervention of obesityinduced retinal inflammation. | Maha Coucha Islam N Mohamed Sally L Elshaer Osinakachuk Mbata Megan L Bartasis Azza B El-Remessy | 2017 | World Journal of Diabetes2017，8，2： | 8 |
| 2 | Neighborhood --based differences in physical activity: an environment scale evaluation显示文摘 | Saelens B E Sallis J F Black J B | 2003 | American Journal of Public Health2003，93，9： | 1 |
| 3 | Neighborhood- based Differences in Physical Activity: An Environment Scale Evaluation 显示文摘 | Saelens B E Sallis J F Black J B Chen D | 2003 | American Journal of Public Health2003，93，9： | 1 |
| 4 | Useof hospital beds : a cohort study of admissions to a provincial teaching hospital 显示文摘 | A Peter M Jill B Sally | 1988 | BMJ1988，297，8： | 1 |
| 5 | Beware of the Pos- sibility of Fingerprinting Techniques Transferring DNA 显示文摘 | Roland AH Sally T James B | 2005 | J Forensic Sci2005，50，6： | 1 |
| 6 | An inter- laboratory study to test the ability of amendments to reduce the availability of Cd, Pb, and Zn in situ 显示文摘 | Sally B Barbara C Enzo L | 2005 | Environmental Pollution2005，138，： | 1 |
| 7 | In situ treatment to reduce the phytoand bioavailability of lead,zinc,and cadmium显示文摘 | Sally B Chancy R Judith H | 2004 | J Environ Qual2004，33，： | 1 |
| 8 | The impact of virtu- al embedded ness on new venture survival:overcoming the Liabilities of Newness 显示文摘 | Eric A M Sally W F Thomas B L | 2007 | Entrepreneurship Theory and Practice2007，31，2： | 1 |
| 9 | BAI 3, CDX 2 and VIL 1: a panel of three antibodies to distinguish small cell from large cell neuroendocrine lung carcinomas显示文摘 | Muhammad F Bari Helen Brown Andrew G Nicholson Keith M Kerr John R Gosney William A Wallace Irshad Soomro Salli Muller Danielle Peat Jonathan D Moore Lesley A Ward Maxim B Freidin Eric Lim Manu Vatish David R J Snead | 2014 | Histopathology2014，，： | 1 |
| 10 | Triggers and Enablers of Sense giving in Organizations显示文摘 | Sally M Lawrence B | | 0，，01： | 1 |
| 11 | Managing your portfolio of connections显示文摘 | Lawrence Thomas B Morse Eric A Fowler Sally W | 2005 | MIT Sloan Management Review Winter2005，46，2： | 1 |
| 12 | Moisture migration during freeze and thaw of unsaturated soils: modeling and large scale experiments显示文摘 | Sally A S Susan R B | 1997 | Cold Regions Science and Technology1997，25，2： | 1 |
| 13 | Human NKG2E is expressed and forms an intracytoplasmic complex with CD94 and DAP12 显示文摘 | Orbelyan GA Tang F Sally B | 2014 | J Immunol2014，193，2： | 1 |
| 14 | Multiresidue Analysis of Cotton Defoliant,Herbicide,and Insecticide Residues in Water by Solid-Phase Extraction and GCNPD,GC-MS,and HPLC-Diode Array Detection显示文摘 | Thomas L P Luz M Sally B | 2000 | Journal of Agricultural and Food Chemistry2000，48，： | 1 |
| 15 | The development of self - efficacy scales for health- related diet and exercise behavior显示文摘 | Sallis J F Pinski R B Grossman R M | 1988 | Health Education Research1988，3，： | 1 |
| 16 | Microwave- Assisted Process (MAP):a new tool for the analytical laboratory显示文摘 | JOCELYN P J R JACQUELINE M R B SALLY S S | 1994 | Trends in Analytical Chemistry1994，13，4： | 1 |
| 17 | Triggers and Enablers of Sense giving in Organizations显示文摘 | Sally M Lawrence B | | 0，，01： | 1 |
| 18 | Psychosocial and environmental correlates of adolescent sedentary behaviors显示文摘 | Norman G J Schmid B A Sallis J F | 2005 | Pediatrics2005，116，4： | 1 |
| 19 | Induction of apoptosis and reduction of MMP gene expression in the U373 cell line by polyphenolics in Aronia melanocarpa and by curcumin显示文摘 | ABDULLAH THANI NA SALLIS B NUTTALL R | 2012 | Oncol Rep2012，28，4： | 1 |
| 20 | Neighborhood- based differences in physical activity: an environment scale evaluation显示文摘 | Saelens B E Sallis J F Black J B | 2003 | American journal of public health2003，93，9： | 1 |
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