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| 1 | Long-term outcome of percutaneous ethanol injection therapy for minimum-sized hepatocellular carcinoma显示文摘AIM: To evaluate long-term follow-up of minimum-sized hepatocellular carcinoma (HCC) treated with percutaneous ethanol injection (PEI). METHODS: PEI was applied to 42 lesions in 31 patients (23 male and eight female) with HCC < 15 mm in diameter, over the past 15 years. RESULTS: Overall survival rate was 74.1% at 3 years, 49.9% at 5 years, 27.2% at 7 years and 14.5% at 10 years. These results are superior to, or at least the same as those for hepatic resection and radiofrequency ablation. Survival was affected only by liver function, but not by sex, age, etiology of Hepatitis B virus or Hepatitis C virus, α-fetoprotein levels, arterial and portal blood flow, histological characteristics, and tumor multiplicity or size. Patients in Child-Pugh class A and B had 5-, 7- and 10-years survival rates of 76.0%, 42.2% and 15.8%, and 17.1%, 8.6% and 0%, respectively (P = 0.025). CONCLUSION: Treatment with PEI is best indicated for patients with HCC < 15 mm in Child-Pugh class A. | Miyuki Taniguchi Soo Ryang Kim Susumu Imoto Hirotsugu Ikawa Kenji Ando Keiji Mita Shuichi Fuki Noriko Sasase Toshiyuki Matsuoka Masatoshi Kudo Yoshitake Hayashi | 2008 | World Journal of Gastroenterology2008，14，13： | 16 |
| 2 | Prebiotic UG1601 mitigates constipation-related events in association with gut microbiota: A randomized placebo-controlled intervention study显示文摘BACKGROUND Constipation is a common functional gastrointestinal disorder and its etiology is multifactorial.Growing evidence suggests that intestinal dysbiosis is associated with the development of constipation.Prebiotics are subjected to bacterial fermentation in the gut to produce short-chain fatty acids(SCFAs),which can help relieve constipation symptoms.The prebiotic UG1601 consists of inulin,lactitol,and aloe vera gel,which are known laxatives,but randomized,controlled clinical trials that examine the effects of this supplement on gut microbiota composition are lacking.AIM To assess the efficacy of the prebiotic UG1601 in suppressing constipation-related adverse events in subjects with mild constipation.METHODS Adults with a stool frequency of less than thrice a week were randomized to receive either prebiotics or a placebo supplement for 4 wk.All participants provided their fecal and blood samples at baseline and at the end of intervention.Gastrointestinal symptoms and stool frequency were evaluated.The concentrations of serum endotoxemia markers and fecal SCFAs were determined.The relative abundance of SCFA-producing bacteria and the gut microbial community in the responders and non-responders in the prebiotics supplementation group were evaluated.RESULTS There were no significant differences in gastrointestinal symptoms between groups,although the prebiotic group showed greater symptom improvement.However,after prebiotic usage,serum cluster of differentiation(CD)14 and lipopolysaccharide(LPS)concentrations were significantly decreased(CD14,P=0.012;LPS,P<0.001).The change in LPS concentration was significantly larger in the prebiotic group than in the placebo group(P<0.001).Fecal SCFAs concentrations did not differ between groups,while the relative abundance of Roseburia hominis,a major butyrate producer,was significantly increased in the prebiotic group(P=0.045).The abundances of the phylum Firmicutes and the family Lachnospiraceae(phylum Firmicutes,class Clostridia)(P=0.009)were decreased in the responders within the prebiotic group.In addition,the proportions of the phylum Firmicutes,the class Clostridia,and the order Clostridiales were inversely correlated with several fecal SCFAs(P<0.05).CONCLUSION Alterations in gut microbiota composition,including a decrease in the phylum Firmicutes and an increase in butyrate-producing bacteria,following prebiotic UG1601 supplementation might help alleviate symptom scores and endotoxemia. | Jae Ryang Chu Saem-Yi Kang Sung-Eun Kim Sol-Ji Lee Young-Chul Lee Mi-Kyung Sung | 2019 | World Journal of Gastroenterology2019，25，40： | 10 |
| 3 | TT virus and hepatitis G virus infections in Korean blood donors and patients with chronic liver disease显示文摘AIM: To determine the prevalences of TTV and HGV infections among blood donors and patients with chronic liver disease in Korea, to investigate the association of TTV and HGV infections with blood transfusion, and to assess the correlation between TTV and HGV viremia and hepatic damage.METHODS: A total of 391 serum samples were examined in this study. Samples were obtained from healthy blood donors (n= 110), hepatitis B surface antigen (HBsAg)-positive donors (n=112), anti-hepatitis C virus (anti-HCV)-positive donors (n=69), patients with type B chronic liver disease (n=81), and patients with type C chronic liver disease (n= 19).TTV DNA was detected using the hemi-nested PCR. HGV RNA was tested using RT-PCR. A history of blood transfusion and serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were also determined.RESULTS: TTV DNA was detected in 8.2 % of healthy blood donors, 16.1% of HBsAg-positive donors, 20.3 % of antiHCV-positive donors, 21.0 % of patients with type B chronic liver disease, and 21.1% of patients with type C chronic liver disease. HGV RNA was detected in 1.8 % of healthy blood donors, 1.8 % of HBsAg-positive donors, 17.4 % of anti-HCV-positive donors, 13.6% of patients with type B chronic liver disease, and 10.5% of patients with type C chronic liver disease. The prevalence of TTV and HGV infections in HBV- or HCV-positive donors and patients was significantly higher than in healthy blood donors (P<0.05),except for the detection rate of HGV in HBsAg-positive donors which was the same as for healthy donors. There was a history of transfusion in 66.7% of TTV DNA-positive patients and 76.9% of HGV RNA-positive patients (P<0.05). No significant increase in serum ALT and AST was detected in the TTV- or HGV-positive donors and patients.CONCLUSION: TTV and HGV infections are more frequently found in donors and patients infected with HBV or HCV than in healthy blood donors. However, there is no significant association between TTV or HGV infections and liver injury. | Mee Juhng Jeon Jong Hee Shin Soon Pal Suh Young Chai Lim Dong Wook Ryang | 2003 | World Journal of Gastroenterology2003，9，4： | 7 |
| 4 | Diagnostic sensitivity of imaging modalities for hepatocellular carcinoma smaller than 2 cm显示文摘AIM:To compare the imaging results with histology and to evaluate the diagnostic sensitivity of imaging modalities for hepatocellular carcinoma(HCC)smaller than 2 cm.METHODS:Nodules smaller than 2 cm(n=34)revealed by ultrasonography(US)in 29 patients with liver cirrhosis were analyzed.Histological diagnosis of HCC was performed by ultrasonographic guidance:moderately-differentiated HCC(n=24);well-differentiated HCC(n=10).The patterns disclosed by the four imaging modalities defined the conclusive diagnosis of HCC:(1)contrast-enhanced computed tomography(CECT),hypervascularity in the arterial phase and washout in the equilibrium phase;(2)Sonazoid contrast-enhanced US(CEUS),hypervascularity in the early vascular phase and defect in the Kupffer phase;(3)gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid(Gd-EOBDTPA)-enhanced magnetic resonance imaging(MRI),hypervascularity in the arterial phase and/or defect in the hepatobiliary phase;and(4)CT arterioportal angiography:hypervascularity by CT during arteriography and/ or perfusion defect by CT during arterial portography.RESULTS:Overall,the sensitivity of diagnosing HCC smaller than 2 cm was 52.9%(18/34)(95%CI:35.170.2)by CECT;67.6%(23/34)(95%CI:49.5-82.6)by Sonazoid CEUS;76.5%(26/34)(95%CI:58.8-89.3) by Gd-EOB-DTPA MRI;and 88.2%(30/34)(95%CI: 72.5-96.7)by CT arterioportal angiography.The diagnostic sensitivity of detecting moderately-differentiated HCC by CECT,Sonazoid CEUS,Gd-EOB-DTPA MRI and CT arterioportal angiography was 62.5%(15/24)(95%CI: 40.6-81.2),79.2%(19/24)(95%CI:57.8-92.9),75.0% (18/24)(95%CI:53.3-90.2)and 95.8%(23/24)(95% CI:78.9-99.9),respectively.A significant difference(P< 0.05)was observed between CECT and CT arterioportal angiography in all nodules.There was no difference between Sonazoid CEUS,Gd-EOB-DTPA MRI,and CT arterioportal angiography.The combined sensitivity of Sonazoid CEUS and Gd-EOB-DTPA MRI was 94.1%(32/34).CONCLUSION:Changing the main diagnostic modality for HCC smaller than 2 cm from CT arterioportal angiography to Sonazoid CEUS and Gd-EOB-DTPA MRI is recommended. | Keiji Mita Soo Ryang Kim Masatoshi Kudo Susumu Imoto Taisuke Nakajima Kenji Ando Katsumi Fukuda Toshiyuki Matsuoka Yoko Maekawa Yoshitake Hayashi | 2010 | World Journal of Gastroenterology2010，16，33： | 7 |
| 5 | Comparison of two Nd:YAG laser posterior capsulotomy: cruciate pattern vs circular pattern with vitreous strand cutting显示文摘AIM: To investigate the effects and safety of neodymium: yttrium-aluminium-garnet(Nd:YAG) laser posterior capsulotomy with vitreous strand cuttingMETHODS: A total of 40 eyes of 37 patients with symptomatic posterior capsular opacity(PCO) were included in this prospective randomized study and were randomly subjected to either cruciate pattern or round pattern Nd:YAG posterior capsulotomy with vitreous strand cutting(modified round pattern). The best corrected visual acuity(BCVA), intraocular pressure(IOP), refractive error, endothelial cell count(ECC), anterior segment parameters, including anterior chamber depth(ACD) and anterior chamber angle(ACA) were measured before and 1 mo after the laser posterior capsulotomy. RESULTS: In both groups, the BCVA improved significantly(P<0.001 for the modified round pattern group, P=0.001 for the cruciate pattern group); the IOP and ECC did not significantly change. The ACD significantly decreased(P<0.001 for both) and the ACA significantly increased(P=0.001 for the modified round pattern group and P=0.034 for the cruciate group). The extent of changes in these parameters was not significantly different between the groups.CONCLUSION: Modified round pattern Nd:YAG laser posterior capsulotomy is an effective and safe method for the treatment of PCO. This method significantly changes the ACD and ACA, but the change in refraction is not significant. Modified round pattern Nd:YAG laser posterior capsulotomy can be considered a good alternative procedure in patients with symptomatic PCO. | Jin-Soo Kim Jung Yeol Choi Ji-Won Kwon Won Ryang Wee Young Keun Han | 2018 | International Journal of Ophthalmology(English edition)2018，11，2： | 6 |
| 6 | Scirrhous hepatocellular carcinoma displaying atypical findings on imaging studies显示文摘We describe a 15-mm scirrhous hepatocellular carcinoma(HCC) in a 60-year-old man with B-type cirrhosis.Ultrasound disclosed a 15-mm hypoechoic nodule in segment 7.Contrast-enhanced US revealed heterogeneous,not diffuse,hypervascularity in the early phase and a defect in the Kupffer phase.Contrast-enhanced computed tomography(CT) revealed a heterogeneous hypervascular nodule in the early phase and a low-density area in the late phase.Magnetic resonance imaging(MRI) revealed iso-to hypointensity at T1 and high intensity at T2-weighted sequences.Contrast-enhanced MRI also revealed a heterogeneous hypervascular nodule in the early phase and washout in the late phase.Super-paramagnetic iron oxide-MRI revealed a hyperintense nodule.CT during hepatic arteriography and CT during arterial portography revealed heterogeneous hyperattenuation and a perfusion defect,respectively.Based on these imaging findings the nodule was diagnosed as a mixed well-differentiated and moderately-differentiated HCC.Histologically,the nodule was moderately-differentiated HCC characterized by typical cytological and structural atypia with dense fibrosis.Immunohistochemically,the nodule was positive for heterochromatin protein 1 and alpha-smooth muscle actin,and negative for cytokeratin 19.From the above findings,the nodule was diagnosed as scirrhous HCC.Clinicians engaged in hepatology should exercise caution with suspected scirrhous HCC when imaging studies reveal atypical findings,as shown in our case on the basis of chronic liver disease. | Soo Ryang Kim Susumu Imoto Taisuke Nakajima Kenji Ando Keiji Mita Katsumi Fukuda Ryo Nishikawa Yu-ichiro Koma Toshiyuki Matsuoka Masatoshi Kudo Yoshitake Hayashi | 2009 | World Journal of Gastroenterology2009，15，18： | 4 |
| 7 | Multistep hepatocarcinogenesis from a dysplastic nodule to well-differentiated hepatocellular carcinoma in a patient with alcohol-related liver cirrhosis显示文摘We describe a rare case of the transformation of a dysplastic nodule into well-differentiated hepato- cellular carcinoma (HCC) in a 56-year-old man with alcoholrelated liver cirrhosis. Ultrasound (US) disclosed a 10 mm hypoechoic nodule and contrast enhanced US revealed a hypovascular nodule, both in segment seven. US-guided biopsy revealed a high-grade dysplastic nodule characterized by enhanced cellularity with a high N/C ratio, increased cytoplasmic eosinophilia, and slight cell atypia. One year later, the US pattern of the nodule changed from hypoechoic to hyperechoic without any change in size or hypovascularity. US-guided biopsy revealed well-differentiated HCC of the same features as shown in the first biopsy, but with additional pseudoglandular formation and moderate cell atypia. Moreover, immunohistochemical staining of cyclase- associated protein 2, a new molecular marker of well- differentiated HCC, turned positive. This is the first case of multistep hepatocarcinogenesis from a dysplastic nodule to well-differentiated HCC within one year in alcohol-related liver cirrhosis. | Soo Ryang Kim Hirotsugu Ikawa Kenji Ando Keiji Mita Shuichi Fuki Michiie Sakamoto Yoshihiro Kanbara Toshiyuki Matsuoka Masatoshi Kudo Yoshitake Hayashi | 2007 | World Journal of Gastroenterology2007，13，8： | 4 |
| 8 | DJ-1 mediates paraquat-induced dopaminergic neuronal cell death显示文摘 | Hyun Joo Kwon Jun Young Heo Jung Hee Shim Ji Hoon Park Kang Sik Seo Min Jeong Ryu Jeong Su Han Minho Shong Jin H. Son Gi Ryang Kweon | 2011 | Toxicology Letters2011，，： | 2 |
| 9 | Anti-complement activity of tiliroside from the flower buds of Magnlia fargesii 显示文摘 | Jung K Y Ryang Oh S Park S H | 1998 | Biol Pharm Bull1998，21，10： | 1 |
| 10 | Prospective surveillance of drain associated meningitis/ventriculitis in a neurosurgery and neurological intensive care unit显示文摘 | Scheithauer S Burgel U Ryang YM | 2009 | J Neurol Neurosurg Psychiatry2009，80，12： | 1 |
| 11 | Immune response and inhibitory effect of ketotifen on the BALB/c and C3H/HeN mice infected with Echinostoma hortonse显示文摘 | Ryang Y S Yang E J Kim J L | 2007 | Parasitol Res2007，101，4： | 1 |
| 12 | Long-termresults of microsurgical treatment of lumbar spinal stenosis by u-nilateral laminotomy for bilateral decompression显示文摘 | OERTEL MF RYANG YM KORINTH MC | 2006 | Neurosurgery2006，59，6： | 1 |
| 13 | Molecular signaling in DNA bisintercalator,echinomycin-induced apoptosis of HT-29 cells;evidence of the apoptotic process via activation of the cytochrome cERK-caspase-3 pathway显示文摘 | Park JY Ryang YS Shim KY | 2006 | Int J Biochem Cell Biol2006，38，2： | 1 |
| 14 | Androstane alkaloids from musk of Moschus moschiferus 显示文摘 | Sei - Ryang OH Jong Pill LEE Seung - Yeup CHANG | 2002 | Chem Pharm Bull2002，50，5： | 1 |
| 15 | PBG-assisted gain enhancement of patch antennas on High-Dielectric Constantsustrate显示文摘 | F Ryang R Coccioli Y Qian | 1999 | IEEE Antenna and Progation Society1999，3，8： | 1 |
| 16 | Sequence aggradation and systems tracts partitioning in the mid-eastern Yellow Sea:roles of glacio-eustasy, subsidence and tidal dynamics显示文摘 | Jin J H Chough S K Ryang W H | 2002 | Marine Geology2002，184，： | 1 |
| 17 | Effects of pulsed electromagnetic field on knee osteoarthritis: a systematic review 显示文摘 | Ryang We S Koog YH Jeong KI | 2013 | Riaeumatology (Oxford)2013，52，5： | 1 |
| 18 | Lateral transmuscular or combined interlaminar/paraisthmic approach to lateral lumbar disc herniation? A comparative clinical series of 48 patients显示文摘 | Ryang Y Rohde I Ince A | 2005 | BM J2005，76，： | 1 |
| 19 | Prediction of response to pegylated interferon/ribavirin combination therapy for chronic hepatitis C genotype 1b and high viral load显示文摘 | Soo Ryang Kim Ahmed El-Shamy Susumu Imoto Ke Ih Kim Yoshi-hiro Ide Lin Deng Ikuo Shoji Yasuhito Tanaka Yutaka Hasegawa Mitsuhiro Ota Hak Hotta | 2012 | Journal of Gastroenterology2012，，10： | 1 |
| 20 | Changes of net photosynthesis, antioxidant enzyme activities, and antioxidant contents of Liriodendron tulipifera under elevated ozone 显示文摘 | Ryang S Z Woo S Y Kwort S Y | 2009 | Photosynthetica2009，47，1： | 1 |
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