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| 1 | Cetuximab plus FOLFOX6 or FOLFIRI in metastatic colorectal cancer: CECOG trial显示文摘AIM: To investigate efficacy and safety of cetuximab combined with two chemotherapy regimens in patients with unresectable metastatic colorectal cancer (mCRC). METHODS: Randomized patients received cetuximab with 5-fluorouracil (5-FU), folinic acid (FA) and oxaliplatin (FOLFOX) 6 (arm A, n = 74) or 5-FU, FA and irinotecan (FOLFIRI) (arm B, n = 77). KRAS mutation status was determined retrospectively in a subset of tumors (n = 117). RESULTS: No significant difference was found between treatment arms A and B in the progression-free survival (PFS) rate at 9 mo, 45% vs 34%; median PFS, 8.6 mo vs 8.3 mo [hazard ratio (HR) = 1.06]; overall response rate (ORR) 43% vs 45% [odds ratio (OR) = 0.93] and median overall survival (OS), 17.4 mo vs 18.9 mo (HR = 0.98). Patients with KRAS wild-type tumors demonstrated improved PFS (HR = 0.55, P = 0.0051), OS, (HR = 0.62, P = 0.0296) and ORR (53% vs 36%) and in arm A, improved PFS (HR = 0.49, P = 0.0196), OS (HR = 0.48, P = 0.0201) and ORR (56%vs 30%), compared with patients with KRAS mutated tumors. In arm B no significant differences were found in efficacy by KRAS mutation status. Treatment in arms A and B was generally well tolerated. CONCLUSION: This study confirms that combinations of cetuximab with FOLFOX6 or FOLFIRI are effective and significantly improve clinical outcome in KRAS wild-type compared with KRAS mutated mCRC. | Janja Ocvirk Thomas Brodowicz Fritz Wrba Tudor E Ciuleanu Galina Kurteva Semir Beslija Ivan Koza Zsuzsanna Pápai Diethelm Messinger Ugur Yilmaz Zsolt Faluhelyi Suayib Yalcin Demetris Papamichael Miklós Wenczl Zrinka Mrsic-Krmpotic Einat Shacham-Shmueli Damir Vrbanec Regina Esser Werner Scheithauer Christoph C Zie-linski | 2010 | World Journal of Gastroenterology2010，16，25： | 17 |
| 2 | Pituicytoma: a distinctive low-grade glioma of the neurohypophysis 显示文摘 | Brat D J Scheithauer B W Staugaitis S M | 2000 | Am J Surg Pathol2000，24，： | 1 |
| 3 | H ras mutation in human pituitary carcinoma metastasis显示文摘 | Pei L Melmend S Scheithauer B | 1994 | J Chin Endocrinol Metab1994，78，： | 1 |
| 4 | Prospective surveillance of drain associated meningitis/ventriculitis in a neurosurgery and neurological intensive care unit显示文摘 | Scheithauer S Burgel U Ryang YM | 2009 | J Neurol Neurosurg Psychiatry2009，80，12： | 1 |
| 5 | High prevalence of human bocavirus detected in young children with severe acute lower respiratory tract disease by use of a standard PCR protocol and a novel real-time PCR protocol显示文摘 | Scheithauer S Rackowitz A | 2007 | J Clin Microbiol2007，45，3： | 1 |
| 6 | The spectrum of malignancy in craniopharyngioma 显示文摘 | Rodriguez FJ Scheithauer BW Tsunoda S | 2007 | Am J Surg Pathol2007，31，7： | 1 |
| 7 | Model for estimation of clinically achievable plasma concentrations for investigational anticancer drugs in man显示文摘 | Scheithauer W Clark G M Salmon S E | 1986 | Cancer Treat Rep1986，70，12： | 1 |
| 8 | Histologically confirmed pineal tumors and other germ cell tumors of the brain显示文摘 | Schild S E Scheithauer B W Haddock M G | 1996 | Cancer1996，78，： | 1 |
| 9 | Role of MGMT in tumor development, progression, diagnosis, treatment and prognosis 显示文摘 | Sharma S Salehi F Scheithauer BW | 2009 | Anticancer Res2009，29，： | 1 |
| 10 | Role of MGMT in tumor development, progression, diagnosis, treatment and prognosis显示文摘 | SHARMA S SALEHI F SCHEITHAUER BW | 2009 | Anticancer Res2009，29，10： | 1 |
| 11 | The spectrum of malignancy in craniopharyngioma显示文摘 | Rodriguez FJ Scheithauer BW Tsunoda S | 2007 | Am J Surg Pathol2007，31，7： | 1 |
| 12 | En- doglin and CD-34 immunoreactivity in the assessment of mi- crovessel density in normal pituitary and adenoma subtypes显示文摘 | ROTONDO F SHARMA S SCHEITHAUER BW | 2010 | Neoplasma2010，57，6： | 1 |
| 13 | Endoglin and CD- 34 immunoreactivity in the assessment of microvessel density in normal pituitary and adenoma subtypes 显示文摘 | Rotondo F Sharma S Scheithauer BW | 2010 | Neoplasma2010，57，6： | 1 |
| 14 | Compliance with hand hygiene in patients with meticillin-resistant Staphylococcus aureus and extended-spectrum β-lactamase-producing enterobacteria显示文摘 | Scheithauer S Oberr?hrmann A Haefner H | | 0，，04： | 1 |
| 15 | Improving hand hygiene compliance rates in the haemodialysis setting: more than just more hand rubs显示文摘 | Scheithauer S Eitner F Mankartz J | 2012 | Nephrol Dial Transplant2012，27，2： | 1 |
| 16 | The pathologic features of carcinomas of type 2 pneumocytes:an immunocytologic study显示文摘 | Singh G Scheithauer B W Katyal S L | 1986 | Cancer1986，57，5： | 1 |
| 17 | Long-term sustainability of hand hygiene improvements in the hemodialysis setting显示文摘 | Scheithauer S Eitner F H/ifner H | 2013 | Infection2013，41，3： | 1 |
| 18 | Role of MGMT in tu- mor development, progression, diagnosis, treatment and prognosis 显示文摘 | Sharma S Salehi F Scheithauer BW | 2009 | Anticancer Res2009，29，10： | 1 |
| 19 | Third ventricular chordoid glioma: a distinct elinicopathologic entity显示文摘 | Brat D J Scheithauer B W Staugaitis S M | 1998 | J Neuropathol Exp Neurol1998，57，3： | 1 |
| 20 | Pathology of invasive pituitary tumors with special reference to functional classification 显示文摘 | Scheithauer BW Kovac S Laws ER | 1986 | Neurosurgery1986，65，7： | 1 |
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