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| 1 | Role of CARD15,DLG5 and OCTN genes polymorphisms in children with inflammatory bowel diseases显示文摘AIM: To investigate the contribution of variants of CARD15, OCTN1/2 and DLG5 genes in disease predispo- sition and phenotypes in a large Italian cohort of pediatric patients with inflammatory bowel diseases (IBD). METHODS: Two hundred patients with Crohn’s disease (CD), 186 ulcerative colitis (UC) patients, 434 par- ents (217 trios), and 347 healthy controls (HC) were studied. Polymorphisms of the three major variants of CARD15, 1672C/T and -207G/C SNPs for OCTN genes, IGR2096a_1 and IGR2198a_1 SNPs for the IBD5 locus, and 113G/A variant of the DLG5 gene were evaluated. Potential correlations with clinical sub-phenotypes were investigated. RESULTS: Polymorphisms of CARD15 were significantly associated with CD, and at least one variant was found in 38% of patients (15% in HC, OR = 2.7, P < 0.001). Homozygosis for both OCTN1/2 variants was more com- mon in CD patients (1672TT 24%, -207CC 29%) than in HC (16% and 21%, respectively; P = 0.03), with an in- creased frequency of the TC haplotype (44.8% vs 38.3% in HC, P = 0.04). No association with the DLG5 variant was found. CD carriers of OCTN1/2 and DLG5 variants more frequently had penetrating disease (P = 0.04 and P = 0.01), while carriers of CARD15 more frequently had ileal localization (P = 0.03). No gene-gene interaction was found. In UC patients, the TC haplotype was morefrequent (45.4%, P = 0.03), but no genotype/phenotype correlation was observed. CONCLUSION: Polymorphisms of CARD15 and OCTN genes, but not DLG5 are associated with pediatric on- set of CD. Polymorphisms of CARD15, OCTN, and DLG5 genes exert a weak influence on CD phenotype. | S Cucchiara A Latiano O Palmieri AM Staiano R D'Incà G Guariso G Vieni V Rutigliano O Borrelli MR Valvano V Annese | 2007 | World Journal of Gastroenterology2007，13，8： | 9 |
| 2 | Pterional orbita decompression in orbital hemorrhage and trauma显示文摘 | Korinth M C Ince A Banghard W | 2002 | J Trauma2002，53，1： | 2 |
| 3 | Fractional particle swarm optimization in multidimensional search space显示文摘 | Kiranyaz S Ince T Yildirim A | 2010 | IEEE Trans on Systems Man and Cybernetics-Part B2010，40，2： | 1 |
| 4 | Changes in the blood chemistry of rainbow trout, Salmo gairdneri fish, in relation to dietary pro- tein level, and an anabolic steroid hormone, ethylestrenol显示文摘 | Lone K P Ince B W Matty A J | 1982 | Journal of Fish Biology1982，20，： | 1 |
| 5 | Analgesia in preterm newborns: the comparative effects of sucrose and glucose 显示文摘 | Okan F Coban A Ince Z | 2007 | Eur J Pediatr2007，166，10： | 1 |
| 6 | Gentamicin negatively influenced osteogenic function in vitro显示文摘 | Ince A Schütze N Karl N | 2007 | Int Orthop2007，31，： | 1 |
| 7 | Effect of methotrexate on the TM joint and facial morphology in juvenile rheumatoid arthritis pa- tients 显示文摘 | Ince DO Ince A Moore TL | 2000 | Am J Ortho Dentofac Orthop2000，118，1： | 1 |
| 8 | Crosslinked PS-DVB microspheres with sulfonated polystyrene brushes as new generation of ion exchange resins显示文摘 | Ozer O Ince A Karagoz B | 2013 | Desalination2013，309，： | 1 |
| 9 | Wavelet packet neural networks for texture classification显示文摘 | Sengur A Turkoglu I Ince M C | 2007 | Expert Systems with Applications2007，32，2： | 1 |
| 10 | Direct observation of the human cerebral microcirculation during aneurysm surgery reveals in- creased arteriolar contractility 显示文摘 | PENNINGS F A BOUMA G J INCE C | 2004 | Stroke2004，35，6： | 1 |
| 11 | Serum and biliary MMP-9 and TIMP-1 concentrations in the diagnosis of cholangiocarcinoma 显示文摘 | Ince A T Yildiz K Gangarapu V | 2015 | Int J Clin Exp Med2015，8，2： | 1 |
| 12 | Inhibition of volatile fatty acid production in granular sludge from a UASB reactor显示文摘 | Dogan T Ince O Oz N A | 2005 | EnvironTechnol2005，40，3： | 1 |
| 13 | Computer estimation of crowd densityusing digitized aerial photographs显示文摘 | Khan M A Ince F | 1989 | The Arabian Journalfor Science and Engineering1989，14，4： | 1 |
| 14 | Scleredema aduhorum of Buschke:a case report and review of the literature 显示文摘 | Beers WH Ince A Moore TL | 2006 | Semin Arthritis Rheum2006，35，： | 1 |
| 15 | Modelling and simulation for safe and efficient navigation in narrow waterways显示文摘 | INCE A N TOPUZ E | 2004 | The Journal of Navigation2004，57，： | 1 |
| 16 | 1,25-Dihydroxyvitamin D3 attenuates the expression of experimental murine lupus of MRL/ 1mice显示文摘 | Lemire JM Ince A Takashima M | 1992 | Autoimmunity1992，12，2： | 1 |
| 17 | Survey Of The OccurrenceOf Aflatoxin M1 In Cheeses Produced By Dairy Ewe'S Milk In Urfa City, Turkey 显示文摘 | Filazi A ince S Temamoaullari F | 2010 | Ankara tiniversitesi Veteriner Fakahesi Dergisi2010，57，3： | 1 |
| 18 | 显示文摘 | Thomas A Fritz L Disaster Relief Inc | 2006 | Harvard Bus- iness Review2006，，11： | 1 |
| 19 | Classification of single trial motor imagery EEG recordings with subject adapted non-dyadic arbitrary time-frequency tilings显示文摘 | Ince N F Arica S Tewfik A | 2006 | J Neural Eng2006，3，3： | 1 |
| 20 | Dominant and diet-responsive groups of bacteria within the human colonic microbiota显示文摘 | WALKER A W INCE J DUNCAN S H | 2011 | The ISME Journal2011，5，2： | 1 |
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