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| 1 | Ca^(2+)-supplying black phosphorus-based scaffolds fabricated with microfluidic technology for osteogenesis显示文摘Effective osteogenesis remains a challenge in the treatment of bone defects.The emergence of artificial bone scaffolds provides an attractive solution.In this work,a new biomineralization strategy is proposed to facilitate osteogenesis through sustaining supply of nutrients including phosphorus(P),calcium(Ca),and silicon(Si).We developed black phosphorus(BP)-based,three-dimensional nanocomposite fibrous scaffolds via microfluidic technology to provide a wealth of essential ions for bone defect treatment.The fibrous scaffolds were fabricated from 3D poly(L-lactic acid)(PLLA)nanofibers(3D NFs),BP nanosheets,and hydroxyapatite(HA)-porous SiO2 nanoparticles.The 3D BP@HA NFs possess three advantages:i)stably connected pores allow the easy entrance of bone marrow-derived mesenchymal stem cells(BMSCs)into the interior of the 3D fibrous scaffolds for bone repair and osteogenesis;ii)plentiful nutrients in the NFs strongly improve osteogenic differentiation in the bone repair area;iii)the photothermal effect of fibrous scaffolds promotes the release of elements necessary for bone formation,thus achieving accelerated osteogenesis.Both in vitro and in vivo results demonstrated that the 3D BP@HA NFs,with the assistance of NIR laser,exhibited good performance in promoting bone regeneration.Furthermore,microfluidic technology makes it possible to obtain high-quality 3D BP@HA NFs with low costs,rapid processing,high throughput and mass production,greatly improving the prospects for clinical application.This is also the first BP-based bone scaffold platform that can self-supply Ca^(2+),which may be the blessedness for older patients with bone defects or patients with damaged bones as a result of calcium loss. | Zhanrong Li Xingcai Zhang Jiang Ouyang Dandan Chu Fengqi Han Liuqi Shi Ruixing Liu Zhihua Guo Grace X.Gu Wei Tao Lin Jin Jingguo Li | 2021 | Bioactive Materials2021，6，11： | 4 |
| 2 | Six sigma robust design optimization for thermal protection system of hypersonic vehicles based on successive response surface method显示文摘Lightweight design is important for the Thermal Protection System(TPS) of hypersonic vehicles in that it protects the inner structure from severe heating environment. However, due to the existence of uncertainties in material properties and geometry, it is imperative to incorporate uncertainty analysis into the design optimization to obtain reliable results. In this paper, a six sigma robust design optimization based on Successive Response Surface Method(SRSM) is established for the TPS to improve the reliability and robustness with considering the uncertainties. The uncertain parameters related to material properties and thicknesses of insulation layers are considered and characterized by random variables following normal distributions. By employing SRSM, the values of objective function and constraints are approximated by the response surfaces to reduce computational cost. The optimization is an iterative process with response surfaces updating to find the true optimal solution. The optimization of the nose cone of hypersonic vehicle cabin is provided as an example to illustrate the feasibility and effectiveness of the proposed method. | Jingjing ZHU Xiaojun WANG Haiguo ZHANG Yuwen LI Ruixing WANG Zhiping QIU | 2019 | Chinese Journal of Aeronautics2019，32，9： | 4 |
| 3 | Deficiency of two-pore segment channel 2 contributes to systemic lupus erythematosus via regulation of apoptosis and cell cycle显示文摘Background:Systemic lupus erythematosus(SLE)is a complex autoimmune disease,and the mechanism of SLE is yet to be fully elucidated.The aim of this study was to explore the role of two-pore segment channel 2(TPCN2)in SLE pathogenesis.Methods:Quantitative reverse transcription polymerase chain reaction(qRT-PCR)was used to detect the expression ofTPCN2 in SLE.We performed a loss-of-function assay by lentiviral construct in Jurkat and THP-1 cell.Knockdown ofTPCN2 were confirmed at the RNA level by qRT-PCR and protein level by Western blotting.Cell Count Kit-8 and flow cytometry were used to analyze the cell proliferation,apoptosis,and cell cycle ofTPCN2-deficient cells.In addition,gene expression profile ofTPCN2-deficient cells was analyzed by RNA sequencing(RNA-seq).Results:TPCN2 knockdown with short hairpin RNA(shRNA)-mediated lentiviruses inhibited cell proliferation,and induced apoptosis and cell-cycle arrest of G2/M phase in both Jurkat and THP-1 cells.We analyzed the transcriptome of knockdown-TPCN2-Jurkat cells,and screened the differential genes,which were enriched for the G2/M checkpoint,complement,and interleukin-6-Janus kinase-signal transducer and activator of transcription pathways,as well as changes in levels of forkhead box O,phosphatidylinositol 3-kinase/protein kinase B/mechanistic target of rapamycin,and T cell receptor pathways;moreover,TPCN2 significantly influenced cellular processes and biological regulation.Conclusion:TPCN2 might be a potential protective factor against SLE. | Keke Li Jingkai Xu Ke Xue Ruixing Yu Chengxu Li Wenmin Fei Xiaoli Ning Yang Han Ziyi Wang Jun Shu Yong Cui | 2022 | Chinese Medical Journal2022，，4： | 2 |
| 4 | Effects of 11 years of conservation tillage on soil organic matter fractions in wheat monoculture in Loess Plateau of China显示文摘 | Haiqing Chen Ruixing Hou Yuanshi Gong Hongwen Li Mingsheng Fan Yakov Kuzyakov | 2009 | Soil & Tillage Research2009，，1： | 2 |
| 5 | UV-shielding properties of zinc oxide-doped ceria fine powders derived via soft solution chemical routes显示文摘 | Ruixing Li Shinryo Yabe | 2002 | Materials Chemistry and Physics2002，75，： | 1 |
| 6 | Comparison of Lipid Levels, Hyperlipidemia Prevalence and Its Risk Factors between Guangxi Hei Yi Zhuang and Han Populations显示文摘 | Yin Ruixing Chen Yuming Pan Shangling He Fengping Liu Tangwei Yang Dezhai Wu Jinzhen Yao Limei Lin Weixiong Li Rongshan Huang Jiandong | 2006 | Archives of Medical Research2006，，6： | 1 |
| 7 | Synthesis of ZrB2 nanoparticles by sol-gel method显示文摘 | Ruixing Li Yun Zhang Haijie Lou | 2011 | Journal of Sol-Gel Science and Technology:2011，58，2： | 1 |
| 8 | Synthesis and UV-shielding properties of ZnO- and CaO-doped CeO 2 via soft solution chemical process显示文摘 | Ruixing Li Shinryo Yabe Mika Yamashita Shigeyosi Momose Sakae Yoshida Shu Yin Tsugio Sato | 2002 | Solid State Ionics2002，，： | 1 |
| 9 | Synthesis of ZrB2 nanoparticles by sol-gel method显示文摘 | Li Ruixing Zhang Yun Lou Haijie | 2011 | Journal of Sol-Gel Science and Technology2011，58，2： | 1 |
| 10 | Morphology evolution of ZrBz nanoparticles synthesized by sol-gel me- thod显示文摘 | Zhang Yun Li Ruixing Jiang Yanshan | 2011 | J Solid State Chem2011，184，8： | 1 |
| 11 | Morphology evolution of ZrB2 nanoparticles synthesized by sol- gel method 显示文摘 | Zhang Yun Li Ruixing Jiang Yanshan | 2011 | J Solid State Chem2011，184，： | 1 |
| 12 | Synthesis and UV- shielding properties of ZnO- and CeO2 via soft solution chemical process 显示文摘 | Ruixing Li Shinryo Yabe Mika Yamashita | 2002 | Solid State Ionies2002，，151： | 1 |
| 13 | UV-shielding properties of zinc oxide- doped ceria fine powders derived via soft solution chemical routes 显示文摘 | Ruixing Li Shinryo Yabe Mika Yamashita | 2002 | Materials Chemistry and Physics2002，，75： | 1 |
| 14 | Association of LIPC - 250G/A polymorphism and several environmental factors with serum lipid levels in the Guangxi Bai Ku Yao and Han populations 显示文摘 | Li Meng Yin Ruixing Li Yiyang | 2010 | Lipids Health Disease2010，9，： | 1 |
| 15 | 显示文摘 | | 2002 | Materials Chemistry and Physics2002，75，： | 1 |
| 16 | 显示文摘 | | 2002 | Solid State Ionics2002，151，： | 1 |
| 17 | 显示文摘 | | 2002 | Materials Chemistry and Physics2002，75，： | 1 |
| 18 | Influence of dielectric barrier materials to the behavior of dielectric barrier discharge plasma for CO2 decomposition显示文摘 | LI Ruixing YAMAGUCHI Y YIN Shu | 2004 | Solid State Ionics2004，172，： | 1 |
| 19 | Plasma catalysis for CO2 decomposition by using different dielectric materials显示文摘 | LI Ruixing TANG Qing YIN Shu | 2006 | Fuel Process Technol2006，87，： | 1 |
| 20 | Morphology evolution of ZrB 2 nanoparticles synthesized by sol–gel method显示文摘 | Yun Zhang Ruixing Li Yanshan Jiang Bin Zhao Huiping Duan Junping Li Zhihai Feng | 2011 | Journal of Solid State Chemistry2011，，8： | 1 |
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