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| 1 | Ca^(2+)-supplying black phosphorus-based scaffolds fabricated with microfluidic technology for osteogenesis显示文摘Effective osteogenesis remains a challenge in the treatment of bone defects.The emergence of artificial bone scaffolds provides an attractive solution.In this work,a new biomineralization strategy is proposed to facilitate osteogenesis through sustaining supply of nutrients including phosphorus(P),calcium(Ca),and silicon(Si).We developed black phosphorus(BP)-based,three-dimensional nanocomposite fibrous scaffolds via microfluidic technology to provide a wealth of essential ions for bone defect treatment.The fibrous scaffolds were fabricated from 3D poly(L-lactic acid)(PLLA)nanofibers(3D NFs),BP nanosheets,and hydroxyapatite(HA)-porous SiO2 nanoparticles.The 3D BP@HA NFs possess three advantages:i)stably connected pores allow the easy entrance of bone marrow-derived mesenchymal stem cells(BMSCs)into the interior of the 3D fibrous scaffolds for bone repair and osteogenesis;ii)plentiful nutrients in the NFs strongly improve osteogenic differentiation in the bone repair area;iii)the photothermal effect of fibrous scaffolds promotes the release of elements necessary for bone formation,thus achieving accelerated osteogenesis.Both in vitro and in vivo results demonstrated that the 3D BP@HA NFs,with the assistance of NIR laser,exhibited good performance in promoting bone regeneration.Furthermore,microfluidic technology makes it possible to obtain high-quality 3D BP@HA NFs with low costs,rapid processing,high throughput and mass production,greatly improving the prospects for clinical application.This is also the first BP-based bone scaffold platform that can self-supply Ca^(2+),which may be the blessedness for older patients with bone defects or patients with damaged bones as a result of calcium loss. | Zhanrong Li Xingcai Zhang Jiang Ouyang Dandan Chu Fengqi Han Liuqi Shi Ruixing Liu Zhihua Guo Grace X.Gu Wei Tao Lin Jin Jingguo Li | 2021 | Bioactive Materials2021，6，11： | 4 |
| 2 | Quercetin promotes human epidermal stem cell proliferation through the estrogen receptor/β-catenin/c-Myc/cyclin A2 signaling pathway显示文摘Skin epidermal stem cells(EpSCs)play an important role in wound healing.Quercetin is a phytoestrogen reported to accelerate skin wound healing,but its effect on EpSCs is unknown.In this study,we investigated the effect of quercetin on human EpSC proliferation and explored the underlying mechanisms.We found that quercetin at 0.1~1μM significantly promoted EpSC proliferation and increased the number of cells in S phase.The pro-proliferative effect of quercetin on EpSCs was confirmed in cultured human skin tissue.Mechanistic studies showed that quercetin significantly upregulated the expressions ofβ-catenin,c-Myc,and cyclins A2 and E1.Inhibitor forβ-catenin or c-Myc significantly inhibited quercetin-induced EpSC proliferation.Theβ-catenin inhibitor XAV-939 suppressed quercetin-induced expressions ofβ-catenin,c-Myc,and cyclins A2 and E1.The c-Myc inhibitor 10058-F4 inhibited the upregulation of c-Myc and cyclin A2 by quercetin.Pretreatment of EpSCs with estrogen receptor(ER)antagonist ICI182780,but not the G protein-coupled ER1 antagonist G15,reversed quercetin-induced cell proliferation and upregulation ofβ-catenin,c-Myc,and cyclin A2.Collectively,these results indicate that quercetin promotes EpSC proliferation through ER-mediated activation ofβ-catenin/c-Myc/cyclinA2 signaling pathway and ER-independent upregulation of cyclin E1 and that quercetin may accelerate skin wound healing through promoting EpSC proliferation.As EpSCs are used not only in clinic to treat skin wounds but also as seed cells in skin tissue engineering,quercetin is a useful reagent to expand EpSCs for basic research,skin wound treatment,and skin tissue engineering. | Zhaodong Wang Guangliang Zhang Yingying Le Jihui Ju Ping Zhang Dapeng Wan Qiang Zhao Guangzhe Jin Hao Su Jinwei Liu Jiaxuan Feng Yi Fu Ruixing Hou | 2020 | Acta Biochimica et Biophysica Sinica2020，52，10： | 3 |
| 3 | Effect of exogenous silicon (Si) on H + -ATPase activity, phospholipids and fluidity of plasma membrane in leaves of salt-stressed barley ( Hordeum vulgare L.)显示文摘 | Yongchao Liang Wenhua Zhang Qin Chen Youliang Liu Ruixing Ding | 2005 | Environmental and Experimental Botany2005，，3： | 1 |
| 4 | Comparison of Lipid Levels, Hyperlipidemia Prevalence and Its Risk Factors between Guangxi Hei Yi Zhuang and Han Populations显示文摘 | Yin Ruixing Chen Yuming Pan Shangling He Fengping Liu Tangwei Yang Dezhai Wu Jinzhen Yao Limei Lin Weixiong Li Rongshan Huang Jiandong | 2006 | Archives of Medical Research2006，，6： | 1 |
| 5 | Exogenous silicon (Si) increases antioxidant enzyme activity and reduces lipid peroxidation in roots of salt-stressed barley ( Hordeum vulgare L.)显示文摘 | Yongchao Liang Q.i.n. Chen Qian Liu Wenhua Zhang Ruixing Ding | 2003 | Journal of Plant Physiology2003，，10： | 1 |
| 6 | Advance in germplasm innovation and gene mining of high-oil maize显示文摘As one of the 3 worldwide major grain crops, maize is the main source of food, feed and edible vegetable oil. High-oil maize has been selectively bred for many years due to its high oil content and nutritional quality. However, compared with normal maize, the progress of high-oil maize breeding is hindered nowadays. Main problems are scarce of high-oil maize germplasm, conventional breeding methods, and slow genetic research progress on oil content and fatty acid composition. In this study, germplasm innovation and gene mining of high-oil maize were reviewed to provide theoretical reference for genetic breeding and utilization. Several high-oil basic populations have been developed after more than 100 years of selection, which have served as the unique resources for high-oil maize breeding. They have also been used to dissect genetic architecture of oil biosynthesis in maize kernel. Using linkage and association analyses, many QTLs and loci associated with oil content and fatty acid composition have been identified and mapped. In addition, some candidate genes for QTLs have been validated to regulate maize grain oil content and fatty acid composition. Prospect for high-oil maize was also discussed to provide knowledge about genetic mechanism of oil biosynthesis and improvement of kernel quality in maize. | Meiyan Hong Xiangxiang Zhang Qiong Liu Lixia Luo Ruixing Guo | 2018 | Oil Crop Science2018，3，4： | 1 |
| 7 | The Optimal Dividend Barrier in the Perturbed Compound Poisson Risk Model with Randomized Observation Time显示文摘This paper considers the dividend problems in the perturbed compound Poisson risk model.Assume that dividends can only be paid at the observation time when the surplus exceeds the barrier level and the excess is paid as dividend.In this paper,integro-differential equations for the expected discounted dividends until ruin and the Laplace transform of ruin time are firstly derived.When the claim is exponentially distributed,explicit expressions for the expected discounted dividends until ruin and the Laplace transform of ruin time are also obtained.Finally,the optimal dividend barrier which maximizes the expected discounted dividends until ruin is given. | LIU Xiao CHEN Zhenlong MING Ruixing | 2015 | Journal of Systems Science & Complexity2015，28，2： | 1 |
| 8 | Disaster mitigation role of urban parks for disaster prevention 显示文摘 | Su Youpo Liu Ruixing | 2004 | Journal of Disaster Prevention and Mitigation Engineering2004，24，2： | 1 |
| 9 | Ulnar artery distal cutaneous descending branch as free flap in hand reconstruction显示文摘 | JU Jihui LIU Yuefei HOU Ruixing | 2009 | Injury2009，40，12： | 1 |
| 10 | Angiopoietin-like 4 promotes epidermal stem cell proliferation and migration and contributes to cutaneous wound re-epithelialization显示文摘Proliferation and migration of epidermal stem cells(EpSCs)are essential for epithelialization during skin wound healing.Angiopoietin-like 4(ANGPTL4)has been reported to play an important role in wound healing,but the mechanisms involved are not fully understood.Here,we investigate the contribution of ANGPTL4 to full-thickness wound re-epithelialization and the underlying mechanisms using Angptl4-knockout mice.Immunohistochemical staining reveals that ANGPTL4 is significantly upregulated in the basal layer cells of the epidermis around the wound during cutaneous wound healing.ANGPTL4 deficiency impairs wound healing.H&E staining shows that ANGPTL4 deficiency significantly reduces the thickness,length and area of the regenerated epidermis postwounding.Immunohistochemical staining for markers of EpSCs(α6 integrin andβ1 integrin)and cell proliferation(PCNA)shows that the number and proliferation of EpSCs in the basal layer of the epidermis are reduced in ANGPTL4-deficient mice.In vitro studies show that ANGPTL4 deficiency impedes EpSC proliferation,causes cell cycle arrest at the G1 phase and reduces the expressions of cyclins D1 and A2,which can be reversed by ANGPTL4 overexpression.ANGPTL4 deletion suppresses EpSC migration,which is also rescued by ANGPTL4 overexpression.Overexpression of ANGPTL4 in EpSCs accelerates cell proliferation and migration.Collectively,our results indicate that ANGPTL4 promotes EpSC proliferation by upregulating cyclins D1 and A2 expressions and accelerating the cell cycle transition from G1 to S phase and that ANGPTL4 promotes skin wound re-epithelialization by stimulating EpSC proliferation and migration.Our study reveals a novel mechanism underlying EpSC activation and re-epithelialization during cutaneous wound healing. | Yuan Yang Chenghao Yu Yingying Le Weijuan Gong Jihui Ju Guangliang Zhang Pengxiang Ji Rui Zuo Zhe Liu Ping Zhang Ruixing Hou Yi Fu | 2023 | Acta Biochimica et Biophysica Sinica2023，55，8： | 0 |
| 11 | Inhibition of Cancer Cell Migration and Glycolysis by Terahertz Wave Modulation via Altered Chromatin Accessibility显示文摘Metastasis and metabolic disorders contribute to most cancer deaths and are potential drug targets in cancer treatment. However, corresponding drugs inevitably induce myeloid suppression and gastrointestinal toxicity. Here, we report a nonpharmaceutical and noninvasive electromagnetic intervention technique that exhibited long-term inhibition of cancer cells. Firstly, we revealed that optical radiation at the specific wavelength of 3.6 μm (i.e., 83 THz) significantly increased binding affinity between DNA and histone via molecular dynamics simulations, providing a theoretical possibility for THz modulation- (THM-) based cancer cell intervention. Subsequent cell functional assays demonstrated that low-power 3.6 μm THz wave could successfully inhibit cancer cell migration by 50% and reduce glycolysis by 60%. Then, mRNA sequencing and assays for transposase-accessible chromatin using sequencing (ATAC-seq) indicated that low-power THM at 3.6 μm suppressed the genes associated with glycolysis and migration by reducing the chromatin accessibility of certain gene loci. Furthermore, THM at 3.6 μm on HCT-116 cancer cells reduced the liver metastasis by 60% in a metastatic xenograft mouse model by splenic injection, successfully validated the inhibition of cancer cell migration by THM in vivo. Together, this work provides a new paradigm for electromagnetic irradiation-induced epigenetic changes and represents a theoretical basis for possible innovative therapeutic applications of THM as the future of cancer treatments. | Lan Suno Yangmei Li Yun Yu Peiliang Wang Shengquan Zhu KaijieWu Yan Liu Ruixing Wang Li Min Chao Chan | 2022 | Research2022，，4： | 0 |
| 12 | Release of deposited MnO2 nanoparticles from aqueous surfaces显示文摘Changes in solution chemistry and transport conditions can lead to the release of deposited MnO2 nanoparticles from a solid interface,allowing them to re-enter the aqueous environment.Understanding the release behavior of Mn02 nanoparticles from naturally occurring surfaces is critical for better prediction of the transport potential and environmental fate of Mn02 nanoparticles.In this study,the release of Mn02 nanoparticles was investigated using a quartz crystal microbalance with dissipation monitoring(QCM-D),and different environmental surface types,solution pH values and representative macromolecular organics were considered.Mn02 nanoparticles were first deposited on crystal sensors at elevated NaN03 concentrations before being rinsed with double-deionized water to induce their remobilization.The results reveal that the release rate of Mn02 depends on the surface type,in the decreasing order:SiO2>Fe304>Al2 O3,resulting from electrostatic interactions between the surface and particles.Moreover,differences in solution pH can lead to variance in the release behavior of Mn02 nanoparticles.The release rate from surfaces was significantly higher at pH 9.8 that at 4.5,indicating that alkaline conditions were more favorable for the mobilization of Mn02 in the aquatic environment.In the presence of macromolecular organics,bovine serum albumin(BSA)can inhibit the release of Mn02 from the surfaces due to attractive forces.In presence of humic acid(HA)and sodium alginate(SA),the Mn02 nanoparticles were more likely to be mobile,which may be associated with a large repulsive barrier imparted by steric effects. | Hainan Wang Ruixing Huang Chengxue Ma Xiaoling Li Caihong Liu Qiang He Zhengsong Wu Jun Ma Xiaoliu Huangfu | 2020 | Journal of Environmental Sciences2020，32，4： | 0 |
| 13 | Rhodium^Ⅲ/Silver^ⅠRelay Catalyzed C-H Aminomethylation with Imine Equivalents and Lewis Acid Catalyzed[4+2]Cycloaddition of Indoles with Triarylhexahydrotriazine显示文摘Summary of main observation and conclusion A Rh^Ⅲ/Ag^Ⅰrelay-catalyzed C(sp^2)—H coupling of indoles with triarylhexahydrotriazine(THT)is reported in this context.Upon merging Rh^Ⅲ-catalyzed C(sp^2)—H bond activation and silver promoted THT dissociation,an efficient indole's C3 aminomethylation protocol is uncovered,providing C3 aminomethyl indoles in good yields and exhibiting potential applications for the synthesis of complicated bioactive compounds.We revealed the C3-selectivity of this reaction through a detailed mechanistic investigation.Meanwhile,during the examination of the reaction conditions,we discovered another[4+2]cycloaddition pathway to afford tetrahydro-indolo[3,2-c]quinoline scaffold products via silver or Lewis acid catalysis. | Ruixing Liu Yin Wei Min Shi | 2020 | Chinese Journal of Chemistry2020，38，9： | 0 |
| 14 | Analysis of yield and quality characteristics of winter oilseed rape in China from 2001 to 2015: towards future breeding goals显示文摘The exciting outcomes of national regional trials have led to production and industrialization of China oilseed rape to a larger extent. To understand current trends of yield and quality traits of new varieties, data of national winter oilseed rape trials from 2001 to 2015 in 4 districts(upper, middle, lower Yangtze River and Huang-Huai River) was comprehensively analyzed. Results showed that average yield of new varieties of winter oilseed rape increased during the study period. In 2013, average yield of each district reached its highest level. Number of pod per plant reached its peak in 2011 and then declined rapidly in the next 4 years. Average number of seeds per pod did not significantly changed in any districts. Moreover, 1,000 seeds weight increased most obviously in Huang-Huai River district. After 2007, new oilseed rape varieties encountered the double-low quality(i.e., low erucic acid and low glucosinolate). In addition, oil content of new oilseed rape varieties increased over 15 years period and average oil content of all tested varieties during 2006-2015 was 42.96%, which was 2.38% higher than in 2005. Future breeding goals should be set to further improve yield, oil content, oil quality(such as high oleic acid and low saturated fatty acids), achieve full mechanization of oilseed rape production process and develop ideotypes. | Xiangxiang Zhang Qiong Liu Meiyan Hong Lixia Luo Ruixing Guo | 2018 | Oil Crop Science2018，3，3： | 0 |
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