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| 1 | A novel m6A reader Prrc2a controls oligodendroglial specification and myelination显示文摘While N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic mRNA, is linked to cell differentiation and tissue development, the biological significance of m6A modification in mammalian glial development remains unknown. Here, we identify a novel m6A reader, Prrc2a (Proline rich coiled-coil 2A), which controls oligodendrocyte specification and myelination. Nestin-Cre-mediated knockout of Prrc2a induces significant hypomyelination, decreased lifespan, as well as locomotive and cognitive defects in a mouse model. Further analyses reveal that Prrc2a is involved in oligodendrocyte progenitor cells (OPCs) proliferation and oligodendrocyte fate determination. Accordingly, oligodendroglial-lineage specific deletion of Prrc2a causes a similar phenotype of Nestin-Cre-mediated deletion. Combining transcriptome-wide RNA-seq, m6A-RIP-seq and Prrc2a RIP-seq analysis, we find that Olig2 is a critical downstream target gene of Prrc2a in oligodendrocyte development. Furthermore, Prrc2a stabilizes Olig2 mRNA through binding to a consensus GGACU motif in the Olig2 CDS (coding sequence) in an m6A-dependent manner. Interestingly, we also find that the m6A demethylase, Fto, erases the m6A modification of Olig2 mRNA and promotes its degradation. Together, our results indicate that Prrc2a plays an important role in oligodendrocyte specification through functioning as a novel m6A reader. These findings suggest a new avenue for the development of therapeutic strategies for hypomyelination-related neurological diseases. | Rong Wu Ang Li Baofa Sun Jian-Guang Sun Jinhua Zhang Ting Zhang Yusheng Chen Yujie Xiao Yuhao Gao Qingyang Zhang Jun Ma Xin Yang Yajin Liao Wei-Yi Lai Xiaolong Qi Shukun Wang Yousheng Shu Hai-Lin Wang Fengchao Wang Yun-Gui Yang Zengqiang Yuan | 2019 | Cell Research2019，29，1： | 32 |
| 2 | Prognostic value of preoperative serum tumor markers in gastric cancer显示文摘AIM:To evaluate the prognostic value of preoperative carcinoembryonic antigen(CEA), carbohydrate antigen(CA)19-9, and CA50 in patients undergoing D2 resection.METHODS:We evaluated 363 patients with gastric cancer who underwent gastrectomy at our hospital from January 2006 to December 2009. Blood samples were obtained from each patient within 1 wk before surgery. The cut-off values for serum CEA, CA19-9,and CA50 were 5 ng/mL, 37 U/mL, and 20 U/mL, respectively. The correlation between preoperative tumor marker levels and prognosis was studied by means of univariate and multivariate analyses.RESULTS:The preoperative serum positive rates of CEA, CA19-9 and CA50 were 24.0%, 18.9% and24.5%, respectively. The positivity rate of serum CEA was significantly correlated with age(P < 0.001), sex(P = 0.022), tumor size(P = 0.007) and depth of invasion(P = 0.018); CA19-9 with tumor size(P = 0.042)and lymph node metastasis(P < 0.001); and CA50 onlywith lymph node metastasis(P = 0.001). In multivariate analysis, tumor size, T category, N category, vascular or neural invasion, and adjuvant chemotherapy were independent prognostic factors for overall survival. CA19-9 had an independent prognostic significance in patients without adjuvant chemotherapy(P = 0.027).CONCLUSION:Preoperative serum CEA, CA19-9 and CA50 are prognostic in patients with gastric cancer. Only CA19-9 is an independent prognostic factor after surgery without adjuvant chemotherapy. | Ze-Bo Huang Xin Zhou Jun Xu Yi-Ping Du Wei Zhu Jian Wang Yong-Qian Shu Ping Liu | 2014 | World Journal of Clinical Oncology2014，5，2： | 30 |
| 3 | Antidiabetic Effects of Gegen Qinlian Decoction via the Gut Microbiota Are Attributable to Its Key Ingredient Berberine显示文摘Gegen Qinlian Decoction(GQD),a traditional Chinese medicine(TCM)formula,has long been used for the treatment of common metabolic diseases,including type 2 diabetes mellitus.However,the main limitation of its wider application is ingredient complexity of this formula.Thus,it is critically important to identify the major active ingredients of GQD and to illustrate mechanisms underlying its action.Here,we compared the effects of GQD and berberine,a hypothetical key active pharmaceutical ingredient of GQD,on a diabetic rat model by comprehensive analyses of gut microbiota,short-chain fatty acids,proinflammatory cytokines,and ileum transcriptomics.Our results show that berberine and GQD had similar effects on lowering blood glucose levels,modulating gut microbiota,inducing ileal gene expression,as well as relieving systemic and local inflammation.As expected,both berberine and GQD treatment significantly altered the overall gut microbiota structure and enriched many butyrate-producing bacteria,including Faecalibacterium and Roseburia,thereby attenuating intestinal inflammation and lowering glucose.Levels of short-chain fatty acids in rat feces were also significantly elevated after treatment with berberine or GQD.Moreover,concentration of serum proinflammatory cytokines and expression of immune-related genes,including Nfkb1,Stat1,and Ifnrg1,in pancreatic islets were significantly reduced after treatment.Our study demonstrates that the main effects of GQD can be attributed to berberine via modulating gut microbiota.The strategy employed would facilitate further standardization and widespread application of TCM in many diseases. | Xizhan Xu Zezheng Gao Fuquan Yang Yingying Yang Liang Chen Lin Han Na Zhao Jiayue Xu Xinmiao Wang Yue Ma Lian Shu Xiaoxi Hu Na Lyu Yuanlong Pan Baoli Zhu Linhua Zhao Xiaolin Tong Jun Wang | 2020 | Genomics, Proteomics & Bioinformatics2020，18，6： | 29 |
| 4 | Prevalence of Thyroid Nodules and Its Relationship with Iodine Status in Shanghai:a Population-based Study显示文摘Objective This study was designed to evaluate the prevalence of thyroid nodules(TNs) and its relationship with urine iodine concentrations(UICs) after the regional rapid economic growth and lifestyle changes. Methods A cross-sectional survey was conducted in the general population aged 15-69 years. A questionnaire regarding general and personal characteristics and relevant information was administered. Ultrasonography of the thyroid was performed, and serum triiodothyronine(T3), tetraiodothyronine(T4), serum thyroid stimulating hormone(TSH), free triiodothyronine(FT3), free tetraiodothyronine(FT4), thyroglobulin antibody(Tg Ab), thyroid peroxidase antibody(TPOAb), and TSH receptor antibody(TRAb) levels were measured for each individual subject. Results The prevalence rates of TNs in the whole population, females and males were 27.76%, 34.04%, and 21.60%, respectively. The prevalence of multiple nodules increased with age, whereas the prevalence peaks differed between males and females. The median UICs in the whole population and females with non-TNs were higher than those of subjects with TNs(P=0.0035, P=0.0068). The median UICs in subjects with a single TN were higher than those in subjects with multiple TNs(P=0.0164, P=0.0127). The result showed a U-shaped curve relationship between UIC and prevalence of TNs. The prevalence of TNs was the lowest when the UIC was 140-400 μg/L. Conclusion The prevalence of TNs was nearly 30% and increased with age. The relationship between UIC and prevalence of TNs is U-shaped, with an increase in risk when the UIC was <140 μg/L and >400 μg/L. Very low or high UIC levels need attention and correction. | SONG Jun ZOU Shu Rong GUO Chang Yi ZANG Jia Jie ZHU Zhen Ni MI Ming HUANG Cui Hua YU Hui Ting LU Xi RUAN Ye WU Fan | 2016 | Biomedical and Environmental Sciences2016，29，6： | 25 |
| 5 | High-resolution remote sensing mapping of global land water显示文摘Land water, one of the important components of land cover, is the indispensable and important basic information for climate change studies, ecological environment assessment, macro-control analysis, etc. This article describes the overall study on land water in the program of global land cover remote sensing mapping. Through collection and processing of Landsat TM/ETM+, China's HJ-1 satellite image, etc., the program achieves an effective overlay of global multi-spectral image of 30 m resolution for two base years, namely, 2000 and 2010, with the image rectification accuracy meeting the requirements of 1:200000 mapping and the error in registration of images for the two periods being controlled within 1 pixel. The indexes were designed and selected reasonably based on spectral features and geometric shapes of water on the scale of 30 m resolution, the water information was extracted in an elaborate way by combining a simple and easy operation through pixel-based classification method with a comprehensive utilization of various rules and knowledge through the object-oriented classification method, and finally the classification results were further optimized and improved by the human-computer interaction, thus realizing high-resolution remote sensing mapping of global water. The completed global land water data results, including Global Land 30-water 2000 and Global Land 30-water 2010, are the classification results featuring the highest resolution on a global scale, and the overall accuracy of self-assessment is 96%. These data are the important basic data for developing relevant studies, such as analyzing spatial distribution pattern of global land water, revealing regional difference, studying space-time fluctuation law, and diagnosing health of ecological environment. | LIAO AnPing CHEN LiJun CHEN Jun HE ChaoYing CAO Xin CHEN Jin PENG Shu SUN FangDi GONG Peng | 2014 | Science China Earth Sciences2014，57，10： | 22 |
| 6 | A novel gene delivery system targeting cells expressing VEGF receptors显示文摘Two ligand oligopeptides GV1 and GV2 were designed according to the putative binding region of VEGF to its receptors. GV1, GV2 and endosome releasing oligopeptide HA20 were conjugated with poly-L-lysine or protamine and the resulting conjugates could interact with DNA in a noncovalent bond to form a complex. Using pSV2-β-galactosidase as a reporter gene, it has been demonstrated that exogenous gene was transferred into bovine aortic arch-derived endothelial cells (ABAE) andhuman malignant melanoma cell lines (A375) in vitro. In vivo experiments, exogenous gene was transferred into tumor vascular endothelial cells and tumor cells of subcutaneously transplanted human colon cancer LOVO, human malignant melanoma A375 and human hepatoma graft in nude mice. This system could also target gene to intrahepatically transplanted human hepatoma injected via portal vein in nude mice. These results are correlated with theGene delivery system targeting VEGF receptors relevant receptors (flt-1, flk-1/KDR) expression on the targeted cells and tissues. | LI JUN MIN JUN SONG HAN YI HUANG PEI KUN TIAN SHU MIN QU MIN YAO HUI QIU JIANG DA FANG WAN JING CHU LUO CHENG XIAO GU JIAN REN GU( National Labomtory for Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai 200032,China)(National Laboratory of | 1999 | Cell Research1999，9，1： | 22 |
| 7 | Perspectives of traditional Chinese medicine in pancreas protection for acute pancreatitis显示文摘Acute pancreatitis(AP)is one of the most common diseases.AP is associated with significant morbidity and mortality,but it lacks specific and effective therapies.Traditional Chinese medicine(TCM)is one of the most popular complementary and alternative medicine modalities worldwide for the treatment of AP.The current evidence from basic research and clinical studies has shown that TCM has good therapeutic effects on AP.This review summarizes the widely used formulas,single herbs and monomers that are used to treat AP and the potential underlying mechanisms of TCM.Because of the abundance,low cost,and safety of TCM as well as its ability to target various aspects of the pathogenesis,TCM provides potential clinical benefits and a new avenue with tremendous potential for the future treatment of AP. | Jun Li Shu Zhang Rui Zhou Jian Zhang Zong-Fang Li | 2017 | World Journal of Gastroenterology2017，23，20： | 20 |
| 8 | Effect of Kuanxiong Aerosol(宽胸气雾剂)on Patients with Angina Pectoris:A Non-inferiority Multi-center Randomized Controlled Trial显示文摘Objective: To evaluate the effect and safety of Kuanxiong Aerosol(宽胸气雾剂, KA) on patients with angina pectoris. Methods: Block randomization was performed to randomly allocate 750 patients into KA(376 cases) and control groups(374 cases). During an angina attack, the KA group received 3 consecutive sublingual sprays of KA(0.6 m L per spray). The control group received 1 sublingual nitroglycerin tablet(NT, 0.5 mg/tablet). Log-rank tests and Kaplan-Meier estimations were used to estimate the angina remission rates at 6 time-points after treatment(1, 2, 3, 4, 5, and >5 min). Logistic regression analysis was performed to observe the factors influencing the rate of effective angina remission, and the remission rates and incidences of adverse reactions were compared for different Canadian Cardiovascular Society(CCS) classes of angina. Results: The 5-min remission rates in the KA and control groups were not significantly different(94.41% vs. 90.64%, P>0.05). The angina CCS class significantly influenced the rate of remission (95% confidence interval = 0.483–0.740, P<0.01). In the CCS subgroup analysis, the 3-and 5-min remission rates for KA and NT were similar in the CCSⅠ and Ⅳ subgroups(P>0.05), while they were significantly better for KA in the CCSⅡ and Ⅲ subgroups(P<0.05 or P<0.01). Furthermore, the incidence of adverse reactions was significantly lower in the KA group than in the control group for the CCSⅡ and Ⅲ subgroups(9.29% vs. 26.22%, 10.13% vs. 20.88%, P<0.05 or P<0.01). Conclusions: KA is not inferior to NT in the remission of angina. Furthermore, in CCSⅡ and Ⅲ patients, KA is superior to NT, with a lower incidence of adverse reactions. | YANG Qiao-ning BAI Rui-na DONG Guo-ju GE Chang-jiang ZHOU Jing-min HUANG Li HE Yan WANG Jun REN Ai-hua HUANG Zhan-quan ZHU Guang-li LU Shu XIONG Shang-quan XIAN Shao-xiang ZHU Zhi-jun SHI Da-zhuo LU Shu-zheng LI Li-zhi CHEN Ke-ji | 2018 | Chinese Journal of Integrative Medicine2018，24，5： | 15 |
| 9 | Characterization and Evaluation of OsLCT1 and OsN ramp5 Mutants Generated Through CRISPR/Cas9-Mediated Mutagenesis for Breeding Low Cd Rice显示文摘To explore how rice(Oryza sativa L.) can be safely produced in Cd-polluted soil, OsLCT1 and OsNramp5 mutant lines were generated by CRISPR/Cas9-mediated mutagenesis. One of OsLCT1 mutant(lct1×1) and two of OsNramp5 mutants(nramp5×7 and nramp5×9) were evaluated for grain Cd accumulation and agronomic performances. In paddy field soil containing approximately 0.9 mg/kg Cd, lct1×1 grains contained approximately 40%(0.17 mg/kg) of the Cd concentration of the wild type parental line, less than the China National Food Safety Standard(0.20 mg/kg). Both OsNramp5 mutants showed low grain Cd accumulation(< 0.06 mg/kg) in the paddy(approximately 0.9 mg/kg Cd) or in pots in soil spiked with 2 mg/kg Cd. However, only nramp5×7 showed normal growth and yield, whereas the growth of nramp5×9 was severely impaired. The study showed that lct1×1 could be used to produce rice grains safe for human consumption in lightly contaminated paddy soils and nramp5×7 used in soils contaminated by much higher levels of Cd. | LIU Songmei JIANG Jie LIU Yang MENG Jun XU Shouling TAN Yuanyuan LI Youfa SHU Qingyao HUANG Jianzhong | 2019 | Rice science2019，26，2： | 15 |
| 10 | Almost Sure Convergence Theorem and Strong Stability for Weighted Sums of NSD Random Variables显示文摘In this paper, Kolmogorov-type inequality for negatively superadditive dependent (NSD) random variables is established. By using this inequality, we obtain the almost sure convergence for NSD sequences, which extends the corresponding results for independent sequences and negatively associated (NA) sequences. In addition, the strong stability for weighted sums of NSD random variables is studied. | Yan SHEN Xue Jun WANG Wen Zhi YANG Shu He HU | 2013 | Acta Mathematica Sinica,English Series2013，29，4： | 14 |
| 11 | Changes in count and function of splenic lymphocytes from patients with portal hypertension显示文摘AIM: To investigate changes in numbers and proliferative function of splenic lymphocytes in patients with hypersplenism due to portal hypertension (PH), to provide evidence for further study of immune status of the spleen during PH. METHODS: Twelve spleens from patients with hypersplenism due to PH served as the PH group, and four spleens from cases of traumatic spleen rupture were regarded as the control group. After weighing the spleen, lymphocytes were separated and counted using a cell counting plate to calculate the lymphocyte count per gram of spleen tissue (relative quantity) and total lymphocyte count in whole spleen (absolute quantity). The immunohistochemical SP method was used to observe the density and distribution of lymphocytes in the spleen. The MTT method was used to observe changes in lymphocyte proliferative function. RESULTS: As compared to the control group, the splenic lymphocytes in the PH group showed that: (1) There was no difference in distribution but a significant decreasein density; (2) the number of lymphocytes per gram of spleen (relative quantity) decreased significantly (0.822 ± 0.157) × 108 vs (1.174 ± 0.254) × 108, P < 0.01]; (3) with the significant increase in the weight of the PH spleen (832.6 ± 278.2 g vs 211.7 ± 85.6 g, P < 0.01), the total quantity of lymphocytes (absolute quantity) increased significantly (0.685 ± 0.072) × 1011 vs (0.366 ± 0.057) × 1011, P < 0.01]; and (4) the proliferative function of lymphocytes was enhanced: T lymphocytes, (0.022 ± 0.005 vs 0.015 ± 0.003, P < 0.05), and B lymphocytes (0.034 ± 0.006 vs 0.023 ± 0.001, P < 0.01). CONCLUSION: Although lymphocyte density in the spleen decreased in patients with PH, the total quantity of lymphocytes increased because spleen weight increased greatly, along with the proliferating function. With respect to changes in lymphocytes, PH spleens may still have immune function, although it may be disordered. However, complete evaluation of the immune function of the spleen in PH requires more research. | Zong-Fang Li Shu Zhang Gao-Bo Lv Ying Huang Wei Zhang Song Ren Jun Yang Shuang-Suo Dang | 2008 | World Journal of Gastroenterology2008，14，15： | 13 |
| 12 | Synthesis and characterization of lower generation broom molecules显示文摘与亢奋的分支被迈克尔增加与 dodecylamine 和甲基压克力在甲醇综合的十二烷基组一起的树枝状的分子作为原料吃了。这新型的树枝状的分子生动地被叫“在这的扫帚分子”报导。扫帚分子的水溶液的表面张力解雇了氨基的组被使用落下卷方法测量。为油 / 水(O/W ) 的扫帚分子的反乳化表演模仿了原油乳状液被检验。试验性的结果揭示了那,作为一表面活化剂新型,扫帚分子解雇了为 O/W 给反乳化看的氨基的组模仿的原油乳状液。 | Jun Wang Cui Qin Li Shu Yan Zhang Fang Sun Teng Jie Ge | 2008 | Chinese Chemical Letters2008，19，1： | 13 |
| 13 | New Triterpenes from Siyekucai (Ixeris chinensis)显示文摘Three new triterpenes, 3β,21α-dihydroxylupen-18(19)-en (1), 3β,25-dihydroxytirucalla-7,23(24)-dien (2), and 21α-hydroxy-19α-hydrogentaraxasterol-20(30)-en (3) were obtained froman ethyl acetate extract of the whole plant of Siyekucai (Ixeris chinensis). The structures of 1-3were determined by spectroscopic methods (EIMS, IR, 1D and 2D NMR). | Shu Jun ZHANG Jin Lan WANG Qi Gang DENG Masayoshi ANDO | 2006 | Chinese Chemical Letters2006，17，2： | 13 |
| 14 | Interferon and lamivudine combination therapy versus lamivudine monotherapy for hepatitis B e antigen-negative hepatitis B treatment:a meta-analysis of randomized controlled trials显示文摘BACKGROUND:It has been demonstrated that only a minority of patients with hepatitis B e antigen(HBeAg)-negative chronic hepatitis B(CHB) obtain a sustained response after either interferon(IFN) or nucleos(t)ide analogue monotherapy.Therefore,combination therapy of drugs with synergistic antiviral effects was proposed to have a sustained response in these patients.We compared the effect and safety of lamivudine monotherapy and its combination with IFN including conventional interferon(CON-IFN) and pegylated interferon(PEG-IFN) for HBeAg-negative CHB patients.DATA SOURCES:A group of three independent reviewers identified 9 eligible randomized controlled trials through electronic searches(MEDLINE,OVID,EMBASE,the Cochrane Library Clinical Trials Registry,and the Chinese Medical Database),manual searches,and contact with experts.Sustained virological and biochemical responses were defined as primary efficacy measures.We performed quantitative meta-analyses to assess differences between CON-IFN plus lamivudine combination and lamivudine monotherapy groups.RESULTS:No greater sustained virological and biochemical rates were found in patients receiving CON-IFN/lamivudine combination therapy [29.1% vs.26.7%,odds ratio(OR)=0.98,95% confidence interval(CI) 0.65-1.50,P=0.94,and 41.8% vs.40.3%,OR=1.13,95% CI 0.78-1.65,P=0.51,respectively],though a reduced YMDD mutation rate was achieved in the combination group [8.39% vs.30.0%,OR=0.16,95% CI 0.076-0.33,P<0.001].However,data from one PEG-IFN trial showed greater sustained virological and biochemical rates in patients receiving combination therapy [response rate 19.5% vs.6.6%,OR=3.42,95% CI 1.71-6.84,P<0.001 and 60.0% vs.44.2%,OR=1.88,95% CI 1.23-2.85,P=0.003,respectively].CONCLUSIONS:Addition of CON-IFN to lamivudine did not improve treatment efficacy but suppressed YMDD mutation by lamivudine.Combination of PEG-IFN and lamivudine might increase the sustained response,and further clinical trials are needed for confirmation. | Shi, Yu Wu, Yi-Hua Shu, Zhe-Yue Zhang, Wan-Jun Yang, Jun Chen, Zhi | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，5： | 12 |
| 15 | THE EFFECTS OF RADIATION STRESS ON WAVE HEIGHTS AND SEA LEVEL IN THE INTERACTION OF COUPLED WAVE-TIDE-SURGE IN THE COASTAL AREA显示文摘Based on coastal high resolution (2′×2′) coupled wave tide surge interaction numerical model, the effects of radiation stress on wave heights and sea level in the coastal area of Huanghe Delta were studied. By comparisons of simulated and measured wave heights and sea level for two mediately strong weather cases, it is demonstrated that the results simulated by coupled wave tide surge model are closer to the measured and particularly in excellent agreement in the extreme values of the wave heights and set up. This study shows that the radiation stress can increase the wave heights maximally to 67cm and sea level to 40cm. It is also found that there are areas of over 50cm wave height increase and an area of over 20cm sea level increase in the Huanghe Delta coastal area, and this find may be very important in engineering. For this reason, it is suggested that in the practical engineering application, the coupled wave tide surge interaction numerical model should be prefered. | Lin Xiang, Yin Bao shu, Hou Yi jun, Su Jing zhi, Cheng Ming hua Institute of Oceanology, Chinese Academy of Sciences, Qingdao, 266071, China | 2003 | Journal of Hydrodynamics2003，15，1： | 12 |
| 16 | EFFECTS OF CONSOLIDATION TIME AND PARTICLE SIZE ON SCOUR RATES OF COHESIVE SEDIMENT显示文摘By means of flumes,experiments have been done in order to determine the effects of consolidation time and particle size on scour rates of cohesive sediment. Experimental results shown dry unit weight increased and scour rates decreased during the course of consolidation,the resistance to scour was related to consolidation time,but it presented different consolidation properties that depended on particle size. For the finer particle,the consolidation process was longer,the range of dry unit weight altered was greater,the consolidated sediments moved in chunks. On the other hand,based on analysis of the relationship of dry unit weight change with consolidation time,the simplified analytical expressions of dry unit weight and scour rates were derived,the results were checked with experimental data in the same flow situation and good agreements were achieved. Since the effects of different particle size were considered during the process of consolidation,the variations of consolidation properties were well reflected in these formulas. | TAN Guang-ming WANG Jun SHU Cai-wen LAI Yong-hui | 2007 | Journal of Hydrodynamics2007，19，2： | 11 |
| 17 | Self-Recirculating Casing Treatment for a Radial Compressor显示文摘Casing treatment is a widely employed technique to increase the stall margins of turbomachineries. In the last several decades,many researches on casing treatment have been carried out. However,the mechanism of its expanding stall margins is still not very clear. Till now,most casing teatment schemes are designed for axial compressors,while the investigations on casing treatments in centrifugal compressors are rarely reported. Moreover,current investigation methods mainly focus on experiments,and perfect theoretical analysis is not yet feasible. In order to study the effectiveness and further the mechanism of casing treatments in centrifugal compressors,in this paper,a computationally based investigation of the impact of the self-recirculating casing treatment on the performance of a radial compressor is carried out. The results indicate that,by casing bleed and injection,the casing treatment with inclined blades in the cavity expands the stall margin most. At low mass flows,the reversed flow through the cavity with inclined blades develops the counter swirl flow in front of the impeller inlet,which is considered to benefit increasing the pressure rise from the injection port to the bleed port and thereby augment the recirculating flow. At 120% design speed,the stall margin is larger than that at the design speed. However,the cost of extending the stall margin is the reduction of isentropic efficiency. A mended casing treatment by shifting the bleed port upstream is also studied. It is demonstrated that,relative to the original casing treatment,this mend can improve the efficiency evidently notwithstanding a little narrowing of the flow range. | XIAO Jun XU Wei GU Chuangang SHU Xinwei | 2009 | Chinese Journal of Mechanical Engineering2009，22，4： | 11 |
| 18 | EXPERIMENTAL STUDY OF SCOUR RATE IN CONSOLIDATED COHESIVE SEDIMENT显示文摘The erosion process of a cohesive sediment after consolidation was studied experimentally in a closed conduit system.The test samples investigated in this study are mixtures of sand and clay with variable compositions and different consolidation times.The main concern of this study is the effects of the dry density of the consolidated sediment on scour rate.A scour rate formula is derived and further interpreted based on the experimental results. | TAN Guang-ming JIANG Lei SHU Cai-wen LV Ping WANG Jun | 2010 | Journal of Hydrodynamics2010，22，1： | 11 |
| 19 | Mid-long Term Optimal Dispatching Method of Hydro-thermal Power System Considering Scheduled Maintenance显示文摘在中长期水火发电调度中考虑检修计划的影响是目前中长期水火发电调度面临的难题。利用现代整数代数建模技术,建立发电计划和检修计划协调优化的多场景调度模型。在该模型中,鉴于设备检修计划的连续性,在预测场景树的基础上,将场景节点划分成不同的场景,通过节点和场景关联矩阵,实现多场景下设备检修模型的构建。同时,鉴于中长期调度计划中发电计划和检修计划对时段间隔要求的不同,分别设置电量相关节点和电力相关节点,实现中长期发电计划和检修计划的协调。上述模型是一个大规模混合整数线性规划(mixed integer linear programming,MILP)问题,采用商用MILP求解器进行求解。大规模实际水火电系统的实例分析结果表明,所提模型和方法是可行、有效的。 | GE Xiaolin SHU Jun ZHANG Lizi | 2012 | 中国电机工程学报2012，32，13： | 11 |
| 20 | Effect of dry density on ^(125)I diffusion in GMZ bentonite显示文摘Gaomiaozi(GMZ) bentonite is regarded as the favorable candidate backfilling material for a potential repository in China.It is important to understand the diffusion behavior of 125 I in GMZ bentonite and compare the diffusion behavior in GMZ and other types of bentonite like MX-80,Avonlea,etc.Therefore,through-and out-diffusion experiments were conducted to obtain the effective diffusion coefficient(D e) and distribution coefficient(K d).A computer code named Fitting for diffusion coefficient(FDP) was used for the experimental data processing and theoretical modeling.At the dry density of GMZ bentonite from 1600-2000 kg/m 3,the D e values of 125 I were(2.4-20.4) × 10-12 m 2 /s and K d values were constants.At dry density above 1800 kg/m 3,the diffusion behaviors were almost the same,indicating that the anion exclusion was ineffective.Out-diffusion results showed that the species of 125 I may be changed during the diffusion processing.It was probably caused by some organic matters or reducing substances in GMZ bentonite.Since the main composition of bentonite is montmorillonite,similar diffusion parameters were obtained in GMZ and other types of bentonite.The relationship of D e and accessible porosity(acc) could be described by Archie's law with exponent n = 1.2-2.8 for 125 I diffusion in bentonite,whereas n = 2.0 in GMZ bentonite.Furthermore,bentonite with the dry density of 1800 kg/m 3 was proposed as the backfilling materials used in the construction of high level radioactivity waste repository. | WU Tao LI JinYing DAI Wei XIAO GuoPing SHU FuJun YAO Jun SU YuLan SHI Lei | 2012 | Science China Chemistry2012，55，9： | 11 |
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