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| 1 | Feature Extraction of Chinese Materia Medica Fingerprint Based on Star Plot Representation of Multivariate Data显示文摘Objective To study a novel feature extraction method of Chinese materia medica(CMM) fingerprint.Methods On the basis of the radar graphical presentation theory of multivariate,the radar map was used to figure the non-map parameters of the CMM fingerprint,then to extract the map features and to propose the feature fusion.Results Better performance was achieved when using this method to test data.Conclusion This shows that the feature extraction based on radar chart presentation can mine the valuable features that facilitate the identification of Chinese medicine. | CUI Jian-xin1,2,HONG Wen-xue1,ZHOU Rong-juan3,GAO Hai-bo1 1.College of Electrical Engineering,Yanshan University,Qinhuangdao 066004,China 2.Key Laboratory of Measurement Technology and Instrumentation of Hebei Province,Qinhuangdao 066004,China 3.Maternal and Child Health Hospital of Qinhuangdao,Qinhuangdao 066004,China | 2011 | Chinese Herbal Medicines2011，3，2： | 14 |
| 2 | Effects of salidroside on glioma formation and growth inhibition together with improvement of tumor microenvironment显示文摘Objective:To test the effects of salidroside on formation and growth of glioma together with tumor microenvironment.Methods:Salidroside extracted from Rhodiola rosea was purified and treated on human glioma cells U251 at the concentration of 20μg/mL.3-(4,5-dimethylthiazol-2-yl)-2,5-dephenyltetrazolium bromide(MTT)assay for cytotoxicity and flow cytometry(FCM)for cell cycle analysis were performed.Then for in vivo study,xenotransplantation tumor model in nude mice was generated and treated with salidroside at the concentration of 50 mg/kg.d for totally 20 d.Body weight and tumor size were detected every 2 d after the treatment.The levels of 8-isoprostane,superoxide dismutase(SOD)and malondialdehyde(MDA),special markers for oxidative stress,were detected while immunofluoresence staining was performed for astrocyte detection.Results:For in vitro study,salidroside could decrease the viability of human glioma cells U251 and the growth of U251 cells at G0/G1checkpoint during the cell cycle.For in vivo study,salidroside could also inhibit the growth of human glioma tissue in nude mice.The body weight of these nude mice treated with salidroside did not decrease as quickly as control group.In the tumor xenotransplantation nude mice model,mice were found of inhibition of oxidative stress by detection of biomarkers.Furthermore,overgrowth of astrocytes due to the stimulation of oxidative stress in the cortex of brain was inhibited after the treatment of salidroside.Conclusions:Salidroside could inhibit the formation and growth of glioma both in vivo and in vitro and improve the tumor microenvironment via inhibition of oxidative stress and astrocytes. | Yanshan Zhang Yunyi Yao Huijuan Wang Yanqin Guo Hui Zhang Liang Chen | 2013 | Chinese Journal of Cancer Research2013，25，5： | 14 |
| 3 | Solution of a hollow thick-wall cylinder subject to quadric function pressures and its limit when l→∞显示文摘The problem of a hollow thick-wall cylinder subject to quadric function pressures is solved with a new stress function, thus laying the basis for solving the spatial symmetric deformation of a hollow cylinder subject to arbitrarily distributed pressures. | LIU Zhubai1,SHAN Rui2,LIU Wen2 & NI Liyong1 1.College of Mechanical Engineering,Yanshan University,Qinhuangdao 066004,China 2.College of Science,Yanshan University,Qinhuangdao 066004,China | 2004 | Science China(Technological Sciences)2004，47，2： | 13 |
| 4 | Arabidopsis NIP3;1 Plays an Important Role in Arsenic Uptake and Root-to-Shoot Translocation under Arsenite Stress Conditions显示文摘在 Arabidopsis, nodulin 26-like 内在的蛋白质(捏) aquaporin 蛋白质的亚科由九个成员,组成哪个中的五个(NIP1; 1, NIP1; 2, NIP5; 1, NIP6; 1,并且 NIP7; 1 ) 以前被识别对亚砷酸盐可渗透。然而,角色在植物在亚砷酸盐的 root-to-shoot translocation 捏仍然保持糟糕理解。在这研究,用反向的基因策略, Arabidopsis NIP3; 1 被识别在亚砷酸盐压力条件下面在砷举起和 root-to-shoot 分发起一个重要作用。nip3; 1 loss-of-function 异种在亚砷酸盐忍耐显示了明显的改进为未葬生长和积累的更少砷在野类型的植物比那些射击,而 nip3; 1 nip1; 1 两倍异种显示出强壮的亚砷酸盐忍耐并且在亚砷酸盐压力条件下面改进了根和射击的生长。一个倡导者 -- glucuronidase 分析揭示了那 NIP3; 1 几乎专门在根被表示(与根尖端的异常) ,并且在酵母 Saccharomyces cerevisiae 的 heterologous 表示表明了那 NIP3; 1 能调停亚砷酸盐运输。一起拿,我们的结果建议那 NIP3; 1 在 Arabidopsis 涉及亚砷酸盐举起和 root-to-shoot translocation,可能作为被动、双向的亚砷酸盐 transporter。 | WenzhongXu Wentao Dai Huili Yan Sheng Li Hongling Shen Yanshan Chen Hua Xu Yangyang Sun Zhenyan He Mi Ma | 2015 | Molecular Plant2015，8，5： | 13 |
| 5 | THE M/M/c QUEUE WITH PH SYNCHRONOUS VACATIONS显示文摘1.IntroductionRecently,singleserverqueueswithvacationshavebeenstudiedextensivelyfromtheirowntheoreticalinterestaswellastheirapplicationstomanyengineeringsystemssuchascomputers,communicationnetworksandmanufacturingsystems.FOrtheM/G/lqueueingsystemswit... | TIAN Nai shuo (Department of Mathematics, Yanshan University, Qinhuangdao 066004,China) LI Quan lin (National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100080, China) | 2000 | Systems Science and Mathematical Sciences2000，13，1： | 13 |
| 6 | PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins显示文摘Mutations in RNA-binding proteins (RBPs) localized in ribonucleoprotein (RNP) granules, such as hnRNP A1 and TDP-43, promote aberrant protein aggregation, which is a pathological hallmark of various neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Protein posttranslational modifications (PTMs) are known to 佗gulate RNP granules. In this study, we investigate the function of poly(ADP-ribosyl)ation (PARylation), an important PTM involved in DNA damage repair and cell death, in RNP granule-related neurodegeneration. We reveal that PARylation levels are a major regulator of the assembly-disassembly dynamics of RNP granules containing disease-related RBPs, hnRNP A1 and TDP-43. We find that hnRNP A1 can both be PARylated and bind to PARylated proteins or poly(ADP-ribose)(PAR). We further uncover that PARylation of hnRNP A1 at K298 controls its nucleocytoplasmic transport, whereas PAR-binding via the PAR-binding motif (PBM) of hnRNP Al regulates its association with stress granules. Moreover, we reveal that PAR not only dramatically enhances the liquid-liquid phase separation of hnRNP A1, but also promotes the co-phase separation of hnRNP A1 and TDP-43 in vitro and their interaction in vivo. Finally, both genetic and pharmacological inhibition of PARP mitigates hnRNP Al- and TDP-43-mediated neurotoxicity in cell and Drosophila models of ALS. Together, our findings suggest a novel and crucial role for PARylation in regulating the dynamics of RNP granules, and that dysregulation in PARylation and PAR levels may con tribute to ALS disease pathoge nesis by promoting protei n aggregation. | Yongjia Duan Aiying Du Jinge Gu Gang Duan Chen Wang Xinrui Gui Zhiwei Ma Beituo Qian Xue Deng Kai Zhang Le Sun Kuili Tian Yaoyang Zhang Hong Jiang Cong Liu Yanshan Fang | 2019 | Cell Research2019，29，3： | 13 |
| 7 | New concept and new theory of mobility calculation for multi-loop mechanisms显示文摘In 2005,Gogu,a Frenchman,analyzed 35 different existing formulas for mobility calculation and pointed that the formulas for quick mobility calculation had some limitations and were not general.Therefore,looking for a general and simple mobility formula is still a hot topic in mechanisms.At the meantime,it is also an important topic to complete the mechanism theory.Gogu proposed a new method that can avoid determining virtual constraints in 2008,but the method is still not general.To solve the problem,this paper defines the new concepts of link-group rank,general-kinematic-pair rank,virtual pair,virtual loop,and virtual-loop rank,and gives a new simple and general formula.Our method converts multi-loop mechanisms into some independent virtual loops,simplifies the problem,avoids calculating virtual constraints,and reduces the calculation difficulty.It is proved that the new formula is simple,general and effective through the mobility analysis of several different kinds of mechanisms.The application of this formula will provide great convenience for general engineers in mobility calculation. | ZHANG YiTong & MU DeJun Mechanical Engineering College of Yanshan University,Qinhuangdao 066004,China | 2010 | Science China(Technological Sciences)2010，53，6： | 12 |
| 8 | Molten salts-modified MgO-based adsorbents for intermediate-temperature CO_2 capture: A review显示文摘Carbon dioxide(CO2) capture using magnesium oxide(MgO)-based adsorbents at intermediate temperatures has been regarded as a very prospective technology for their relatively high adsorption capacity,low cost, and wide availability. During the past few years, great effort has been devoted to the fabrication of molten salts-modified MgO-based adsorbents. The extraordinary progress achieved by coating with molten salts greatly promotes the CO_2 capture capacity of MgO-based adsorbents. Therefore, we feel it necessary to deliver a timely review on this type of CO_2 capturing materials, which will benefit the researchers working in both academic and industrial areas. In this work, we classified the molten saltsmodified MgO adsorbents into four categories:(1) homogenous molten salt-modified MgO adsorbents,(2) molten salt-modified double salts-based MgO adsorbents,(3) mixed molten salts-modified MgO adsorbents, and(4) molten salts-modified MgO-based mixed oxides adsorbents. This contribution critically reviews the recent developments in the synthetic method, adsorption capacity, reaction kinetics, promotion mechanism, operational conditions and regenerability of the molten salts-modified MgO CO_2 adsorbents. The challenges and prospects in this promising field of molten salts-modified MgO CO_2 adsorbents in real applications are also briefly mentioned. | Wanlin Gao Tuantuan Zhou Yanshan Gao Benoit Louis Dermot O'Hare Qiang Wang | 2017 | Journal of Energy Chemistry2017，26，5： | 12 |
| 9 | A Novel Method for Flatness Pattern Recognition via Least Squares Support Vector Regression显示文摘To adapt to the new requirement of the developing flatness control theory and technology, cubic patterns were introduced on the basis of the traditional linear, quadratic and quartic flatness basic patterns. Linear, quadratic, cubic and quartic Legendre orthogonal polynomials were adopted to express the flatness basic patterns. In order to overcome the defects live in the existent recognition methods based on fuzzy, neural network and support vector regression (SVR) theory, a novel flatness pattern recognition method based on least squares support vector regression (LS-SVR) was proposed. On this basis, for the purpose of determining the hyper-parameters of LS-SVR effectively and enhancing the recognition accuracy and generalization performance of the model, particle swarm optimization algorithm with leave-one-out (LOO) error as fitness function was adopted. To overcome the disadvantage of high computational complexity of naive cross-validation algorithm, a novel fast cross-validation algorithm was introduced to calculate the LOO error of LS-SVR. Results of experiments on flatness data calculated by theory and a 900HC cold-rolling mill practically measured flatness signals demonstrate that the proposed approach can distinguish the types and define the magnitudes of the flatness defects effectively with high accuracy, high speed and strong generalization ability. | ZHANG Xiu-ling, ZHANG Shao-yu, TAN Guang-zhong, ZHAO Wen-bao (Key Laboratory of Industrial Computer Control Engineering of Hebei Province, National Engineering Research Center for Equipment and Technology of Cold Strip Rolling, Yanshan University, Qinhuangdao 066004, Hebei, China) | 2012 | Journal of Iron and Steel Research(International)2012，19，3： | 9 |
| 10 | RESEARCH ON ZERO CLEARANCE CYCLOID BALL TRANSMISSION显示文摘RESEARCHONZEROCLEARANCECYCLOIDBALLTRANSMISSIONQuJifangAnZijunYanshanUniversityAbstract:Thesteelballtransmissionofzerogearclea... | Qu Jifang An Zijun Yanshan University | 1994 | Chinese Journal of Mechanical Engineering1994，7，1： | 9 |
| 11 | METH0D USED IN SINGULARITY RESEARCH BASED 0N KINEMATICS AND ITS EXAMPLE IN APPLICATION显示文摘First the kinematic principle of singularity is proved,that is the in-tersecting point of three normal planes of three velocities at three non-collinear points in a rigid body lying in the plane determined by the three corresponding points.It is a sufficient and necessary condition that the velocities of three non-collinear points in a rigid body can determine a screw motion of the body.Based on this principle,a simple and direct new method to distinguish the singularity of the parallel manipulator is derived.With this new kinematic method,the 3-RPS parallel manipulator is studied.Its singularity loci are ob-tained for some orientations for the first time and verified with Grassmann line geometry and screw theory and the force Jacobian matrix. | Li Yanwen Huang Zhen Robotics Research Center,Yanshan University,Qinhuangdao 066004, China | 2004 | Chinese Journal of Mechanical Engineering2004，17，2： | 8 |
| 12 | Crystallization and thermal fatigue of ZrTiCuNiBe bulk amorphous alloys heated by laser pulses显示文摘The crystallization and thermal fatigue behavior of Zr41Ti14Cu12.5Ni10Be22.5 bulk amorphous alloys heated by laser pulses was investigated. The results showed that crystallization occurred even below the crystallization temperature Tx in a low cycle time. Cracks appearred before or after crystallization of the heated area in the sample. The crystallization degree increased with the heating temperature and cycles. An increase in the fatigue cracks number was also observed. The plastic deformation in the heated area of the sample surface occurred, and became more pronounced with cycles and heating temperature. | JING Qin, ZHAO Liang, YUAN Hui, ZHANG Bing, NIU RunBing, ZHANG Jin, LI Gong, MA MingZhen & LIU RiPing State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao 066004, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，3： | 8 |
| 13 | Development of welding technique for petrochemical industry in China显示文摘DevelopmentofweldingtechniqueforpetrochemicalindustryinChina￥LIQinglin(Sino-PetrochemicalCorporation,Beijing(100029)ZHOUZhend... | LI Qinglin (Sino-Petrochemical Corporation, Beijing (100029)ZHOU Zhende and CHEN Ke (Sinopec Yanshan Petrochemical Company, Beijing)ZHEN Guorui and ZHANG Youchuan (The Third Construction Company of Sinopec, Beijing) | 1994 | China Welding1994，3，2： | 7 |
| 14 | ANALYSIS OF ROLLING BY ELASTO-PLASTIC FINITE DEFORMATION CONTACT BOUNDARY ELEMENT METHOD显示文摘ANALYSISOFROLLINGBYELASTOPLASTICFINITEDEFORMATIONCONTACTBOUNDARYELEMENTMETHODHuangQingxueShenGuangxianXiaoHongTaiyuanHeavyMa... | Huang Qingxue Shen Guangxian Xiao Hong Taiyuan Heavy Mahcinery Institute Yanshan University | 1997 | Chinese Journal of Mechanical Engineering1997，10，4： | 7 |
| 15 | Energy efficient design for multiuser downlink energy and uplink information transfer in 5G显示文摘Simultaneous wireless information and power transfer(SWIPT) is studied in this paper for the wireless powered downlink(DL) and multiuser information uplink(UL) systems. The objective is to maximize the energy efficiency defined as the ratio of the achieved throughput over the energy cost by optimizing the time allocation for the DL and multi-user UL traffics and its goal is to obtain the analytical expression to the optimal time allocation yet the resulting difficulty comes from the sum throughput of the multiuser in UL as well as the corresponding power consumption. To tackle this, the Jensen inequality is applied to approximating the exact expression of the sum throughput for the UL multi-users, leading to an upper-bound of the counterpart.The final closed form is exact in the single-user scenario yet approximate in the multi-user scenario. Numerical simulations verify the tightness of this approximation and the performances of the proposed analytical scheme. | Chunguo LI Yanshan LI Kang SONG Luxi YANG | 2016 | Science China(Information Sciences)2016，59，2： | 7 |
| 16 | Corrosion behavior of bulk metallic glasses in different aqueous solutions显示文摘The corrosion behavior of as-cast fully amorphous, structural relaxed amorphous and crystallized Fe65.5Cr4Mo4Ga4P12C5B5.5 bulk metallic glasses (BMGs) in NaCl, HCl and NaOH solutions was investigated by electrochemical polarization and immersion methods. X-ray photoelectron spectroscopy measurements was used to analyze the changes of the elements on the alloy surface before and after immersion in various solutions. The corrosion resistance of the Fe65.5Cr4Mo4Ga4P12C5B5.5 BMG was better than its structural relaxation/crystallization counterparts and common alloys (such as stainless steel, carbonized steel, and steel) in the selected aqueous solutions. The high corrosion resistance of this alloy in corrosive solutions leads to the formation of Fe-, Cr- and Mo-enriched protective thin surface films. | LI Gong, HUANG Lei, DONG YanGuo, HE GuoWei, QI Li, JING Qin, MA MingZhen & LIU RiPing State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao 066004, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，3： | 6 |
| 17 | Arsenic redox transformation by Pseudomonas sp.HN-2 isolated from arsenic-contaminated soil in Hunan,China显示文摘A mesophilic,Gram-negative,arsenite[As(Ⅲ)]-oxidizing and arsenate[As(V)]-reducing bacterial strain,Pseudomonas sp.HN-2,was isolated from an As-contaminated soil.Phylogenetic analysis based on 16 S r RNA gene sequencing indicated that the strain was closely related to Pseudomonas stutzeri.Under aerobic conditions,this strain oxidized 92.0%(61.4 μmol/L) of arsenite to arsenate within 3 hr of incubation.Reduction of As(V) to As(Ⅲ) occurred in anoxic conditions.Pseudomonas sp.HN-2 is among the first soil bacteria shown to be capable of both aerobic As(Ⅲ) oxidation and anoxic As(V) reduction.The strain,as an efficient As(Ⅲ) oxidizer and As(V) reducer in Pseudomonas,has the potential to impact arsenic mobility in both anoxic and aerobic environments,and has potential application in As remediation processes. | Zhennan Zhang Naiyi Yin Xiaolin Cai Zhenzhou Wang Yanshan Cui | 2016 | Journal of Environmental Sciences2016，28，9： | 6 |
| 18 | Feedback Stabilization over Wireless Network Using Adaptive Coded Modulation显示文摘In this paper, we apply adaptive coded modulation (ACM) schemes to a wireless networked control system (WNCS)to improve the energy efficiency and increase the data rate over a fading channel. To capture the characteristics of varying rate,interference, and routing in wireless transmission channels, the concepts of equivalent delay (ED) and networked condition index (NCI)are introduced. Also, the analytic lower and upper bounds of EDs are obtained. Furthermore, we model the WNCS as a multicontroller switched system (MSS) under consideration of EDs and loss index in the wireless transmission. Sufficient stability condition of the closed-loop WNCS and corresponding dynamic state feedback controllers are derived in terms of linear matrix inequality (LMI).Numerical results show the validity and advantage of our proposed control strategies. | Li Yang Xin-Ping Guan~* Cheng-Nian Long Xiao-Yuan Luo Department of Electrical Engineering, University of Yanshan, Qinhuangdao 066004, PRC | 2008 | International Journal of Automation and computing2008，5，4： | 5 |
| 19 | Morphologies of Fe-66.7 at.%Si alloy solidified in a drop tube显示文摘Solidification of 0.1―1.0 mm diameter droplets of Fe-66.7 at.%Si alloy was achieved in a 3 m drop tube. The XRD, EDS, and SEM measurements reveal that all the droplets are composed of the primary phase α and the α+ε eutectic. With decreasing droplet diameter, the growth mode of the primary phase α changes from faceted to nonfaceted growth and the eutectic changes from needle-like to anomalous eutectic. In addition, the width of the primary phase α decreases with decreasing droplet size. The different cooling rates and undercooling levels corresponding to the samples with different sizes are responsible for the morphology changes. The cooling rates of the samples with different diameters during free fall were calculated and their effects on the microstructure formation were discussed. This kind of transition is also found inside the same sample, which is due to the larger cooling rate on the surface than at the center. | WANG Haiyan1,2, LIU Riping1, MA Mingzhen1, JING Qin1, LI Gong1, SUN Liling2 & WANG Wenkui1,2 1. Key Laboratory of Metastable Materials Science & Technology, Yanshan University, Qinhuangdao 066004, China 2. Institute of Physics, Chinese Academy of Sciences, Beijing 100080, China | 2005 | Science China(Physics,Mechanics & Astronomy)2005，48，6： | 5 |
| 20 | Optimization of Pass Schedule in Hot Strip Rolling显示文摘Rolling schedule not only determines the rolling process to be going smoothly, but also affects the shape accuracy and structure properties of finished strip. In order to gain good strip crown and flatness, the calculation formulas of the most suitable rolling force and bending force are deduced. By taking relatively equal load of rolling power and good shape as objective functions, the optimization mathematical models of finish rolling schedule are established. By contrast, the rolling schedules after optimization can improve the rolling mill working status and ensure the strip crown and flatness to be good. At the same time, the setting value of bending force is improved and this leaves more space for on-line shape control. | QI Xiang-dong, WANG Tao, XIAO Hong (National Engineering Research Center for Equipment and Technology of Cold Strip Rolling, Yanshan University, Qinhuangdao 066004, Hebei, China) | 2012 | Journal of Iron and Steel Research(International)2012，19，8： | 5 |
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