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| 1 | Repeatability and Reproducibility of Quantitative Assessment of the Retinal Microvasculature Using Optical Coherence Tomography Angiography Based on Optical Microangiography显示文摘Objective The aim of this study was to determine the repeatability and reproducibility of optical coherence tomography angiography(OCTA) based on optical microangiography(OMAG) measurements of macular vessels in normal eyes. Methods In this prospective cohort study, 40 eyes of 40 healthy volunteers underwent repeated OCTA(Cirrus HD-OCT 5000 angiography system, Carl Zeiss Meditec, Inc.) scans on two separate visit days. On each visit day, the eyes were scanned three times. The following parameters were used to quantitatively describe the OCTA images of the superficial vascular network: vessel area density(VAD), vessel skeleton density(VSD), vessel diameter index(VDI), vessel perimeter index(VPI), vessel complexity index(VCI), flux, and foveal avascular zone(FAZ). Coefficient of variation(CV) and intraclass correlation coefficient(ICC) were calculated for evaluating intravisit and intervisit repeatability, as well as interobserver reproducibility. Results The measurements showed high repeatability [CVs ≤ 4.2%(intravisit) and ≤ 4.6%(intervisit)] and interobserver reproducibility(ICCs ≥ 0.923) for all parameters. Conclusion This study demonstrated good repeatability and reproducibility of OCTA based on OMAG for the measurement of superficial vessel parameters in normal eyes. | ZHAO Qi YANG Wen Li WANG Xiao Na Ruikang K Wang YOU Qi Sheng CHU Zhong Di XIN Chen ZHANG Meng Yu LI Dong Jun WANG Zi Yang CHEN Wei LI Yi Feng CUI Rui SHEN Lin WEI Wen Bin | 2018 | Biomedical and Environmental Sciences2018，31，6： | 8 |
| 2 | 基于光学微血流成像技术的相干光断层扫描血流成像对视网膜血流定量分析的可重复性评价显示文摘目的评价基于光学微血流成像技术(OMAG)的相干光断层扫描血流成像(OCTA)在正常眼视网膜血流定量分析的可重复性。设计诊断试验。研究对象 40名(40眼)健康志愿者,年龄22~55岁,平均(33.0±8.8)岁。方法使用Zeiss Cirrus HD-OCT 5000扫描,以基于OMAG技术的AngioPlex^(TM)软件对视网膜浅层3 mm×3 mm OCTA图像的血流长度密度(VLD)、灌注密度(PD)及黄斑中心凹无血流信号区(FAZ)面积、周长、圆形度进行自动定量分析。采用变异系数(CV)评价观察日内及观察日间重复性,组内相关系数(ICC)评价观察者间再现性。主要指标变异系数(CV)和组内相关系数(ICC)。结果各血流参数观察日内CV(1.2±1.0)%^(4.2±5.5)%,均≤4.2%,观察日间CV(1.4±0.8)%^(4.6±4.9)%,均≤4.6%,观察日间CV高于观察日内CV,而中心凹、FAZ各参数CV高于旁中心凹CV;各血流参数观察者间ICC(0.923~0.994),均≥0.923,中心凹、FAZ各参数ICC高于旁中心凹。结论基于OMAG技术的OCTA对正常眼视网膜浅层血流各参数测量均具有较好的重复性和再现性。 | 赵琦 王霄娜 杨文利 魏文斌 WANG Ruikang K. 游启生 楚仲頔 辛晨 | 2018 | 眼科2018，27，2： | 7 |
| 3 | Nanomodification of living organisms by biomimetic mineralization显示文摘在自然,象硅藻, magnetotactic 细菌,和鸡蛋那样的一些生活有机体开发了特定的矿物质结构,它能提供广泛的保护或唯一的功能。然而,大多数有机体没由于他们 biomineralization 能力的缺乏有如此的结构化的材料。构造 biomimetic 的 nanominerals 的人工的介绍是挑战性的,但是保持大诺言。在这概述,我们加亮矿物质生活建筑群系统的二种典型类型。一个人包含生物导致表面的 nanomaterials,它生产象 mineralencapsulated 酵母, cyanobacteria,细菌和病毒那样的人工的生活矿物质的核心壳结构。其它包含能赋予有机体以唯一的结构和性质的内部 nanominerals。这些 biomimetic 的应用程序产生了 nanominerals 进一步被讨论,主要在四个潜在的区域:存储,保护,秘密和交货。因为 biomineralization 联合化学药品, nano 和生物技术,我们建议那个 nanobiomimetic 矿化作用可以为学科交差的研究开创另一扇窗户。明确地,这是新奇基于材料的生物规定策略,有功能的 nanomaterials 的生活有机体的集成能为 biotechnological 惯例创造超级或聪明的 nanoscale 生活建筑群。 | Wei Chen Guangchuan Wang Ruikang Tang | 2014 | Nano Research2014，7，10： | 6 |
| 4 | 应用光学相干层析成像对大鼠舌的在体显微检测研究显示文摘目的 应用自行装置的光学相干层析成像(OCT)设备对大鼠舌苔与舌苔下浅表组织进行在体的显微成像研究,为光学相干层析成像技术在中医舌诊的应用可能性与其价值进行初步的探讨.方法 应用OCT,以Lab VIEW编写软件操作平台,将大鼠舌上表面进行显微成像检测,并对舌苔的某些观测内容进行量化处理;同时,与大鼠舌的常规组织切片结果进行对比性分析.结果 大鼠舌表面显微成像显示:分辨率为10~20 μm,深度约2 mm,能够清楚地分辨出舌苔层、舌苔舌体连接层与舌体层结构,在舌苔苔质的某些观察内容可以实现量化;OCT与组织学检测大鼠舌显微结构结果显示具有一定的相似性.结论 光学相干层析成像技术在大鼠舌诊中能实现成像研究,能实现一定的量化研究,具有一定的实用性价值. | 曾常春 钟会清 刘汉平 郭周义 何永红 Ruikang K Wang | 2007 | 北京中医药大学学报2007，30，8： | 6 |
| 5 | Nano-hydroxyapatite accelerates vascular calcification via lysosome impairment and autophagy dysfunction in smooth muscle cells显示文摘Vascular calcification(VC)is a common characteristic of aging,diabetes,chronic renal failure,and atherosclerosis.The basic component of VC is hydroxyapatite(HAp).Nano-sized HAp(nHAp)has been identified to play an essential role in the development of pathological calcification of vasculature.However,whether nHAp can induce calcification in vivo and the mechanism of nHAp in the progression of VC remains unclear.We discovered that nHAp existed both in vascular smooth muscle cells(VSMCs)and their extracellular matrix(ECM)in the calcified arteries from patients.Synthetic nHAp had similar morphological and chemical properties as natural nHAp recovered from calcified artery.nHAp stimulated osteogenic differentiation and accelerated mineralization of VSMCs in vitro.Synthetic nHAp could also directly induce VC in vivo.Mechanistically,nHAp was internalized into lysosome,which impaired lysosome vacuolar H+-ATPase for its acidification,therefore blocked autophagic flux in VSMCs.Lysosomal re-acidification by cyclic-3′,5′-adenosine monophosphate(cAMP)significantly enhanced autophagic degradation and attenuated nHAp-induced calcification.The accumulated autophagosomes and autolysosomes were converted into calcium-containing exosomes which were secreted into ECM and accelerated vascular calcium deposit.Inhibition of exosome release in VSMCs decreased calcium deposition.Altogether,our results demonstrated a repressive effect of nHAp on lysosomal acidification,which inhibited autophagic degradation and promoted a conversion of the accumulated autophagic vacuoles into exosomes that were loaded with undissolved nHAp,Ca^(2+),Pi and ALP.These exosomes bud off the plasma membrane,deposit within ECM,and form calcium nodules.Vascular calcification was thus accelerated by nHAP through blockage of autophagic flux in VSMCs. | Qi Liu Yi Luo Yun Zhao Pingping Xiang Jinyun Zhu Wangwei Jing Wenjing Jin Mingyao Chen Ruikang Tang Hong Yu | 2022 | Bioactive Materials2022，7，2： | 5 |
| 6 | Polarization sensitive optical coherence tomography with single input for imaging depth-resolved collagen organizations显示文摘Collagen organization plays an important role in maintaining structural integrity and determining tissue function.Polarization-sensitive optical coherence tomography(PSOCT)is a promising noninvasive three-dimensional imaging tool for mapping collagen organization in vivo.While PSOCT systems with multiple polarization inputs have demonstrated the ability to visualize depth-resolved collagen organization,systems,which use a single input polarization state have not yet demonstrated sufficient reconstruction quality.Herein we describe a PSOCT based polarization state transmission model that reveals the depth-dependent polarization state evolution of light backscattered within a birefringent sample.Based on this model,we propose a polarization state tracing method that relies on a discrete differential geometric analysis of the evolution of the polarization state in depth along the Poincare sphere for depth-resolved birefringent imaging using only one single input polarization state.We demonstrate the ability of this method to visualize depth-resolved myocardial architecture in both healthy and infarcted rodent hearts(ex vivo)and collagen structures responsible for skin tension lines at various anatomical locations on the face of a healthy human volunteer(in vivo). | Peijun Tang Mitchell A.Kirby Nhan Le Yuandong Li Nicole Zeinstra G.Nina Lu Charles E.Murry Ying Zheng Ruikang K.Wang | 2021 | Light(Science & Applications)2021，10，12： | 2 |
| 7 | Influence of viscosity on the phase transformation of amorphous calcium carbonate in fluids:An understanding of the medium effect in biomimetic mineralization显示文摘Biological mineral generation via an amorphous precursor is a topic of great current interest. Various factors such as the temperature, solution composition and presence of organic molecules can influence this important inorganic process. Here we demonstrate that this mineral transformation can actually readily be regulated by solution viscosity, a fundamental but often overlooked property. In our experiment, amorphous calcium carbonate (ACC), a key model compound in biomimetic mineralization studies, is synthesized and dispersed into inert dispersants with different viscosities and the crystallization process is examined by using FT-IR spectroscopy and XRD. It is found that the inhibition of the transformation of ACC becomes more significant with increasing fluid viscosity. This phenomenon can be explained by the differences in ion diffusion in different media. Furthermore, the resulting crystals always have different morphologies and size distributions although they all have the calcite structure. This study implies that the importance of the fluid medium cannot be ignored in building a complete understanding of biological control of biomimetic crystallizations. | XIE YiDong, XU XuRong & TANG RuiKang Center for Biomaterials and Biopathways and Department of Chemistry, Zhejiang University, Hangzhou 310027, China | 2010 | Science China Chemistry2010，53，10： | 2 |
| 8 | Biomineralization: Biomimetic Synthesis of Materials and Biomimetic Regulation of Organisms显示文摘What is the most favorite and original chemistry developed in your research group?The discovery of ionic oligomers and their crosslinking following a new concept of inorganic ionic polymerization.How do you get into this specific field?Could you please share some experiences with our readers?I got into the field of biomineralization when I was a graduate student.A challenge in biomineralization community is how we can achieve a moldable construction of inorganic materials(biominerals). | Zaiqiang Ma Benke Li Ruikang Tang | 2021 | Chinese Journal of Chemistry2021，39，8： | 2 |
| 9 | HIV-1 Vpr protein activates the NF-κB pathway to promote G2/M cell cycle arrest显示文摘Viral protein R(Vpr) plays an important role in the replication and pathogenesis of Human immunodeficiency virus type 1(HIV-1). Some of the various functions attributed to Vpr, including the induction of G2/M cell cycle arrest, activating the NF-κB pathway, and promoting viral reverse transcription, might be interrelated. To test this hypothesis, a panel of Vpr mutants were investigated for their ability to induce G2/M arrest and to activate the NF-κB pathway. The results showed that the Vpr mutants that failed to activate NF-κB also lost the activity to induce G2/M arrest, which suggests that inducing G2/M arrest via Vpr depends at least partially on the activation of NF-κB. This latter possibility is supported by data showing that knocking down the key factors in the NF-κB pathway – p65, Rel B, IKKα, or IKKβ– partially rescued the G2/M arrest induced by Vpr.Our results suggest that the NF-κB pathway is probably involved in Vpr-induced G2/M cell cycle arrest. | Zhibin Liang Ruikang Liu Yongquan Lin Chen Liang Juan Tan Wentao Qiao | 2015 | Virologica Sinica2015，30，6： | 1 |
| 10 | Constant composition dissolution of mixed phases显示文摘 | Ruikang Tang Michael Hass Wenju Wu Stacey Gulde George H Nancollas | 2003 | Journal of Colloid And Interface Science2003，，2： | 1 |
| 11 | Optimal Weighted Median Filtering Under Structural Con - straints 显示文摘 | Yang Ruikang | 1995 | IEEE transactions on signal processing1995，43，59： | 1 |
| 12 | Investigation on wavelength switching of widely tunable SGDBR lasers显示文摘The sampled-grating distributed Bragg reflector(SGDBR) laser is a typical and important photonic integrated device,and has potential wide application to agile optical networks.A new dynamic model for this device has been developed,which combines the traveling-wave method for the active region and the transfer-matrix method for the passive sections into a single procedure.The behaviors of wave-length switching of the SGDBR laser,which include the transient spectrum and mode competition,have been studied in detail using this model.A new efficient way has been proposed to improve the wavelength switching performance only by increasing the coupling coefficients without changing the carrier density. | JIANG Shan DONG Lei ZHANG RuiKang XIE ShiZhong | 2009 | Chinese Science Bulletin2009，54，20： | 1 |
| 13 | Inhibition of Factor XII-Mediated Activation of Factor XI Provides Protection Against Experimental Acute Ischemic Stroke in Mice显示文摘 | Philberta Leung Sawan Hurst Michelle Berny-Lang Norah Verbout David Gailani Erik Tucker Ruikang Wang Owen McCarty András Gruber | 2012 | Translational Stroke Research2012，，3： | 1 |
| 14 | Inorganic ionic polymerization:From biomineralization to materials manufacturing显示文摘Biomineralization process regulates the growth of inorganic minerals by complex molecules,proteins,and cells,endowing bio-materials with marvels structures and excellent properties.The intricate structures and compositions found in biominerals have inspired scientists to design and synthesize numerous artificial biomimetic materials.The methodology for controlling the formation of inorganics plays a pivotal role in achieving biomimetic structures and compositions.However,the current approach predominantly relies on the classical nucleation theory,which hinders the precise preparation of inorganic materials by replicating the biomineralization strategy.Recently,the development of“inorganic ionic polymerization”strategy has enabled us to regulate the arrangement of inorganic ions from solution to solid phase,which establishes an artificial way to produce inorganic materials analogous to the biomineralization process.Based on inorganic ionic polymerization,a series of achievements have been realized for the biomimetic preparation,including moldable construction of inorganic materials,hard tissue regeneration,and high-performance biomimetic materials.Moreover,the utilization of inorganic ionic polymerization has also facilitated the production of numerous advanced materials,including novel structures that exceed the current knowledge of materials science.The inorganic ionic polymerization system provides new artificial strategies and methodologies for the controllable synthesis of inorganics,which mimics the biomineralization process,paving the way for the future development of more high-performance materials. | Yanhua Sang Kexin Qin Ruikang Tang Zhaoming Liu | 2024 | Nano Research2024，17，2： | 1 |
| 15 | Routine analysis of off flavor compounds in water at sub - part - per - trillion level by large volume injection GC/MS with programmable temperature vaporizing inlet 显示文摘 | Lifeng Zhang Ruikang Hu Zhaoguang Yang | 2006 | Water Res2006，40，： | 1 |
| 16 | Thrombin Mutant W215A/E217A Treatment Improves Neurological Outcome and Reduces Cerebral Infarct Size in a Mouse Model of Ischemic Stroke显示文摘 | Michelle A. Berny-Lang Sawan Hurst Erik I. Tucker Leslie A. Pelc Ruikang K. Wang Patricia D. Hurn Enrico Di Cera Owen J.T. McCarty András Gruber | 2011 | Stroke2011，，6： | 1 |
| 17 | Spectral Domain Polarization Sensitive Optical Coherence Tomography Achieved by Single Camera Detection 显示文摘 | Fan Chuanmao Wang Yi Wang Ruikang K | 2007 | Optics Express2007，15，13： | 1 |
| 18 | Optimal Weighted Median Filtering Under Structural Con-straints 显示文摘 | Yang Ruikang | 1995 | IEEE transactions on signal Processing1995，43，3： | 1 |
| 19 | Weighted median filters: a tutorial显示文摘 | Yin Lin Yang Ruikang Gabbouj M | 1996 | IEEE Trans Circuits and System1996，43，3： | 1 |
| 20 | Effect of Dehydration on Optical Cleating and OCT Imaging Contrast after Impregnation of Biological Tissue with Biochemical Agents 显示文摘 | RUIKANG K WANG | 2004 | SPIE2004，5316，： | 1 |
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