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| 1 | A mathematical model for simulating the phase-based transmissibility of a novel coronavirus显示文摘Background:As reported by the World Health Organization,a novel coronavirus(2019-nCoV)was identified as the causative virus of Wuhan pneumonia of unknown etiology by Chinese authorities on 7 January,2020.The virus was named as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)by International Committee on Taxonomy of Viruses on 11 February,2020.This study aimed to develop a mathematical model for calculating the transmissibility of the virus.Methods:In this study,we developed a Bats-Hosts-Reservoir-People transmission network model for simulating the potential transmission from the infection source(probably be bats)to the human infection.Since the Bats-HostsReservoir network was hard to explore clearly and public concerns were focusing on the transmission from Huanan Seafood Wholesale Market(reservoir)to people,we simplified the model as Reservoir-People(RP)transmission network model.The next generation matrix approach was adopted to calculate the basic reproduction number(R0)from the RP model to assess the transmissibility of the SARS-CoV-2.Results:The value of R0 was estimated of 2.30 from reservoir to person and 3.58 from person to person which means that the expected number of secondary infections that result from introducing a single infected individual into an otherwise susceptible population was 3.58.Conclusions:Our model showed that the transmissibility of SARS-CoV-2 was higher than the Middle East respiratory syndrome in the Middle East countries,similar to severe acute respiratory syndrome,but lower than MERS in the Republic of Korea. | Tian-Mu Chen Jia Rui Qiu-Peng Wang Ze-Yu Zhao Jing-An Cui Ling Yin | 2020 | Infectious Diseases of Poverty2020，9，1： | 22 |
| 2 | Development of mechatronic driving system for seed meters equipped on conventional precision corn planter显示文摘Precision planters are more and more widely used for planting corn in China.Seed meters of conventional precision corn planters are usually driven by ground wheel and chain and sprocket system at present.Because of the slippage of ground wheels and vibration of chains,planting accuracy cannot be ensured,especially at higher forward speed.To improve the planting performance of precision planters,a mechatronic driving system was designed and its field working performance was evaluated in this research.A two-row pneumatic precision planter was modified to allow simultaneously using two different driving systems,i.e,with one row unit equipped with the newly designed mechatronic driving system and the other row unit equipped with conventional mechanical driving system,and used for planting at three forward speeds(9,11 and 12 km/h)on no-tillage and rotary-tillage lands.The distances between adjacent seeds in each plot were measured and the indices of uniformity in seed spacing,quality of feeding index(QFI),missing-seeding index and precision index were analyzed.With the average 4.70%increase of QFI and 3.54%decrease of missing-seeding index,the mechatronic driving system performed better than the mechanical driving system both on no-tillage and rotary-tillage lands at each forward speed.The values of QFI,missing-seeding index and precision index of the mechatronic driving system on rotary-tillage land are comparable to those on no-tillage land,by contrast,these indices of the mechanical driving system on rotary-tillage land are significantly worse than those on no-tillage land.The result indicates that the mechatronic driving system can eliminate the effect of ground wheel slippage on planting quality and maintain the uniformity of seed distribution.Although the QFI,missing-seeding index and precision index become worse with the increase of forward speed,with the worst values of QFI of 89.93%,missing-seeding index of 5.08%and precision index of 18.92%at the highest forward speed of 12 km/h,the mechatronic driving system can reduce the effect of forward speed on planting accuracy effectively.The result indicates that planters equipped with the mechatronic driving system are suitable for high speed planting.As compared to the mechanical driving system,the advantage of the mechatronic driving system is more noticeable especially when the forward speed is more than 11 km/h. | Yang Li He Xiantao Cui Tao Zhang Dongxing Shi Song Zhang Rui Wang Mantao | 2015 | International Journal of Agricultural and Biological Engineering2015，8，4： | 22 |
| 3 | Status of glycosylated hemoglobin and prediction of glycemic control among patients with insulin-treated type 2 diabetes in North China:a multicenter observational study显示文摘Background:Blood glucose control is closely related to type 2 diabetes mellitus(T2DM)prognosis.This multicenter study aimed to investigate blood glucose control among patients with insulin-treated T2DM in North China and explore the application value of combining an elastic network(EN)with a machine-learning algorithm to predict glycemic control.Methods:Basic information,biochemical indices,and diabetes-related data were collected via questionnaire from 2787 consecutive participants recruited from 27 centers in six cities between January 2016 and December 2017.An EN regression was used to address variable collinearity.Then,three common machine learning algorithms(random forest[RF],support vector machine[SVM],and back propagation artificial neural network[BP-ANN])were used to simulate and predict blood glucose status.Additionally,a stepwise logistic regression was performed to compare the machine learning models.Results:The well-controlled blood glucose rate was 45.82%in North China.The multivariable analysis found that hypertension history,atherosclerotic cardiovascular disease history,exercise,and total cholesterol were protective factors in glycosylated hemoglobin(HbAlc)control,while central adiposity,family history,T2DM duration,complications,insulin dose,blood pressure,and hypertension were risk factors for elevated HbAlc.Before the dimensional reduction in the EN,the areas under the curve of RF,SVM,and BP were 0.73,0.61,and 0.70,respectively,while these figures increased to 0.75,0.72,and 0.72,respectively,after dimensional reduction.Moreover,the EN and machine learning models had higher sensitivity and accuracy than the logistic regression models(the sensitivity and accuracy of logistic were 0.52 and 0.56;RF:0.79,0.70;SVM:0.84,0.73;BP-ANN:0.78,0.73,respectively).Conclusions:More than half of T2DM patients in North China had poor glycemic control and were at a higher risk of developing diabetic complications.The EN and machine learning algorithms are alternative choices,in addition to the traditional logistic model,for building predictive models of blood glucose control in patients with T2DM. | Jiao Wang Meng-Yang Wang Hui Wang Hong-Wei Liu Rui Lu Tong-Qing Duan Chang-Ping Li Zhuang Cui Yuan-Yuan Liu Yuan-Jun Lyu Jun Ma | 2020 | Chinese Medical Journal2020，，1： | 19 |
| 4 | Microstructure Design and Heat Response of Powder Metallurgy Ti_2AlNb Alloys显示文摘Pre-alloyed powder of Ti-22Al-24Nb-0.5Mo(atomic fraction,%) was prepared by gas atomization.Powder metallurgy(PM) Ti_2AlNb alloys were prepared by a hot isostatic pressing(HIPing) route.The influence of experimental variables including HIPing temperatures,solution and aging temperatures on microstructure and properties of PM Ti_2AlNb alloys was studied.The results showed that HIPing temperature affected the porosity distribution and mechanical properties of PM Ti_2AlNb alloys.The microstructure and mechanical properties of the PM Ti_2AlNb alloys changed obviously after various post heat treatments,and a good combination of tensile strength,ductility and rupture lifetime was obtained through an optimized heat treatment in the present work. | Jie Wu Lei Xu Zhengguan Lu Bin Lu Yuyou Cui Rui Yang | 2015 | Journal of Materials Science & Technology2015，31，12： | 14 |
| 5 | The Qitai radio telescope显示文摘This study presents a general outline of the Qitai radio telescope(QTT)project.Qitai,the site of the telescope,is a county of Xinjiang Uygur Autonomous Region of China,located in the east Tianshan Mountains at an elevation of about 1800 m.The QTT is a fully steerable,Gregorian-type telescope with a standard parabolic main reflector of 110 m diameter.The QTT has adopted an umbrella support,homology-symmetric lightweight design.The main reflector is active so that the deformation caused by gravity can be corrected.The structural design aims to ultimately allow high-sensitivity observations from 150 MHz up to115 GHz.To satisfy the requirements for early scientific goals,the QTTwill be equipped with ultra-wideband receivers and large field-of-view multi-beam receivers.A multi-function signal-processing system based on RFSo C and GPU processor chips will be developed.These will enable the QTT to operate in pulsar,spectral line,continuum and Very Long Baseline Interferometer(VLBI)observing modes.Electromagnetic compatibility(EMC)and radio frequency interference(RFI)control techniques are adopted throughout the system design.The QTT will form a world-class observational platform for the detection of lowfrequency(nano Hertz)gravitational waves through pulsar timing array(PTA)techniques,pulsar surveys,the discovery of binary black-hole systems,and exploring dark matter and the origin of life in the universe.The QTT will also play an important role in improving the Chinese and international VLBI networks,allowing high-sensitivity and high-resolution observations of the nuclei of distant galaxies and gravitational lensing systems.Deep astrometric observations will also contribute to improving the accuracy of the celestial reference frame.Potentially,the QTT will be able to support future space activities such as planetary exploration in the solar system and to contribute to the search for extraterrestrial intelligence. | Na Wang Qian Xu Jun Ma Zhiyong Liu Qi Liu Hailong Zhang Xin Pei Maozheng Chen Richard N.Manchester Kejia Lee Xingwu Zheng Hans J.Kärcher Wulin Zhao Hongwei Li Dongwei Li Martin Süss Matthias Reichert Zhongyi Zhu Congsi Wang Mingshuai Li Rui Li Ning Li Guljaina Kazezkhan Wenming Yan Gang Wu Lang Cui Ming Zhang Haitao Li | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，8： | 14 |
| 6 | Distinct characteristics and new prognostic scoring system for Chinese patients with Waldenstr(o)m macroglobulinemia显示文摘 | Yi Shuhua Cui Rui Li Zengjun An Gang Qi Junyuan Zou Dehui Zhang Peihong Chen Huishu Wang Jianxiang Chang Hong Qiu Lugui | 2014 | Chinese Medical Journal2014，，12： | 12 |
| 7 | Deep-learning-based extraction of the animal migration patterns from weather radar images显示文摘Continental coverage and year-round operation of the weather radar networks provide an unprecedented opportunity for studying large-scale airborne migration.The broad and local-scale airborne information collected by these infrastructures can answer many ecological questions.However,extracting and interpreting the biological information from such massive weather radar data remains an intractable problem.Recently,many big-data problems have been solved using the deep learning technology.In this study,the biological information in the weather radar data is identified using the advanced deep learning method.The proposed method consists of two main parts,i.e.,a rendering and casting procedure and an image segmentation procedure based on a convolutional neural network.The biological data are automatically extracted by rendering and mapping,image segmentation,and result masking.By analyzing the typical radar data from single and multiple stations,we partly reveal the intensity and speed of the migration pattern.We present the first feasibility study of the extraction of local and large-scale biological phenomena from the Chinese weather radar network data. | Kai CUI Cheng HU Rui WANG Yi SUI Huafeng MAO Huayu LI | 2020 | Science China(Information Sciences)2020，63，4： | 11 |
| 8 | Boxb mediate BALB/c mice corneal inflammation through a TLR4/MyD88-dependent signaling pathway in Aspergillus fumigatus keratitis显示文摘AIM: To investigate whether high-mobility group box 1(HMGB1) Boxb exacerbates BALB/c mice corneal immune responses and inflammatory through the Toll-like receptor 4(TLR4)/myeloid differentiation primary response 88(My D88)-dependent signaling pathway in Aspergillus fumigatus(A. fumigatus) keratitis.METHODS: The mice corneas were pretreated with phosphate buffer saline(PBS), Boxb before A. fumigatus infection. The abdominal cavity extracted macrophages were pretreated with PBS, Boxb, TLR4 inhibitor(CLI-095), Dimethyl sulfoxide(DMSO) separately before A. fumigatus hyphae stimulation. HMGB1 was detected in normal and infected mice corneas and macrophages by real-time reverse transcriptase polymerase chain reaction(RT-PCR), the TLR4, My D88, interleukin-1β(IL-1β), tumor necrosis factor-α(TNF-α) were detected by Western blot and PCR.RESULTS: In BALB/c mice corneas, the expressions of TLR4, HMGB1, IL-1β, TNF-α were increased after A. fumigatus infection. While pretreatment with Boxb significantly increased the expressions of TLR4, HMGB1, My D88, IL-1β, TNF-α compared with PBS control after infection. In BALB/c mice abdominal cavity extracted macrophages, pretreatment with Boxb increased the expressions of TLR4, HMGB1, My D88, IL-1β, TNF-α, while pretreatment with CLI-095 and Boxb significantly decreased the expressions of TLR4, HMGB1, My D88, IL-1β, TNF-α. CONCLUSION: In A. fumigatus keratitis, Boxb play a proinflammatory role in corneal anti-fungi immune response through the HMGB1-TLR4-My D88 signal pathway. | Min Liu Cui Li Gui-Qiu Zhao Jing Lin Cheng-Ye Che Qiang Xu Qian Wang Rui Xu Ya-Wen Niu | 2018 | International Journal of Ophthalmology(English edition)2018，11，4： | 10 |
| 9 | Effect of Hot Isostatic Pressing Loading Route on Microstructure and Mechanical Properties of Powder Metallurgy Ti_2AlNb Alloys显示文摘In this work, hot isostatic pressing(HIPing) technique was used to densify the Ti_2AlNb pre-alloyed powder.The influence of HIPing loading route parameters(temperature and rates of heating and pressurizing)on microstructure and properties of PM Ti_2AlNb alloys was studied. The results showed that HIPing loading route parameters affected the densification process and mechanical properties(especially high temperature rupture lifetime) of PM Ti_2AlNb alloys in the present work. A finite element method(FEM) model for predicting the final densification was developed and was used to optimize the HIPing procedure. | Jie wu Ruipeng Guo Lei Xu Zhengguan Lu Yuyou Cui Rui Yang | 2017 | Journal of Materials Science & Technology2017，33，2： | 10 |
| 10 | TNF-α suppresses sweat gland differentiation of MSCs by reducing FTO-mediated m^6 A-demethylation of Nanog mRNA显示文摘An effect of inhibition of tumor necrosis factor-α(TNF-α)on differentiation of mesenchymal stromal cells(MSCs)has been demonstrated,but the exact mechanisms that govern MSCs differentiation remain to be further elucidated.Here,we show that TNF-αinhibits the differentiation of MSCs to sweat glands in a specific sweat gland-inducing environment,accompanied with reduced expression of Nanog,a core pluripotency factor.We elucidated that fat mass and obesity-associated protein(FTO)-mediated m^6 A demethylation is involved in the regulation of MSCs differentiation potential.Exposure of MSCs to TNF-αreduced expression of FTO,which demethylated Nanog m RNA.Reduced expression of FTO increased Nanog m RNA methylation,decreased Nanog m RNA and protein expression,and significantly inhibited MSCs capacity for differentiation to sweat gland cells.Our finding is the first to elucidate the functional importance of m^6 A modification in MSCs,providing new insights that the microenvironment can regulate the multipotency of MSCs at the post-transcriptional level.Moreover,to maintain differentiation capacity of MSCs by regulating m^6 A modification suggested a novel potential therapeutic target for stem cellmediated regenerative medicine. | Yihui Wang Rui Wang Bin Yao Tian Hu Zhao Li Yufan Liu Xiaoli Cui Liuhanghang Cheng Wei Song Sha Huang Xiaobing Fu | 2020 | Science China(Life Sciences)2020，63，1： | 9 |
| 11 | Slope spectrum variation in a simulated loess watershed显示文摘在黄土材料和消除适当地代表真黄土表面的地方,一个模仿的黄土分水岭被采用与黄土分水岭进化在斜坡光谱调查变化。模仿的黄土分水岭的进化被人工的降雨的 exogenetic 力量驾驶。为三个月的一个时期,有不同紧张和持续时间的二十个人工的降雨事件被执行。在这个过程,九个 DEM 数据设定,有 10 公里格子分辨率的各个,被靠近范围的摄影测量学的方法建立。斜坡系列然后从这些 DEM 被提取。小心地设计的量的分析的随后的系列显示了在斜坡光谱和模仿的黄土分水岭的进化之间的一种强壮的关系。斜坡光谱的量的索引变化了定期跟随模仿的黄土分水岭的进化。吝啬的斜坡,斜坡光谱信息熵(H),地面驱动力( T d ),平均数补丁区域( AREA_MN ),传染索引( CONTAG ),和补丁结合索引(结合)不停地增加跟随模仿的分水岭的进化,当时偏斜度(S),周界区域分数维的尺寸( PAFRAC ),和散布和并排索引( IJI )代表了一个相反的趋势。所有这些索引在早、活跃的发展时期活跃地变化了,但是慢慢地在稳定的发展时期。这些试验性的结果显示斜坡系列的时间系列能有效地描绘模仿的黄土分水岭的斜坡分发,因此为为黄土地形建模介绍一个潜在的方法。 | Fayuan LI Guoan TANG Chun WANG Lingzhou CUI Rui ZHU | 2016 | Frontiers of Earth Science2016，10，2： | 9 |
| 12 | Observations of atmospheric pollutants at Lhasa during 2014-2015:Pollution status and the influence of meteorological factors显示文摘Atmospheric pollutants including SO_2, NO_2, CO, O_3 and inhalable particulate matter(PM2.5 and PM10) were monitored continuously from March 2014 to February 2015 to investigate characteristics of air pollution at Lhasa, Tibetan Plateau. Species exhibited similar seasonal variations except O_3, with the peaks in winter but low valleys in summer. The maximum O_3 concentration was observed in spring, followed by summer, autumn, and winter. The positive correlation between O_3 and PM10 in spring indicated similar sources of them, and was assumed to be turbulent transport. Temperature was the dominant meteorological factor for most species in spring. High temperature accelerates O_3 photochemistry, and favors air disturbance which is conductive to dust resuspension in spring. Relative humidity(RH) and atmospheric pressure were the main meteorological factors in summer. RH showed negative correlations with species, while atmospheric pressure posed opposite situation. Wind speed(WS) was the dominant meteorological factor in autumn, the negative correlations between WS and species indicated diffusion by wind. Most species showed non-significant correlations with meteorological factors in winter, indicating the dependence of pollution on source emission rather than restriction by meteorology. Pollution weather character indicated that emissions were from biomass burning and dust suspension, and meteorological factors also played an important role. Air stream injection from the stratosphere was observed during O_3 pollution period. Air parcels from Southwest Asia were observed during air pollution period in winter. An enhancement in air pollutants such as O_3 would be expected in the future, more attention should be given to countermeasures for prevention of air pollution in the future. | Bu Duo Lulu Cui Zhenzhen Wang Rui Li Liwu Zhang Hongbo Fu Jianmin Chen Huifang Zhang A.Qiong | 2018 | Journal of Environmental Sciences2018，30，1： | 9 |
| 13 | Spatial Distribution and Risk Assessment of Heavy Metals in Paddy Soils of Yongshuyu Irrigation Area from Songhua River Basin,Northeast China显示文摘There is an increasing concern for potentially hazardous metals pollution, which can threaten crops production and human health. In this study, the spatial distribution and environmental risks of eight heavy metals in surface soil samples collected from the paddy fields in Yongshuyu irrigation area, Northeast China were investigated. The mean concentrations of Pb, Cr, Cu, Ni, Zn, Cd, Hg and As were 34.6 ± 4.67, 82.8 ± 9.51, 17.3 ± 4.09, 21.2 ± 12.0, 88.6 ± 17.9, 0.18 ± 0.15, 0.22 ± 0.07 and 8.77 ± 2.47 mg/kg, respectively, which were slightly higher than their corresponding background values of Jilin Province, indicating enrichment of these metals in the paddy soils, especially for Ni, Cd and Hg. The spatial distribution of heavy metals was closely correlated with local anthropogenic activities, such as agricultural production, mining and transportation. The hot-spot areas of As and Cd were mainly concentrated in the up-midstream where were associated with agricultural activities. Cr and Cu showed similar spatial distributions with hot-spot areas distributed the whole irrigation area uniformly. Ni was mainly distributed in the downstream where Ni quarries concentrated, while the spatial distribution patterns of Hg was mainly located in the upstream and downstream where the soil was significantly influenced by irrigation and coal mining emission. The spatial distributions of Pb and Zn were mainly concentrated along the highway side. The pollution levels of Yongshuyu irrigation area were estimated through index of geo-accumulation(Igeo), Nemerow integrated pollution index(NIPI) and potential ecological risk index(PERI). The results showed that Cd and Hg were the main pollutants in the study area. Health risk assessment results indicated that children were in higher non-carcinogenic and carcinogenic risks than adults with the carcinogenic metal of As. Ingestion was the main exposure pathway to non-carcinogenic and carcinogenic risk for both adults and children. Principal component analysis(PCA) indicated that Cr and Cu were mainly from parent materials, while Cd and As were mainly affected by agricultural activities. Pb and Zn were controlled by traffic activities, and the accumulations of Ni and Hg were associated with mining activities. This study would be valuable for preventing heavy metals inputs and safety in rice production of the Songhua river basin. | CUI Zhengwu WANG Yang ZHAO Na YU Rui XU Guanghui YU Yong | 2018 | Chinese Geographical Science2018，28，5： | 9 |
| 14 | Performance of no-till corn precision planter equipped with row cleaners显示文摘In the continuous annual wheat-corn cropping area of North China Plain,no-till planting that promotes soil conservation and crop yield while reducing operation cost has been gradually accepted by local farmers.However,previous wheat residue is the main limiting factor affecting the performance of existing planters in placing seeds at uniform spacing and optimum depth in residue covered fields.In order to solve this problem,a kind of ground-wheel-driven row cleaner was designed,developed and mounted on row units of a four-row pneumatic precision planter.The planter has two adjacent row units equipped with the newly designed row cleaners and the other two adjacent row units equipped with the commonly used inactive row cleaners.This was used for planting at three forward speeds(4 km/h,6 km/h and 8 km/h)into half residue(HR)and whole residue(WR)plots.The amount of residue removal,seeding depth,emergence rate and indices of uniformity in seed spacing(missing-seeding index,quality of feeding index and precision index)were measured.The newly designed row cleaner performed better with regard to residue removal,with the average percentage of residue cleared as 63.0%compared to 40.3%for the inactive row cleaner.For the HR and WR plots,percentage of residue cleared of the newly designed row cleaner reached 57.1%and 68.9%respectively,suggesting that the newly designed row cleaner can work more effectively at high residue level.By contrast,with the percentage of residue cleared of the inactive row cleaner as 43.1%and 37.5%in HR and WR plots,suggesting that the inactive row cleaner just can work effectively under low residue condition.Values of missing-seeding index,QFI,precision index,coefficient of variation of depth and percent emergence for the newly designed row cleaner under whole residue level are comparable to those for the inactive row cleaner under half residue level.The result indicates that the effect of using the newly designed row cleaner is equal to that of reducing surface residue,and can help to maintain the uniformity of seed spacing and seeding depth.The newly designed row cleaner generally performed better at forward speed of 6 km/h,based on the distribution of seeds along rows and seeding depth uniformity. | Yang Li Zhang Rui Gao Nana Cui Tao Liu Quanwei Zhang Dongxing | 2015 | International Journal of Agricultural and Biological Engineering2015，8，5： | 9 |
| 15 | Development of genome-wide insertion/deletion markers in rice based on graphic pipeline platform显示文摘DNA markers play important roles in plant breeding and genetics.The Insertion/Deletion(InDel) marker is one kind of co-dominant DNA markers widely used due to its low cost and high precision.However,the canonical way of searching for InDel markers is time-consuming and laborintensive.We developed an end-to-end computational solution(InDel Markers Development Platform,IMDP) to identify genome-wide InDel markers under a graphic pipeline environment.IMDP constitutes assembled genome sequences alignment pipeline(AGA-pipe) and next-generation resequencing data mapping pipeline(NGS-pipe).With AGA-pipe we are able to identify 12,944 markers between the genome of rice cultivars Nipponbare and 93-11.Using NGS-pipe,we reported 34,794 InDels from re-sequencing data of rice cultivars Wu-Yun-Geng7 and Guang-Lu-Ai4.Combining AGApipe and NGS-pipe,we developed 205,659 InDels in eight japonica and nine indica cultivars and 2,681 InDels showed a subgroup-specific pattern.Polymerase chain reaction(PCR)analysis of subgroup-specific markers indicated that the precision reached 90%(86 of 95).Finally,to make them available to the public,we have integrated the InDels/markers information into a website(Rice InDel Marker Database,RIMD,http://gffzz71b3756633b74a6ehxvfb0b09wc9n6q9c.ffgz.tsg.suse.edu.cn/).The application of IMDP in rice will facilitate efficiency for development of genome-wide InDel markers,in addition it can be used in other species with reference genome sequences and NGS data. | Yang L Xiao Cui Rui Li Piaopiao Huang Jie Zong Danqing Yao Gang Li Dabing Zhang Zheng Yuan | 2015 | Journal of Integrative Plant Biology2015，57，11： | 9 |
| 16 | Influence of Processing Conditions on Microstructure and Mechanical Properties of Large Thin-Wall Centrifugal Ti–6Al–4V Casting显示文摘在这个工作,包括张力的静电干扰和扔的大薄墙的圆柱的 Ti-6Al-4V 的损坏忍耐性质,温度并且热均衡说的紧迫(HIPping ) 在微结构特征和机械性质上处理的模子预热的效果被学习了。试验性的结果显示出那,增加的模子预热从 673 的温度到 873K,扔的微观结构从 Widmanst 的混合物变化 ? tten 和殖民地微观结构到一个主要殖民地。厚墙节的中心比边和薄节有相对粗糙的微观结构。更低的模子预热温度引起更多的孔。HIPping 过程,它不仅有效地减少扔的毛孔而且增加优先的谷物边界结合并且变粗微观结构,对改进扔的韧性必要。由于表面上的氧污染和更好的微观结构,生气的节上的微坚硬的侧面从表面介绍一个减少的趋势给内部。为预热的不同模子的反应层的厚度温度将近一样(~ 450 畃洠捩潲 ' 跍?湩琠敨戠楬摮栠汯? 楷桴愠搠慩敭整 ? 景 ? 0? | Xin Feng Jianke Qiu Yingjie Ma Jiafeng Lei Yuyou Cui Xinhua Wu Rui Yang | 2016 | Journal of Materials Science & Technology2016，32，4： | 9 |
| 17 | Analysis of Health Service Utilization and its Influencing Factors among Patients with Pneumoconiosis in China显示文摘Pneumoconiosis,an interstitial lung disease that occurs from breathing in certain kinds of damaging dust particles,is a major occupational disease in China.Patients diagnosed with occupational pneumoconiosis can avail of free medical treatment,whereas patients without a diagnosis of occupational diseases cannot not claim free medical treatment in most provinces from the government before 2019.This study aimed to analyze the priority of medical facility selection and its influencing factors among patients with pneumoconiosis. | WANG Huan Qiang JIA Jun Lin JIANG Zhao Qiang JIN Qi LI Dong Xia LING Rui Jie LI Ying CUI Ping CHEN Gang ZHAO Hong Yu LI Yan WEN Ke LYU Xiang Pei LOU Jian Lin LI Tao | 2021 | Biomedical and Environmental Sciences2021，34，1： | 9 |
| 18 | The gut microbial metabolite, 3,4-dihydroxyphenylpropionic acid, alleviates hepatic ischemia/reperfusion injury via mitigation of macrophage pro-inflammatory activity in mice显示文摘Hepatic ischemia/reperfusion injury(HIRI) is a serious complication that occurs following shock and/or liver surgery. Gut microbiota and their metabolites are key upstream modulators of development of liver injury. Herein, we investigated the potential contribution of gut microbes to HIRI.Ischemia/reperfusion surgery was performed to establish a murine model of HIRI. 16 S r RNA gene sequencing and metabolomics were used for microbial analysis. Transcriptomics and proteomics analysis were employed to study the host cell responses. Our results establish HIRI was significantly increased when surgery occurred in the evening(ZT12, 20:00) when compared with the morning(ZT0, 08:00);however, antibiotic pretreatment reduced this diurnal variation. The abundance of a microbial metabolite3,4-dihydroxyphenylpropionic acid was significantly higher in ZT0 when compared with ZT12 in the gut and this compound significantly protected mice against HIRI. Furthermore, 3,4-dihydroxyphenylpropionic acid suppressed the macrophage pro-inflammatory response in vivo and in vitro. This metabolite inhibits histone deacetylase activity by reducing its phosphorylation. Histone deacetylase inhibition suppressed macrophage pro-inflammatory activation and diminished the diurnal variation of HIRI. Our findings revealed a novel protective microbial metabolite against HIRI in mice. The potential underlying mechanism was at least in part, via 3,4-dihydroxyphenylpropionic acid-dependent immune regulation and histone deacetylase(HDAC) inhibition in macrophages. | Rui Li Li Xie Lei Li Xiaojiao Chen Tong Yao Yuanxin Tian Qingping Li Kai Wang Chenyang Huang Cui Li Yifan Li Hongwei Zhou Neil Kaplowitz Yong Jiang Peng Chen | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 8 |
| 19 | Identfication of new naphthalenones from Juglans mandshurica and evalution of their anticancer activities显示文摘Two new naphthalenone compounds were isolated from green walnut husks of Juglans mandshurica and their structures were identified as 4-butoxybutoxy-5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one(1), 4-ethoxyethoxy-5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one(2). Compounds 1 and 2 were named as Juglanstetralone A(1) and Juglanstetralone B(2). Compound 1 showed more significant anti-tumor activity than 2 against gastric cancer BGC-823 cells, wih the IC50 of 125.89 ?g?mL –1. | GUO Li-Na ZHANG Rui GUO Xue-Ying CUI Tao DONG Wei HUO Jin-Hai WANG Wei-Ming | 2015 | Chinese Journal of Natural Medicines2015，13，9： | 8 |
| 20 | Repeatability and Reproducibility of Quantitative Assessment of the Retinal Microvasculature Using Optical Coherence Tomography Angiography Based on Optical Microangiography显示文摘Objective The aim of this study was to determine the repeatability and reproducibility of optical coherence tomography angiography(OCTA) based on optical microangiography(OMAG) measurements of macular vessels in normal eyes. Methods In this prospective cohort study, 40 eyes of 40 healthy volunteers underwent repeated OCTA(Cirrus HD-OCT 5000 angiography system, Carl Zeiss Meditec, Inc.) scans on two separate visit days. On each visit day, the eyes were scanned three times. The following parameters were used to quantitatively describe the OCTA images of the superficial vascular network: vessel area density(VAD), vessel skeleton density(VSD), vessel diameter index(VDI), vessel perimeter index(VPI), vessel complexity index(VCI), flux, and foveal avascular zone(FAZ). Coefficient of variation(CV) and intraclass correlation coefficient(ICC) were calculated for evaluating intravisit and intervisit repeatability, as well as interobserver reproducibility. Results The measurements showed high repeatability [CVs ≤ 4.2%(intravisit) and ≤ 4.6%(intervisit)] and interobserver reproducibility(ICCs ≥ 0.923) for all parameters. Conclusion This study demonstrated good repeatability and reproducibility of OCTA based on OMAG for the measurement of superficial vessel parameters in normal eyes. | ZHAO Qi YANG Wen Li WANG Xiao Na Ruikang K Wang YOU Qi Sheng CHU Zhong Di XIN Chen ZHANG Meng Yu LI Dong Jun WANG Zi Yang CHEN Wei LI Yi Feng CUI Rui SHEN Lin WEI Wen Bin | 2018 | Biomedical and Environmental Sciences2018，31，6： | 8 |
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