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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Correction of the min- eralization defect in hyp mice treated with protease inhibitors CA074 and pepstatin显示文摘 | Rowe PS Matsumoto N Jo OD | 2006 | Bone2006，39，4： | 1 |
| 3 | MEPE has the properties of an osteoblastic phosphatonin and minhibin显示文摘 | Kumagai Y Gutierrez G | 2004 | Bone2004，34，： | 1 |
| 4 | Surface plasmon resonance (SPR) confirms that MEPE binds to PHEX via the MEPE-ASARM motif:a model for impaired mineralization in X-linked rickets (HYP)显示文摘 | Garrett IR Schwarz PM | 2005 | Bone2005，36，： | 1 |
| 5 | MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia 显示文摘 | Rowe PS de Zoysa PA Dong R | 2000 | Genomies2000，67，1： | 1 |
| 6 | MEPE,a new gene expressed in bone marrow and tumors causing osteomalacia显示文摘 | Rowe PS de Zoysa PA Dong R | 2000 | Genomics2000，67，1： | 1 |
| 7 | 显示文摘 | Rowe PS Kreitman RJ Vitetta DA | 2000 | Genomics2000，67，： | 1 |
| 8 | The wriekkened pathways of FGF23, MEPE and PHEX显示文摘 | Rowe PS | 2004 | CritRevOralBiolMed2004，15，5： | 1 |
| 9 | MEPE has the properties of an osteoblastic phosphatonin and minhibin 显示文摘 | Rowe PS Kumagai Y Gutierrez G | 2004 | Bone2004，34，2： | 1 |
| 10 | Sclerostin is a locally acting regulator of late-osteoblast/preosteocyte differentiation and regulates mineralization through a MEPEASARM-dependent mechanism显示文摘 | Atkins GJ Rowe PS Lim HP | | 0，，07： | 1 |
| 11 | MEPE/OF45 as a new target for sensitizing human tumour cells to DNA damage inducers 显示文摘 | Zhang P Wang H Rowe PS | 2010 | Br J Cancer2010，102，5： | 1 |
| 12 | MEPE,a new gene expressed in bone marrow and tumors causing osteomalacia显示文摘 | Rowe PS de Zoysa PA Dong R | 2000 | Genomics2000，67，1： | 1 |
| 13 | Sclerostin is a locally actingregulator of late-osteoblast/preosteocyte differentiation and regulatesmineralization through a MEPE-ASARM-dependent mechanism显示文摘 | Atkins GJ Rowe PS Lim HP | 2011 | J Bone Miner Res2011，26，7： | 1 |
| 14 | MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia 显示文摘 | Rowe PS Zoysa PA Dong R | 2000 | Genomics2000，67，1： | 1 |
| 15 | Inhibition of MEPE clea- vage by Phex 显示文摘 | Guo R Rowe PS Liu S | 2002 | Biochem Biophys Res Commun2002，297，1： | 1 |
| 16 | Surface plasmon resonance (SPR) confirms that MEPE binds to PHEX via the MEPE-ASARM motif:a model for impaired mineralization in X-linked rickets (HYP)显示文摘 | Rowe PS Garrett IR Schwarz PM | 2005 | Bone2005，36，1： | 1 |
| 17 | MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia 显示文摘 | Rowe PS de Zoysa PA Dong R | 2000 | Genomics2000，67，1： | 1 |
| 18 | selerostin is a locally acting regulator of late-osteoblast/ preosteocyte differentiation and regulates mineralization through a MEPE-ASARM-dependent mechanism 显示文摘 | Atkins GJ Rowe PS Lim HP | 2011 | J Bone Miner Res2011，26，： | 1 |
| 19 | MEPE,a new gene expressed in bone marrow and tumors causing osteomalacia显示文摘 | Rowe PS De Zoysa PA Dong R | | 0，，01： | 1 |
| 20 | Inhibition of MEPE cleavage by Phex显示文摘 | Guo R Rowe PS Liu S | 2002 | Biochem Biophys Res Commun2002，297，1： | 1 |
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