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| 1 | High prevalence of hepatic steatosis and vascular thrombosis in COVID-19:A systematic review and meta-analysis of autopsy data显示文摘BACKGROUND Coronavirus disease 2019(COVID-19)disease can frequently affect the liver.Data on hepatic histopathological findings in COVID-19 is scarce.AIM To characterize hepatic pathological findings in patients with COVID-19.METHODS We conducted a systematic review with meta-analysis registered on PROSPERO(CRD42020192813),following PRISMA guidelines.Eligible trials were those including patients of any age and COVID-19 diagnosis based on a molecular test.Histopathological reports from deceased COVID-19 patients undergoing autopsy or liver biopsy were reviewed.Articles including less than ten patients were excluded.Proportions were pooled using random-effects models.Q statistic and I2 were used to assess heterogeneity and levels of evidence,respectively.RESULTS We identified 18 studies from 7 countries;all were case reports and case series from autopsies.All the patients were over 15 years old,and 67.2%were male.We performed a meta-analysis of 5 studies,including 116 patients.Pooled prevalence estimates of liver histopathological findings were hepatic steatosis 55.1%[95%confidence interval(CI):46.2-63.8],congestion of hepatic sinuses 34.7%(95%CI:7.9-68.4),vascular thrombosis 29.4%(95%CI:0.4-87.2),fibrosis 20.5%(95%CI:0.6-57.9),Kupffer cell hyperplasia 13.5%(95%CI:0.6-54.3),portal inflammation 13.2%(95%CI:0.1-48.8),and lobular inflammation 11.6%(95%CI:0.3-35.7).We also identified the presence of venous outflow obstruction,phlebosclerosis of the portal vein,herniated portal vein,periportal abnormal vessels,hemophagocytosis,and necrosis.CONCLUSION We found a high prevalence of hepatic steatosis and vascular thrombosis as major histological liver features.Other frequent findings included portal and lobular inflammation and Kupffer cell hyperplasia or proliferation.Further studies are needed to establish the mechanisms and implications of these findings. | Luis Antonio Díaz Francisco Idalsoaga Macarena Cannistra Roberto Candia Daniel Cabrera Francisco Barrera Alejandro Soza Rondell Graham Arnoldo Riquelme Marco Arrese Michael D Leise Juan Pablo Arab | 2020 | World Journal of Gastroenterology2020，26，48： | 3 |
| 2 | Clinical Outcomes for Anaplastic Pancreatic Cancer: A Population-Based Study显示文摘 | Clancy J. Clark Rondell P. Graham Janani S. Arun W. Scott Harmsen Kaye M. Reid-Lombardo | 2012 | Journal of the American College of Surgeons2012，，5： | 2 |
| 3 | Primary epithelial tumours of the appendix in a black population:A review of cases显示文摘AIM:To determine the prevalence,histologic types and clinical features of primary epithelial tumours of the vermiform appendix in a predominantly black population.METHODS:All cases of primary tumours of the appendix identified by review of the histopathology records at the University of the West Indies between January 1987 and June 2007 were selected.Relevant pathologic and clinical data were extracted with supplementation from patient charts where available.Non-epithelial tumours were excluded.The total number of appendectomy specimens over the period was also ascertained.RESULTS:Forty-two primary epithelial tumours were identified out of 6 824 appendectomies yielding a prevalence rate of approximately 0.62%.Well- differentiated neuroendocrine cell tumours(carcinoids,47.6%)and benign non-endocrine cell tumours(adenomas,45.2%)were most common with nearly equal frequency.The median age was 43 years,with no sex predilection.Carcinoid tumours occurred in younger patients(mean age 32 years),with a male-to-female ratio of 1.2:1.A clinical diagnosis of acute appendicitis was the most common reason for appendectomy(57.1%)and was histologically confirmed in 75%(18 of 24)of cases.In total,16.7%of cases were diagnosed after incidental appendectomy.CONCLUSION:Appendiceal epithelial tumours arerare in our experience,and are represented principally by carcinoid tumours and adenomas.Carcinoid tumours occurred in younger patients but were slightly more common in men than women.Tumours were not suspected clinically and were diagnosed incidentally in specimens submitted for acute appendicitis supporting the need for histological evaluation in all resection specimens. | Rondell Patrell Darrell Graham Nadia Patricia Williams Kamille Aisha West | 2009 | World Journal of Gastroenterology2009，15，12： | 2 |
| 4 | Phase sensitive optical near-field mapping using frequency-shifted laser optical feedback interferometry显示文摘 | Blaize S Bérenguier B Stéfanon I Bruyant A Lérondel G Royer P Hugon O Jacquin O Lacot E | | 0，，16： | 1 |
| 5 | Double-blind, comparative study of rufloxacin once daily versus amoxicillin three times a day in treatment of outpati ents with exacerbations of chronic bronchitis显示文摘 | Klietmann W Cesana M Rondel RK | 1993 | Antimicrob Agent Chemother1993，37，： | 1 |
| 6 | 显示文摘 | Monticone E Boarino L Lérondel G | 1999 | Applied Surface Science1999，142，14： | 1 |
| 7 | Evaluation of Langerhans Cell Infiltrate by CD1a Immunostain in Liver Biopsy for the Diagnosis of Primary Biliary Cirrhosis显示文摘 | Rondell P.D. Graham Thomas C. Smyrk Lizhi Zhang | 2012 | The American Journal of Surgical Pathology2012，，5： | 1 |
| 8 | Splenic infarction during Plasmodium ovale acute malaria: first case reported 显示文摘 | Cinquetti G Banal F Rondel C | 2010 | Malar J2010，9，： | 1 |
| 9 | Neutropenic Enterocolitis: New Insights Into a Deadly Entity显示文摘 | Taha Sachak Michael A. Arnold Bita V. Naini Rondell P. Graham Sejal S. Shah Michael Cruise Jason Y. Park Lindsey Clark Laura Lamps Wendy L. Frankel Nicole Theodoropoulos Christina A. Arnold | 2015 | The American Journal of Surgical Pathology2015，，12： | 1 |
| 10 | Doulale-blind, comparative study of rufloxacin once daily versus amoxicillin three times a day in treatment of outpatients with exacerbations of chronic bronchitis 显示文摘 | Klietmann W Cesana M Rondel RK | 1993 | Antimicrob Agent Chemother1993，37，： | 1 |
| 11 | Damage Control Resuscitation Is Associated With a Reduction in Resuscitation Volumes and Improvement in Survival in 390 Damage Control Laparotomy Patients显示文摘 | Bryan A. Cotton Neeti Reddy Quinton M. Hatch Eric LeFebvre Charles E. Wade Rosemary A. Kozar Brijesh S. Gill Rondel Albarado Michelle K. McNutt John B. Holcomb | 2011 | Annals of Surgery2011，，4： | 1 |
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