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| 1 | Ivabradine in the treatment of systolic heart failure- A systematic review and meta-analysis显示文摘AIM To perform a systematic-review and meta-analysis to compare outcomes of ivabradine combined with betablocker to beta-blocker alone in heart failure with reduced ejection fraction(HFr EF).METHODS We searched PubM ed, Cochrane, EMBASE, CINAHL and Web of Science for trials comparing ivabradine + betablocker to beta-blocker alone in HFr EF. We performed a systematic-review and meta-analysis of published literature. Primary end-point was combined end point of cardiac death and hospitalization for heart failure.RESULTS Six studies with 17671 patients were included. Mean follow-up was 8.7 ± 7.9 mo. Combined end-point of heart failure readmission and cardiovascular death was better in ivabradine + beta-blocker group compared to beta-blocker alone(RR: 0.93, 95%CI: 0.79-1.09, P = 0.354). Mean difference(MD) in heart rate was higher in the ivabradine + beta-blocker group(MD: 6.14, 95%CI: 3.80-8.48, P < 0.001). There was no difference in all cause mortality(RR: 0.98, 95%CI: 0.89-1.07, P = 0.609), cardiovascular mortality(RR: 0.99, 95%CI: 0.86-1.15, P = 0.908) or heart failure hospitalization(RR: 0.87, 95%CI: 0.68-1.11, P = 0.271). CONCLUSION From the available clinical trials, ivabradine + betablocker resulted in a significantly greater reduction in HRcoupled with improvement in combined end-point of heart failure readmission and cardiovascular death but with no improvement in all cause or cardiovascular mortality. Given the limited evidence, further randomized controlled trials are essential before widespread clinical application of ivabradine + beta-blocker is advocated for HFrEF. | Mahesh Anantha Narayanan Yogesh NV Reddy Janani Baskaran Abhishek Deshmukh David G Benditt Ganesh Raveendran | 2017 | World Journal of Cardiology2017，9，2： | 5 |
| 2 | Clinical Outcomes for Anaplastic Pancreatic Cancer: A Population-Based Study显示文摘 | Clancy J. Clark Rondell P. Graham Janani S. Arun W. Scott Harmsen Kaye M. Reid-Lombardo | 2012 | Journal of the American College of Surgeons2012，，5： | 2 |
| 3 | Intra articular use of so- dium hyaluronate (2,2, 2,7 MDa) in the treatment of Moroc can patients withknee osteoarthritis: randomized controlled trial 显示文摘 | Watik A Rachidi W Janani S | 2014 | Rev Med Brux2014，35，6： | 1 |
| 4 | Elevated serum visfatin levels in patients with acute myocardial infarction 显示文摘 | Mazaherioun M Hosseinzadeh-Attar M J Janani L | 2012 | Arch Isan Med2012，15，11： | 1 |
| 5 | PPAR gamma gene - a review显示文摘 | Janani C Ranjitha Kumari BD | 2015 | Diabetes Metab Syndr2015，9，1： | 1 |
| 6 | Pachydermoperiostosis:a case report显示文摘 | Kabi F Mkinsi O Janani S | 2006 | Rev Med Interne2006，27，9： | 1 |
| 7 | Investigation of a strategy for well controlled inducement of microcellu- lar and nanoeellular morphologies in polymers 显示文摘 | JANANI H FAMILI M H N | 2010 | Polym Eng Sci2010，50，8： | 1 |
| 8 | Coded Cooperation in WirelessCommunications: Space Time Transmission and herative Decoding 显示文摘 | Mohammad Janani | 2004 | IEEE Transactions on Signal Processing2004，52，2： | 1 |
| 9 | Coded Cooperation in Wireless Communications: Space-time Transmission and Iterative Decoding 显示文摘 | Janani M Hedayat A Hunter T E | 2004 | IEEE Trans on Signal Processing2004，52，2： | 1 |
| 10 | High conductive yttrium doped Li7La3Zr2O12 cubic lithium garnet显示文摘 | Murugan R Ramakumar S Janani N | 2011 | Electrochemistry Communications2011，13，12： | 1 |
| 11 | Coded Cooperation in Wireless Communications:Space-Time Transmissionand Iterative Decoding显示文摘 | | 2004 | IEEE TRANSACTIONS ON SIGNAL PROCESSING2004，52，2： | 1 |
| 12 | Slow versus fast sub-cutaneous heparin injections for prevention of bruising and site painintensity显示文摘 | Akbari Sari A Janani L Mohammady M | 2014 | Cochrane Database Syst Rev2014，，00： | 1 |
| 13 | Coded cooperation in wireless communications:space-time transmission and iterative decoding显示文摘 | Hedayat A Hunter T E | 2004 | IEEE Transactions on Signal Processing2004，52，2： | 1 |
| 14 | Coded co- operation in wireless communications: space-time transmission and iterative decoding 显示文摘 | Janani M Hedayat A Hunter T E | 2004 | IEEE Transactions on Signal Processing2004，52，2： | 1 |
| 15 | Li+transport properties of W substituted Li7La3Zr2O12 cubic lithium garnets显示文摘 | Dhivya L Janani N Palanivel B Murugan R | 2013 | Aip Advances2013，3，08： | 1 |
| 16 | A new look at yeast culture as probiotics for ruminants显示文摘 | Janany J P | 2001 | Feed Mix2001，9，6： | 1 |
| 17 | Calcinosis universalis complica- ting juvenile dermatomyositis : improvement after intravenous immuno- globulin therapy显示文摘 | Touimy M Janani S Rachidi W | 2013 | Joint Bone Spine2013，80，1： | 1 |
| 18 | Synthesis of IL-13 by hu- man B lymphoeytes: regulation and role in IgE production 显示文摘 | Hajoui O Janani R Tulie M | 2004 | J Allergy Clin Immunol2004，114，3： | 1 |
| 19 | Elevated serum visfatin levels in patients with acute myocardial infarction显示文摘 | Mazaherioun M Hosseinzadeh-Attar MJ Janani L | 2012 | Arch Iran Med2012，15，11： | 1 |
| 20 | Coded cooperation in wireless communications:space-time transmission and iterative decoding显示文摘 | Janani M Hedayat A Hunter T E | 2004 | IEEE Transactions on Signal Processing2004，52，2： | 1 |
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