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| 1 | Liver fat deposition and mitochondrial dysfunction in morbid obesity:An approach combining metabolomics with liver imaging and histology显示文摘AIM: To explore the usefulness of magnetic resonance imaging(MRI) and spectroscopy(MRS) for assessment of non-alcoholic fat liver disease(NAFLD) as compared with liver histological and metabolomics findings. METHODS: Patients undergoing bariatric surgery following procedures involved in laparoscopic sleeve gastrectomy were recruited as a model of obesityinduced NAFLD in an observational, prospective, singlesite, cross-sectional study with a pre-set duration of 1 year. Relevant data were obtained prospectively and surrogates for inflammation, oxidative stress and lipid and glucose metabolism were obtained through standard laboratory measurements. To provide reliable data from MRI and MRS, novel procedures were designed to limit sampling variability and other sources of error using a 1.5T Signa HDx scanner and protocols acquired from the 3D or 2D Fat SAT FIESTA prescription manager. We used our previously described 1H NMRbased metabolomics assays. Data were obtained immediately before surgery and after a 12-mo period including histology of the liver and measurement of metabolites. Values from 1H NMR spectra obtained after surgery were omitted due to technical limitations.RESULTS: MRI data showed excellent correlation with the concentration of liver triglycerides, other hepatic lipid components and the histological assessment, w h i c h e xc l u d e d t h e p r e s e n c e o f n o n-a l c o h o l i c steatohepatitis(NASH). MRI was sufficient to follow up NAFLD in obese patients undergoing bariatric surgery and data suggest usefulness in other clinical situations. The information provided by MRS replicated that obtained by MRI using the-CH3 peak(0.9 ppm), the-CH2- peak(1.3 ppm, mostly triglyceride) and the-CH=CH- peak(2.2 ppm). No patient depicted NASH. After surgery all patients significantly decreased their body weight and steatosis was virtually absent even in patients with previous severe disease. Improvement was also observed in the serum concentrations of selected variables. The most relevant findings using metabolomics indicate increased levels of triglyceride and monounsaturated fatty acids in severe steatosis but those results were accompanied by a significant depletion of diglycerides, polyunsaturated fatty acids, glucose-6-phosphate and the ATP/AMP ratio. Combined data indicated the coordinated action on mitochondrial fat oxidation and glucose transport activity and may support the consideration of NAFLD as a likely mitochondrial disease. This concept may helpto explain the dissociation between excess lipid storage in adipose tissue and NAFLD and may direct the search for plasma biomarkers and novel therapeutic strategies. A limitation of our study is that data were obtained in a relatively low number of patients.CONCLUSION: MRI is sufficient to stage NAFLD in obese patients and to assess the improvement after bariatric surgery. Other data were superfluous for this purpose. | Nahum Calvo Raúl Beltrán-Debón Esther Rodríguez-Gallego Anna Hernández-Aguilera Maria Guirro Roger Mariné-Casadó Lidón Millá Josep M Alegret Fàtima Sabench Daniel del Castillo María Vinaixa Miguelàngel Rodríguez Xavier Correig Roberto García-álvarez Javier A Menendez Jordi Camps Jorge Joven | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 2 | Solid phase microextraction(SPME)technique for measurement of generation of fresh cucumber flavor compounds显示文摘 | CHERYL P H ROGER F | 2001 | J Agric Food Chem2001，49，： | 2 |
| 3 | Sarcopenia: An Undiagnosed Condition in Older Adults. Current Consensus Definition: Prevalence, Etiology, and Consequences. International Working Group on Sarcopenia显示文摘 | Roger A. Fielding Bruno Vellas William J. Evans Shalender Bhasin John E. Morley Anne B. Newman Gabor Abellan van Kan Sandrine Andrieu Juergen Bauer Denis Breuille Tommy Cederholm Julie Chandler Capucine De Meynard Lorenzo Donini Tamara Harris Aimo Kannt F | 2011 | Journal of the American Medical Directors Association2011，，4： | 2 |
| 4 | Mutual coupling between finite lengths parallel or angled horizontal earth return conductors显示文摘 | Rogers J E White F J | 1989 | IEEE Trans PWRD1989，4，1： | 2 |
| 5 | A Supplier Development Program: Rational Process or Institutional Image Construction? 显示文摘 | Rogers K W Purdy L Safayeni F Duimering P R | 2007 | Journal of Operations Management2007，25，2： | 1 |
| 6 | High-resolution ultrasound to diagnose melanoma metastases in patients with clinically palpable lymph nodes显示文摘 | Uren R Howman G | 1999 | Australasian Radiology1999，43，： | 1 |
| 7 | Cblique stepwise rise and growth of the Tibet Plateau显示文摘 | Tapponnier P Xu Zhiqin Roger F | 2001 | Science2001，294，： | 1 |
| 8 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 9 | Particle packing in loess deposits and the problem of structure collapse and hydroconsolidation 显示文摘 | DIJKSTRA T A SMALLEY I J ROGERS E D F | 1995 | Engi- neering Geology1995，40，： | 1 |
| 10 | An optimal multiedge detector for SAR image segment显示文摘 | ROGER F ARMAND L PHII IPPE M | 1988 | IEEE Trans actions on Geoscience and Re note Sensing1988，36，3： | 1 |
| 11 | Physiological and pathologi- cal regulation of thyroid cell proliferation and differentiation by thyrotropin and other factors显示文摘 | Dumont JE Lamy F Roger P | 1992 | Physiol Rev1992，72，3： | 1 |
| 12 | Bcl-2 family protein expression and platinum drug resistance in ovarian carinoma显示文摘 | Beale PJ Rogers P Boxall F | | 0，，02： | 1 |
| 13 | C-peptide stimulates Na+ ,K+ ATPase activity via PKC alpha in rat medullary thick ascending limb显示文摘 | Tsimaratos M Roger F Chabardes D | 2003 | Diabetologia2003，46，1： | 1 |
| 14 | Characteristic Impedance De-termination Using Propagation Constant Measurement显示文摘 | Roger B M Dylan F W | 1991 | IEEE Microwave and Guided Wave Letters1991，，1： | 1 |
| 15 | Inflammation and restenosis in the stent era 显示文摘 | Welt F G Rogers C | 2002 | Arterioscler Thromb Vasc Biol2002，22，11： | 1 |
| 16 | Mechanistic approach to predict real machining time for milling free- form geometries applying high feed rate显示文摘 | COELHO R T SOUZA A F ROGER A R | 2010 | International Journal of Advanced Manufacturing Technology2010，46，9101112： | 1 |
| 17 | Mesoporous tin oxides as lithium intercalation anode materials 显示文摘 | YU A ROGER F | 2002 | J Power Sources2002，104，1： | 1 |
| 18 | C -peptide stimulates Na^+-K^+-ATPase activity via PKC alpha in rat medullary thick ascending limb显示文摘 | Tsimaratos M Roger F Chabardes D | 2003 | Diabetologia2003，46，1： | 1 |
| 19 | An Integrative Model of Organizational Trust : Past, Present, and Future 显示文摘 | F David Schoorman Roger C Mayer James H Davis | 2007 | The A- cademy of Management Review2007，，： | 1 |
| 20 | Expression and regulation by insulin of GLUT 3 in UMR 106-01, a clonal rat osteosarcoma cell line 显示文摘 | Thomas DM F Maher SD Rogers | 1996 | Biochem Biophys Res Commun1996，218，： | 1 |
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