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| 1 | 导致成人与儿童患者30天脑室腹腔分流失败的原因分析(英文)显示文摘OBJECTIVE The aim of this study was to provide a comprehensive benchmark of 30-day ventriculoperitoneal(VP)shunt failure rates for a single institution over a 5-year study period for both adult and pediatric patients,to compare this with the results in previously published literature,and to establish factors associated with shunt failure.METHODS A retrospective database search was undertaken to identify all VP shunt operations performed in a single,regional neurosurgical unit during a 5-year period.Data were collected regarding patient age,sex,origin of hydrocephalus,and whether the shunt was a primary or secondary shunt.Operative notes were used to ascertain the type of valve inserted,which components of the shunt were adjusted/replaced(in revision cases),level of seniority of the most senior surgeon who participated in the operation,and number of surgeons involved in the operation.Where appropriate and where available,postoperative imaging was assessed for grade of shunt placement,using a recognized grading system.Univariate and multivariate models were used to establish factors associated with early(30-day)shunt failure.RESULTS Six hundred eighty-three VP shunt operations were performed,of which 321 were pediatric and 362 were adult.The median duration of postoperative follow-up for nonfailed shunts(excluding deaths)was 1263 days(range 525-2226 days).The pediatric 30-day shunt failure rates in the authors'institution were 8.8%for primary shunts and 23.4%for revisions.In adults,the 30-day shunt failure rates are 17.7%for primary shunts and 25.6%for revisions.In pediatric procedures,the number of surgeons involved in the operating theater was significantly associated with shunt failure rate.In adults,the origin of hydrocephalus was a statistically significant variable.Primary shunts lasted longer than revision shunts,irrespective of patient age.CONCLUSIONS A benchmark of 30-day failures is presented and is consistent with current national databases and previously published data by other groups.The number of surgeons involved in shunt operations and the origin of the patient's hydrocephalus should be described in future studies and should be controlled for in any prospective work.The choice of shunt valve was not a significant predictor of shunt failure.Most previous studies on shunts have concentrated on primary shunts,but the high rate of early shunt failure in revision cases(in both adults and children)is perhaps where future research efforts should be concentrated. | Anderson IA Saukila LF Robins JMW Akhunbay-Fudge CY Goodden JR Tyagi AK Phillips N Chumas PD | 2018 | 中华神经外科疾病研究杂志2018，17，3： | 3 |
| 2 | Safety of Green Tea Extracts: A Systematic Review by the US Pharmacopeia显示文摘 | Sarma Dandapantula N Barrett Marilyn L Chavez Mary L Gardiner Paula Ko Richard Mahady Gail B Marles Robin J Pellicore Linda S Giancaspro Gabriel I Dog Tieraona Low | 2008 | Drug Safety2008，，6： | 2 |
| 3 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 4 | Precision atomic gravimeter based on Bragg diffraction显示文摘 | P A Altin M T Johnsson V Negnevitsky G R Dennis R P Anderson J E Debs S S Szigeti K S Hardman S Bennetts G D McDonald L D Turner J D Close N P Robins | 2013 | New Journal of Physics2013，，2： | 2 |
| 5 | Why momentum width matters for atom interferometry with Bragg pulses显示文摘 | S S Szigeti J E Debs J J Hope N P Robins J D Close | 2012 | New Journal of Physics2012，，2： | 2 |
| 6 | Wavelet Transform Methods for Object Detection and Recovery显示文摘 | Robin N Strickland Hee Hahn | 1995 | IEEE Transactions on Image Processing1995，5，： | 1 |
| 7 | Maximum likelihood from incomplete data via the EM algorithm显示文摘 | Dempster A P Laird N M Robin D B | 1977 | Journal of the Royal Statistical Society1977，39，1： | 1 |
| 8 | 20,26-Dihydro-xyecdysone, a new steroid with moulting hormone activity from the tobacco homworm, Manduca sexta (Johannson) 显示文摘 | Thompson M J Kaplanis J N Robins W E | 1967 | Chem Comm1967，38，： | 1 |
| 9 | High - power picosecond fiber amplifier based on nonlinear spectral compression 显示文摘 | Limpert J Deguil -Robin N Manek -Honinger I | 2005 | Opt Lett2005，30，7： | 1 |
| 10 | Clinical classification of pulmonary hypertension 显示文摘 | Simonneau G Galie N Robin LJ | 2004 | J Am Coll Candiol2004，43，12： | 1 |
| 11 | Transient focal ischemia increases endothelial nitric oxide synthase in cerebral blood vessels 显示文摘 | Vehkamp R Rajapakse N Robins G | 2002 | Stroke2002，33，11： | 1 |
| 12 | Turning, compacting and the addition of water as factors affecting gaseous emissions in farm manure composting显示文摘 | E1 Kader N A Robin P Paillat J M | 2007 | Bioresource Technology2007，98，14： | 1 |
| 13 | Transient focal ischemia increases endothelial nitric oxide synthase in cerebral blood vessels 显示文摘 | Vehkamp R Rajapa kse N Robins G | 2002 | Stroke2002，33，9： | 1 |
| 14 | Learning and teaching programming: a review and discussion显示文摘 | Robins A Rountree J Rountree N | 2003 | Computer Science Education2003，，13： | 1 |
| 15 | Clinical classification of pulmonary hypertension显示文摘 | Galie N Robin LJ | 2004 | J Am Coll Candiol2004，43，： | 1 |
| 16 | Emergency nursing:Historical,current,and future roles显示文摘 | JOHN A SCHRIVER M D ROBIN TALMADGE R N | 2003 | Journal of Emergency Nursing2003，29，5： | 1 |
| 17 | Semiparametric approaches to stochastic panel frontiers with applications in the banking industry显示文摘 | Robert M Adams Allen N Berger Robin C Sickles | 1999 | Journal of Business and Economic Statistics1999，17，3： | 1 |
| 18 | Criteria used by venture capitalists to evaluate new proposals显示文摘 | IAN C MACMILLAN ROBIN SIEGEL SUBBA NARASIMHA P N | 1985 | Journal of Business Venturing 11985，，： | 1 |
| 19 | Histone H3 lysine 4 trimethylation marks meiotic recombination initiation sites 显示文摘 | Borde V Robine N Lin W | 2009 | EMBO J2009，28，2： | 1 |
| 20 | Turning,compacting and the addition of water as factors affecting gaseous emissions in farm manure composting显示文摘 | EL KADER N A ROBIN P PAILLAT J M | 2007 | Bioresource Technology2007，98，14： | 1 |
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