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| 1 | Stem cell therapy for Parkinson’s disease: safety and modeling显示文摘For decades,clinicians have developed medications and therapies to alleviate the symptoms of Parkinson’s disease,but no treatment currently can slow or even stop the progression of this localized neurodegeneration.Fortunately,sparked by the genetic revolution,stem cell reprogramming research and the advancing capabilities of personalization in medicine enable forward-thinking to unprecedented patient-specific modeling and cell therapies for Parkinson’s disease using induced pluripotent stem cells(iPSCs).In addition to modeling Parkinson’s disease more accurately than chemically-induced animal models,patient-specific stem cell lines can be created,elucidating the effects of genetic susceptibility and sub-populations’differing responses to in vitro treatments.Sourcing cell therapy with iPSC lines provides ethical advantages because these stem cell lines do not require the sacrifice of human zygotes and genetically-specific drug trails can be tested in vitro without lasting damage to patients.In hopes of finally slowing the progression of Parkinson’s disease or re-establishing function,iPSC lines can ultimately be corrected with gene therapy and used as cell sources for neural transplantation for Parkinson’s disease.With relatively localized neural degeneration,similar to spinal column injury,Parkinson’s disease presents a better candidacy for cell therapy when compared to other diffuse degeneration found in Alzheimer’s or Huntington’s Disease.Neurosurgical implantation of pluripotent cells poses the risk of an innate immune response and tumorigenesis.Precautions,therefore,must be taken to ensure cell line quality before transplantation.While cell quality can be quantified using a number of assays,a yielding a high percentage of therapeutically relevant dopaminergic neurons,minimal de novo genetic mutations,and standard chromosomal structure is of the utmost importance.Current techniques focus on iPSCs because they can be matched with donors using human leukocyte antigens,thereby reducing the severity and risk of immune rejection.In August of 2018,researchers in Kyoto,Japan embarked on the first human clinical trial using iPSC cell therapy transplantation for patients with moderate Parkinson’s disease.Transplantation of many cell sources has already proven to reduce Parkinson’s disease symptoms in mouse and primate models.Here we discuss the history and implications for cell therapy for Parkinson’s disease,as well as the necessary safety standards needed for using iPSC transplantation to slow or halt the progression of Parkinson’s disease. | Theo Stoddard-Bennett Renee Reijo Pera | 2020 | Neural Regeneration Research2020，15，1： | 5 |
| 2 | Enhanced generation of induced pluripotent stem cells from a subpopulation of human fibroblasts显示文摘 | Byrne JA Nguyen HN Reijo Pera RA | 2009 | PLoS One2009，4，9： | 1 |
| 3 | Modeling human germ cell development with embryonic stem cells显示文摘 | Clark AT Reijo Pera RA | 2006 | Regen Med2006，1，1： | 1 |
| 4 | Identification and characterization of RNA sequences to which human PUMILIO-2 (PUM2) and deleted in Azoospermia-like (DAZL) bind 显示文摘 | Fox M Urano J Reijo Pera R A | 2005 | Genomics2005，85，1： | 1 |
| 5 | Male infertility,genetic analysis of the DAZ genes on the human Y chromosome and genetic analysis of DNA repair显示文摘 | Mark S Fox Renee A Reijo Pera | 2001 | Molecular and Cellular Endocrinology2001，184，： | 1 |
| 6 | Evolutionary comparison of the reproductive genes, DAZL and BOULE, in primates with and without DAZ显示文摘 | Joyce Y. Tung C. Marc Luetjens Joachim Wistuba Eugene Y. Xu Renee A. Reijo Pera J?rg Gromoll | 2006 | Development Genes and Evolution2006，，3： | 1 |
| 7 | NANOS3 function in human germ cell development 显示文摘 | Julaton V T Reijo Pera R A | 2011 | Hum Mol Genet2011，20，11： | 1 |
| 8 | Modeling Parkinson's disease using induced pluripotent stem cells显示文摘 | Byers B Lee H Reijo Pera R | 2012 | Curr Neurol Neurosci Rep2012，12，3： | 1 |
| 9 | NANOS3 function in human germ ceil development 显示文摘 | Julaton V T Reijo Pera R A | 2011 | Hum Mol Genet2011，20，11： | 1 |
| 10 | Biomarkers identified with time-lapse imaging – Discovery, validation, and practical application显示文摘 | Alice A. Chen Lei Tan Vaishali Suraj Renee Reijo Pera Shehua Shen | 2013 | Fertility and Sterility2013，，： | 1 |
| 11 | Male infertility,genetic analysis of the DAZ genes on the human Y chromosome and genetic analysis of DNA repair显示文摘 | Fox MS Reijo Pera RA | | 0，，： | 1 |
| 12 | Activation of Innate Immunity Is Required for Efficient Nuclear Reprogramming显示文摘 | Jieun Lee Nazish Sayed Arwen Hunter Kin Fai Au Wing H. Wong Edward S. Mocarski Renee Reijo Pera Eduard Yakubov John P. Cooke | 2012 | Cell2012，，3： | 1 |
| 13 | Dazl functions in maintenance of pluripotency and genetic and epigenetic programs of differentiation in mouse primordial germ cells in vivo and in vitro 显示文摘 | Haston K M Tung J Y Reijo Pera R A | 2009 | PLoS One2009，4，5： | 1 |
| 14 | Male infertility, genetic analysis of the DAZ genes on the human Y chromosome and genetic analysis of DNA repair 显示文摘 | Fox MS Reijo Pera RA | 2001 | Mol Cell Endoerinol2001，184，： | 1 |
| 15 | Dazl Functions in Maintenance of Pluripotency and Genetic and EpigeneticPrograms of Differentiation in Mouse Primordial Germ Ceils In Vivo and In Vitro显示文摘 | Kelly M Haston Joyce Y Tung Renee A Reijo Pera | 2009 | PLoS ONE2009，4，5： | 1 |
| 16 | Ethical and Legal Issues Arising in Research on Inducing Human Germ Cells from Pluripotent Stem Cells显示文摘 | Tetsuya Ishii Renee A. Reijo Pera Henry T. Greely | 2013 | Cell Stem Cell2013，，： | 1 |
| 17 | Identification and charac- terization of RNA sequences to which human PUMILIO-2 (PUM2) and deleted in Azoospermia-like (DAZL) bind 显示文摘 | Fox M Urano J Reijo Pera R A | 2005 | Genomics2005，85，1： | 1 |
| 18 | Modeling Parkinson’s Disease Using Induced Pluripotent Stem Cells显示文摘 | Blake Byers Hsiao-lu Lee Renee Reijo Pera | 2012 | Current Neurology and Neuroscience Reports2012，，3： | 1 |
| 19 | Spontaneous differentiation of germ cells from human embryonic stem cells in vitro 显示文摘 | Clark AT Bodnar MS Reijo Pera RA | 2004 | Human Molecular Genetics2004，13，7： | 1 |
| 20 | Downregulation of miRNA-200c Links Breast Cancer Stem Cells with Normal Stem Cells显示文摘 | Yohei Shimono Maider Zabala Robert W. Cho Neethan Lobo Piero Dalerba Dalong Qian Maximilian Diehn Huiping Liu Sarita P. Panula Eric Chiao Frederick M. Dirbas George Somlo Renee A. Reijo Pera Kaiqin Lao Michael F. Clarke | 2009 | Cell2009，，3： | 1 |
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