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| 1 | Parkin promotes intracellular Aβ1–42 clearance显示文摘 | Burns M P Zhang L Rebeck G W | 2009 | Human Molecular Genetics2009，18，17： | 1 |
| 2 | Progression of cerebral amyloid angiopathy: accumulation of amyloid-β 40in affected vessels 显示文摘 | Alonzo NC Hyman BT Rebeck GW | 1998 | J Neuropathol Exp Neurol1998，57，4： | 1 |
| 3 | Apolipoprotein E affects the amount, form, and anatomical distribution of amy loid beta-peptide deposition in homozygous APP (V717F) transgenic mice显示文摘 | Cheung BS Rebeck GW | 2000 | Acta Neuropathol2000，100，： | 1 |
| 4 | Apolipoprotein E in sporadic Alzheimer disease: Allelic variation and receptor interaction 显示文摘 | Rebeck GW Reiter JS Strickland DK | 1993 | Neuro1993，11，3： | 1 |
| 5 | Cerebrospinal fluid levels of amyloid β protein in Alzheimer's disease: inverse correlation with severity of dementia and effect of apolipoprotein E genotype显示文摘 | Nitsch RM Rebeck GW Deng M | 1995 | Ann Neurol1995，37，： | 1 |
| 6 | 炎症过程中载脂蛋白E亚型在星形胶质细胞和小胶质细胞的表达和分泌显示文摘神经炎症是神经退行性疾病的常见特征,受阿尔茨海默病危险因素载脂蛋白E(APOE)的调节。apoE蛋白在大脑中由星形胶质细胞和小胶质细胞合成。在人类APOE(E2、E3和E4)靶向替代小鼠的星形胶质细胞和小胶质细胞的原代培养物中,我们发现星形胶质细胞分泌2种apoE,而细胞内apoE只包含1种。2种形式的分泌型星形胶质细胞apoE在糖蛋白分离过程中均发生结合,酶促去除聚糖使2种形式的apoE融合为单一形式。因此,星形胶质细胞分泌的2种apoE是不同的糖基化的蛋白。小胶质细胞仅释放1种apoE,而细胞内apoE则由2种形式组成;分泌的apoE和2种细胞内apoE中的其中1种是糖基化的。我们用内源性肿瘤坏死因子α(TNFα)或外源性脂多糖(LPS)促炎刺激物处理原代培养的胶质细胞。LPS对星形细胞的apoE没有影响,而APOE2和APOE3小胶质细胞释放的apoE增加;对APOE4小胶质细胞也没有影响。与APOE2和APOE3小胶质细胞相比,APOE4小胶质细胞显示出更高的TNFα基线分泌。TNFα处理仅降低了APOE4星形胶质细胞中apoE的分泌和细胞表达。星形胶质细胞和小胶质细胞产生apoE种类的模式不受炎症的影响。2种处理后的星形胶质细胞中均未显示APOE mRNA的变化。总之,我们的数据表明,星形胶质细胞和小胶质细胞差异表达和分泌糖基化形式的apoE;并且相较于APOE2和APOE3,APOE4星形胶质细胞和小胶质细胞在免疫调节方面存在缺陷。 | Maria Fe Lanfranco Jordy Sepulveda Gregory Kopetsky GWilliam Rebeck 杜一星(编译) | 2021 | 神经损伤与功能重建2021，16，6： | 1 |
| 7 | Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions显示文摘 | Rebeck GW Reiter JS Strickland DK | 1993 | Neuron1993，11，： | 1 |
| 8 | Multiple pathways of apolipo-protein E signaling in primary neurons显示文摘 | Hoe HS Harris DC Rebeck GW | | 0，，01： | 1 |
| 9 | Role of the low-density lipoprotein receptor-related protein in β-Amyloid metabolism and Alzheimer disease显示文摘 | Hyman BT Strickland D Rebeck GW | 2000 | Arch Neurol2000，57，： | 1 |
| 10 | Apolipoprotein E in sporadic Alzheimer's disease:Allelic Variation and receptor interaction显示文摘 | Rebeck GW Reiter JS Strickland Dk | 1993 | Neuron1993，11，： | 1 |
| 11 | Lack of association of a polymorphism in the low-density lipoprotein receptor-related protein gene with Alzheimer disease显示文摘 | Clatworthy AE Gomez-Isla T Rebeck GW | 1997 | Arch Neurol1997，54，： | 1 |
| 12 | Epidemiological, clinical, and neuropathological study of apolipoprotein E genotype in Alzheimer's disease显示文摘 | Hyman BT Gomez-Isla T Rebeck GW | 1996 | Ann N Y Acad Sci1996，777，： | 1 |
| 13 | Options for screening colonoscopy without sedation: sequel to a pilot study in U.S. veterans显示文摘 | Felix W. Leung Surinder K. Mann Rodelei Salera Lee Toomsen Hazel Cabrera Dannie Prather Rebeck Gutierrez Joseph W. Leung | 2008 | Gastrointestinal Endoscopy2008，，4： | 1 |
| 14 | Progression of cerebral amyloid angiopathy: accumulation of amyloid- beta 40 in affected vessels显示文摘 | Hyman BT Rebeck GW | 1998 | J Neuropathol Exp Neurol1998，57，： | 1 |
| 15 | Multiple pathways of apolipoprotein E signaling in primary neurons 显示文摘 | Hoe HS Harris DC Rebeck GW | 2005 | Neuroehem Neurochemistry2005，93，1： | 1 |
| 16 | ApoE in sporadic Alzheimer' s disease: Allelic variation and receptor interaction显示文摘 | Reiter JS Strickland DK | 1993 | Neuron1993，11，： | 1 |
| 17 | Synthesis of α, α-dialkylated amino acids with adenine or thymine residues: a new mild and facile hydrolysis of hydantoins 显示文摘 | Kubik S Meissner RS Rebeck J | 1994 | Tetrahedron Lett1994，36，35： | 1 |
| 18 | Reduced apolipoproteinε4 allele frequency in the oldest old Alzheimer's patients and cognitively normal individuals显示文摘 | Rebeck GW Perls TT West HL | 1994 | Neurology1994，44，8： | 1 |
| 19 | Apolipoprotein E de- creases tan kinases and phospho-tau levels in primary neu- rons显示文摘 | Hoe HS Freeman J Rebeck GW | 2006 | Mol Neurodegener2006，1，： | 1 |
| 20 | Apolipoprotein E ε4 and cerebral hemorrhage associated with amyloid angiop athy显示文摘 | Rebeck GW Vonsattel JP e t al | 1995 | Aun Neurol1995，，： | 1 |
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