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| 1 | Retinoic acid can improve autophagy through depression of the PI3K-Akt-mTOR signaling pathway via RARαto restore spermatogenesis in cryptorchid infertile rats显示文摘Cryptorchidism-caused adult infertility is a common component of idiopathic reasons for male infertility.Retinoic acid(RA)has a vital effect on the spermatogenesis process.Here,we found that the expression of c-Kit,Stra8,and Sycp3 could be up-regulated via the activation of retinoic acid receptorα(RARα)after RA supplementation in neonatal cryptorchid infertile rats.We also demonstrated that the protein expression of PI3K,p-Akt/pan-Akt,and p-mTOR/mTOR was higher in cryptorchid than in normal testes,and could be suppressed with RA in vivo.After RA treatment in infertile cryptorchid testis in vivo,the levels of the autophagy proteins LC3 and Beclin1 increased and those of P62 decreased.Biotin tracer indicated that the permeability of blood-testis barrier(BTB)in cryptorchid rats decreased after RA administration.Additionally,after blocking the RARαwith AR7(an RARαantagonist)in testicle culture in vitro,we observed that compared with normal testes,the PI3K-Akt-mTOR signaling pathway and the autophagy pathway was increased and decreased,respectively,which were coincident with cryptorchisd testes in vivo.Additionally,the appropriate concentrations of RA treatment could depress the PI3K-Akt-mTOR signaling pathway and improve the autophagy pathway.The results confirmed that RA can rehabilitate BTB function and drive key protein levels in spermatogonial differentiation through depressing the PI3K-Akt-mTOR signaling pathway via RARα. | Chunlan Long Yu Zhou Lianju Shen Yihang Yu Dong Hu Xing Liu Tao Lin Dawei He Tao Xu Deying Zhang Jing Zhu Guanghui Wei | 2022 | Genes & Diseases2022，9，5： | 2 |
| 2 | 药物治疗在二次经皮附睾穿刺取精中的作用显示文摘目的 探讨药物治疗在二次经皮附睾穿刺取精(PESA)中的作用。方法 选取2019年12月至2021年1月北京大学深圳医院收治的22例混合型无精子症患者作为研究对象。首次PESA均未获取精子。特发性患者给予托瑞米芬+十一酸睾酮治疗;合并精索静脉曲张患者给予迈之灵-阿司匹林治疗。每个月检测卵泡刺激素(FSH)及雌二醇(E_(2))水平,根据FSH变化调整药物。3个月后,所有患者行二次PESA。若二次PESA未获精,即行睾丸切开取精(TESE)。统计治疗结果。结果 22例中,16例(72.72%)PESA获精,4例(18.18%)TESE获精,1例拒行TESE,获精率为90.90%;8例(36.36%)冻存精子。15例行卵胞浆内单精子注射,分娩1例,待产1例,13例拟行冷冻胚胎移植。结论 对于混合型无精子症患者,初次PESA获精失败后,可以通过药物治疗恢复患者的生精功能,提高二次PESA获精率。 | 宋博 孙洪梅 刘群龙 钱卫平 | 2022 | 中国性科学2022，31，9： | 0 |
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