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| 1 | Design,synthesis,and biological evaluation of novel benzimidazole derivatives and their interaction with calf thymus DNA and synergistic effects with clinical drugs显示文摘A series of new benzimidazole derivatives was synthesized and characterized by IR,1H NMR,13C NMR,MS,and HRMS spectra.All the new compounds were screened for their antimicrobial activities in vitro by a twofold serial dilution technique.The bioactive evaluation showed that 3,5-bis(trifluoromethyl)phenyl benzimidazoles were comparably or even more strongly antibacterial and antifungal than the reference drugs Chloromycin,Norfloxacin,and Fluconazole.The combination of2,4-difluorobenzyl benzimidazole derivative 5l and its hydrochloride 7 respectively with the antibacterials Chloromycin,Norfloxacin,and the antifungal Fluconazole was more sensitive to methicillin-resistant MRSA and Fluconazole-insensitive A.flavus.In addition,the interaction of compound 5l with calf thymus DNA demonstrated that this compound could effectively intercalate into DNA to form a compound 5l-DNA complex that might block DNA replication and thereby exert good antimicrobial activity. | ZHANG HuiZhen LIN JianMei RASHEED Syed ZHOU ChengHe | 2014 | Science China Chemistry2014，57，6： | 5 |
| 2 | 槟榔子中抗血小板聚集及抑制乙酰胆碱酯酶活性的有效成分(英文)显示文摘目的:研究槟榔子(Areca catechu)粗提取物中所含的抗血小板聚集及抑制乙酰胆碱酯酶活性的有效成分及其作用机制。方法:使用70%甲醇水溶液对槟榔子进行粗提取。使用生物发光血小板凝集仪在富血小板血浆中测定槟榔子粗提取物的抗血小板聚集作用,使用分光光度计在试管内测定槟榔子粗提取物对乙酰胆碱酯酶活性的抑制作用。检测槟榔子中的多种化合物以测定槟榔子中抗血小板聚集及抑制乙酰胆碱酯酶活性的有效成分。结果:槟榔子粗提取物能够抑制花生四烯酸、二磷酸腺苷、血小板活化因子、肾上腺素及钙离子载体引起的血小板聚集,尤其对二磷酸腺苷及钙离子载体引起的血小板聚集的抑制最为明显;槟榔子粗提取物能够显著抑制乙酰胆碱酯酶的活性。在所检测的槟榔子所含化合物中,只有儿茶素对肾上腺素引起的血小板聚集有显著的抑制作用,而这种抑制作用显著弱于槟榔子粗提取物,提示槟榔子中的其他成分参与了这种抑制作用;鞣酸、没食子酸、薯蓣皂苷元和异去甲槟榔次碱能够抑制乙酰胆碱酯酶的活性,其中鞣酸的抑制作用强于槟榔子粗提取物。结论:槟榔子中含有抗血小板聚集及抑制乙酰胆碱酯酶活性的有效成分,而发挥这些功效的确切成分有待进一步的研究证实。 | Muhammad Nabeel Ghayur Syed Faraz Kazim Huma Rasheed Asaad Khalid Maliha Iqbal Jumani Muhammad Iqbal Choudhary Anwarul Hassan Gilani | 2011 | 中西医结合学报2011，9，6： | 4 |
| 3 | )plication of geo-microbial prospecting method for finding oil and gas reservoirs显示文摘 | M. A. Rasheed Syed Zaheer Hasan P. L. Srinivasa Rao Annapurna Boruah V.Sudarshan B. Kumar T. Harinarayana | 2015 | Frontiers of Earth Science2015，9，1： | 3 |
| 4 | Design,synthesis and biological evaluation of amino organophosphorus imidazoles as a new type of potential antimicrobial agents显示文摘A series of amino organophosphorus imidazoles were designed and synthesized as a novel structural type of antimicrobial agents.Bioactive evaluation in vitro showed that compound 3f exhibited equipotent or superior anti-methicillin-resistant Staphylococcus aureus(anti-MRSA) and anti-S. cerevisiae efficiencies(minimal inhibitory concentration(MIC)=2 μg/mL) to clinical drugs,and the combinations with antibacterial or antifungal drugs enhanced the antimicrobial efficiency. Highly active molecule 3f showed low propensity for bacteria to develop resistance, and the preliminary action mechanism studies demonstrated that 3f was membrane-active, but had no significant intercalation towards MRSA DNA. The computational study on 3f reasonably explained its high antimicrobial activity. Experimental data revealed that ground-state 3f-HSA complexes were formed mainly through hydrophobic interactions and hydrogen bonds with a spontaneous process, and the non-radioactive energy transfer from HSA to 3f occurred beyond F鰎ster resonance energy transfer theory. The participation of metal ions in 3f-HSA supramolucular system could increase the concentration of free compound 3f, and shorten its storage time and half-life in the blood to improve the maximum antimicrobial efficacy. | Wei-Wei Gao Syed Rasheed VijaiKumarReddy Tangadanchu Yi Sun Xin-Mei Peng Yu Cheng Feng-Xiu Zhang Jian-Mei Lin Cheng-He Zhou | 2017 | Science China Chemistry2017，60，6： | 3 |
| 5 | The Pakistan Risk of Myocardial Infarction Study: a resource for the study of genetic, lifestyle and other determinants of myocardial infarction in South Asia显示文摘 | Danish Saleheen Moazzam Zaidi Asif Rasheed Usman Ahmad Abdul Hakeem Muhammed Murtaza Waleed Kayani Azhar Faruqui Assadullah Kundi Khan Shah Zaman Zia Yaqoob Liaquat Ali Cheema Abdus Samad Syed Zahed Rasheed Nadeem Hayat Mallick Muhammad Azhar Rashid Jooma | 2009 | European Journal of Epidemiology2009，，6： | 1 |
| 6 | Noninvasive therapy for the management of patients with advanced coronary artery disease显示文摘 | Waqar H. Kazmi Syed Z. Rasheed Saeed Ahmed Mohammad Saadat Saqib Altaf Abdus Samad | 2012 | Coronary Artery Disease2012，，： | 1 |
| 7 | Fruits and Vegetables Freshness Categorization Using Deep Learning显示文摘The nutritional value of perishable food items,such as fruits and vegetables,depends on their freshness levels.The existing approaches solve a binary class problem by classifying a known fruit\vegetable class into fresh or rotten only.We propose an automated fruits and vegetables categorization approach that first recognizes the class of object in an image and then categorizes that fruit or vegetable into one of the three categories:purefresh,medium-fresh,and rotten.We gathered a dataset comprising of 60K images of 11 fruits and vegetables,each is further divided into three categories of freshness,using hand-held cameras.The recognition and categorization of fruits and vegetables are performed through two deep learning models:Visual Geometry Group(VGG-16)and You Only Look Once(YOLO),and their results are compared.VGG-16 classifies fruits and vegetables and categorizes their freshness,while YOLO also localizes them within the image.Furthermore,we have developed an android based application that takes the image of the fruit or vegetable as input and returns its class label and its freshness degree.A comprehensive experimental evaluation of proposed approach demonstrates that the proposed approach can achieve a high accuracy and F1score on gathered FruitVeg Freshness dataset.The dataset is publicly available for further evaluation by the research community. | Labiba Gillani Fahad Syed Fahad Tahir Usama Rasheed Hafsa Saqib Mehdi Hassan Hani Alquhayz | 2022 | Computers, Materials & Continua2022，，6： | 1 |
| 8 | A New Discovery towards Novel Skeleton of Benzimidazole-Conjugated Pyrimidinones as Unique Effective Antibacterial Agents显示文摘A class of new potential antibacterial agents with distinctive pyrimidinone benzimidazole skeleton was developed through nucleophilic substitution and Biginelli reaction starting from urea,ethyl 4-chloroacetoacetate and various aldehydes.Some target molecules exhibited strong antibacterial activities,especially pyrimidinone benzimidazole hybrid 9e possessed the strongest inhibitory effects on the growth of E.faecalis and P.aeruginosa with a lower MIC value of 1μg/mL than norfloxacin.Moreover,compound 9e displayed strong antibiofilm capacity,low drug resistance and excellent biosafety toward human red blood cells.Further research revealed that compound 9e could disrupt membrane integrity and cause leakage of cellular components such as proteins and nucleic acids.Meanwhile,compound 9e could decrease lactate dehydrogenase activity,block cell metabolism and interact with DNA in an intercalation manner. | Xi Yang Rasheed Syed Bo Fang Cheng-He Zhou | 2022 | Chinese Journal of Chemistry2022，40，22： | 0 |
| 9 | New Hybrid EWMA Charts for Efficient Process Dispersion Monitoring with Application in Automobile Industry显示文摘The EWMAcharts are thewell-knownmemory-type charts used formonitoring the small-to-intermediate shifts in the process parameters(location and/or dispersion).The hybrid EWMA(HEWMA)charts are enhanced version of the EWMA charts,which effectivelymonitor the process parameters.This paper aims to develop two new uppersided HEWMAcharts for monitoring shifts in process variance,i.e.,HEWMA1 and HEWMA2 charts.The design structures of the proposed HEWMA1 and HEWMA2 charts are based on the concept of integrating the features of two EWMAcharts.TheHEWMA1 and HEWMA2charts plotting statistics are developed using one EWMAstatistic as input for the other EWMAstatistic.AMonte Carlo simulations method is used as a computational technique to determine the numerical results for the performance characteristics,such as average run length(ARL),median run length,and standard deviation run length(SDRL)for assessing the performance of the proposed HEWMA1 and HEWMA2 charts.In addition,to evaluate the overall performance of the proposed HEWMA1 and HEWMA2 charts,other numerical measures consisting of the extra quadratic loss(EQL),relative average run length(RARL),and performance comparison index(PCI)are also computed.The proposed HEWMA1 and HEWMA2 charts are compared to some existing charts,such as CH,CEWMA,HEWMA,AEWMAHHW1,HHW2,AIB-EWMA-I,and AIB-EWMA-II charts,on the basis aforementioned numerical measures.The comparison reveals that the proposed HEWMA1 and HEWMA2 charts achieve better detection ability against the existing charts.In the end,a real-life data application is also provided to enhance the implementation of the proposed HEWMA1 and HEWMA2 charts practically. | Xuechen Liu Majid Khan Zahid Rasheed Syed Masroor Anwar Muhammad Arslan | 2022 | Computer Modeling in Engineering & Sciences2022，，5： | 0 |
| 10 | Ranked-Set Sampling Based Distribution Free Control Chart with Application in CSTR Process显示文摘Nonparametric(distribution-free)control charts have been introduced in recent years when quality characteristics do not follow a specific distribution.When the sample selection is prohibitively expensive,we prefer ranked-set sampling over simple random sampling because ranked set sampling-based control charts outperform simple random sampling-based control charts.In this study,we proposed a nonparametric homogeneously weighted moving average based on theWilcoxon signed-rank test with ranked set sampling(NPHWMARSS)control chart for detecting shifts in the process location of a continuous and symmetric distribution.Monte Carlo simulations are used to obtain the run length characteristics to evaluate the performance of the proposed NPHWMARSS control chart.The proposed NPHWMARSS control chart’s performance is compared to that of parametric and nonparametric control charts.These control charts include the exponentially weighted moving average(EWMA)control chart,Wilcoxon signed-rank with simple random sampling based the nonparametric EWMA control chart,the nonparametric EWMA sign control chart,Wilcoxon signed-rank with ranked set sampling-based the nonparametric EWMA control chart,and the homogeneously weighted moving average control charts.The findings show that the proposed NPHWMARSS control chart performs better than its competitors,particularly for the small shifts.Finally,an example is presented to demonstrate how the proposed scheme can be implemented practically. | Ibrahim M.Almanjahie Zahid Rasheed Majid Khan Syed Masroor Anwar Ammara Nawaz Cheema | 2023 | Computer Modeling in Engineering & Sciences2023，，6： | 0 |
| 11 | Maternal salinity improves yield, size and stress tolerance of Suaeda fruticosa seeds显示文摘Shrubby seablite or lani(Suaeda fruticosa Forssk)is a perennial euhalophyte with succulent leaves,which could be planted on arid-saline lands for restoration and cultivated as a non-conventional edible or cash crop.Knowledge about the impacts of maternal saline environment on seed attributes of this important euhalophyte is lacking.This study investigated the effects of maternal salinity on yield,size and stress tolerance of S.fruticosa seeds.Seedlings of S.fruticosa were grown in a green net house under increasing maternal salinity levels(0,300,600 and 900 mM NaCl)until seed production.Total yield,size,stress tolerance and germination of the descended seeds under different maternal saline conditions were examined.Plants grown under saline conditions(300,600 and 900 mM NaCl)produce a substantially higher quantity of seeds than plants grown under non-saline condition(0 mM NaCl).Low maternal salinity(300 mM NaCl)improves seed size.Seeds produced under all maternal salinity levels display a higher tolerance to low temperature(night/day thermoperiod of 10℃/20℃),whereas seeds produced under 300 mM NaCl maternal saline condition show a better tolerance to high temperature(night/day thermoperiod of 25℃/35℃)during germination.Seeds from all maternal saline conditions germinate better in the 12 h photoperiod(12 h light/12 h dark)than in the dark(24 h dark);however,seeds produced from low and moderate maternal saline conditions(300 and 600 mM NaCl)show a higher germination in the dark than those from control and high maternal saline conditions(0 and 900 mM NaCl).In general,maternal salinity is found to improve yield,size and stress tolerance of S.fruticosa seeds. | Syed Z SHAH Aysha RASHEED Bilquees GUL Muhammad A KHAN Brent LNIELSEN Abdul HAMEED | 2020 | Journal of Arid Land2020，12，2： | 0 |
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