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| 1 | Mesenchymal Stromal Cells: A New Tool against Graft-versus-Host Disease?显示文摘 | Frédéric Baron Rainer Storb | 2012 | Biology of Blood and Marrow Transplantation2012，，6： | 2 |
| 2 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 3 | Broadband Dielectric Spec- troscopy Studies of Hyperbranched Polyglycerols显示文摘 | Abel G Ricardo D Rainer H | 2006 | Ma- cromolecular Chemistry and Physics2006，207，11： | 1 |
| 4 | A Simple Micro Controller Based Digital Lock-in Amplifier for The Detection of Low Level Optical Signals 显示文摘 | Adria A D Rainer K | 2002 | Proceedings of the First IEEE International Workshop on Electronic Design2002，7，2： | 1 |
| 5 | Hypothermia reduces perihemorrhagic edema after intracerebral hemorrhage显示文摘 | Rainer K Dimitre A Arnd D | 2010 | Stroke2010，41，8： | 1 |
| 6 | Vibration criteria for long-span floors显示文摘 | ALLEN D E RAINER J H | 1980 | Canadian Journal of Civil Engineering1980，3，2： | 1 |
| 7 | Increased mortality associated with growth hormone treatment in critically ill adults显示文摘 | Rainer D | 2000 | N Engl J Med2000，342，： | 1 |
| 8 | Historical Perspective on Fifteen Years of Laser Damage Thresholds at LLNL显示文摘 | Rainer F Frank P Marco D | 1993 | SPIE Proceedings1993，2114，： | 1 |
| 9 | Transcrip- tion analysis of arabidopsis membrane transporters and hormone pathways during developmental and induced leaf senescence 显示文摘 | Graaff V D G Rainer S Ania S | 2006 | Plant Physiology2006，141，2： | 1 |
| 10 | Preparation β-silicon nitride seeds for self-reinforced silicon nitride ceramics显示文摘 | Peelamedu D Ramesh Rainer Oberacker Michael J Hoffmann | | 0，，06： | 1 |
| 11 | Sustained decrease in blood pressure following missed doses of aliskiren or telmisartan: the ASSERTIVE double-blind, randomized study显示文摘 | Rainer Düsing Patrick Brunel InYoung Baek Fabio Baschiera | 2012 | Journal of Hypertension2012，，5： | 1 |
| 12 | Analysis of proteoglycans derived sulphated disaccharides by liquid chromatography/ mass spectrometry显示文摘 | Begona B Mihaela D Rainer B | 2005 | Journal of Chromatography A2005，1080，： | 1 |
| 13 | Mechanisms involved in postconditioning protection of cardiomyocytes against acute reperfusion injury显示文摘 | Tayyab Shahzad Sascha Andreas Kasseckert Wisam Iraqi Victoria Johnson Rainer Schulz Klaus-Dieter Schlüter Oliver D?rr Mariana Parahuleva Christian Hamm Yury Ladilov Yaser Abdallah | 2013 | Journal of Molecular and Cellular Cardiology2013，，： | 1 |
| 14 | Small Satellites for Global Coverage:Potential and Limits显示文摘 | Rainer S Klaus B Marco D E | 2010 | ISPRS Journal of Photogrammetry and Remote Sensing2010，65，6： | 1 |
| 15 | Dynamic loading and response of footbridges显示文摘 | Rainer J H Pernica G Allen D E | 1988 | Canadian Journal of Civil Engineering1988，15，1： | 1 |
| 16 | Analysis of lignin-derived phenols in standard referencematerials and ocean dissolved organic matter by gaschromatography/tandem mass spectrometry 显示文摘 | PATRICK L RAINER M W A SHUIWANG D | 2010 | MarineChemistry2010，118，： | 1 |
| 17 | Isolation and charac- terization of isochorismate synthase and cinnamate 4 - hydroxylase during salinity stress, wounding, and salicylic acid treatment in Carthamus tinctorius 显示文摘 | Mahnaz S Sara D Rainer F | 2013 | Plant signaling & Behavior2013，8，： | 1 |
| 18 | The uptake on montmorillonite:a powder and polarized extended X-ray absorption fine structure (EXAFS) study显示文摘 | RAINER D ANDRE M S ALAIN M | 2002 | Colloid Interface Sci2002，249，： | 1 |
| 19 | Glucose-transporter-mediated positive inotropic effects inhuman myocardium of diabetic and nondiabeticpatients显示文摘 | Von Lewinski D Rainer PP Gasser R | 2010 | Metabolism2010，59，7： | 1 |
| 20 | Genetic factors in depression and suicide显示文摘 | Rainer J D | 1984 | Am J Psy- chother1984，8，8： | 1 |
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