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| 1 | Pharmaceuticals and personal care products (PPCPs) in the freshwater aquatic environment显示文摘Pharmaceuticals and personal care products(PPCPs)are a unique group of emerging environmental contaminants,due to their inherent ability to induce physiological effects in human at low doses.An increasing number of studies has confirmed the presence of various PPCPs in different environmental compartments,which raises concerns about the potential adverse effects to humans and wildlife.Therefore,this article reviews the current state-of-knowledge on PPCPs in the freshwater aquatic environment.The environmental risk posed by these contaminants is evaluated in light of the persistence,bioaccumulation and toxicity criteria.Available literature on the sources,transport and degradation of PPCPs in the aquatic environment are evaluated,followed by a comprehensive review of the reported concentrations of different PPCP groups in the freshwater aquatic environment(water,sediment and biota)of the five continents.Finally,future perspectives for research on PPCPs in the freshwater aquatic environment are discussed in light of the identified research gaps in current knowledge. | Anekwe Jennifer Ebele Mohamed Abou-Elwafa Abdallah Stuart Harrad | 2017 | Emerging Contaminants2017，3，1： | 44 |
| 2 | 通脉颗粒药渣对杜寒杂交母羊屠宰性能、器官指数及瘤胃发酵参数的影响显示文摘【目的】研究日粮添加通脉颗粒药渣(Tongmai granule residues, TGR)对羊屠宰性能、器官指数、复胃发育及瘤胃发酵参数的影响。【方法】选取1岁左右、平均体重为(29.64±1.80) kg的健康杜寒杂交母羊15只,随机分为3组,每组5个重复,分别为对照组(不含TGR)、10%TGR组和15%TGR组。参照NY/T816-2004配制基础日粮,精粗质量比均为6∶4,饲养至第76天屠宰。【结果】(1)日粮添加15%TGR眼肌面积显著降低(P<0.05),但对宰前活重、胴体重、屠宰率均无显著影响(P>0.05)。(2)日粮添加15%TGR肾脏指数显著高于对照组(P<0.05),但其他器官指数差异均不显著(P>0.05)。(3)各组瘤胃、网胃、瓣胃、皱胃的绝对重量及其与宰前活重的相对重量差异不显著(P>0.05),15%TGR组瘤胃重与复胃重之比显著升高(P<0.05),皱胃重与复胃重比例显著下降(P<0.05)。(4)日粮添加15%TGR瘤胃pH和氨态氮质量浓度较对照组和10%TGR组显著升高(P<0.05),乙酸、丙酸、丁酸和TVFA浓度较对照组和10%TGR组显著降低(P<0.05)。【结论】在本试验条件下,杜寒杂交母羊日粮中TGR添加水平为10%时,饲喂效果较好。 | 张佩 Abdallah ABEDIN 孙泽威 | 2019 | 云南农业大学学报(自然科学版)2019，34，4： | 18 |
| 3 | 黑龙江省全沟硬蜱携带伯氏疏螺旋体广义种和斑点热群立克次体的研究显示文摘为了解黑龙江省牡丹江市、鹤岗市萝北县、哈尔滨市通河县全沟硬蜱携带伯氏疏螺旋体和斑点热群立克次体的情况,在获得25只全沟硬蜱细菌组学数据的基础上,通过PCR扩增16S r RNA和fla基因检测伯氏疏螺旋体,扩增glt A和r Omp A基因检测斑点热群立克次体。结果显示,伯氏疏螺旋体的阳性率为20.0%(5/25),斑点热群立克次体的阳性率为68.0%(17/25)。另外,伯氏疏螺旋体阳性样品均显示斑点热群立克次体阳性,这两种病原的混合感染率为20.0%(5/25)。序列分析结果显示,16S r RNA基因与伽氏疏螺旋体Nov405菌株的相似性为99.65%,fla基因与伽氏疏螺旋体SZ菌株的相似性为99.73%;glt A和r Omp A基因与塔拉塞维奇立克次体暂定株(Candidatus Rickettsia tarasevichiae)的相似性均为100%。结果表明,斑点热群立克次体(Candidatus Rickettsia tarasevichiae)和伯氏疏螺旋体广义种在全沟硬蜱中广泛存在,这两种病原的混合感染增加了蜱传人兽共患病的风险。 | 潘玉平 杨吉飞 牛庆丽 Omar Abdallah Mirza 翟斌涛 曾巧英 殷宏 | 2017 | 中国兽医科学2017，47，1： | 15 |
| 4 | Circulating tumor and cancer stem cells in hepatitis C virusassociated liver disease显示文摘AIM:To assess the role of circulating tumor cells(CTCs)and cancer stem cells(CSCs)in hepatitis C virus(HCV)-associated liver disease.METHODS:Blood and/or tissue samples were obtained from HCV(genotype 4)-associated hepatocellularcarcinoma patients(HCC;n=120),chronic hepatitis C patients(CH;n=30)and 33 normal control subjects(n=33).Serum levels of alpha-fetoprotein(AFP),alkaline phosphatase,and alanine and aspartate aminotransferases were measured.Cytokeratin 19(CK19)monoclonal antibody was used to enumerate CTCs,and CD133 and CD90 were used to enumerate CSCs by flow cytometry.The expression levels of the CSCs markers(CD133 and CD90)as well as telomerase,melanoma antigen encoding gene 1(MAGE1)and MAGE3 were assessed by RTPCR and quantitative real-time polymerase chain reactions.The number of CTCs and/or the expression levels of CK19,CD133,telomerase,MAGE1 and MAGE3 were correlated to the standard clinicopathologic prognostic factors and disease progression.RESULTS:Levels of AFP,alkaline phosphatase and aspartate aminotransferase were significantly different among the HCC,CH and control groups(P<0.001),whereas alanine aminotransferase differed significantly between patient(HCC and CH)and control groups(P<0.001).At the specified cutoff values determine by flow cytometry,CK19(49.8),CD90(400)and CD133(73)were significantly higher in the blood of HCC patients compared to those in the CH and control groups(P<0.001).On the other hand,CD133 at a 69.5 cutoff was significantly higher in the CH compared to the control group(P≤0.001).Telomerase,MAGE1 and MAGE3RNA were expressed in 55.71%,60.00%and 62.86%of the HCC patients,respectively,but were not detected in patients in the CH or control groups,which were statistically significant(Ps<0.001).The expression levels of telomerase,CD90,MAGE3,CD133 and CK19 were all significantly associated with high tumor grade and advanced stage in HCC patients(all P s<0.05).CONCLUSION:CTC counts and AFP,CK19,telomerase,and MAGE1/MAGE3 expression predict disease progression in patients with HCV,whereas telomerase,MAGE3,CD90,CD133 and CK19 are prognostic mark- | Abeer A Bahnassy Abdel-Rahman N Zekri Ahmed El-Bastawisy Amal Fawzy Marwa Shetta Nehal Hussein Dalia Omran Abdallah A S Ahmed Samir S El-Labbody | 2014 | World Journal of Gastroenterology2014，20，48： | 9 |
| 5 | Pathological,immunohistochemical and microbiologicalal analysis of lacrimal sac biopsies in patients with chronic dacrocystitis显示文摘AIM:To analyze cases of obstruction of the nasolacrimal duct which creates a fertile environment for secondary bacterial Infection and can result in dacryocystitis,which is a constant threat to cornea and orbital soft tissue and a potential source of endophthalmitis following intraocular surgery.The majority of obstructions of the lacrimal excretory outflow system are acquired ones occurring in adulthood and involving the distal parts of the system.Acquired obstruction may be primary/idiopathic or secondary to a wide variety of infectious,inflammatory,traumatic,mechanical,toxic or neoplastic causes mimicking idiopathic inflammation.These cases are treated by dacryocystorhinostomy(DCR).METHODS:The present study was conducted to determine the histopathologic,immunohistochemical and current microbiologic characteristics of lacrimal sac specimens in patients undergoing external dacryocystorhinostomy.RESULTS:Non-specific lacrimal sac pathology was present in all 33 cases and 81.8%of the cases showed moderate chronic inflammation with a chronic inflammatory score(CIS)ranging between 4 and 6,whereas 12.12%showed severe inflammatory changes with a CIS of 7.Mild degree of inflammation was seen in6.06%with a CIS of 3.The total prevalence of grampositive,gram-negative,and culture-negative samples were 59.4%,37.5%,and 3%respectively.CONCLUSION:Non-specific chronic inflammation withfibrosis is indeed the most commonly reported histopathological finding in lacrimal sac wall biopsy specimens. | Rowayda Mahmoud Amin Faten Aly Hussein Hisham Farouk Idriss Nesrine Fathy Hanafy Dina Mohamed Abdallah | 2013 | International Journal of Ophthalmology(English edition)2013，6，6： | 7 |
| 6 | Influence of gut bacteria on development and progression of non-alcoholic fatty liver disease显示文摘The intestine of the human contains a dynamic population of microbes that have a symbiotic relationship with the host. In addition, there is an effect of the intestinal microbiota on metabolism and digestion. Non-alcoholic fatty liver disease(NAFLD) is a common cause worldwideof hepatic pathology and is thought to be the hepatic manifestation of the metabolic syndrome. In this review we examine the effect of the human microbiome on the components and pathogenesis of the metabolic syndrome. We are now on the threshold of therapeutic interventions on the human microbiome in order to effect human disease including NAFLD. | Ali Abdul-Hai Ali Abdallah Stephen DH Malnick | 2015 | World Journal of Hepatology2015，7，12： | 7 |
| 7 | Molecular detection of monocyte chemotactic protein-1 polymorphism in spontaneous bacterial peritonitis patients显示文摘AIM: To investigate the association of the functional monocyte chemotactic protein-1(MCP-1) promoter polymorphism(A-2518G) with spontaneous bacterial peritonitis(SBP).METHODS: Fifty patients with post-hepatitis C liver cirrhosis and ascites were categorized into two groups; group Ⅰ included 25 patients with SBP and group Ⅱ included 25 patients free from SBP. In addition, a group of 20 healthy volunteers were included. We assessed the MCP-1 gene polymorphism and gene expression as well as interleukin(IL)-10 levels in both blood and ascitic fluid. RESULTS: A significant MCP-1 gene polymorphism was detected in groups Ⅰ and Ⅱ(P = 0.001 and 0.02 respectively). Group Ⅰ was associated with a significantly higher frequency of AG genotype [control 8(40%) vs SBP 19(76.0%), P < 0.001], and group Ⅱ was associated with a significantly higher frequency of GG genotype when compared to healthy volunteers [control 1(5%) vs cirrhotic 16(64%), P < 0.001]. Accordingly, the frequency of G allele was significantly higher in both groups(Ⅰ and Ⅱ) [control 10(25%) vs SBP 27(54%), P < 0.001 and vs cirrhotic 37(74.0%), P < 0.001, respectively]. The total blood and ascetic fluid levels of IL-10 and MCP-1 gene expression were significantly higher in group Ⅰ than in group Ⅱ. Group Ⅰ showed significant reductions in the levels of MCP-1 gene expression and IL-10 in the whole blood and ascetic fluid after therapy. CONCLUSION: MCP-1 GG genotype and G allele may predispose HCV infected patients to a more progressive disease course, while AG genotype may increase the susceptibility to SBP. Patients carrying these genotypes should be under supervision to prevent or restrict further complications. | Maysa Kamal Salama Dina Sabry Mohamed AS Al-Ghussein Rasha Ahmed Sayed AbdAllah Fatma Mohamed Taha Wael Fathy Miriam Safwat Wadie Mona Nabih Amr Abul-Fotouh Tarneem Darwish | 2014 | World Journal of Gastroenterology2014，20，33： | 7 |
| 8 | Octreotide ameliorates gastric lesions in chronically mild stressed rats显示文摘AIM:To evaluate the effect of chronic mild stress(CMS) on the emergence of gastric ulcers and possible modulation by octreotide,a synthetic somatostatin analogue. METHODS:Adult male Wistar rats were subjected to nine different unpredictable random stress procedures for 21 d,a multifactorial interactional animal model for CMS.Octreotide was administered daily for 21 d at two dose levels(50 and 90μg/kg)before exposure to stress procedure.Macro-and microscopical assessments were made,in addition to quantification of plasma corticosterone and gastric mucosal inflammatory,oxidative stress, and apoptotic biomarkers. RESULTS:Exposure to CMS elevated plasma corticosterone(28.3±0.6μg/dL,P=0.002),an event that was accompanied by gastric lesions(6.4±0.16 mm,P=0.01) and confirmed histopathologically.Moreover,the insult elevated gastric mucosal lipid peroxides(13±0.5 nmol/g tissue,P=0.001),tumor necrosis factor-α(3008.6±78.18 pg/g tissue,P<0.001),prostaglandin E2(117.1 ±4.31 pg/g tissue,P=0.002),and caspase-3 activity (2.4±0.14 OD/mg protein,P=0.002).Conversely,CMS mitigated interleukin-10(627.9±12.82 pg/g tissue,P= 0.001).Furthermore,in animals exposed to CMS,octreotide restored plasma corticosterone(61%and 71%from CMS,P=0.002)at both dose levels.These beneficial effects were associated with a remarkable suppression of gastric lesions(38%and 9%from CMS,P=0.01)and reversal of derangements in gastric mucosa. CONCLUSION:The current investigation provides evidence that exposure to CMS induces gastric ulceration, which was alleviated by administration of octreotide possibly possessing antioxidant,anti-inflammatory,and anti-apoptotic actions. | Noha N Nassar Mona F Schaalan Hala F Zaki Dalaal M Abdallah | 2011 | World Journal of Gastroenterology2011，17，9： | 6 |
| 9 | 老年人尿路感染大肠埃希菌遗传谱系分型及其耐药性研究显示文摘的 研究老年人尿路感染大肠埃希菌遗传谱系分型与4种常用抗生素耐药性间的关系. 方法 收集天津市3所综合性医院133株老年尿路感染的大肠埃希菌临床分离院内感染株,菌株的药敏试验采用Kirby-Bauer(K-B纸片扩散法);用煮沸法提取菌株DNA;采用两步三重聚合酶链式反应(PCR)技术对菌株进行遗传谱系分型. 结果 133株老年人尿路感染的大肠埃希菌,对抗生素耐药率最高的是左氧氟沙星占54.1%(72株),最低的是哌拉西林和(或)他唑巴坦占15.0%(20株),差异有统计学意义(Z=51.57,P<0.01);遗传谱系分型中A型、B1型、B2型、D型的检出率分别为33株(24.8%)、20株(15.0%)、24株(18.0%)和56株(42.1%),D型与其他类型比较,差异有统计学意义(Z=31.23,P<0.01).遗传谱系B2型菌株多见于左氧氟沙星敏感株,耐药株、敏感株分别为29.5%(18/61)、8.3%(6/72),差异有统计学意义(x2=10.01,P<0.01),D型菌株多见于左氧氟沙星耐药株,分别为31.1% (19/61)与51.4%(37/72),差异有统计学意义(x2=5.55,P<0.05);未发现大肠埃希菌4个基因型与其他3种抗生素耐药性有关(均P>0.05). 结论 遗传谱系分型中D型检出率最高,与左氧氟沙星耐药相关,通过遗传谱系分型可初步判断老年人尿路感染的大肠埃希菌的耐药性. | 马全玲 Kamalsaid Abdallah 魏爱琳 魏殿军 | 2013 | 中华老年医学杂志2013，32，5： | 5 |
| 10 | Cytokine and apoptosis gene polymorphisms influence the outcome of hepatitis C virus infection显示文摘BACKGROUND:Hepatitis C virus (HCV) infection is thought to be chronic and the factors leading to viral clearance or persistence are poorly understood.This study was undertaken to investigate the possibility of a significant relationship between the spontaneous clearance or the persistence of hepatitis C virus (HCV) infection and cytokine and apoptosis gene polymorphisms in Tunisian patients on hemodialysis.METHODS:Polymorphisms of the genes IL-1 (-889 IL-1α,-511 and +3954 IL-1β,IL-1Ra),IL-18 (-137 and-607),IL-12 (-1188) and Apo1/Fas (-670) were determined by PCR-RFLP,PCR-SSP and PCR-VNTR in 100 healthy blood donors and 100 patients infected with HCV and undergoing hemodialysis.The patients were classified into two groups:G1 consisted of 76 active chronic hepatitis patients (positive for HCV RNA) and G2 consisted of 24 hemodialysed patients who spontaneously eliminated the virus (negative for HCV RNA).RESULTS:The frequency of genotype association [-137GC/-607CA] IL-18 was higher in G2 (41.7%) than in G1 (15.8%) (P=0.008;OR=0.26;95% CI,0.10-0.73).We also found a higher frequency of the AA genotype of the Apo1/Fas gene in G2 (41.6%) than in G1 (17.5%) (P=0.026;OR=3.49;95% CI,1.13-10.69).Adjustment for known covariate factors (age,gender and genotype) confirmed these univariate findings and revealed that the genotype association GC-CA of the (-137 and-607) IL-18 gene and the AA genotype of the Apo1/Fas gene were associated with the clearance of HCV (P=0.041 and 0.017,respectively).CONCLUSION:The two genotypes GC-CA of the (-137 and-607) IL-18 polymorphism and the AA genotype of the Apo1/Fas gene influence the outcome of HCV infection in Tunisian patients on hemodialysis. | Leila Ksiaa Cheikhrouhou Imen Sfar Hajer Aounallah-Skhiri Houda Aouadi Salwa Jendoubi-Ayed Taieb Ben Abdallah Khaled Ayed Yousr Lakhoua-Gorgi | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 4 |
| 11 | DECAY ESTIMATES FOR ISENTROPIC COMPRESSIBLE MAGNETOHYDRODYNAMIC EQUATIONS IN BOUNDED DOMAIN显示文摘In this paper,under the hypothesis that is upper bounded,we construct a Lyapunov functional for the multidimensional isentropic compressible magnetohydrodynamic equations and show that the weak solutions decay exponentially to the equilibrium state in L2 norm.Our result verifies that the method of Daoyuan Fang,Ruizhao Zi and Ting Zhang [1] can be adapted to magnetohydrodynamic equations. | Mohamed Ahmed Abdallah 江飞 谭忠 | 2012 | Acta Mathematica Scientia2012，32，6： | 4 |
| 12 | Preparation of PVC/PVP composite polymer membranes via phase inversion process for water treatment purposes显示文摘In this work, new composite membranes were successfully prepared via phase inversion technique using polyvinyl chloride(PVC) and polyvinylpyrrolidone(PVP) as polymers and tetrahydrofuran(THF) and N-methyl-2-pyrrolidone(NMP) as solvents. The prepared membranes have been characterized by scanning electron microscope(SEM), and fourier transforms infrared spectroscopy(FTIR). The scanning electron microscope results prove that the prepared membranes are smooth and their pores are distributed throughout the whole surface and bulk body of the membrane without any visible cracks. The stress–strain mechanical test showed an excellent mechanical behavior enhanced by the presence of PVP in the prepared membranes. The membranes performance results showed that the salt rejection reached 98% with a high flux. This, in turn, makes the prepared membranes can be applied for sea and brackish water treatment through membrane distillation technology. | Ahmed Bhran Abeer Shoaib Doaa Elsadeq Ayman El-gendi Heba Abdallah | 2018 | Chinese Journal of Chemical Engineering2018，26，4： | 4 |
| 13 | A randomized open-label trial of on-demand rabeprazole vs ranitidine for patients with non-erosive reflux disease显示文摘AIM:To compare the efficacy of the proton-pump inhibitor,rabeprazole,with that of the H 2-receptor antagonist,ranitidine,as on-demand therapy for relieving symptoms associated with non-erosive reflux disease(NERD).METHODS:This is a single center,prospective,randomized,open-label trial of on-demand therapy with rabeprazole(group A) vs ranitidine(group B) for 4 wk.Eighty-three patients who presented to the American University of Beirut Medical Center with persistent gastroesophageal reflux disease(GERD) symptoms and a normal upper gastrointestinal endoscopy were eligible for the study.Patients in group A(n = 44) were allowed a maximum rabeprazole dose of 20 mg twice daily,while those in group B(n = 39) were allowed a maximum ranitidine dose of 300 mg twice daily.Efficacy was assessed by patient evaluation of global symptom relief,scores of the SF-36 quality of life(QoL) questionnaires,total number of pills used,and number of medication-free days.RESULTS:Among the 83 patients who were enrolled in the study,76 patients(40 in the rabeprazole group and 36 in the ranitidine group) completed the 4-wk trial.Baseline characteristics were comparable between both groups.After 4 wk,there was no significant difference in the subjective global symptom relief between the rabeprazole and the ranitidine groups(71.4% vs 65.4%,respectively;P = 0.9).There were no statistically significant differences between mean cumulative scores of the SF-36 QoL questionnaire for the two study groups(rabeprazole 22.40 ± 27.53 vs ranitidine 17.28 ± 37.06;P = 0.582).There was no significant difference in the mean number of pills used(rabeprazole 35.70 ± 29.75 vs ranitidine 32.86 ± 26.98;P = 0.66).There was also no statistically significant difference in the mean number of medication-free days between both groups.CONCLUSION:Rabeprazole has a comparable efficacy compared to ranitidine when given on-demand for the treatment of NERD.Both medications were associated with improved quality of life. | Abdallah A Kobeissy Jana G Hashash Faek R Jamali Assaad M Skoury Reham Haddad Sarah El-Samad Rami Ladki Rola Aswad Assaad M Soweid | 2012 | World Journal of Gastroenterology2012，18，19： | 4 |
| 14 | Pancreatic Anastomotic Leakage after Pancreaticoduodenectomy. Risk factors, Clinical predictors, and Management (Single Center Experience)显示文摘 | Ayman El Nakeeb Tarek Salah Ahmad Sultan Mohamed El Hemaly Waleed Askr Helmy Ezzat Emad Hamdy Ehab Atef Ehab El Hanafy Ahmed El-Geidie Mohamed Abdel Wahab Talaat Abdallah | 2013 | World Journal of Surgery2013，，6： | 4 |
| 15 | Occurrence,seasonal variation and human exposure to pharmaceuticals and personal care products in surface water,groundwater and drinking water in Lagos State,Nigeria显示文摘The occurrence of 28 pharmaceuticals and personal care products(PPCPs)was investigated in 17 surface water samples(rivers,canals,and lagoons),12 groundwater samples(wells and boreholes,which can also be consumed for drinking)and 8 drinking water samples(bottles and sachets)during dry and rainy seasons in Lagos state,Nigeria.The most prevalent compound detected in all samples was amoxicillin(an antibiotic)at median concentrations of 1614,238 and 358 ng/L in surface water,ground water and drinking water,respectively.This is of concern due to potential impact on development of antibioticresistant microbial strains.Other frequently-detected compounds include acetaminophen,nicotine,ibuprofen,and codeine with detection frequencies of more than 70%.Investigation of seasonal variability revealed that glyburide,caffeine,naproxen and diclofenac concentrations were significantly(P<0.05)higher during the dry season(winter),while Nicotine and Codeine levels were higher during the rainy season(summer).The factors influencing such seasonal variability include:dilution by extensive rainfall,agricultural activity(for nicotine)and usage patterns of pharmaceuticals among the local community.Measured concentrations in drinking water samples were used to assess inadvertent human exposure to PPCPs in Nigerian adults.Results revealed average daily exposures of 81,14 and 3 ngƩPPCPs/kg BW/day via drinking borehole,sachet water and bottled water,respectively.While there exists no health-based limit value(HBLV)for chronic exposure to mixtures of PPCPs,our results raise concern and warrant further investigation of the potential health implications of such unintended PPCPs exposure. | Anekwe Jennifer Ebele Temilola Oluseyi Daniel S.Drage Stuart Harrad Mohamed Abou-Elwafa Abdallah | 2020 | Emerging Contaminants2020，6，1： | 4 |
| 16 | 老年性泌尿系统感染的大肠埃希菌毒力因子检测及其与耐药性的关系显示文摘目的了解引起老年患者泌尿系统感染大肠埃希菌的30种毒力因子与4种常用抗菌药物(左氧氟沙星、庆大霉素、头孢吡肟和哌拉西林/他唑巴坦)耐药性之间的关系。方法收集2009年至2011年天津市三家综合性医院泌尿系统院内感染老年患者尿液标本分离的133株大肠埃希菌,采用K—B纸片扩散法检测菌株的药物敏感性,以多重PCR检测133株大肠埃希菌中的30种毒力因子。应用R×C表资料的双侧x2检验对药物敏感结果进行分析,Logistic回归分析毒力因子与抗菌药物耐药性之间的相关性。结果分离的133株大肠埃希菌对左氧氟沙星耐药率最高,为72株,占54.1%,最低的为哌拉西林/他唑巴坦20株,占15.0%(x2=51.57,P〈0.01)。引起老年性泌尿系统感染大肠埃希菌中,毒力因子fimH检出率最高,为79.7%。30种毒力因子与4种常用抗菌药物之间,papC、sfaS、pagGalleleⅡ、papA、papEF、sfa/focDE、hlyA、rfc、cnfl等毒力因子在左氧氟沙星敏感组中多见(P值分别一0.004、0.029、0.001、0.031、0.007、0.001、0.006、0.010和0.013);iutA,kpsMTⅢ和cva等毒力因子在庆大霉素耐药组中多见(P值分别-0.003、0.010和0.000);sfa/focDE和K1等毒力因子在庆大霉素敏感组中多见(P值分别-0.007和0.050),kpsMTⅢ在头孢吡肟耐药组中多见(P=0.024),cnfl在头孢吡肟敏感组中更多见(P=0.014);traT在哌拉西林/他唑巴坦耐药组中多见(P=0.026),kpsMTⅡ在哌拉西林/他唑巴坦敏感组中多见(P=0.024)。结论引起老年性泌尿系统感染的大肠埃希菌同时携带多种毒力因子,大肠埃希菌耐药性与其所携带的毒力因子有关,应引起临床重视。 | 马全玲 Kamai Said Abdallah 魏殿军 | 2013 | 中华传染病杂志2013，31，4： | 3 |
| 17 | Impact of cirrhosis on surgical outcome after pancreaticoduodenectomy显示文摘AIM:To elucidate surgical outcomes of pancreaticoduodenectomy(PD)in patients with liver cirrhosis.METHODS:We studied retrospectively all patients who underwent PD in our centre between January 2002and December 2011.Group A comprised patients with cirrhotic livers,and Group B comprised patients with non-cirrhotic livers.The cirrhotic patients had ChildPugh classes A and B(patient’s score less than 8).Preoperative demographic data,intra-operative data and postoperative details were collected.The primary outcome measure was hospital mortality rate.Secondary outcomes analysed included duration of the operation,postoperative hospital stay,postoperative morbidity and survival rate.RESULTS:Only 67/442 patients(15.2%)had cirrhotic livers.Intraoperative blood loss and blood transfusion were significantly higher in group A(P=0.0001).The mean surgical time in group A was significantly longer than that in group B(P=0.0001).Wound complications(P=0.02),internal haemorrhage(P=0.05),pancreatic fistula(P=0.02)and hospital mortality(P=0.0001)were significantly higher in the cirrhotic patients.Postoperative stay was significantly longer in group A(P=0.03).The median survival was 19 mo in group A and 24 mo in group B.Portal hypertension(PHT)was present in 16/67 cases of cirrhosis(23.9%).The intraoperative blood loss and blood transfusion were significantly higher in patients with PHT(P=0.001).Postoperative morbidity(0.07)and hospital mortality(P=0.007)were higher in cirrhotic patients with PHT.CONCLUSION:Patients with periampullary tumours and well-compensated chronic liver disease should be routinely considered for PD at high volume centres with available expertise to manage liver cirrhosis.PD is associated with an increased risk of postoperative morbidity in patients with liver cirrhosis;therefore,it is only recommended in patients with Child A cirrhosis without portal hypertension. | Ayman El Nakeeb Ahmad M Sultan Tarek Salah Mohamed El Hemaly Emad Hamdy Ali Salem Ahmed Moneer Rami Said Ahmed AbuEleneen Mostafa Abu Zeid Talaat Abdallah Mohamed Abdel Wahab | 2013 | World Journal of Gastroenterology2013，19，41： | 3 |
| 18 | Endothelial cell-derived GABA signaling modulates neuronal migration and postnatal behavior显示文摘服的外皮为集成是必要的并且为大多数行为被要求的信息处理。当神经原从室的地区连续地移居联合进特定的外皮的层时,服的外皮的精致地精确的 laminar 组织在胚胎的开发期间产生。当时指南为设计神经原移植责骂的光线的神经胶质行为, pre-formed 脉管的网络为 GABAergic interneuron 移植提供支持和指导暗示。这研究提供新奇概念、机械学的卓见进 vascular-neuronal 相互作用的这个范例,揭示伽马氨基丁酸并且它经由胚胎的前脑 endothelial 房间的调停受体的发信号的新机制。与二个新 endothelial 房间的使用,特定的有条件的老鼠 GABA 小径当模特儿(Gabrb3 Tie2-Cre 和 Vgat 我们显示出的 Tie2-Cre ), 从 endothelial 房间的伽马氨基丁酸版本的那部分或完全的损失在 embryogenesis 期间导致脉管的缺点并且损害长途的移植并且外皮的 interneurons 放。使不安的 endothelial 的下游的效果导出房间的伽马氨基丁酸发信号是批评的,导致上次修改到外皮的电路和坚持的行为的赤字。而且,我们说明在支持他们血大脑障碍性质的迁居, angiogenesis 和获得的前脑 endothelial 房间发信号的伽马氨基丁酸的激活的新机制。我们的调查结果揭开并且阐明在从表明小径的古典 neuronal 伽马氨基丁酸是不同的并且在 neuropsychiatric 疾病的病原学和 pathophysiology 上打开新灯的 CNS 表明小径的新奇 endothelial 伽马氨基丁酸例如孤独性光谱混乱,癫痫,焦虑,消沉和精神分裂症。 | Suyan Li Peeyush Kumar Sampada Joshee Timo Kirschstein Sivan Subburaju Jahan S Khalili Jonas Kloepper Chuang Du Abdallah Elkhal Gabor Szabo Rakesh K Jain Rudiger Kohling Anju Vasudevan | 2018 | Cell Research2018，28，2： | 3 |
| 19 | Self-compatibility in peach[Prunus persica(L.)Batsch]:patterns of diversity surrounding the S-locus and analysis of SFB alleles显示文摘Self-incompatibility(SI)to self-compatibility(SC)transition is one of the most frequent and prevalent evolutionary shifts in flowering plants.Prunus L.(Rosaceae)is a genus of over 200 species most of which exhibit a Gametophytic SI system.Peach[Prunus persica(L.)Batsch;2n=16]is one of the few exceptions in the genus known to be a fully selfcompatible species.However,the evolutionary process of the complete and irreversible loss of SI in peach is not well understood and,in order to fill that gap,in this study 24 peach accessions were analyzed.Pollen tube growth was controlled in self-pollinated flowers to verify their self-compatible phenotypes.The linkage disequilibrium association between alleles at the S-locus and linked markers at the end of the sixth linkage group was not significant(P>0.05),except with the closest markers suggesting the absence of a signature of negative frequency dependent selection at the S-locus.Analysis of SFB1 and SFB2 protein sequences allowed identifying the absence of some variable and hypervariable domains and the presence of additionalα-helices at the C-termini.Molecular and evolutionary analysis of SFB nucleotide sequences showed a signature of purifying selection in SFB2,while the SFB1 seemed to evolve neutrally.Thus,our results show that the SFB2 allele diversified after P.persica and P.dulcis(almond)divergence,a period which is characterized by an important bottleneck,while SFB1 diversified at a transition time between the bottleneck and population expansion. | Donia Abdallah Ghada Baraket Veronica Perez Amel Salhi Hannachi Jose I.Hormaza | 2020 | Horticulture Research2020，7，1： | 3 |
| 20 | 伦理学与SARS:多伦多的教训显示文摘SARS的流行说明传染病在世界范围内流行是件多么容易的事,为了更好地应对下一次流行病,我们不仅要解决医学方面的问题,也同样需要解决伦理学方面的问题。 | Peter A Singer Solomon R Benatar Mark Bernstein Abdallah S Daar Bernard M Dickens Susan K MacRae Ross E G Upshur Linda Wright Randi Zlotnik Shaul 肖月 | 2004 | 英国医学杂志中文版2004，7，4： | 3 |
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