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| 1 | Ultraviolet radiation-induced non-melanoma skin cancer:Regulation of DNA damage repair and inflammation显示文摘Exposure to ultraviolet(UV)radiation is associated with approximately 65%of melanoma cases,and 90%of non-melanoma skin cancers(NMSC),including basal cell carcinoma(BCC)and squamous cell carcinoma(SCC).While the incidence of most other malignancies has either stabilized or declined,that of NMSC has increased and is developing even in younger age groups.NMSCs account for nearly 15,000 deaths,3.5 million new cases,and more than 3 billion dollars a year in medical costs in the United States alone,representing a major public health concern.As sun protection efforts have not been proven effective,targeted chemoprevention strategies are much needed.Skin carcinogenesis by DNA damage is considered a predominant paradigm for UV toxicity.Exposure to UV radiation can activate various oncogenes while inactivating tumor suppressor genes,resulting in inappropriate survival and proliferation of keratinocytes that harbor these damages.Moreover,increasing evidence demonstrate that inflammatory responses by the immune cells within the tumor microenvironment also contribute significantly to skin tumorigenesis.Initiation and progression of skin carcinogenesis mediated by UV radiation involve complex pathways,including those of apoptosis,proliferation,autophagy,DNA repair,checkpoint signaling,metabolism,and inflammation.In this review,we highlight the recent advances in two of these key molecular processes that result in UV-mediated skin carcinogenesis.In particular,we discuss 1)pathways that regulate DNA damage repair and 2)the regulation of the inflammatory process its crosstalk with DNA repair potentially leading to non-melanoma skin carcinogenesis. | InYoung Kim Yu-Ying He | 2014 | Genes & Diseases2014，1，2： | 8 |
| 2 | Tonicity response element binding protein associated with neuronal cell death in the experimental diabetic retinopathy显示文摘AIM: To study the contribution of tonicity response element binding protein(Ton EBP) in retinal ganglion cell(RGC) death of diabetic retinopathy(DR).METHODS: Diabetes was induced in C57BL/6 mice by five consecutive intraperitoneal injections of 55 mg/kg streptozotocin(STZ). Control mice received vehicle(phosphate-buffered saline). All mice were killed 2mo after injections, and the extent of cell death and the protein expression levels of Ton EBP and aldose reductase(AR) were examined.RESULTS: The Ton EBP and AR protein levels and the death of RGC were significantly increased in the retinas of diabetic mice compared with controls 2mo after the induction of diabetes. Terminal deoxynucleotidyl transferase(Td T)-mediated d UTP nick end labeling(TUNEL)-positive signals co-localized with Ton EBP immunoreactive RGC. These changes were increased in the diabetic retinas compared with controls.CONCLUSION: The present data show that AR and Ton EBP are upregulated in the DR and Ton EBP may contribute to apoptosis of RGC in the DR. | Seong-Jae Kim Hwajin Kim Jeongsook Park Inyoung Chung Hyug-Moo Kwon Wan-Sung Choi Ji-Myong Yoo | 2014 | International Journal of Ophthalmology(English edition)2014，7，6： | 5 |
| 3 | Photoinduced difunctionalization with bifunctional reagents containing N-heteroaryl moieties显示文摘Bifunctional reagents that serve as dual coupling partners with an activating species have emerged as valuable synthetic tools in organic chemistry.They allow for the development of diverse reaction modes with enhanced efficiency and structural variability,which is in high demand for atom-economic and sustainable synthesis.Among them,bifunctional reagents containing Nheteroaryl groups have received much attention due to their ability to introduce privileged N-heteroaryl moieties into complex molecules that are otherwise challenging to access.Furthermore,these reagents have been employed under visible-light conditions to achieve various synthetic applications,enabling difunctionalization of alkenes,alkynes,and[1.1.1]propellanes under mild reaction conditions,providing access to highly functionalized N-heteroarenes.In this review,we provide an overview of the recent achievements and applications of photoinduced difunctionalization using bifunctional reagents containing N-heteroaryl groups.We systematically categorize the representative contributions in the field based on bifunctional reagents and their reactivity patterns.This review aims to highlight the potential of these reagents as powerful synthetic tools for sustainable and diverse synthesis. | Wooseok Lee Inyoung Park Sungwoo Hong | 2023 | Science China Chemistry2023，66，6： | 2 |
| 4 | RNA-stimulated ATPase and RNA helicase activities and RNA binding domain of hepatitis G virus nonstucture protein 3显示文摘 | Yousang G Hyouna Y Inyoung S | 1999 | J Virol1999，73，： | 1 |
| 5 | Sustained decrease in blood pressure following missed doses of aliskiren or telmisartan: the ASSERTIVE double-blind, randomized study显示文摘 | Rainer Düsing Patrick Brunel InYoung Baek Fabio Baschiera | 2012 | Journal of Hypertension2012，，5： | 1 |
| 6 | Percutaneous radiofrequency ablation of hepatocellular carcinoma abutting the diaphragm and gastrointestinal tracts with the use of artificial ascites: safety and technical efficacy in 143 patients显示文摘 | Inyoung Song Hyunchul Rhim Hyo K. Lim Young-sun Kim Dongil Choi | 2009 | European Radiology2009，，11： | 1 |
| 7 | Anal ysis of TiO2 thickness effect on characteristic of a dye-sensi tized solar cell by using electrochemical impedance spectros copy显示文摘 | Inyoung Shin Hyunwoong Seo Min-Kyu Son | 2010 | Curr Appl Phys2010，10，： | 1 |
| 8 | A new charge pump without degradation in threshold voltage due to body effect 显示文摘 | Shin Jongshin Chung Inyoung Young Junepark | 2000 | IEEE Journal of Solid-State Circuits2000，35，8： | 1 |
| 9 | Development of deformation structures in low carbon steel by equal channel angular pressing 显示文摘 | KIM Jongryol KIM Inyoung SHIN Dong hyuk | 2001 | Scripta Mater2001，45，4： | 1 |
| 10 | A study on the enhancement of printing location accuracy in a roll-to-roll gravure offset printing system 显示文摘 | Noh Jae-Ho Kim Inyoung Park Sang Ho | 2013 | International Journal of Advanced Manufacturing Technology2013，68，58： | 1 |
| 11 | A study on the electrical and mechanical properties of printed Ag thin films for flexible device application 显示文摘 | Kim Inyoung Lee Taik-Min Kim Jongryou | 2014 | Journal of Alloys and Compounds2014，596，5： | 1 |
| 12 | RNA-stimulated ATPase and RNA helicase activities and RNA binding domain of hepatitis G virus nonstructural protein 3显示文摘 | Hyouna yoo Inyoung song | 1999 | J Virology1999，73，4： | 1 |
| 13 | Grain refinement mechanism during equal-channel angular pressing of a low-carbon steel显示文摘 | Dong Hyuk Shin Inyoung Kim Jongryoul Kim | 2001 | Acta mater2001，49，： | 1 |
| 14 | Development of deformation structures in low carbon steel by equal channel angularpressing显示文摘 | KIM Jongryol KIM Inyoung SH N Dung hyuk | 2001 | Scrip ta Mater2001，45，4： | 1 |
| 15 | Grain Refinement Mechanical During Equal-Channel Angular Pressing of a Low Carbon Steel显示文摘 | Dong Hyuk Shin Inyoung Kim Jongryoul Kim | 2001 | Acta Materialia2001，49，1： | 1 |
| 16 | Transparent conductive film with printable embedded patterns for organic solar cells显示文摘 | Jong-Su Yu Gwan Ho Jung Jeongdai Jo Jung Su Kim Jun Woo Kim Sun-Woo Kwak Jong-Lam Lee Inyoung Kim Dojin Kim | 2013 | Solar Energy Materials and Solar Cells2013，，： | 1 |
| 17 | Deformation structure of pure Ti produced by equal channel angular pressing 显示文摘 | Kim Inyoung Jeong Won-Sik Kim jongryoul Kyung-T Park Dong Hyuk Shin | 2001 | Scripta Materialia2001，45，： | 1 |
| 18 | Design of W buffer layer for adhesion improvement of DLC films on tool steels显示文摘 | Lee Kwang-Ryeol Eun Kwang Yong Kim Inyoung | 2000 | Thin Solid Films2000，，： | 1 |
| 19 | A new charge pump without degradation in threshold voltage due to body effect显示文摘 | SHIN Jongshin CHUNG Inyoung PARK Y J | 2000 | IEEE J Solid-State Circuits2000，35，12： | 1 |
| 20 | Composition effect on high frequency properties of carbonyl iron compos ites显示文摘 | Inyoung K Seok B Jongryoul K | 2008 | Mater Lett2008，62，： | 1 |
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