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| 1 | Neutrophil depletion-but not prevention of Kupffer cell activation-decreases the severity of cerulein-induced acute pancreatitis显示文摘瞄准:为了决定嗜中性的弄空和 Kupffer 房间抑制是否可能联合,他们的 protective 完成尖锐胰腺炎的严厉到减少。方法:老鼠有 cerulein 管理导致尖锐胰腺炎并且是有任何一个反老鼠 neutrophil 浆液或金轧氯化物(GdCl3 ) 的 pretreated 阻止 Kupffer 房间激活,或两个处理。损害在胰和肺被估计。Myeloperoxidases (军邮局) 估计了嗜中性的渗入。Interleukin-6 (IL-6 ) 和 IL-10 在浆液,胰,肺和肝被测量。结果:在有尖锐胰腺炎的老鼠,嗜中性的弄空减少了胰腺炎和联系胰腺炎的肺损害的严厉。在由 GdCl3 的激活的 Kupffer 房间有更少的保护的效果,尽管 IL-6 和 IL-10 集中显著地被减少。嗜中性的弄空带的普雷茨氏疗法没被 Kupffer 房间在激活提高,两个处理没联合他们的保护的效果。结论:当 Kupffer 房间激活的角色是不太明显的时,我们的结果在在尖锐胰腺炎加重机关损害证实激活的 neutrophils 的角色。 | Catherine M Pastor Alain Vonlaufen Fabianna Georgi Antoine Hadengue Philippe Morel Jean-Louis Frossard | 2006 | World Journal of Gastroenterology2006，12，8： | 22 |
| 2 | Clinical development of reovirus for cancer therapy:An oncolytic virus with immune-mediated antitumor activity显示文摘 | Jun Gong Esha Sachdev Alain C Mita Monica M Mita | 2016 | World Journal of Methodology2016，6，1： | 8 |
| 3 | Helical tomotherapy and volumetric modulated arc therapy:New therapeutic arms in the breast cancer radiotherapy显示文摘AIM To analyse clinical and dosimetric results of helical tomotherapy(HT) and volumetric modulated arc therapy(VMAT) in complex adjuvant breast and nodes irradiation.METHODS Seventy-three patients were included(31 HT and 42 VMAT). Dose were 63.8 Gy(HT) and 63.2 Gy(VMAT) in the tumour bed, 52.2 Gy in the breast, 50.4 Gy in supraclavicular nodes(SCN) and internal mammary chain(IMC) with HT and 52.2 Gy and 49.3 Gy in IMC and SCN with VMAT in 29 fractions. Margins to particle tracking velocimetry were greater in the VMAT cohort(7 mm vs 5 mm).RESULTS For the HT cohort, the coverage of clinical target volumes was as follows: Tumour bed: 99.4% ± 2.4%; breast: 98.4% ± 4.3%; SCN: 99.5% ± 1.2%; IMC:96.5% ± 13.9%. For the VMAT cohort, the coverage was as follows: Tumour bed: 99.7% ± 0.5%, breast: 99.3% ± 0.7%; SCN: 99.6% ± 1.4%; IMC: 99.3% ± 3%. For ipsilateral lung, Dmean and V20 were 13.6 ± 1.2 Gy, 21.1% ± 5%(HT) and 13.6 ± 1.4 Gy, 20.1% ± 3.2%(VMAT). Dmean and V30 of the heart were 7.4 ± 1.4 Gy, 1% ± 1%(HT) and 10.3 ± 4.2 Gy, 2.5% ± 3.9%(VMAT). For controlateral breast Dmean was 3.6 ± 0.2 Gy(HT) and 4.6 ± 0.9 Gy(VMAT). Acute skin toxicity grade 3 was 5% in the two cohorts.CONCLUSION HT and VMAT in complex adjuvant breast irradiation allow a good coverage of target volumes with an acceptable acute tolerance. A longer follow-up is needed to assess the impact of low doses to healthy tissues. | Olivier Lauche Youlia M Kirova Pascal Fenoglietto Emilie Costa Claire Lemanski Celine Bourgier Olivier Riou David Tiberi Francois Campana Alain Fourquet David Azria | 2016 | World Journal of Radiology2016，8，8： | 7 |
| 4 | Standard forward-viewing colonoscopy versus full-spectrum endoscopy: an international, multicentre, randomised, tandem colonoscopy trial显示文摘 | Ian M Gralnek Peter D Siersema Zamir Halpern Ori Segol Alaa Melhem Alain Suissa Erwin Santo Alan Sloyer Jay Fenster Leon M G Moons Vincent K Dik Ralph B D’Agostino Douglas K Rex | 2014 | Lancet Oncology2014，，3： | 6 |
| 5 | Late biliary complications in human alveolar echinococcosis are associated with high mortality显示文摘AIM:To evaluate the incidence of late biliary complications in non-resectable alveolar echinococcosis(AE)under long-term chemotherapy with benzimidazoles.METHODS:Retrospective analysis of AE patients with biliary complications occurring more than three years after the diagnosis of AE.We compared characteristics of patients with and without biliary complications,analyzed potential risk factor for biliary complications and performed survival analyses.RESULTS:Ninety four of 148 patients with AE in Zurich had non-resectable AE requiring long-term benzimidazole chemotherapy,of which 26(28%)patients developed late biliary complications.These patients had a median age of 55.5(35.5-65)years at diagnosis of AE and developed biliary complications after 15(8.25-19)years of chemotherapy.The most common biliary complications during long-term chemotherapy were late-onset cholangitis(n=14),sclerosing cholangitis-like lesions(n=8),hepatolithiasis(n=5),affection of the common bile duct(n=7)and secondary biliary cirrhosis(n=7).Thirteen of the 26 patients had undergone surgery(including 12 resections)before chemotherapy.Previous surgery was a risk factor for late biliary complications in linear regression analysis(P=0.012).CONCLUSION:Late biliary complications can be observed in nearly one third of patients with non-resectable AE,with previous surgery being a potential risk factor.After the occurrence of late biliary complications,the median survival is only 3 years,suggesting that late biliary complications indicate a poor prognostic outcome. | Pascal Frei Benjamin Misselwitz Meher K Prakash Alain M Schoepfer Bettina M Prinz Vavricka Beat Müllhaupt Michael Fried Kuno Lehmann Rudolf W Ammann Stephan R Vavricka | 2014 | World Journal of Gastroenterology2014，20，19： | 5 |
| 6 | Dabigatran etixilate and traumatic brain injury: Evolving anticoagulants require evolving care plans显示文摘AIM: To investigate the outcomes of trauma patients with traumatic brain injury(TBI) on Dabigatran Etexilate(DE). METHODS: Following IRB approval, all patients taking DE who were admitted to our level 1 trauma service were enrolled in the study. Injury complexity, length of stay(LOS), intensive care length of stay, operative intervention, therapeutic interventions and outcomes were analyzed retrospectively. RESULTS: Twenty-eight of 4310 admissions were taking DE. Eleven patients were excluded on concurrent antiplatelet therapy. Average age was 77.14 years(64-94 years), and average LOS was 4.7 d(1-35 d). Thirty-two percent were admitted with intracranial hemorrhage. Eighteen percent received factor Ⅶ, and 22% received dialysis in attempts to correct coagulopathy. Mortality was 21%.CONCLUSION: The low incidence, absence of reversal agents, and lack of practice guidelines makes managing patients with TBI taking DE frustrating and provider specific. Local practice guidelines may be helpful in managing such patients. | Sam Pakraftar Daniela Atencio John English Alain Corcos Eric M Altschuler Kurt Stahlfeld | 2014 | World Journal of Clinical Cases2014，2，8： | 3 |
| 7 | Why Is the Climate Forcing of Sulfate Aerosols So Uncertain?显示文摘Sulfate aerosol particles have strong scattering effect on the solar radiation transfer which results in in- creasing the planet albedo and, hence, tend to cool the earth-atmosphere system, Also, aerosols can act as the cloud condensation nuclei (CCN) which tend to increase the albedo of clouds and cool the global warm- ing. The ARPEGE-Climat version 3 AGCM with FMR radiation scheme is used to estimate the direct and indirect radiative forcing of sulfate aerosols. For minimizing the uncertainties in assessing this kind of cool- ing effect, all kinds of factors are analyzed which have been mixed in the assessment process and may lead to the different results of the radiative forcing of aerosols, It is noticed that one of the uncertainties to assess the climate forcing of aerosols by GCM results from the different definition of radiative forcing that was used. In order to clarify this vague idea, the off-line case for considering no feedbacks and on-line case for including all the feedbacks have been used for assessment. The direct forcing of sulfate aerosols in off-line case is -0.57 W/ m2 and -0.38 W / m2 for the clear sky and all sky respectively. The value of on-line case appears to be a little larger than that in off-line case chiefly due to the feedback of clouds. The indirect forc- ing of sulfate aerosols in off line case is -1 .4 W / m2 and -1 .0 W / m2 in on-line case. The radiative forcing of sulfate aerosols has obvious regional characteristics. There is a larger negative radiative forcing over North America, Europe and East Asia. If the direct and indirect forcing are added together, it is enough to offset the positive radiative forcing induced by the greenhouse gases in these regions. | Hu Rongming, Serge Planton, Michel Deque, Pascal Marquet and Alain Braun Centre national de recherches m t orologiques, Meteo-France | 2001 | Advances in Atmospheric Sciences2001，18，6： | 2 |
| 8 | Concurrent use of aromatase inhibitors and hypofractionated radiation therapy显示文摘AIM: To retrospectively assess the acute and long-term toxicity using aromatase inhibitors (AI) therapy concurrently with hypofractionated radiotherapy (HFRT) in breast cancer patients. METHODS: From November 1999 to October 2007, 66 patients were treated with breast HFRT and concurrent AI. In 63 patients (95.5%), HFRT delivered a total dose of 32.5 Gy to the whole breast within 5 wk (five fractions, one fraction per week). Other fractionations were chosen in three patients for the patients' personal convenience. A subsequent boost to the tumor bed was delivered in 35 patients (53.0%). Acute toxicities were scored according to the Common Toxicity Criteria for Adverse Events v3. Late toxicity was defined as any toxicity occurring more than 6 mo after completion of HFRT and was scored according to the Late Effects Normal Tissue Task Force-Subjective, Objective, Management and Analytic scale. RESULTS: At the end of the HFRT course, 19 patients (28.8%) had no irradiation-related toxicity. Acute grade 1-2 epithelitis was observed in 46 patients (69.7%). One grade 3 toxicity (1.5%) was observed. With a median follow-up of 34 mo (range: 12-94 mo), 31 patients (47%) had no toxicity, and 35 patients (53%) presented with grade 1-2 fibrosis. No grade 3 or greater delayed toxicity was observed. CONCLUSION: We found that AI was well tolerated when given concurrently with HFRT. All toxicities were mild to moderate, and no treatment disruption was necessary. Further prospective assessment is warranted. | Cyrus Chargari Pablo Castro-Pena Ivan Toledano Marc A Bollet Alexia Savignoni Paul Cottu Fatima Laki Franois Campana Patricia De Cremoux Alain Fourquet Youlia M Kirova | 2012 | World Journal of Radiology2012，4，7： | 2 |
| 9 | Job Strain and Masked Hypertension显示文摘 | Xavier T Chantal B Alain M | 2010 | Psychosom Med2010，72，10： | 1 |
| 10 | Coupling of Organic Halides with Carbonyl Compounds Promoteds by SmI2 ,the Kagan Reagent 显示文摘 | ALAIN K ANNE M L | 1999 | Chem Rew1999，99，： | 1 |
| 11 | 显示文摘 | ALAIN M MICHEL B MICHEL A | 1986 | J Chem Edu1986，63，4： | 1 |
| 12 | Hypertension:a novel regulator of adaptive immunity in atherosclerosis显示文摘 | Ziad M | 2004 | Hypertension2004，44，： | 1 |
| 13 | Corporate strategies and environmental regulations:an organizing framework显示文摘 | Rugman Alan M Verbeke Alain | 1998 | Strategic Management Journal1998，19，4： | 1 |
| 14 | Partitioning of ethoxylated alkylphenol surfactants in microemulsion-oil-water Systems显示文摘 | Nelson M Raquel A Alain G | 1995 | Colloids and Surfaces A: Physicochemical and Engineering Aspects1995，100，25： | 1 |
| 15 | Spinal Metastases:indications for and resuits of percutaneous injection of acrylic surgical cement显示文摘 | Alain W M Jacques C Jean M S | 1996 | Radiology1996，199，3： | 1 |
| 16 | Rehabilitation for high frequency sensorineural hearing impairment in adults with the symphonix vibrant soundbridge: a comparative study显示文摘 | Alain U Michel M Paul H | 2003 | O tology & Neurotology2003，24，： | 1 |
| 17 | Amphotericin B inhibits the generation of the serapie isoform of the prion protein in infected cultures显示文摘 | Alain M Noriyuki N Ollivier M | 2000 | J Virol2000，，： | 1 |
| 18 | Low cycle behaveiour in vacuum of a 316 L type austenitic stainless steel between 20 and 600℃-Part Ⅱ: Dislocation structure evolution and correlation with cyclic behaveiour显示文摘 | Gerland M Alain R AitSaadi B | 1997 | Material Science and Engineering1997，，229： | 1 |
| 19 | How to illustrate ligand - protein binding in a class experiment:An elementary fluorescent assay 显示文摘 | Alain M Michel B Michel A | 1986 | J Chem Edu1986，63，4： | 1 |
| 20 | On the nonlinear deformations of thin unsymmetric 0/90 composite plates under hygrothermal loads 显示文摘 | Marco G Jerome M Frederic J Alain V | 2006 | Composites Part A2006，37，4： | 1 |
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