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| 1 | Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner显示文摘遇到 hypoxic 应力的房间由 downregulating 保存资源和精力蛋白质合成。这里我们 demonstratethat 在这回答的一机制是最高的 mRNAs 的翻译压抑编码 translationalapparatus 的部件。规定的这个模式包含 TSC 和 Rheb,当 Rheb 的 TSC1 或 TSC2 或 overexpression 的大美人在剥夺氧的房间救了最高的 mRNA 翻译。导致压力的翻译 repressionof 这些 mRNAs 密切与 4E-BP 的 hypophosphorylated 状态相关,一个翻译抑压者。然而, seriesof 4E-BP loss-of-function 和 gain-of-function 实验在氧或生长因素剥夺下面反驳在 phosphorylation statusof 4E-BP 和最高的 mRNAs 的翻译压抑之间的一种 cause-and-effect 关系。而且,血缺氧的 repressiveeffect 类似于由 Torin 1,而是更多 pronouncedthan 猛禽或 rictor 大美人由 mTOR 活动的有效抑制到达了那。同样,猛禽或 rictor 的缺乏它温和地 downregulated TOPmRNAs 的基础翻译效率,没能压制最高的 mRNAs 的调停氧的翻译激活。最后, TIA-1 和 TIAR co 击倒,二 RNA 有约束力的蛋白质以前在氨基的酸饥饿的房间在最高的 mRNAs 的翻译压抑含有, failedto 在另外的压力条件下面减轻最高的 mRNA 翻译。因此,近似翻译管理者 ofTOP mRNAs 的性质留下逃犯。 | Rachel Miloslavski Elad Cohen Adam Avraham Yifat I luz Zvi Hayouka Judith Kasir Rajini Mudhasani Stephen N. Jones Nadine Cybulski Markus A. Ruegg Ola Larsson Valentina Gandin Arjuna Rajakumar Ivan Topisirovic Oded Meyuhas | 2014 | Journal of Molecular Cell Biology2014，8，3： | 3 |
| 2 | Hemolysis of PM_(10) on RBCs in vitro:An indoor air study in a coal-burning lung cancer epidemic area显示文摘Epidemiological studies have suggested that inhalation exposure to indoor ambient air from coal-burning environments is causally associated with respiratory health risks.In order to explore the toxicological mechanisms behind the adverse health effects,the hemolytic activity of PM_(10)(particulate matter with an aerodynamic diameter of 10 um or less)samples collected from homes burning coal in the recognized China'cancer village'Xuanwei were evaluated and matched against their trace elemental contents.The results demonstrated that the hemolytic activity of indoor PM_(10) in coal-burning environments ranged from 4.28%to 5.24%,with a clear positive dose-response relationship.Although low dose samples exhibited a reduced hemolytic activity,PM_(10) could have a toxic effect upon people in a coal-burning indoor environment for extended time periods.The concentrations of analyzed trace elements in PM_(10) samples ranged from 6966 to 12,958 ppm.Among the analyzed elements,Zn,Ti,Ni,Cu,Pb,Ba,Mn,Cr and V were found at higher concentrations and accounted for over 95%of the total elements.The concentrations of total analyzed elements in the PM_(10) samples revealed a significant positive correlation with PM_(10) hemolytic activity.Of the analyzed elements,Zn,Pb and Cs positively correlated with hemolysis,while Li,U and V negatively correlated with the hemolysis of human red blood cells(RBCs).Therefore,the heavy metal elements could be one of the main factors responsible for the hemolytic capacity of indoor PM_(10) in coal-burning environments. | Mengyuan Zhang Longyi Shao Tim Jones Ying Hu Rachel Adams Kelly BéruBé | 2022 | Geoscience Frontiers2022，13，1： | 2 |
| 3 | Varicella zoster virus infection in inflammatory bowel disease显示文摘 | Garret Cullen Rachel P. Baden Adam S. Cheifetz | 2012 | Inflamm Bowel Dis2012，，12： | 2 |
| 4 | Detection of honey bee ( Apis mellifera) viruses with an oligonucleotide microarray显示文摘 | Rachel H. Glover Ian P. Adams Giles Budge Selwyn Wilkins Neil Boonham | 2011 | Journal of Invertebrate Pathology2011，，3： | 1 |
| 5 | Complications of epilepsy surgery in the first 8 years after neurosurgical training显示文摘 | A. Chris Heller Rachelle V. Padilla Adam N. Mamelak | 2009 | Surgical Neurology2009，，6： | 1 |
| 6 | Higher prevalence of thrombophilia in patients with varicose veins and venous ulcers than controls显示文摘 | Katy A.L. Darvall Rachel C. Sam Donald J. Adam Stanley H. Silverman Christopher D. Fegan Andrew W. Bradbury | 2009 | Journal of Vascular Surgery2009，，5： | 1 |
| 7 | Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial显示文摘 | Raj R Makkar Rachel R Smith Ke Cheng Konstantinos Malliaras Louise EJ Thomson Daniel Berman Lawrence SC Czer Linda Marbán Adam Mendizabal Peter V Johnston Stuart D Russell Karl H Schuleri Albert C Lardo Gary Gerstenblith Eduardo Marbán | 2012 | The Lancet2012，，9819： | 1 |
| 8 | Polyethylene Devices:Passive Samplers for Measuring Dissolved Hydrophobic Organic Compounds in Aquatic Environments显示文摘 | RACHEL G ADAMS | 2007 | Environmental Science and Technology2007，41，： | 1 |
| 9 | Type-1 polarized dendritic cells primed for high IL-12 production show enhanced activity as cancer vaccines显示文摘 | Adam S. Giermasz Julie A. Urban Yutaro Nakamura Payal Watchmaker Rachel L. Cumberland William Gooding Pawel Kalinski | 2009 | Cancer Immunology, Immunotherapy2009，，8： | 1 |
| 10 | Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial显示文摘 | Raj R Makkar Rachel R Smith Ke Cheng Konstantinos Malliaras Louise EJ Thomson Daniel Berman Lawrence SC Czer Linda Marbán Adam Mendizabal Peter V Johnston Stuart D Russell Karl H Schuleri Albert C Lardo Gary Gerstenblith Eduardo Marbán | 2012 | 2012 (9819)2012，，9819： | 1 |
| 11 | A phase II study of adoptive immunotherapy using dendritic cells pulsed with tumor lysate in patients with hepatocellular carcinoma显示文摘 | Daniel H. Palmer Rachel S. Midgley Noweeda Mirza Elizabeth E. Torr Forhad Ahmed Jane C. Steele Neil M. Steven David J. Kerr Lawrence S. Young David H. Adams | 2008 | Hepatology2008，，1： | 1 |
| 12 | Long-Term Survival After Pancreatoduodenectomy for Pancreatic Adenocarcinoma: Is Cure Possible?显示文摘 | Thomas Schnelldorfer Adam L. Ware Michael G. Sarr Thomas C. Smyrk Lizhi Zhang Rui Qin Rachel E. Gullerud John H. Donohue David M. Nagorney Michael B. Farnell | 2008 | Annals of Surgery2008，，3： | 1 |
| 13 | Global prevalence of occult hepatitis C virus: A systematic review and meta-analysis显示文摘BACKGROUND Occult hepatitis C infection(OCI)is characterized by the presence of hepatitis C virus(HCV)RNA in the liver,peripheral blood mononuclear cells(PBMC)and/or ultracentrifuged serum in the absence of detectable HCV-RNA in serum.OCI has been described in several categories of populations including hemodialysis patients,patients with a sustained virological response,immunocompromised individuals,patients with abnormal hepatic function,and apparently healthy subjects.AIM To highlight the global prevalence of OCI.METHODS We performed a systematic and comprehensive literature search in the following 4 electronic databases PubMed,EMBASE,Global Index Medicus,and Web of Science up to 6th May 2021 to retrieve relevant studies published in the field.Included studies were unrestricted population categories with known RNA status in serum,PBMC,liver tissue and/or ultracentrifuged serum.Data were extracted independently by each author and the Hoy et al tool was used to assess the quality of the included studies.We used the random-effect meta-analysis model to estimate the proportions of OCI and their 95%confidence intervals(95%CI).The Cochran's Q-test and the I2 test statistics were used to assess heterogeneity between studies.Funnel plot and Egger test were used to examine publication bias.R software version 4.1.0 was used for all analyses.RESULTS The electronic search resulted in 3950 articles.We obtained 102 prevalence data from 85 included studies.The pooled prevalence of seronegative OCI was estimated to be 9.61%(95%CI:6.84-12.73)with substantial heterogeneity[I^(2)=94.7%(95%CI:93.8%-95.4%),P<0.0001].Seropositive OCI prevalence was estimated to be 13.39%(95%CI:7.85-19.99)with substantial heterogeneity[I^(2)=93.0%(90.8%-94.7%)].Higher seronegative OCI prevalence was found in Southern Europe and Northern Africa,and in patients with abnormal liver function,hematological disorders,and kidney diseases.Higher seropositive OCI prevalence was found in Southern Europe,Northern America,and Northern Africa.CONCLUSION In conclusion,in the present study,it appears that the burden of OCI is high and variable across the different regions and population categories.Further studies on OCI are needed to assess the transmissibility,clinical significance,long-term outcome,and need for treatment. | Donatien Serge Mbaga Sebastien Kenmoe Jacky Njiki Bikoï Guy Roussel Takuissu Marie Amougou-Atsama Etienne Atenguena Okobalemba Jean Thierry Ebogo-Belobo Arnol Bowo-Ngandji Martin Gael Oyono Jeannette Nina Magoudjou-Pekam Ginette Irma Kame-Ngasse Alex Durand Nka Alfloditte Flore Feudjio Cromwel Zemnou-Tepap Elie Adamou Velhima Juliette Laure Ndzie Ondigui Rachel Audrey Nayang-Mundo Sabine Aimee Touangnou-Chamda Yrene Kamtchueng Takeu Jean Bosco Taya-Fokou Chris Andre Mbongue Mikangue Raoul Kenfack-Momo Cyprien Kengne-Ndé Carole Stephanie Sake Seraphine Nkie Esemu Richard Njouom Lucy Ndip Sara Honorine Riwom Essama | 2022 | World Journal of Methodology2022，12，3： | 0 |
| 14 | Healthcare staff well-being and use of support services during COVID-19:a UK perspective显示文摘Background The COVID-19 pandemic has drastically increased demands on healthcare workers(HCWs)leaving them vulnerable to acute psychological distress,burnout and post-traumatic stress.In response,supportive services in a central London hospital mobilised mental health support specifically for HCWs.Aims This rapid evaluation assessed HCW psychological welfare during the acute phase of the COVID-19 pandemic and their use of supportive services made available.Methods During the acute phase of COVID-19(April to May 2020)all staff working for the hospital were invited to complete an online survey assessing well-being(self-rated health,moral distress exposure,symptoms of burnout and psychological distress)and use of available supportive services(awareness of,use and perceived helpfulness).Associations among personal characteristics and psychological well-being were explored using correlations and linear regression.Results A total of 1127 staff participated in the rapid evaluation.On average,psychological distress was high(mean(SD):22(7.57))regardless of role,with 84%of this sample scoring above the general population mean(14.5).Nearly half of the sample reported feeling emotionally drained and a profile emerged displaying higher levels of psychological distress and burnout in those who were younger and exposed to morally distressing situations,with this group also exhibiting greater support service use.Greater levels of burnout were associated with increased psychological distress when controlling for personal factors.During this acute phase of the pandemic,majority of staff used at least one service and rated it as helpful.Conclusion HCWs experienced high levels of psychological distress requiring continued support as the COVID-19 pandemic evolved.Although HCWs were aware of supportive services,uptake varied.In order to mitigate the risk of burnout and post-traumatic stress,long-term,effective strategies that facilitate staff accessing support are urgently required. | Anika R Petrella Luke Hughes Lorna A Fern Lisa Monaghan Benjamin Hannon Adam Waters Rachel M Taylor | 2021 | General Psychiatry2021，34，3： | 0 |
| 15 | 公平司法系统需要开放数据访问显示文摘尽管美国法院文件可在网上公开获得,但它们位于难以导航的数据库中,且需要支付昂贵的费用。美国西北大学的研究团队认为,这些障碍对建立公正和平等的司法系统所需的透明度造成了阻碍。如果能够公开并提供所有法院记录,那研究人员便能够系统地研究和评估美国司法系统,为相关政策的制定提供有价值的信息。研究人员正在开发一个由人工智能驱动的名为SCALES-OKN(诉讼事件的系统内容分析开放知识网络)的平台,无论用户的数据和分析技能如何,都可以为用户提供隐藏在联邦法院记录中的信息和见解。 | 本刊讯 Adam R.Pah David L.Schwartz SarathSanga Zachary D.Clopton Peter Dicola Rachel Davis Mersey Charlotte S.Alexander Kristian J.Hammond Luís A.NunesAmara | 2020 | 数据分析与知识发现2020，4，7： | 0 |
| 16 | Potential impacts of UV exposure on lichen communities:a pilot study of Nothofagus dombeyi trunks in southernmost Chile显示文摘High-latitude terrestrial ecosystems face the triple threats of climate warming,increased exposure to UV arising from polar ozone depletion,and deforestation.Lichen communities of southernmost Chile are recognized for their high diversity,which includes nitrogen-fixing cyanolichens.Such lichens are common on forest trees,contribute nitrogen to forests,and are sensitive to exposure following deforestation(widespread in this region).In a pilot study of exposure effects on tree lichens,using nondestructive imaging methods,we compared lichen communities on trunks of isolated vs.forest tree trunks of southern Chilean beech(Nothofagus dombeyi,Nothofagaceae).We chose trees of similar diameter and trunk lean angle in conserved forest and nearby logged meadow on Navarino Island,XII Region Magallanes and Chilean Antarctica,Chile,within the annual southern ozone hole.Ninety-five percent of cyanolichen records,including Nephroma antarcticum,and 66%of records for other foliose lichens were from the forest,whereas pendulous usneoid lichens dominated N.dombeyi bark at the meadow site.Limitation of cyanolichen growth on isolated trees could affect ecosystem function in this poorly studied habitat.Possible factors contributing to strong community differences were increased light intensity,UV radiation,and wind stress,plus limited ability of lichens to colonize isolated trees in the logged meadow.UV radiation was likely an important stressor for some lichen species but not others.We recommend more extensive monitoring to pinpoint causes of differing lichen communities,and we encourage better protection of bark-dwelling lichens in southern hemisphere regions facing multiple threats. | Marie T.Trest Susan Will-Wolf Rachel Keuler Nathaniel Shay Karen Hill Alyssa Studer Andy Muench Zachary Alexander Axel Adams Leah Dittberner Martin Feehan Hannah Lee Nicholas Galleguillos-Katz Joy B.Zedler Linda Graham Patricia Arancibia-Avila | 2015 | Ecosystem Health and Sustainability2015，1，4： | 0 |
| 17 | 当一个品牌长期停止广告支出时,会发生什么?显示文摘当品牌停止广告投放一年或更长时间后,销量通常会同比下降(平均而言,一年后销量下降16%,两年后下降25%);那些在停止广告投放前就已经在下滑品牌之下滑速度更快;品牌规模也是一个重要的影响因素——小品牌通常比大品牌遭受更大的损失:较大的增长势头良好的品牌在广告停止一至两年之后仍可继续增长,而小品牌即使原本增长态势不错也会不可避免地走向下滑通道。 | Adam Gelzinis Rachel Kennedy Virginia Beal Nicole Hartnett Byron Sharp 岳璐(译) | 2022 | 国际品牌观察2022，，3： | 0 |
| 18 | “植物造景”——自然的装饰艺术显示文摘从中国古代瓷器上的植物纹样到英国建筑、家具及织物图案设计师William Morris设计的花卉图案,人们总是喜欢从植物中寻找美学灵感。不管是以植物为原型设计的各种家居小物,还是用来盛装植物的花瓶器皿,有了植物的加入,人们就自然从空间中获得一种朴素与平衡的审美意趣。 | Jungmo Seungyeon Seoul-Bund Jeremy Cole Moebe Paper Collective Norm Architect Carl Kleiner Bloc Studios we+ Juniper Pascale Giradin Adam Cigler&Samuel Cigler Adriano Rachele Slamp weiwe mao Nendo Sèvre 彭佳 | 2017 | 现代装饰2017，0，12： | 0 |
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