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| 1 | Soil Microbiological Activity and Carbon Dynamics in the Current Climate Change Scenarios:A Review显示文摘Microbial activities are affected by a myriad of factors with end points involved in nutrient cycling and carbon sequestration issues.Because of their prominent role in the global carbon balance and their possible role in carbon sequestration, soil microbes are very important organisms in relation to global climate changes. This review focuses mainly on the responses of soil microbes to climate changes and subsequent effects on soil carbon dynamics. An overview table regarding extracellular enzyme activities(EAA) with all relevant literature data summarizes the effects of different ecosystems under various experimental treatments on EAA. Increasing temperature, altered soil moisture regimes, and elevated carbon dioxide significantly affect directly or indirectly soil microbial activities.High temperature regimes can increase the microbial activities which can provide positive feedback to climate change, whereas lower moisture condition in pedosystem can negate the increase, although the interactive effects still remain unanswered. Shifts in soil microbial community in response to climate change have been determined by gene probing, phospholipid fatty acid analysis(PLFA),terminal restriction length polymorphism(TRFLP), and denaturing gradient gel electrophoresis(DGGE), but in a recent investigations,omic technological interventions have enabled determination of the shift in soil microbe community at a taxa level, which can provide very important inputs for modeling C sequestration process. The intricacy and diversity of the soil microbial population and how it responds to climate change are big challenges, but new molecular and stable isotope probing tools are being developed for linking fluctuations in microbial diversity to ecosystem function. | Javid A.SOFI Aabid H.LONE Mumtaz A.GANIE Naseer A.DAR Sajad A.BHAT Malik MUKHTAR Mohd Ashraf DAR Shazia RAMZAN | 2016 | Pedosphere2016，26，5： | 13 |
| 2 | Antibacterial efficacy of the seed extracts of Melia azedarach against some hospital isolated human pathogenic bacterial strains显示文摘Objective:To investigate the antibacterial potential of the polar and non-polar extracts of the seeds of Melia azedarach(M.azedarach) L.(Meliaceae) against eighteen hospital isolated human pathogenic bacterial strains.Methods:Petrol,benzene,ethyl acetate,methanol,and aqueous extracts at five different concentrations(1,2,5,10 and 15 mg/mL) were evaluated.Disk diffusion method was followed to evaluate the antibacterial efficacy.Results:All extracts of the seeds demonstrated significant antibacterial activity against tested pathogens.Among all extracts,ethyl acetate extract revealed the highest inhibition comparatively.The present study also favored the traditional uses reported earlier.Conclusions:Results of this study strongly confirm that the seed extracts of M.azedarach could be effective antibiotics,both in controlling gram-positive and gram-negative human pathogenic infections. | Abdul Viqar Khan Qamar Uddin Ahmed M Ramzan Mir Indu Shukla Athar Ali Khan | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，6： | 11 |
| 3 | Pharmacotherapy for the management of achalasia: Current status, challenges and future directions显示文摘This article reviews currently available pharmacological options available for the treatment of achalasia, with a special focus on the role of botulinum toxin(BT) injection due to its superior therapeutic effect and side effect profile. The discussion on BT includes the role of different BT serotypes, better pharmacological formulations, improved BT injection techniques, the use of sprouting inhibitors, designer recombinant BT formulations and alternative substances used in endoscopic injections. The large body of ongoing research into achalasia and BT may provide a stronger role for BT injection as a form of minimally invasive, cost effective and efficacious form of therapy for patients with achalasia. The article also explores current issues and future research avenues that may prove beneficial in improving the efficacy of pharmacological treatment approaches in patients with achalasia. | Ammar Nassri Zeeshan Ramzan | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，4： | 5 |
| 4 | 从野生与突变株云芝IBL-04提纯锰过氧化物酶及其表征(英文)显示文摘由野生及突变株云芝IBL-04制得细胞外锰过氧化物酶(MnPs),并经过硫酸铵沉淀、透析、离子交换和凝胶渗透层析法等步骤提纯.纯化的酶在十二烷基硫酸钠-聚丙烯酰胺凝胶电泳(SDS-PAGE)上于43 kDa区域呈现单一谱带,它适宜的pH值和温度分别为5.0和40°C.突变株MnPs表现出比野生株MnPs更宽的活性pH值范围和更高的热稳定性.从所选突变株所得纯化的MnPs表现出与野生株MnP几乎相同的电泳性质、稳态动力学、金属离子和EDCs降解效率.该生物酶与Mn^(2+)一起催化的反应速率最快,但最高的亲和性对应于ABTS、甲氧基羟苯基乙二醇、4-氨基苯酚和活性染料.Mn^(2+)和Cu^(2+)可显著提高MnPs的活性,但Zn^(2+),Fe^(2+),EDTA和半胱氨酸则会不同程度地抑制其活性,Hg^(2+)是最强的活性抑制剂.所有来源的MnPs均可有效催化EDCs、壬基苯酚和二氯苯氧氯酚降解,处理3 h可除去80%以上,在MnPs-介质体系中可进一步提高到90%.综上,云芝MnPs生物酶具有较高的pH适用性和热稳定性、独特的Michaelis-Menten动力学参数和高的EDCs去除效率等特点。 | Muhammad Asgher Muhammad Ramzan Muhammad Bilal | 2016 | Chinese Journal of Catalysis2016，37，4： | 4 |
| 5 | Relapse of Inflammatory Bowel Disease Associated With Use of Nonsteroidal Anti-Inflammatory Drugs显示文摘 | Angela M. Meyer Nizar N. Ramzan Russell I. Heigh Jonathan A. Leighton | 2006 | Digestive Diseases and Sciences2006，，： | 3 |
| 6 | Lymphocyte-to-monocyte ratio can predict mortality in pancreatic adenocarcinoma显示文摘AIM To determine if the lymphocyte-to-monocyte ratio(LMR) could be helpful in predicting survival in patients with pancreatic adenocarcinoma.METHODS We retrospectively reviewed the medical records of all patients diagnosed with pancreatic adenocarcinoma in the VA North Texas Healthcare System from January 2005 to December 2010. The LMR was calculated from peripheral blood cell counts obtained at the time of diagnosis of pancreatic cancer by dividing the absolute lymphocyte count by the absolute monocyte count. A Univariable Cox regression analysis was performed using these data, and hazard ratios(HR) and 95%CI were calculated. The median LMR(2.05) was used to dichotomize patients into high-LMR and low-LMR groups and the log rank test was used to compare survivalbetween the two groups.RESULTS We identified 97 patients with pancreatic adenocarcinoma(all men, 66% white, 30% African-American). The mean age and weight at diagnosis were 66.0 ± 0.9(SEM) years and 80.4 ± 1.7 kg respectively. Mean absolute lymphocyte and monocyte values were 1.50 ± 0.07 K/mL and 0.74 ± 0.03 K/mL respectively. Mean, median and range of LMR was 2.36, 2.05 and 0.4-12 respectively. In the univariable Cox regression analysis, we found that an increased LMR was a significant indicator of improved overall survival in patients with pancreatic adenocarcinoma(HR = 0.83; 95%CI: 0.70-0.98; P = 0.027). Kaplan-Meier analysis revealed an overall median survival of 128 d(95%CI: 80-162 d). The median survival of patients in the high-LMR(> 2.05) group was significantly greater than the low-LMR group(≤ 2.05)(194 d vs 93 d; P = 0.03), validating a significant survival advantage in patients with a high LMR.CONCLUSION The LMR at diagnosis is a significant predictor for survival and can provide useful prognostic information in the management of patients with pancreatic adenocarcinoma. | Gurshawn Singh Ammar Nassri David Kim Hong Zhu Zeeshan Ramzan | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，1： | 3 |
| 7 | 层状双氢氧化物(LDHs)的合成及应用(英文)显示文摘Layered double hydroxides, a class of anionic clays possessing sandwich like structure in which negative anions are sandwiched into positively charged metal layers in a repeating manner, have been studied extensively. Layered double hydroxides could be fabricated with combination of different divalent(Cd^(2+), Mn^(2+), Fe^(2+), Pb^(2+)) and trivalent(Al^(3+), Cr^(3+), Fe^(3+)) metals and layered arrangement imparts unique properties such as adsorption properties and catalytic properties in these compounds. Exciting feature of these compounds is the memory effect. There are a number of methods to synthesize these layered compounds, such as co-precipitation, hydrothermal, sol-gel, urea hydrolysis,?etc. The synthesized LDHs can be characterized morphologically and compositionally i.e. scanning electron microscopy, transmission electron microscopy, powder X-Ray diffraction, Mossbauer spectroscopy, thermogravimetric analysis, XPS, etc. The wonderful feature of layered double hydroxides is the pliancy of interlayer space enabling them to accommodate various anionic species, and high surface area making them efficient in numerous applications such as adsorbents, anion exchange, catalysts, and biological compatible. | Saba Jamil Afaaf Rahat Alvi Shanza Rauf Khan Muhammad Ramzan Saeed Ashraf Janjua | 2019 | 化学进展2019，31，2： | 3 |
| 8 | Current controversies and advances in the management of pancreatic adenocarcinoma显示文摘Pancreatic adenocarcinoma is a lethal disease with a mortality rate that has not significantly improved over decades.This is likely due to several challenges unique to pancreatic cancer.Most patients with pancreatic cancer are diagnosed at a late stage of disease due to the lack of specific symptoms prompting an early investigation.A small subset of patients who are diagnosed at an early stage have a better chance at survival with curative surgical resection,but most patients still succumb to the disease in a few years.The dismal overall prognosis is due to suspected micro-metastasis at an early stage.Due to this reason,there is a recent interest in treating all patients with pancreatic cancers with systemic therapy upfront(including the ones that are surgically resectable).This approach is still not the standard of care due to the lack of robust prospective data available.Recent advancements in treatment regimens of chemotherapy,radiation and immunotherapy have improved the overall short-term survival but the long-term survival still remains poor.Novel approaches in diagnosis and treatment have shown promise in clinical studies but long-term clinical data is lacking.The following manuscript presents an overview of the epidemiology,diagnosis,staging,recent advances,novel approaches and controversies in the management of pancreatic adenocarcinoma. | Muhammad Shehroz Zeeshan Zeeshan Ramzan | 2021 | World Journal of Gastrointestinal Oncology2021，13，6： | 2 |
| 9 | 尼龙66/针状硅灰石复合材料的制备和性能研究显示文摘以针状硅灰石为填料,用双螺杆挤出机共混制备尼龙(PA)66/硅灰石复合材料,研究了硅灰石含量、处理方法和加工工艺对复合材料性能的影响,并观察了硅灰石共混前后和PA66/硅灰石复合材料冲击试样断面的形貌。结果表明,硅灰石用KH–560预处理时比用KH–550预处理所制备的PA66/硅灰石复合材料的力学性能好。硅灰石以侧喂料方式加入并采用较低的螺杆转速时,可使复合材料具有较高的力学性能。随着硅灰石含量的增加,复合材料的拉伸强度、弯曲强度和缺口冲击强度都大幅提高。经过1%KH560预处理的硅灰石质量分数在30%时,PA66/硅灰石复合材料的力学性能最好。 | 陆波 王博识 Hafiz Muhammad Ramzan 李鹏 | 2013 | 工程塑料应用2013，41，7： | 2 |
| 10 | On the Exact Solution for Axisymmetric Flow and Heat Transfer over a Nonlinear Radially Stretching Sheet显示文摘We investigate the boundary-layer flow and heat transfer of a magnetohydrodynamic viscous fluid over a nonlinear radially porous stretching sheet within a porous medium.The flow is generated due to a nonlinear stretching sheet and influenced by a continuous suction/blowing of the fluid through the porous sheet.The governing momentum and thermal boundary layer equations are converted into ordinary differential equations by appropriate similarity transformations.The exact solution for the velocity and the temperature fields are derived in the form of an incomplete Gamma function.Also analytic solutions are found by the homotopy analysis method.The graphical results for velocity and temperature fields are presented and discussed.Further,the numerical values of the skin friction coefficient and the Nusselt number are calculated and discussed. | Azeem Shahzad Ramzan Ali Masood Khan | 2012 | Chinese Physics Letters2012，29，8： | 2 |
| 11 | Development and testing of a detailed kinetic mechanism of natural gas combustion in internal combustion engine显示文摘A detailed chemical mechanism to describe the combustion of natural gas in internal combustion (IC) engine has been developed,which is consisting of 233 reversible reactions and 79 species.This mechanism accounts for the oxidation of methane,ethane,propane and nitrogen.It has been tested using IC engine model of CHEMKIN 4.1.1 and experimental measurements.The performance of the proposed mechanism was evaluated at various equivalence ratios (φ=0.6 to φ=1.3),initial reactor conditions (Tini=500 to 3500 ℃;Pini=1.0 to 10 atm) and engine speed (2000-7000 rpm).The proposed kinetic mechanism shows good concordances with GRI3.0 mechanism especially in the prediction of temperature,pressure and major product species (H2O,CO2) profiles at stoichiometric conditions (φ=1.0).The experimental results of measured cylinder pressure,species fractions were also in agreement with simulation results derived from the proposed kinetic mechanism.The proposed mechanism successfully predicts the formation of gaseous pollutants (CO,NO,NO2,NH3) in the engine exhaust.Although there are some discrepancies among each simulation profile,the proposed detailed mechanism is good to represent the combustion of natural gas in IC engine. | M.Mansha A.R.Saleemi Badar M.Ghauri Naveed Ramzan | 2010 | Journal of Natural Gas Chemistry2010，19，2： | 2 |
| 12 | Degenerative diseases, oxidative stress and cytochrome c oxidase func-tion显示文摘 | KADENBACH B RAMZAN R VOGT S | 2009 | Trends Mol Med2009，15，4： | 1 |
| 13 | Molecular Pathways for Cancer Chemoprevention by Dietary Phytochemicals显示文摘 | AaronC. Tan Izabela Konczak DanielM.-Y. Sze Iqbal Ramzan | 2011 | Nutrition and Cancer2011，，4： | 1 |
| 14 | Video streaming over P2P networks : challenges and opportunities 显示文摘 | Ramzan N Park H Izquierdo E | 2012 | Signal Processing : Image Communiation2012，27，5： | 1 |
| 15 | Novel splice (IVS18 q-IGC) mutation in COL2A1 causing Kniest dysplasia显示文摘 | A1-Hashmi N Imtiaz F Ramzan K | 2013 | Clin Dysmorphol2013，22，1： | 1 |
| 16 | Continuous glucose monitoring in gastroparesis显示文摘 | Ramzan Z Duffy F Gomez J | 2011 | Dig Dis Sci2011，56，9： | 1 |
| 17 | New Era: Endoscopic treatment options in obesity–a paradigm shift显示文摘The prevalence of obesity continues to rise,and along with it comes a multitude of health-related consequences.The healthcare community has consistently struggled with providing treatment options to obese patients,in part due to the reluctance of patients in pursuing the more effective(yet invasive)surgical approaches such as sleeve gastrectomy and Rou-en-Y gastric bypass.On the other hand,the less invasive approach such as lifestyle/behavioral interventions and pharmacotherapy(Orlistat,Phenteramine,Phentermine/Topiramate,Locaserin,Naltrexon/Buproprion,and Liraglutide)have very limited efficacy,especially in the morbidly obese patients.Despite our best efforts,the epidemic of obesity continues to rise and pose enormous costs on our healthcare system and society.Bariatric endoscopy is an evolving field generated to combat this epidemic through minimally invasive techniques.These procedures can be performed in an ambulatory setting,are potentially reversible,repeatable,and pose less complications than their invasive surgical counterparts.These modalities are designed to alter gut metabolism by means of space occupation,malabsorption,or restriction.In this review we will discuss different bariatric endoscopic options(such as intragastric balloons,endoscopic sleeve gastroplasty,endoscopic aspiration therapies and gastrointestinal bypass sleeves),their advantages and disadvantages,and suggest a new paradigm where providers may start incorporating this modality in their treatment approach for obese patients. | Jason Glass Ahson Chaudhry Muhammad S Zeeshan Zeeshan Ramzan | 2019 | World Journal of Gastroenterology2019，25，32： | 1 |
| 18 | Impaired micro- somai oxidation of the atypical antipsychotic agent clozapine in hepatic steatosis显示文摘 | Zhang WV Ramzan I Murray M | 2007 | J Pharmacol Exp Ther2007，322，2： | 1 |
| 19 | Degenerative diseases,oxida-tive stress and cytochrome c oxidase function 显示文摘 | Kadenbach B Ramzan R Voqt S | 2009 | Trends Mol Med2009，15，4： | 1 |
| 20 | A Lymphotoxin-Driven Pathway to Hepatocellular Carcinoma显示文摘 | Johannes Haybaeck Nicolas Zeller Monika Julia Wolf Achim Weber Ulrich Wagner Michael Odo Kurrer Juliane Bremer Giandomenica Iezzi Rolf Graf Pierre-Alain Clavien Robert Thimme Hubert Blum Sergei A. Nedospasov Kurt Zatloukal Muhammad Ramzan Sandra Ciesek Th | 2009 | Cancer Cell2009，，4： | 1 |
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