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| 1 | Modulation of tau phosphorylation by environmental copper显示文摘Background:The transition metal copper enhances amyloidβaggregation and neurotoxicity,and in models of concomitant amyloid and tau pathology,copper also promotes tau aggregation.Since it is not clear if the effects of environmental copper upon tau pathology are dependent on the presence of pathological amyloidβ,we tested the effects of copper overload and complexing in disease models which lack pathological amyloidβ.Methods:We used cell culture and transgenic murine models to test the effects of environmental copper on tau phosphorylation.We used oral zinc acetate as a copper lowering agent in mice and examined changes in blood and brain metals through inductively coupled plasma mass spectroscopy.Behavioral effects of copper lowering were assessed with Morris water maze and novel object recognition tasks.Changes in tau phosphorylation were examined by phosphorylation specific antibodies on Western blots.Results:In human neuroblastoma cells,excess copper promoted tau phosphorylation and a copper complexing agent,tetrathiomolybdate,attenuated tau phosphorylation.In a transgenic mouse model expressing wild type human tau,copper-lowering by oral zinc suppressed plasma and brain levels of copper,and resulted in a marked attenuation of tau phosphorylation.No significant changes in behavior were observed with copper lowering,but a trend to improved recognition of the novel object was observed in zinc acetate treated mice.Conclusions:We propose that reduction of brain copper by blocking uptake of copper from the diet may be a viable strategy for modulating tau pathology in Alzheimer’s disease.The potential benefits of this approach are tempered by the absence of a behavioral benefit and by the health risks of excessive lowering of copper. | Kellen Voss Christopher Harris Martina Ralle Megan Duffy Charles Murchison Joseph F Quinn | 2014 | Translational Neurodegeneration2014，3，1： | 3 |
| 2 | Isolation in cell cultures and initial characterization of two novel Bocavirus species from swine in Northern Ireland显示文摘 | McKillen J McNeilly F Duffy C | 2011 | Vet Mierobiol2011，152，12： | 1 |
| 3 | The CD14 C-159T polymorphism is not associated with asthma or asthma severity in an Australian adult population 显示文摘 | Kedda MA Lose F Duffy D | 2005 | Thorax2005，60，3： | 1 |
| 4 | Effects of NatustatTM supplementation on performance, feed efficiency and intestinal lesion scores in broiler chickens challenged with Eimeria acervulina, Eimeria maxima and Eimeria tenella 显示文摘 | Duffy C F Mathis G F Power R F | 2005 | Vet Para2005，130，： | 1 |
| 5 | The immunoreaetive 116 kDa surface protein of Mycoplasma pneumoniae is encoded in an Operon显示文摘 | DUFFY M F WALKER I D BROWNING G F | 1997 | Microbiology1997，143，10： | 1 |
| 6 | Improving surface finish in pulsed laser micro polishing using thermocapillary flow显示文摘 | PFEFFERKORN F E DUFFIE N A LI X | 2013 | CIRP Annals:Manufacturing Technology2013，62，1： | 1 |
| 7 | Growth of Listeria monocytogenes on vacuum-packed cooked meats: effects of pH, a w, nitrite and ascorbate 显示文摘 | Duffy L L Vanderlinde P B Grau F H | 1994 | International Journal of Food Microbiology1994，23，3： | 1 |
| 8 | Intravenous aminophylline in patients admitted to hospital with non-acidotic exacerbations of chronic obstructive pulmonary disease:a prospective randomised controlled trial显示文摘 | Duffy N Walker P Diamantea F | 2005 | Thorax2005，60，9： | 1 |
| 9 | Do Plasma melatonin concentrations decline with age?显示文摘 | Zeiter J M Daniele J E Duffy J F | 1999 | Am J Med1999，107，5： | 1 |
| 10 | Continuous glucose monitoring in gastroparesis显示文摘 | Ramzan Z Duffy F Gomez J | 2011 | Dig Dis Sci2011，56，9： | 1 |
| 11 | Isolation in cell cultures and initial characterization of two novel bocavir- us species from swine in Northern Ireland 显示文摘 | McKillen J McNeilly F Duffy C | 2011 | Vet Mi- croboi12011，152，12： | 1 |
| 12 | Thermal and dynamicmechanical properties ofpolyurethaneureas显示文摘 | Hartman B Duffy J V Lee G F | 1988 | Journal of Applied Polymer Science1988，35，7： | 1 |
| 13 | Lack of genomic evidence of AI-2 receptors suggests a non-quorum sensing role for luxS in most bacteria显示文摘 | Rezzonico F Duffy B | 2008 | BMC Microbiol2008，8，： | 1 |
| 14 | et al , Elasticity, shear strength, and equation of state of molybdenum and gold from x-ray diffraction under nonhydrostatic compression to 24 GPa 显示文摘 | Duffy T S Shen G Y Shu J F | 1999 | J Appl Phys1999，86，12： | 1 |
| 15 | Isolation in cell cultures and initial characterisation of two novel bo- cavirus species from swine in Northern Ireland显示文摘 | McKillen J McNeilly F Duffy C | 2011 | Vet Microbiol2011，152，12： | 1 |
| 16 | An evidence-based project for evaluating strategies to improve knowledge acquisition and critical thinking performance in nursing students显示文摘 | Bonnie F Angel Margery Duffy | 2000 | Journal of Nursing Education2000，39，5： | 1 |
| 17 | Elasticity,shear strength,and equation of state of molybdenum and gold from x-ray diffraction under nonhydrostatic compression to 24 GPa显示文摘 | DUFFY T S SHEN G Y SHU J F | 1999 | J Appl Phys1999，86，： | 1 |
| 18 | Sevoflurane and anesthesia for neurosurgery : a review显示文摘 | DUFFY C M MATTA B F | 2000 | J Neurosurg Anesthesiol2000，12，2： | 1 |
| 19 | The Liverpool Care Pathway: does it improve quality of dying显示文摘 | Duffy A Payne S Timmins F | 2011 | Br J Nurs2011，20，15： | 1 |
| 20 | Hepatocellular carcinoma from an immunologic perspective显示文摘 | Greten TF Duffy AG Korangy F | 2013 | Clin Cancer Res2013，19，24： | 1 |
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