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| 1 | The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming显示文摘新陈代谢对房间功能的每个方面重要,然而,导致的 pluripotent 干细胞(iPSCs ) 的 metabolome 仍然保持大部分未经勘探。这里,我们报导,用一条 untargeted metabolomics 途径,那人的 iPSCs 份额有从他们的父母房间是不同的胚胎的干细胞(转换字符) 的 pluripotent metabolomic 签名,并且那被变化在涉及细胞的呼吸的代谢物描绘。细胞的 bioenergetics 的检查与我们的 metabolomic 分析支持了,并且证明体的房间在 pluripotency 从一个氧化状态变换成一个 glycolytic 状态。有趣地,各种各样的体的房间的 bioenergetics 与他们的 reprogramming 效率相关。我们进一步识别了在 iPSCs 和转换字符之间不同的代谢物,它揭示了在调整体的房间 reprogramming 起一个关键作用的新奇新陈代谢的小径。我们的调查结果是第一全球性分析 iPSCs 的 metabolome,并且提供机械学的卓见进涉及导致 pluripotency,并且在评估 iPSC 和转换字符等价的规定的新层。 | Athanasia D Panopoulos Oscar Yanes Sergio Ruiz Yasuyuki S Kida Dinh Diep Ralf Tautenhahn Aida Herrerias Erika M Batchelder Nongluk Plongthongkum Margaret Lutz W Travis Berggren Kun Zhang Ronald M Evans Gary Siuzdak Juan Carlos Izpisua Belmonte] | 2012 | Cell Research2012，22，1： | 12 |
| 2 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 3 | HydrIS:一个用于地下水管理的开放的GIS决策支持系统——以Morocco为例(英文)显示文摘A regional groundwater management system has been elaborated, integrating Relational Database Management System (RDBMS) and various web services. It consists of web geospatial application so-called HydrIS ( Hydrogeological Information System) based on Open Source components and technologies, leading to a feasible and low-cost solution. Therefore, HydrIS permits delivery of data from a number of heterogeneous sources to standards supported by the Open Geospatial Consortium (OGC). The protocols used for exchanging data are also derived from OGC standards, i.e., WMS (Web Mapping Service), WFS (Web Feature Service), and WCS (Web Coverage Service). Finally, a geoportal was developed, which consists of client-applications that communicate with different Web Services (WMS, WCS, anAd WprFoSto) ttyhpreo ufogrh wHeTbT-Pb-aresqeude GstISs. application was designed using the deegree Framework to provide systematic interfaces and functions. This system was developed to demonstrate the value of making hydrogeological data more widely accessible through client/server architecture. This experience and knowledge already gained in this project will be a source for technology transfer and policy decisions. Otherwise, this will enable user groups to improve the management of their ground-water resources and contribute to enhanced decision support capabilities. | JARAR OULIDI Hassane LWNER Ralf BENAABIDATE Lahcen WCHTER Joachim | 2009 | Geo-Spatial Information Science2009，12，3： | 1 |
| 4 | Curvature-directed crystallization of poly-(vinylidene difluoride) in nanotube walls 显示文摘 | Martin S Stephan S Ralf B W | 2003 | Macromolecules2003，36，： | 1 |
| 5 | Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial显示文摘 | Marcia S Brose Christopher M Nutting Barbara Jarzab Rossella Elisei Salvatore Siena Lars Bastholt Christelle de la Fouchardiere Furio Pacini Ralf Paschke Young Kee Shong Steven I Sherman Johannes W A Smit John Chung Christian Kappeler Carol Pe?a István Mo | 2014 | The Lancet2014，，： | 1 |
| 6 | Sensor= A Tool for the Simulation of Hyperspectral Remote Sensing System 显示文摘 | Anko B Lorenz W Ralf R | 2001 | ISPRS Journal of Photogrammetry and Remote Sensing2001，55，6： | 1 |
| 7 | Human cytomegalovirus prevents replication licensing by inhibiting MCM loading onto chromatin 显示文摘 | Luder W Ralf U Christian H | 2003 | EMBO reports2003，4，1： | 1 |
| 8 | Curvature-directed crystallization of poly(vinylidene difluoride) in nanotube walls 显示文摘 | Martin S Stephan S Ralf B W | 2003 | Macromolecules2003，36，10： | 1 |
| 9 | Blockade of the intermediat-conductance calcium-activated potassium channel as a new therapeutic strategy for restenosis显示文摘 | Ralf K Heike W Ines E | 2003 | Circulation2003，108，9： | 1 |
| 10 | Ruthenium - modified zinc oxide, a highly activevis - photocatalyst: the nature and reactivity of photoactive centres 显示文摘 | Jonathan Z B Ralf D Detlef W B | 2014 | View Article Ordine2014，，16： | 1 |
| 11 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 12 | Flupyradifurone: a brief profile of a new butenolide insecticide显示文摘 | Ralf Nauen Peter Jeschke Robert Velten Michael E Beck Ulrich Ebbinghaus‐Kintscher Wolfgang Thielert Katharina W?lfel Matthias Haas Klaus Kunz Georg Raupach | 2015 | Pest. Manag. Sci2015，，： | 1 |
| 13 | Human cytomegalovirus prevents replication licensing by inhibiting MCM loading onto chromation显示文摘 | Lüder W Ralf U Christian H | 2003 | EMBO Reports2003，4，1： | 1 |
| 14 | Effects of temporary clipping during aneurysm surgery显示文摘 | Chris W Ralf DR Ruth A | 2008 | Neurological Research2008，30，： | 1 |
| 15 | Integrating direct and indirect sales channels under decentralized decision -making显示文摘 | Ralf W Seifert Ulrich W Thonemann and Marcel A Sieke | 2006 | International Journal of Production Economics2006，103，： | 1 |
| 16 | Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland显示文摘 | GANG L GERTRAUD W R RALF L | 2002 | Development2002，129，： | 1 |
| 17 | Direct and reverse ATRP of MMA in aqueous dispersed medium in the presence of a bipyridine-functionalized block copolymer support显示文摘 | Thomas K oskar N Ralf W | 2004 | Macromol Chem Phys2004，205，： | 1 |
| 18 | Three-dimensional monitoring of small tempeiature changes for therapeutic hyperthermia using MR显示文摘 | Waldemar W Ralf B Michael H | 1998 | JMRI1998，8，： | 1 |
| 19 | The angiotensin 11 type 2 receptor in renal disease 显示文摘 | Ulrich W Christian K Ralf B | 2010 | Journal of Renin - Angiotensin - Aldosterone System March2010，11，1： | 1 |
| 20 | Catalytic influence of ash elments on NOx formation in char combustion under fluidized bed condition显示文摘 | RALF F W KOPSE L HALANG S | 1997 | Fuel1997，76，4： | 1 |
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