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| 1 | Gene expression changes in spleens of the wildlife reservoir species,Eurasian wild boar(Sus scrofa),naturally infected with Brucella suis biovar 2显示文摘Brucella suis is responsible for swine brucellosis worldwide.Of the five different B.suis biovars(bv.),bv.2 appears restricted to Europe where it is frequently isolated from wild boar and hares,can infect pigs and can cause human brucellosis.In this study,the differential gene expression profile was characterized in spleens of Eurasian wild boar naturally infected with B.suis bv.2.Of the 20,201 genes analyzed in the microarray,633 and 1,373 were significantly(fold change > 1.8;P < 0.01) upregulated and downregulated,respectively,in infected wild boar.The analysis was focused on genes that were over represented after conditional test for biological process gene ontology.Upregulated genes suggested that B.suis bv.2 infection induced cell maturation,migration and/or proliferation in infected animals.The genes downregulated in infected wild boar impaired the activity of several important cellular metabolic pathways such as metabolism,cytoskeleton organization and biogenesis,immune response and lysosomal function and vesicle-mediated transport.In addition,the response to stress,sperm fertility,muscle development and apoptosis seemed to be also impaired in infected animals.These results suggested that B.suis bv.2 may use strategies similar to other smooth brucellae to facilitate intracellular multiplication and the development of chronic infections.To our knowledge,this is the first report of the analysis of gene expression profile in hosts infected with B.suis bv.2,which is important to understand the molecular mechanisms at the host-pathogen interface in the main reservoir species with possible implications in the zoonotic cycle of the pathogen. | Ruth C.Galindo Pilar M.Muoz María J.de Miguel Clara M.Marin Javier Labairu Miguel Revilla José M.Blasco Christian Gortazar José de la Fuente | 2010 | Journal of Genetics and Genomics2010，37，11： | 6 |
| 2 | Gastroenterology case report of mesalazine-induced cardiopulmonary hypersensitivity显示文摘Mesalazine is a 5-aminosalicylic acid derivative that has been widely used to treat patients with inflammatory bowel disease. Accumulating evidence indicates that mesalazine has a very low rate of adverse drug reactions and is well tolerated by patients. However, a few cases of pulmonary and cardiac disease related to mesalazine have been reported in the past, though infrequently, preventing clinicians from diagnosing the conditions early. We describe the case of a 32-yearold man with ulcerative colitis who was admitted with a two-month history of persistent fever following mesalazine treatment initiated 14 mo earlier. At the time of admission, mesalazine dose was increased from 1.5 to 3.0 g/d, and antibiotic therapy was started with no improvement. Three weeks after admission, the patient developed dyspnea, non-productive cough, and chest pain. Severe eosinophilia was detected in laboratory tests, and a computed tomography scan revealed interstitial infiltrates in both lungs, as well as a large pericardial effusion. The bronchoalveolar lavage reported a CD4/CD8 ratio of 0.5, and an increased eosinophil count. Transbronchial biopsy examination showed a severe eosinophilic infiltrate of the lung tissue. Mesalazine-induced cardiopulmonary hypersensitivity was suspected after excluding other possible etiologies. Consequently, mesalazine treatment was suspended, and corticosteroid therapy was initiated, resulting in resolution of symptoms and radiologic abnormalities. We conclude that mesalazine-induced pulmonary and cardiac hypersensitivity should always be considered in the differential diagnosis of unexplained cardiopulmonary symptoms and radiographic abnormalities in patients with inflammatory bowel disease. | José Ferrusquía Isabel Pérez-Martínez Ricardo Gómez de la Torre María Luisa Fernández-Almira Ruth de Francisco Luis Rodrigo Sabino Riestra | 2015 | World Journal of Gastroenterology2015，21，13： | 5 |
| 3 | Management of opioid side effects in cancer-related and chronic noncancer pain: a systematic review显示文摘 | Ewan McNicol Nathalie Horowicz-Mehler Ruth A Fisk Kyle Bennett Maria Gialeli-Goudas Priscilla W Chew Joseph Lau Daniel Carr | 2003 | Journal of Pain2003，，5： | 3 |
| 4 | Human Papillomavirus (HPV) DNA Copy Number Is Dependent on Grade of Cervical Disease and HPV Type显示文摘 | David C S Ruth A T Guillermo T L | 1999 | Clin Microbiol1999，37，： | 1 |
| 5 | Characterization and expression pattern of zebrafish anti-Mullerian hormone (AMH) relative to sox9a, sox9b, and cyp191a, during gonad development 显示文摘 | Adriana R M Yan Y L Ruth A B | 2005 | Gene Expression Patterns2005，5，： | 1 |
| 6 | Pesticide application practices, pest knowledge, and cost-benefits of plantain production in the Bribri-Caber car Indigenous Territories, Costa Rica显示文摘 | Beth A Polidoro Ruth M Dahlquist | 2008 | Environmental Research2008，108，： | 1 |
| 7 | A comparison of double- focusing sector field ICP-MS, ICP-OES and octopole collision cell 1CP-MS for the high-accuracy determination of calcium in human serum 显示文摘 | Loma A Simpson Ruth Hearn | 2005 | Talanta2005，65，： | 1 |
| 8 | Wound management with vacuum-assisted closure:experience in 51 pediatric patients显示文摘 | CANIANO D A RUTH B TEICH S | 2005 | J Pediatr Surg2005，40，1： | 1 |
| 9 | Studies of the uptake of nitrate barley显示文摘 | SIDDIGI M Y GLASS A D M RUTH T J | 1990 | Plant Physiology1990，93，： | 1 |
| 10 | Tandem DNA recognition by PhoB, a two - component signal transduction transcriptional activator显示文摘 | BLANCO A G SOLA M GOMIS - RUTH F X | 2002 | Structure (Camb)2002，10，5： | 1 |
| 11 | Studies of theuptake of nitrate in barley显示文摘 | Siddiqi M Y Glass A D Ruth T J | 1990 | Plant Physiology1990，，93： | 1 |
| 12 | Global consequences of land use显示文摘 | FOLEY J A RUTH D ASNER G F | 2005 | Science2005，309，5734： | 1 |
| 13 | Regional energy demand responses to climate change methodology and application to the commonwealth of Massachusetts 显示文摘 | Amato A D Ruth M Kirshen P | 2005 | Climate Change2005，71，1： | 1 |
| 14 | TDDFT study of one-and two-photon absorption properties:Donor-π-acceptor chromophores显示文摘 | Paul N Day Kiet A Nguyen Ruth Pachter | 2005 | J Phys Chem B2005，109，5： | 1 |
| 15 | Energy from municipal solid waste: A comparison with coal combustion technology显示文摘 | RUTH L A | 1998 | Prog Energy Combust Sci1998，24，6： | 1 |
| 16 | Role of su- peroxide dismutases (SODs) in controlling oxidative stress in plants 显示文摘 | RUTH G A NEVAL E LENWOOD S H | 2002 | Journal of Experimental Botany2002，53，： | 1 |
| 17 | Toxicity of cytore- ductive surgery and hyperthermic in- traperitoneal chemotherapy 显示文摘 | Verwaal V J van Tinteren H Ruth S V Zoetmulder F A | 2004 | J Surg Oncol2004，85，2： | 1 |
| 18 | Endoplasmic reticulum stress links dyslipidemia to inhibition of proteasome activity and glucose transport by HIV protease inhibitors 显示文摘 | Rex A Parker Oliver P Flint Ruth Mulvey | 2005 | Mol Pharmacol2005，67，6： | 1 |
| 19 | Effects of the multidrug transporter P-glycoprotein on cellular responses to ionizing radiation显示文摘 | Ruth A C Roninson I B | 2000 | Cancer Res2000，60，10： | 1 |
| 20 | Health-related quality of life and psychosocial adjustment in steroid-sensitive nephrotic syndrome 显示文摘 | RUTH E M LANDOLT M A NEUHAUS T J el al | 2004 | J Pediatr2004，145，6： | 1 |
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