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| 1 | A systematic review and meta-analysis of clinical trials implementing aromatase inhibitors to treat male infertility显示文摘Aromatase activity has commonly been associated with male infertility characterized by testicular dysfunction with low serum testosterone and/or testosterone to estradiol ratio.In this subset of patients,and particularly in those with hypogonadism,elevated levels of circulating estradiol may establish a negative feedback on the hypothalamic–pituitary–testicular axis by suppressing follicle-stimulating hormone(FSH)and luteinizing hormone(LH)production and impaired spermatogenesis.Hormonal manipulation via different agents such as selective estrogen modulators or aromatase inhibitors to increase endogenous testosterone production and improve spermatogenesis in the setting of infertility is an off-label option for treatment.We carried out a systematic review and meta-analysis of the literature of the past 30 years in order to evaluate the benefits of the use of aromatase inhibitors in the medical management of infertile/hypoandrogenic males.Overall,eight original articles were included and critically evaluated.Either steroidal(Testolactone)or nonsteroidal(Anastrozole and Letrozole)aromatase inhibitors were found to statistically improve all the evaluated hormonal and seminal outcomes with a safe tolerability profile.While the evidence is promising,future prospective randomized placebo-controlled multicenter trials are necessary to better define the efficacy of these medications. | Francesco Del Giudice Gian Maria Busetto Ettore De Berardinis Isabella Sperduti Matteo Ferro Martina Maggi Martin S Gross Alessandro Sciarra Michael L Eisenberg | 2020 | Asian Journal of Andrology2020，22，4： | 5 |
| 2 | Functional magnetic resonance imaging and the brain: A brief review显示文摘Functional magnetic resonance imaging(fMRI) is em-ployed in many behavior analysis studies, with blood oxygen level dependent-(BOLD-) contrast imaging being the main method used to generate images. The use of BOLD-contrast imaging in f MRI has been refined over the years, for example, the inclusion of a spin echo pulse and increased magnetic strength were shown to produce better recorded images. Taking careful precautions to control variables during measurement, comparisons between different specimen groups can be illustrated by f MRI imaging using both quantitative and qualitative methods. Differences have been observed in comparisons of active and resting, developing and aging, and defective and damaged brains in various studies. However, cognitive studies using f MRI still face a number of challenges in interpretation that can only be overcome by imaging large numbers of samples. Furthermore, f MRI studies of brain cancer, lesions and other brain pathologies of both humans and animals are still to be explored. | Maggie SM Chow Sharon L Wu Sarah E Webb Katie Gluskin DT Yew | 2017 | World Journal of Radiology2017，9，1： | 4 |
| 3 | Proliferation and migration of endothelial cells ispromoted by endothelia via activation of EFB receptor 显示文摘 | Morbidlli L Qrlando C Maggi CA | 1995 | AMJ Physiol1995，269，22： | 1 |
| 4 | Rarity of human T helper 17 ceils is due to retinoie acid orphan receptor depend ent mechanisms that limit their expansion显示文摘 | Santarlasci V Maggi L Capone M | 2012 | Immunity2012，36，2： | 1 |
| 5 | Adjunctive diagnostic value of ultrasonography evaluation in patients with suspected ductal breast disease 显示文摘 | Ballesio L Maggi C Savelli S | 2007 | Radiol Med (Torino)2007，112，3： | 1 |
| 6 | Diagnosis and treatment of haemorrhoids in the elderly:results from 291 patients显示文摘 | Navarra L Pietroletti R Maggi G | 1999 | Tech Coloproctol1999，3，： | 1 |
| 7 | Effect of pre-operative physiotherapy in patients with end-stage osteoarthritis undergoing hip arthroplasty显示文摘 | Ferrara P Rabini A Maggi L | | 0，，： | 1 |
| 8 | Th17 cells:new players in asthma pathogenesis显示文摘 | Cosmi L Liotta F Maggi E | 2011 | Allergy2011，66，8： | 1 |
| 9 | Role of breast Magnetic Resonance Imaging (MRI) in patients with unilateral nipple di charge : preliminary study显示文摘 | Ballesio L Maggi C Savelli S | 2008 | Radiol Med( Torino)2008，113，2： | 1 |
| 10 | Therapeutic management ofcomplicated talar extrusion : literature review and case report 显示文摘 | Vaienti L Maggi F Gazzola R | 2011 | JOrthop Traumatol2011，1，： | 1 |
| 11 | Phenotypic and functional features of human Th17 cells显示文摘 | Annunziato F Cosmi L Santarlasci V Maggi L Liotta F Mazzinghi B et at | 2007 | J Exp Med2007，204，8： | 1 |
| 12 | High molecular weight polyethylene oxides (PEOs) as an alternative to HPMC in controlled release dosage forms 显示文摘 | Maggi L Bruni R and Conte U | 2000 | lnt J Pharm2000，195，1： | 1 |
| 13 | Multimodal management of stages III–IVa malignant thymoma显示文摘 | S Bretti A Berruti C Loddo P Sperone C Casadio M Tessa F Ardissone G Gorzegno M Sacco E Manzin P Borasio G.L Sannazzari G Maggi L Dogliotti | 2003 | Lung Cancer2003，，1： | 1 |
| 14 | Celsior solution and clinical liver transplantation显示文摘 | Maggi U Caccamo L Gatti S | 2000 | Transplant Proc2000，32，1： | 1 |
| 15 | Fast - and slow - release tablets for oral administration of flavonoids: rutin and quercetin 显示文摘 | Lauro MR Torre ML Maggi L | 2002 | Drug Dev Ind Pharm2002，28，4： | 1 |
| 16 | Evidence for a cross-talk between human neutrophils and Th17 cells显示文摘 | Pelletier M Maggi L Micheletti A | 2010 | Blood2010，115，2： | 1 |
| 17 | Matrices containing NaCMC and HPMC 2:Swel ing and release mechanism study显示文摘 | Conti S Maggi L Segale L | | 0，，： | 1 |
| 18 | Supramicellar solution of sodium dodecyl sulphate as dissolution media to study the in vitro release characteristics of sustained-release formulations containing an insoluble drug:Nifedipine显示文摘 | Maggi L Torre M L Giunchedi P | 1996 | Int J Pharm1996，135，： | 1 |
| 19 | NK1 receptors and vascular permeability in rat airways显示文摘 | Abelli L Nappi F Maggi CA | 1991 | Ann N Y Acad Sci1991，632，： | 1 |
| 20 | Treatment of myasthenia gravis focus on pyri- dostlgmine 显示文摘 | Maggi L Mantegazza R | 2011 | Clin Drug Investig2011，31，10： | 1 |
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