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| 1 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 2 | Antiepileptic drugs and cortical excitability: a study with repetitive transcra- nial stimulation显示文摘 | M INGHILLERI A CONTE V FRASCA | 2004 | Exp Brain Res2004，154，48： | 1 |
| 3 | P16^INK4A hypermethylation detected by fluorescent methylation-specific PCR in plasmas from non-small cell lung cancer 显示文摘 | Bearzatto A Conte D Frattini M | 2002 | Clin Cancer Res2002，8，12： | 1 |
| 4 | Genetic and physiological influences on the alkenone/alkenoate versus growth temperature relationship in Emiliania huxleyi and Gephyrocapsa oceanica 显示文摘 | Conte M H Thompson A Lesley D | 1998 | Geochimica et Cosmochimica Acta1998，62，1： | 1 |
| 5 | Potential availability of heavy metals to phytoextraction from contaminated soils induced by exogenous humic sub- stances 显示文摘 | HALIM M CONTE P PICCOLO A | 2003 | Chemosphere2003，52，： | 1 |
| 6 | Severe coronary artery disease after radiation therapy of the chest and mediastinum: clinical presentation and treatment 显示文摘 | ORZAN F BRUSCA A CONTE M R | 1993 | Br Heart J1993，69，6： | 1 |
| 7 | Hydrochlorination of acetylene using supported bimetallic Au-based cata- lysts显示文摘 | Conte M Carley A Attard G | 2008 | Journal of Catalysis2008，257，1： | 1 |
| 8 | Controlled release of thymol from zein based film显示文摘 | Mastromatteo M Barbuzzi G Conte A | 2009 | Innov Food Sci Emerg2009，10，2： | 1 |
| 9 | The importance of the number of reflux episodes in the diagnosis of laryngopharyngeal reflux disease显示文摘 | FUSCONI M DE VIRGILIO A CONTE M | 2013 | Otolaryngol Head Neck Surg2013，148，： | 1 |
| 10 | Use of natural compounds to improve the microbial stability of Amaranthbased homemade fresh pasta显示文摘 | Del Nobile M A Suriano N Conte A | 2009 | Food Microbiology2009，26，： | 1 |
| 11 | Potential availability of heavy metals to phytoext raction from contaminated soils induced by exogenous humic substances显示文摘 | Halim M Conte P Piccolo A | 2003 | Chemosphere2003，52，1： | 1 |
| 12 | Is the cutaneous si lent period an opiate sensitive noc cept ve reflex? 显示文摘 | Inghilleri M Conte A Frasca V | 2002 | Muscle Nerve2002，25，： | 1 |
| 13 | Economic Growth and the Expanding Public Sector: A Reexamination显示文摘 | Conte M A A F Darrar | 1988 | The Review of Economics and Statistics1988，70，2： | 1 |
| 14 | Shelf life of ready to use peeled shrimps as affected by thymol essential oil and modified atmosphere packaging显示文摘 | Mastromatteo M Danza A Conte A | 2010 | International Journal of Food Microbiology2010，144，： | 1 |
| 15 | A GIS approach toingest Meteosat Second Generation data into the Local Analysisand Prediction System显示文摘 | Conte D Miglietta M M Moscatello A | 2010 | Environmental Modelling & Software2010，25，10： | 1 |
| 16 | Influence of protein content on spaghetti cooking quality显示文摘 | DEL NOBILE M A BAIANO A CONTE A | 2005 | Journal of Cereal Science2005，41，3： | 1 |
| 17 | Model matching and factorization for nonlinear systems: A structural approach显示文摘 | Perdon A M Conte G | 1991 | SIAM J Control and Optimez1991，29，7： | 1 |
| 18 | Cooling kinetics experiments on different Stromboli lavas:effects on crystal morphologies and phase composition显示文摘 | Conte A M Perinelli C Trigila R | 2006 | Journal of Volcanology and Geothermal Research2006，155，： | 1 |
| 19 | Phosphorylation of the TGBpl movement protein of Potato virus X by a Nicotiana tabacum CK2-like activity显示文摘 | Modena N A Zelada A M Conte F | 2008 | Virus Res2008，137，1： | 1 |
| 20 | Increased cancer risk in a cohort of 230 patients with hereditary haemochromatosis in comparison to matched control patients with non-iron-related chronic liver disease显示文摘 | FRACANZANI A L CONTE D FRAQUELLI M | 2001 | Hepatology2001，33，： | 1 |
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