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| 1 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 2 | MiR-181a-5p regulates 3T3-L1 cell adipogenesis by targeting Smad7 and Tcf7I2显示文摘 | Dan Ouyang Lifeng Xu Lihua zhang Dongguang Guo Xiaotong Tan Xiaofang Yu Junjie Qi Yaqiong Ye Qihong Liu Yongjiang Ma Yugu Li | 2016 | Acta Biochimica et Biophysica Sinica2016，48，11： | 9 |
| 3 | Nanoparticle monolayer-based flexible strain gauge with ultrafast dynamic response for acoustic vibration detection显示文摘The relatively poor dynamic response of current flexible strain gauges has prevented their wide adoption in portable electronics. In this work, we present a greatly improved flexible strain gauge, where one strip of Au nanoparticle (NP) monolayer assembled on a polyethylene terephthalate film is utilized as the active unit. The proposed flexible gauge is capable of responding to applied stimuli without detectable hysteresis via electron tunneling between adjacent nanoparticles within the Au NP monolayer. Based on experimental quantification of the time and frequency domain dependence of the electrical resistance of the proposed strain gauge, acoustic vibrations in the frequency range of 1 to 20,000 Hz could be reliably detected. In addition to being used to measure musical tone, audible speech, and creature vocalization, as demonstrated in this study, the ultrafast dynamic response of this flexible strain gauge can be used in a wide range of applications, including miniaturized vibratory sensors, safe entrance guard management systems, and ultrasensitive pressure sensors. | Lizhi Yi Weihong Jiao Ke Wu Lihua Qian Xunxing Yu Qi Xia Kuanmin Mao Songliu Yuan Shuai Wang Yingtao Jiang | 2015 | Nano Research2015，8，9： | 6 |
| 4 | New approach to determine the priorities from interval fuzzy preference relations显示文摘An approach is proposed to solve the problem how to obtain the priorities from interval fuzzy preference relations. Firstly, another expression of interval numbers is given. Then, some basic definitions on consistency and weak transitivity of real and interval fuzzy preference relations are described. Based on these definitions, a two-phase process for determining the priorities from interval fuzzy preference relations is presented. Finally, two exam- ples are used to illustrate the use of the proposed approach. | Qi Yue Zhiping Fan Lihua Shi | 2011 | Journal of Systems Engineering and Electronics2011，22，2： | 6 |
| 5 | Antiferromagnetic element Mn modified PtCo truncated octahedral nanoparticles with enhanced activity and durability for direct methanol fuel cells显示文摘Pt-based magnetic nano catalysts are one of the most suitable cand idates for electrocatalytic materials due to their high electrochemistry activity and retrievability.Unfortunately,the inferior durability prevents them from being scaled-up,limiting their commercial applications.Herein,an antiferromagnetic element Mn was introduced into PtCo nanostructured alloy to synthesize uniform Mn-PtCo truncated octahedral nanoparticles(TONPs)by one-pot method.Our results show that Mn can tune the blocking temperature of Mn-PtCo TONPs due to its an tiferromag netism.At low temperatures,Mn-PtCo TONPs are ferromag netic,and the coercivity in creases gradually with in creasi ng Mn contents.At room temperature,the Mn-PtCo TONPs display superparamag netic behavior,which is greatly helpful for in dustrial recycling.Mn doping can not only modify the electronic structure of PtCo TONPs but also enhanee electrocatalytic performance for methanol oxidation reaction.The maximum specific activity of Mn-PtCo-3 reaches 8.1 A`m^-2,3.6 times of commercial Pt/C(2.2 A·m^-2)and 1.4 times of PtCo TONPs(5.6 A`m^-2),respectively.The mass activity decreases by only 30%after 2,000 cycles,while it is 45%and 99%(nearly inactive)for PtCo TONPs and commercial Pt/C catalysts,respectively. | Qiqi Zhang Jialong Liu Tianyu Xia Jie Qi Haochang Lyu Baoyuan Luo Rongming Wang Yizhong Guo Lihua Wang and Shouguo Wang | 2019 | Nano Research2019，12，10： | 5 |
| 6 | Coastal Erosion Along the West Coast of the Taiwan Strait and It’s Influencing Factors显示文摘Based on the field surveys and repeated cross-profile observations combined with the comparison of many years’ topog-raphic maps,this study shows the spatial variability and varying patterns of coastal erosion along the west coast of the Taiwan Strait.Regional differentiation in the Meso-Cenozoic coastal tectonics determined the irregular coastline and geological background for large-scale coastal erosion distribution.The intensity of coastal erosion on the west side of the Taiwan Strait is mild in the northern region,severe in the central region and modest in the southern region.The beaches along the coast are mainly backed by dunes,sea-walls or cliffs.The dunes and beaches show periodic erosion and recovery along the coast adjacent to river mouths,while persistent retreat of frontal dunes and beaches tends to occur in other areas.The beach erosion occurs mainly in front of seawalls.Due to the low strength of the unconsolidated sediment the soft cliffs suffer the severest coastline recession.Sea level rise and river sediment discharge reduction are main causes of coastal erosion.Storm surge is common in the studied area and plays an important role in the progress of coastal erosion.Human activities including coastal constructions and sand mining also tend to interfere strongly with the balance of sediment budget in some coastal cells. | LIU Jianhui CAI Feng QI Hongshuai LEI Gang CAO Lihua | 2011 | Journal of Ocean University of China2011，10，1： | 4 |
| 7 | Stability Analysis on Rotor Systems Supported by Self-acting Tilting-pad Gas Bearings with Frequency Effects显示文摘The recent research on stability of gas bearing-rotor systems still mostly adopts the same method as in oil-lubricated bearing-rotor systems.The dynamic coefficients of gas bearings in the case that the perturbation frequencies are same as the rotating speed are used to carry out the stability analysis of rotor systems.This method does not contact the frequency characteristics of dynamic stiffness and damping coefficients of gas bearings with the dynamical behaviors of rotor systems.Furthermore,the effects of perturbation frequencies on the stability of systems are not taken into account.In this paper,the dynamic stiffness and damping coefficients of tilting-pad gas bearings are calculated by the partial derivative method.On the base of solution of dynamic coefficients,two computational models are produced for stability analysis on rotor systems supported by tilting-pad gas bearings according to whether the degrees of the freedom of pads tilting motions are included in the equations of motion or not.In the condition of considering the frequency effects of dynamic coefficients of tilting-pad gas bearings,the corresponding eigenvalues of the rigid and first five vibration modes of the system with the working speeds of 8-30 kr/min are computed through iteratively solving the equations of motion of rotor-system by using two computational models,respectively.According to the obtained eigenvalues,the stability of rotor system is analyzed.The results indicate that the eigenvalues and the stability of rotor system obtained by these two computational models are well agreement each other.They all can more accurately analyze the stability of rotor systems supported by tilting-pad gas bearings.This research has important meaning for perfecting the stability analysis method of rotor systems supported by gas bearings. | YANG Lihua QI Shemiao GENG Haipeng YU Lie | 2011 | Chinese Journal of Mechanical Engineering2011，24，3： | 4 |
| 8 | Identification of Histoplasma causing an unexplained disease cluster in Matthews Ridge, Guyana显示文摘Here,we report the identification of Histoplasma causing an unexplained disease cluster in Matthews Ridge,Guyana.In March 2019,14 employees of Chongqing Bosai Mining Company,China,working in a manganese mining of Guyana,had unexplained fever,and two of them died.We obtained lung and brain tissues as well as the blood samples from the two deceased cases(patient No.1 and 2),and bronchoscopy lavages and cerebrospinal fluid samples from one severe case(patient No.3),respectively.All samples were tested by pathological examination,high-throughput sequencing,and real-time PCR.Pathological detection showed the presence of spore-like structures in the lung tissue of patient No.1,indicating a fungal infection in this patient.Nanopore sequencing identified the existing of H.capsulatum in the lung tissue sample within 13 h.Next-generation sequencing identified specific fragments of H.capsulatum in all of the samples tested(lung,brain and blood serum from the deceased cases,and plasma from the severe case).Real-time PCR assays did not reveal any viral infection related to transmission from bat feces.We conclude that H.capsulatum was the causative pathogen of this disease cluster based on epidemiologic,clinical,pathological and nucleic acid evidence. | Ji Wang Weimin Zhou Hua Ling Xiaoping Dong Yi Zhang Jiandong Li Yong Zhang Jingdong Song William J.Liu Yang Li Ruiqing Zhang Wei Zhen Kun Cai Shuangli Zhu Dongyan Wang Jinbo Xiao Yigang Tong Wenli Liu Lihua Song Wei Wu Yang Liu Xiang Zhao Ruihuan Wang Sheng Ye Jing Wang Roujian Lu Baoying Huang Fei Ye Wenwen Lei Rongbao Gao Qi Shi Cao Chen Jun Han Wenbo Xu George F.Gao Xuejun Ma Guizhen Wu | 2019 | Biosafety and Health2019，1，3： | 3 |
| 9 | Graphene-wrapped multiloculated nickel ferrite:A highly efficient electromagnetic attenuation material for microwave absorbing and green shielding显示文摘Dedicating to the exploration of efficient electromagnetic(EM)absorption and electromagnetic interference(EMI)shielding materials is the main strategy to solve the EM radiation issues.The development of multifunction EM attenuation materials that are compatible together EM absorption and EMI shielding properties is deserved our exploration and study.Here,the graphenewrapped multiloculated NiFe_(2)O_(4) composites are reported as multifunction EM absorbing and EMI shielding materials.The conductive networks configurated by the overlapping flexible graphene promote the riched polarization genes,as well as electron transmission paths,and thus optimize the dielectric constant of the composites.Meanwhile,the introduction of magnetic NiFe_(2)O_(4) further establishes the magnetic-dielectric synergy effect.The abundant non-homogeneous interfaces not only generate effective interfacial polarization,also the deliberate multiloculated structure of NiFe_(2)O_(4) strengthens multi-scattering and multi-reflection sites to expand the transmission path of EM waves.As it turns out,the best impedance matching is matched at a lower filled concentration to achieve the strongest reflection loss value of−48.1 dB.Simultaneously,green EMI shielding based on a predominantly EM absorption and dissipation is achieved by an enlargement of the filled concentration,which is helpful to reduce the secondary EM wave reflection pollution to the environment.In addition,the electrocatalytic properties are further examined.The graphene-wrapped multiloculated NiFe_(2)O_(4) shows the well electrocatalytic activity as electrocatalysts for hydrogen evolution reaction(HER)and oxygen evolution reaction(OER),which is mainly attributed to the interconnected structures formed by graphene and NiFe_(2)O_(4) connection.The structural advantages of multiloculated NiFe_(2)O_(4) expose more active sites,which plays an important role in optimizing catalytic reactions.This work provides an excellent jumping-off point for the development of multifunction EM absorbing materials,eco-friendliness EMI shielding materials and electrocatalysts. | Yuchang Wang Lihua Yao Qi Zheng Mao-Sheng Cao | 2022 | Nano Research2022，15，7： | 3 |
| 10 | Impact of Land Use Change on Vegetation Carbon Storage During Rapid Urbanization:A Case Study of Hangzhou,China显示文摘Land use changes have significant impacts on the carbon balance in an urban ecosystem.When there is rapid development in urbanizing regions,land use changes have a dramatic effect on vegetation carbon storage(VCS).This study investigates the impact of land use change on VCS in a period of rapid urbanization in Hangzhou,China.The results show that:1)from 2000 to 2015,land use in Hangzhou underwent huge changes,mainly reflected in decrease in cropland and wetland and the increased settlement.More than 34.58%of the land was transformed,and the land use changes are primarily characterized by a significant decrease in cropland due to the occupation by settlement.2)over the 15 years,changes in land use led to a decrease of 3.93×10^(5) t of VCS in the urban ecosystem.The large-scale transformation of cropland and wetland,which have a comparatively high carbon density,into land for settlement exerted a negative impact on VCS.3)The central city,which with the Circle-E/I/O mode,had the lowest comprehensive land use dynamic degree,leading to moderate land use change and an increase in VCS;Yuhang and Xiaoshan,which with Multicore-E/O/I mode and Fan-E/O/I modes,had a higher comprehensive land use dynamic degree,drastic changes in land use,and a decrease in VCS.This study proposes a reliable method of estimating changes in VCS,clarifies the relationship between land use change and VCS during rapid urbanization,and provides recommendations for sustainable urban development. | WANG Zhi XU Lihua SHI Yijun MA Qiwei WU Yaqi LU Zhangwei MAO Liwei PANG Enqi ZHANG Qi | 2021 | Chinese Geographical Science2021，31，2： | 3 |
| 11 | MicroRNA-195a-5p inhibits mouse medullary thymic epithelial cells proliferation by directly targeting Smad7显示文摘MiR-195 在在肿瘤的不同类型禁止房间增长被含有。它是否贡献 thymic 的过程上皮的房间(侦探) 增长仍然保持不清楚。在这研究,我们发现 miR-195a-5p 在从变老的老鼠孤立的侦探是高度起来调整的。进一步的实验证明 miR-195a-5p 模仿禁止的 transfection 老鼠的增长髓的 thymic 第 1 行上皮的房间(MTEC1 ) ,而在 MTEC1 的 miR-195a-5p 禁止者的 transfection 有相反的效果。另外, miR-195a-5p 没在 MTEC1 apoptosis 上有明显的效果。而且, Smad7,转变生长因素小径的一个否定管理者,被酶试金作为 miR-195a-5p 的一个直接目标证实。一起拿,我们的结果显示 miR-195a-5p 禁止 MTEC1 增长,至少部分地,经由 Smad7 的下面规定。 | Dongguang Guo Yaqiong Ye Junjie Qi Lifeng Xu Lihua Zhang Xiaolong Tan Zhigang Tan Xiaofang Yu Yuan Zhang Yongjiang Ma Yugu Li | 2016 | Acta Biochimica et Biophysica Sinica2016，48，3： | 3 |
| 12 | Development of a class-specific monoclonal antibody-based ELISA for aflatoxins in peanut显示文摘 | Peiwu Li Qi Zhang Wen Zhang Jinyang Zhang Xiaomei Chen Jun Jiang Lihua Xie Daohong Zhang | 2008 | Food Chemistry2008，，1： | 2 |
| 13 | The speciation, leachability and bioaccessibility of Cu and Zn in animal manure-derived biochar: effect of feedstock and pyrolysis temperature显示文摘 | Qi Lin Xin Xu Lihua, Wang Qian Chen Jing Fang Xiaodong Shen Liping Lou Guangming Tian | 2017 | Frontiers of Environmental Science & Engineering2017，11，3： | 2 |
| 14 | MicroRNA-181a-5p enhances cell proliferation in medullary thymic epithelial cells via regulating TGF-β signaling显示文摘在从不同年龄的老鼠的胸腺纸巾的 miRNAs 的表示侧面在我们的以前的学习被表明了。在 miRNA 表达式侧面的综合分析以后,我们证明 miR-181a-5p 的表达式显著地在 thymic 被减少从 10- 的上皮的房间(侦探) 到 19-month-old 鼠标当与那相比在从 1-month-old 的侦探由量的反向的 transcriptase 聚合酶的鼠标锁住反应时。我们在侦探假设了那 miR-181a-5p 可能通过调整一些基因或发信号的小径与年龄相关的胸腺复杂物被联系。测试这个假设,老鼠髓的 thymic 上皮的房间(MTEC1 ) 被使用。有 miR-181a-5p 的 Transfection 模仿支持了 MTEC1 房间的增长,但是没影响 apoptosis。效果被颠倒 miR-181a-5p 的表示什么时候在 MTEC1 房间被压制。而且,转变生长因素贝它受体(Tgfbr1 ) 我被酶试金作为 miR-181a-5p 的一个直接目标证实。而且,它被发现 miR-181a-5p 的那 overexpression 下面调整 Smad3 的 phosphorylation 并且堵住了发信号的转变生长因素贝它的激活。不过,一相反地,关联在 Tgfbr1 的表示之间被观察,在侦探的 miR-181a-5p 源于不同年龄的老鼠。一起,我们提供 miR-181a-5p 可以是在侦探,和表示的增长的一个重要内长的管理者的证据在侦探的 miR-181a-5p 的层次可以与年龄相关的胸腺复杂物被联系。 | Dongguang Guo Yaqiong Ye Junjie Qi Lihua Zhang Lifeng Xu Xiaotong Tan Xiaofang Yu Qihong Liu Jilong Liu Yuan Zhang Yongjiang Ma Yugu Li | 2016 | Acta Biochimica et Biophysica Sinica2016，48，9： | 2 |
| 15 | Regulating bifunctional flower-like NiFe_(2)O_(4)/graphene for green EMI shielding and lithium ion storage显示文摘Environment and energy are the eternal hot topics in the world,multiloculated microscale materials have attracted great attention in the field of electromagnetic interference(EMI)shielding and lithium ions storage.Herein,a novel flower-like NiFe_(2)O_(4)/graphene composite with adjustable structure was fabricated as EMI shielding material and anode material of lithium-ion batteries.NiFe_(2)O_(4)/graphene composite is a potential green EMI shielding material.The EMI shielding effectiveness(SE)increases with the increase of graphene content in NiFe_(2)O_(4)/graphene composite,and the total EMI SE of NiFe_(2)O_(4)/graphene with 73.6 wt.%graphene increases from 26.5 to 40.6 d B with the increase of frequency in 2–18 GHz.Furthermore,it exhibits long-life and large capacity lithium storage performance at high current density.The capacity reaches 732.79 m Ah g^(-1)after 100 cycles at 0.1 A g^(-1),recovering to more than 139%from the minimum capacity value.After 300 cycles at 0.5 A g^(-1),the capacity increases to 688.5 mAh g^(-1).The initial capacities at 2 and 5 A g^(-1)are 704.9 and 717.8 mAh g^(-1),and remain 297.9 and 203.2 m Ah g^(-1)after 1000 cycles.The distinguished EMI shielding performance and electrochemical performance are mainly ascribed to the structure regulation of NiFe_(2)O_(4)/graphene composite,as well as the synergistic effect of graphene and NiFe_(2)O_(4).This research opens up infinite opportunities for the application of multifunctional and interdisciplinary materials. | Lihua Yao Wenqiang Cao Jianguo Zhao Qi Zheng Yuchang Wang Shang Jiang Qiliang Pan Jie Song Youqi Zhu Maosheng Cao | 2022 | Journal of Materials Science & Technology2022，，32： | 2 |
| 16 | Integrated Reform of Electronic Technology Courses in Higher Vocational Colleges Based on the OBE Concept显示文摘The education model based on outcomes-based education(OBE)emphasizes on taking educational achievements as the guide as well as focusing on student-centered and ability-based concepts.OBE is consistent with the talent output goals of higher vocational and technical education.Using the construction of electronic technology courses in higher vocational and technical colleges as an example,this article takes the course reform as an important carrier to promote ability training and explores the course reform scheme to meet the ability needs of higher vocational talents in the new era based on the concept of OBE in order to provide a useful reference for improving the level of talent training in higher vocational colleges. | Jian Pan Li Wen Lihua Qi Dongqiu Xing Yuting Zhao | 2021 | Journal of Contemporary Educational Research2021，5，9： | 2 |
| 17 | Stability analysis of the building foundation for goaf显示文摘 | Zhang Changming Qi Lihua Shen Naiqi | | 0，，04： | 1 |
| 18 | Biosorption of methyleneblue from aqueous solution using a bioenergy forest Waste:Xanthoceras sorbi folia seed coat显示文摘 | Zengyu Yao Lihua Wang Jianhua Qi | 2009 | Clean2009，37，8： | 1 |
| 19 | Cryptosporidium spp. in pet birds: Genetic diversity and potential public health significance显示文摘 | Meng Qi Rongjun Wang Changshen Ning Xiaoyu Li Longxian Zhang Fuchun Jian Yanru Sun Lihua Xiao | 2011 | Experimental Parasitology2011，，4： | 1 |
| 20 | Bioconcentration and metabolism of decabromodiphenyl ether (BDE-209) result in thyroid endocrine disruption in zebrafish larvae显示文摘 | Qi Chen Liqin Yu Lihua Yang Bingsheng Zhou | 2012 | Aquatic Toxicology2012，，： | 1 |
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