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| 1 | Effects of Water-table Depth and Soil Moisture on Plant Biomass, Diversity, and Distribution at a Seasonally Flooded Wetland of Poyang Lake, China显示文摘Hydrological regime has been widely recognized as one of the major forces determining vegetation distribution in seasonally flooded wetland. Poyang Lake, the largest freshwater lake in China, has been encountering dramatic changes in hydrological conditions in last decade, which greatly influenced the wetland vegetations. To explore the relationships between hydrology and vegetation distribution, water-table depth, soil moisture, species composition, diversity and biomass were measured at a seasonally flooded wetland section at Wucheng National Nature Reserve. Three plant communities, Artemisia capillaris, Phragmites australis and Carex cinerascens communities, were examined which are zonally distributed from upland to lakeshore with decreasing elevation. Canonical correspondence analysis(CCA), spearmen correlation and logistic regression were adopted to analyze the relationships between vegetation characteristics and hydrological variables of water-table depth and soil moisture. Results show that significant hydrological gradient exist along the wetland transect. Water-table demonstrates a seasonal variation and is consistently deepest in A. capillaris community(ranging from –0.5 m above ground to +10.3 m below ground), intermediate in P. australis community(–2.6 m to +7.8 m) and shallowest in C. cinerascens community(–4.5 m to +6.1 m). Soil moisture is lowest and most variable in A. capillaris community, highest and least variable in P. australis community, and intermediate and moderate variable in C. cinerascens community. The CCA ordination indicated that variables of water-table depth and soil moisture are strongly related to community distribution, which explained 81.7% of the vegetation variations. Species diversity indices are significantly positively correlated with soil moisture and negatively correlated with moisture variability, while above- and belowground biomass are positively correlated with moisture. Above- and belowground biomass present Gaussian models along the gradient of average water-table depth in growing season, while species diversity indices show bimodal patterns. The optimal average water-table depths for above- and belowground biomass are 0.8 m and 0.5 m, respectively, and are 2.2 m and 2.4 m for species richness and Shannon-Wiener indices, respectively. Outcomes of this work improved the understandings of the relationship between hydrology and vegetation. | XU Xiuli ZHANG Qi TAN Zhiqiang LI Yunliang WANG Xiaolong | 2015 | Chinese Geographical Science2015，25，6： | 24 |
| 2 | Artificial intelligence in drug design显示文摘Thanks to the fast improvement of the computing power and the rapid development of the computational chemistry and biology,the computer-aided drug design techniques have been successfully applied in almost every stage of the drug discovery and development pipeline to speed up the process of research and reduce the cost and risk related to preclinical and clinical trials.Owing to the development of machine learning theory and the accumulation of pharmacological data, the artificial intelligence(AI) technology, as a powerful data mining tool, has cut a figure in various fields of the drug design, such as virtual screening,activity scoring, quantitative structure-activity relationship(QSAR) analysis, de novo drug design, and in silico evaluation of absorption, distribution, metabolism, excretion and toxicity(ADME/T) properties. Although it is still challenging to provide a physical explanation of the AI-based models, it indeed has been acting as a great power to help manipulating the drug discovery through the versatile frameworks. Recently, due to the strong generalization ability and powerful feature extraction capability,deep learning methods have been employed in predicting the molecular properties as well as generating the desired molecules,which will further promote the application of AI technologies in the field of drug design. | Feisheng Zhong Jing Xing Xutong Li Xiaohong Liu Zunyun Fu Zhaoping Xiong Dong Lu Xiaolong Wu Jihui Zhao Xiaoqin Tan Fei Li Xiaomin Luo Zhaojun Li Kaixian Chen Mingyue Zheng Hualiang Jiang | 2018 | Science China(Life Sciences)2018，61，10： | 10 |
| 3 | Mass production of 2D materials by intermediate-assisted grinding exfoliation显示文摘The scalable and high-efficiency production of 2D materials is a prerequisite to their commercial use.Currently,only graphene and graphene oxide can be produced on a ton scale,and the inability to produce other 2D materials on such a large scale hinders their technological applications.Here we report a grinding exfoliation method that uses micro-particles as force intermediates to resolve applied compressive forces into a multitude of small shear forces,inducing the highly efficient exfoliation of layer materials.The method;referred to as intermediate-assisted grinding exfoliation(iMAGE);can be used for the large-scale production of many 2D materials.As an example;we have exfoliated bulk h-BN into 2D h-BN with large flake sizes;high quality and structural integrity,with a high exfoliation yield of 67%,a high production rate of 0.3 g h^-1 and a low energy consumption of 3.01 x 106 J g^-1.The production rate and energy consumption are one to two orders of magnitude better than previous results.Besides h-BN,this iMAGE technology has been used to exfoliate various layer materials such as graphite,black phosphorus,transition metal dichalcogenides;and metal oxides;provings universality.Molybdenite concentrate,a natural low-cost and abundant mineral;was used as a demo for the large-scale exfoliation production of 2D M0S2 flakes.Our work indicates the huge potential of the iMAGE method to produce large amounts of various 2D materials;which paves the way for their commercial application. | Chi Zhang Junyang Tan Yikun Pan Xingke Cai Xiaolong Zou Hui-Ming Cheng Bilu Liu | 2020 | National Science Review2020，7，2： | 10 |
| 4 | Electroacupuncture at Tianshu (ST 25) for diarrhea-predominant irritable bowel syndrome using positron emission tomography Changes in visceral sensation center显示文摘Previous studies have demonstrated that electroacupuncture therapy is effective in the treatment of irritable bowel syndrome. However, the precise mechanism of this therapy is unknown. The present study served to investigate the effects of electroacupuncture therapy on treatment of patients with diarrhea-predominant irritable bowel syndrome (IBS). We compared brain activation maps based on the changes of cerebral glucose metabolism obtained by 18-fluorodeoxyglucose positron emission tomography scanning under three conditions: resting, rectal balloon distension and rectal balloon distension plus electroacupuncture. Under the resting condition, compared with healthy controls, IBS patients displayed an increasing regional cerebral metabolic rate of glucose over a wide range: bilateral superior temporal gyrus, right middle occipital gyrus, superior frontal gyrus and bilateral middle frontal gyrus. However, there was no significant activity in the visceral pain center. Compared with the resting condition, under the rectal balloon distension condition, patients with IBS had a greater regional cerebral metabolic rate of glucose in the prefrontal cortex, left anterior cingulate cortex, postcentral gyrus, precentral gyrus and temporal gyrus. Under the rectal balloon distension plus electroacupuncture condition, stimulation by electroacupuncture at Tianshu (ST 25) manifested a decreased regional cerebral metabolic rate of glucose in the left cingulate gyrus, right insula, right caudate nucleus, fusiform gyrus and hippocampal gyrus. Electroacupuncture therapy relieved abdominal pain, distension or discomfort by decreasing glucose metabolism in the brain. | Huirong Liu Li Qi Xiaolong Wang Yihui Guan Chuantao Zuo Linying Tan Lingsong Yuan Xiaopeng Ma Xiaomei Wang Enhua Zhou Huangan Wu | 2010 | Neural Regeneration Research2010，5，16： | 6 |
| 5 | Development of EST-SSR primers and their practicability test for Laminaria显示文摘Laminaria (Saccharina) is one of the economic important seaweeds.Through sequence analysis of 4 099 ESTs from Laminaria (971 were generated from our own cDNA laboratories and 3 128 were downloaded from updated EST databases) with SSRIT software,two hundred and fifty-four SSRs in 206 ESTs were found.From the 254 SSRs,sixty-three SSR primer-pairs were designed. In order to test their practicability, the 63 primer-pairs were tested in commonly used SSR reaction conditions using 12 Laminara DNA samples as templates. The results show that 23 SSR primer-pairs gave good amplification patterns on most (more than 80%) of the 12 Laminara DNA templates. Genetic diversity study of 12 Laminaria lines,which were widely used in breeding and economic cultivation in China,was performed based on the obtained SSR data. | WANG Guoliang TAN Xiaolong SHEN Junling LI Jian ZHANG Lei SUN Jianwei WANG Bin WENG Manli LIU Tao | 2011 | Acta Oceanologica Sinica2011，30，3： | 3 |
| 6 | MicroRNA-195a-5p inhibits mouse medullary thymic epithelial cells proliferation by directly targeting Smad7显示文摘MiR-195 在在肿瘤的不同类型禁止房间增长被含有。它是否贡献 thymic 的过程上皮的房间(侦探) 增长仍然保持不清楚。在这研究,我们发现 miR-195a-5p 在从变老的老鼠孤立的侦探是高度起来调整的。进一步的实验证明 miR-195a-5p 模仿禁止的 transfection 老鼠的增长髓的 thymic 第 1 行上皮的房间(MTEC1 ) ,而在 MTEC1 的 miR-195a-5p 禁止者的 transfection 有相反的效果。另外, miR-195a-5p 没在 MTEC1 apoptosis 上有明显的效果。而且, Smad7,转变生长因素小径的一个否定管理者,被酶试金作为 miR-195a-5p 的一个直接目标证实。一起拿,我们的结果显示 miR-195a-5p 禁止 MTEC1 增长,至少部分地,经由 Smad7 的下面规定。 | Dongguang Guo Yaqiong Ye Junjie Qi Lifeng Xu Lihua Zhang Xiaolong Tan Zhigang Tan Xiaofang Yu Yuan Zhang Yongjiang Ma Yugu Li | 2016 | Acta Biochimica et Biophysica Sinica2016，48，3： | 3 |
| 7 | B cell-derived anti-beta 2 glycoprotein I antibody mediates hyperhomocysteinemia-aggravated hypertensive glomerular lesions by triggering ferroptosis显示文摘Hyperhomocysteinemia(HHcy)is a risk factor for chronic kidney diseases(CKDs)that affects about 85%CKD patients.HHcy stimulates B cells to secrete pathological antibodies,although it is unknown whether this pathway mediates kidney injury.In HHcytreated 2-kidney,1-clip(2K1C)hypertensive murine model,HHcy-activated B cells secreted anti-beta 2 glycoprotein I(β2GPI)antibodies that deposited in glomerular endothelial cells(GECs),exacerbating glomerulosclerosis and reducing renal function.Mechanistically,HHcy 2K1C mice increased phosphatidylethanolamine(PE)(18:0/20:4,18:0/22:6,16:0/20:4)in kidney tissue,as determined by lipidomics.GECs oxidative lipidomics validated the increase of oxidized phospholipids upon Hcy-activated B cells culture medium(Hcy-B CM)treatment,including PE(18:0/20:4+3[O],PE(18:0a/22:4+1[O],PE(18:0/22:4+2[O]and PE(18:0/22:4+3[O]).PE synthases ethanolamine kinase 2(etnk2)and ethanolamine-phosphate cytidylyltransferase 2(pcyt2)were increased in the kidney GECs of HHcy 2K1C mice and facilitated polyunsaturated PE synthesis to act as lipid peroxidation substrates.In HHcy 2K1C mice and Hcy-B CM-treated GECs,the oxidative environment induced by iron accumulation and the insufficient clearance of lipid peroxides caused by transferrin receptor(TFR)elevation and down-regulation of SLC7A11/glutathione peroxidase 4(GPX4)contributed to GECs ferroptosis of the kidneys.In vivo,pharmacological depletion of B cells or inhibition of ferroptosis mitigated the HHcy-aggravated hypertensive renal injury.Consequently,our findings uncovered a novel mechanism by which B cell-derived pathogenic anti-β2GPI IgG generated by HHcy exacerbated hypertensive kidney damage by inducing GECs ferroptosis.Targeting B cells or ferroptosis may be viable therapeutic strategies for ameliorating lipid peroxidative renal injury in HHcy patients with hypertensive nephropathy. | Xing Du Xiaolong Ma Ying Tan Fangyu Shao Chun Li Yang Zhao Yutong Miao Lulu Han Guohui Dang Yuwei Song Dongmin Yang Zhenling Deng Yue Wang Changtao Jiang Wei Kong Juan Feng Xian Wang | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 2 |
| 8 | Biodegradable lubricating mesoporous silica nanoparticles for osteoarthritis therapy显示文摘Osteoarthritis is characterized by lubrication failure of the articular cartilage and severe inflammation of the joint capsule.Lubricating mesoporous silica nanoparticles(MSNs)have been developed for the treatment of osteoarthritis based on enhanced lubrication and local drug delivery.However,MSNs are difficult to degrade in vivo in a short time,resulting in potential toxic effect due to bioaccumulation.In this study,biodegradable MSNs(bMSNs)were prepared through an oil–water biphase stratification method,and modified with poly(2-methacryloyloxyethyl phosphocholine)(PMPC)to synthesize lubricating drug-loaded nanoparticles(bMSNs–NH_(2)@PMPC)by photopolymerization.The in vitro degradation test demonstrated that the bMSNs and bMSNs–NH_(2)@PMPC almost degraded within 7 days.The tribiological test showed that the lubrication property of the bMSNs–NH2@PMPC was greatly improved,with a reduction of 50%in the friction coefficient(COF)compared with the bMSNs.It was attributed to hydration lubrication mechanism by which a tenacious hydration layer is formed surrounding the zwitterionic headgroups(N+(CH_(3))^(3)and PO4-)in PMPC polyelectrolyte polymer.Additionally,the bMSNs–NH_(2)@PMPC maintained excellent lubrication property under degradation and achieved sustained drug release behavior compared with the bMSNs.In summary,the biodegradable bMSNs–NH2@PMPC developed in this study with the properties of enhanced lubrication and drug delivery may be a promising approach for osteoarthritis therapy. | Li WAN Yi WANG Xiaolong TAN Yulong SUN Jing LUO Hongyu ZHANG | 2022 | Friction2022，10，1： | 2 |
| 9 | The ap- plication of LabVIEW in data Acquisition system of solar absorption refrigerator 显示文摘 | Wang Lin Tan Yingying Cui Xiaolong | 2012 | Advanced Materials Re- search2012，，： | 1 |
| 10 | Metabolism of arachidonic acid by the cytochrome P450 enzyme in patientswith chronic Keshan disease and dilated cardiomyopathy显示文摘 | Bing Zhou Shulan He Xi Wang Xiaolong Zhen Xiaohui Su Wuhong Tan | 2016 | Biomedical Reports2016，，： | 1 |
| 11 | Tribological properties of Ni-based alloy composite coating modified by both graphite and TiC partieles显示文摘 | CA1 Bin TAN Yefa WANG Xiaolong | 2011 | Transaction of Nonfer rous Metals Society of China2011，2，11： | 1 |
| 12 | Over‐expression of circadian clock gene Bmal1 affects proliferation and the canonical Wnt pathway in NIH‐3T3 cells显示文摘 | Fuwei Lin Yijia Chen Xiaolong Li Qing Zhao Zhen Tan | 2012 | Cell Biochem Funct2012，，2： | 1 |
| 13 | Preparation of Na-zeolite with Kaolinite for Wastewater Treatment显示文摘Kaolinite as a raw material was modified to prepare a Na-zeolite product via calcination and alkaline treatment. According to the measurement of the cation-exchange capacity, the prepared Na-zeolite product with an ammonium ion-exchange capacity of >75 mg/g can be used to remove ammonia nitrogen in water. The Na-zeolite products were characterized by scanning electron microscopy, infrared spectroscopy and X-ray diffraction, respectively. The refinement of the structure was simulated by a software named Full Prof. The results show that the Si–O stretching vibrations of the prepared product in the range of 1008–1115 cm–1 disappear, only a small bend appears at 1103 cm–1 and the Al–OH vibration peaks at 912 cm–1 and 940 cm–1 both disappear. It is indicated that after calcination and alkaline treatment, the Si–O tetrahedral and Al–O octahedral structures are severely damaged, resulting in changes in the flexural vibrations of Si–O and Al–OH. Kaolinite is a lamellar structure with the space group of C1, classified into a triclinic system, and cell parameters(such as a=0.5154 nm, b=0.8941 nm, and c=0.74 nm). Kaolinite with a lamellar structure is completely dissolved after calcination and alkaline treatment, resulting in the formation of Na-zeolite with a cage cubic structure. | LIU Qiongqiong TAN Xin SHAO Xiaolong | 2015 | Journal of the Chinese Ceramic Society2015，，1： | 1 |
| 14 | Energy-Efficient Target Channel Sequence Design for Spectrum Handoffs in Cognitive Radio Networks显示文摘Cognitive radio is considered as an efficient way to improve the spectrum efficiency. As one of its key technologies,spectrum handoff can guarantee the transmission continuity of secondary users(SUs). In this paper,we address a new and more generalized spectrum handoff problem in cognitive radio networks(CRNs),by considering simultaneously energy efficiency,multiple spectrum handoffs and multiple channels. Furthermore,effects of the primary users'(PUs')arrival and service rate on the target channel sequence selection are also considered. In order to obtain the energy-efficient target channel sequence,we firstly analyze the energy consumption and the number of delivered bits per hertz in the spectrum handoff process,and formulate a ratio-type energy efficiency optimization problem,which can be transformed into a parametric problem by utilizing fractional programming. Then,we propose an algorithm combining dynamic programming with bisection(DPB)algorithm to solve the energy efficiency optimization problem. Our simulation results verify that the designed target channel sequence has better performance than the existing algorithms in terms of energy efficiency. | Xiaolong Yang Xuezhi Tan | 2017 | China Communications2017，14，5： | 1 |
| 15 | Effect of partitioning procedure on microstructure and mechanical properties of a hot-rolled directly quenched and partitioned steel 显示文摘 | Tan Xiaodong Xu Yunbo Yang Xiaolong | 2014 | Materials Science and Engineering: A2014，594，31： | 1 |
| 16 | Fe3Oa-Au@ mesoporous SiO2 microspheres: an ideal artificial enzymatic cascade system 显示文摘 | He Xiaolong Tan Longfei Chen Dong | 2013 | Chem Commun2013，49，41： | 1 |
| 17 | High-timing-precision detection of single X-ray photons by superconducting nanowires显示文摘Precisely acquiring the timing information of individual X-ray photons is important in both fundamental research and practical applications. The timing precision of commonly used X-ray single-photon detectors remains in the range of one hundred picoseconds to microseconds. In this work, we report on high-timing-precision detection of single X-ray photons through the fast transition to the normal state from the superconductive state of superconducting nanowires. We successfully demonstrate a free-running X-ray single-photon detector with a timing resolution of 20.1 ps made of 100-nm-thick niobium nitride film with an active area of 50 μm by 50 μm. By using a repeated differential timing measurement on two adjacent X-ray single-photon detectors, we demonstrate a precision of 0.87 ps in the arrival-time difference of X-ray photon measurements. Therefore, our work significantly enhances the timing precision in X-ray photon counting, opening a new niche for ultrafast X-ray photonics and many associated applications. | Shuya Guo Jingrou Tan Hengbin Zhang Jinguang Wang Tianhao Ji Labao Zhang Xiaolong Hu Jian Chen Jun Xie Kai Zou Yun Meng Xiaomin Bei Ling-An Wu Qi Chen Hao Wang Xuecou Tu Xiaoqing Jia Qing-Yuan Zhao Lin Kang Peiheng Wu | 2024 | National Science Review2024，11，1： | 0 |
| 18 | Research on the Reform of the Course“Reading of Concrete Structure Plan and Construction Drawings”Under the Background of“Promoting Teaching and Learning Through Competitions”显示文摘The inherent teaching approach can no longer meet the demands of society.In this paper,current issues within the teaching landscape of architectural engineering technology in higher vocational colleges as well as the policies and teaching demands that formed the basis of this model were analyzed.The study shows the importance of the implementation of the teaching model“promoting teaching and learning through competitions.”This model puts emphasis on the curriculum and teaching resources,while also integrating the teaching process and evaluation with competition.These efforts aim to drive education reform in order to better align with the objectives of vocational education personnel training,while also acting as a reference for similar courses. | Guixiang Yu Xiaolong Tan | 2023 | Journal of Architectural Research and Development2023，7，4： | 0 |
| 19 | Deformation pre-compensated optimization design of cam ring for low pulsation hydraulic motors显示文摘Cam-lobe radial-piston hydraulic motors are widely used in large machinery due to their excellent capability to withstand high loading at low speed.However,the line contact between the roller and cam ring generates elastic deformation of the cam ring under high loading,leading to obvious speed and torque pulsations and even the detrimental crawl problem of hydraulic motors.To address this issue,we propose a deformation pre-compensated optimization design approach to compensate for the cam ring deformation in advance,thereby eliminating the influence of cam ring deformation on the hydraulic motor’s pulsation.In this approach,the design process is divided into two steps:first,the overall profile of the cam ring is optimized based on the calculated elastic deformation;second,the local profile of cam ring is further optimized until the hydraulic motor’s pulsations no longer reduce.Finally,a case study is carried out to verify the effectiveness of this approach.The result indicates the pulsation rate of a deformation pre-compensated cam ring is 40%lower than that of an uncompensated one.This study offers an easy and feasible way to design an optimized cam ring profile for low pulsation hydraulic motors. | Chao ZHANG Hao TAN Yu FANG Xiaolong ZHANG Yu YANG Yiman DUAN Min HAN Shaojian CUI Bing XU Junhui ZHANG | 2023 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2023，24，2： | 0 |
| 20 | Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma显示文摘Detailed characterizations of genomic alterations have not identified subtype-specific vulnerabilities in adult gliomas. Mapping gliomas into developmental programs may uncover new vulnerabilities that are not strictly related to genomic alterations. After identifying conserved gene modules co-expressed with EGFR or PDGFRA (EM or PM), we recently proposed an EM/PM classification scheme for adult gliomas in a histological subtype- and grade-independent manner. By using cohorts of bulk samples, paired primary and recurrent samples, multi-region samples from the same glioma, single-cell RNA-seq samples, and clinical samples, we here demonstrate the temporal and spatial stability of the EM and PM subtypes. The EM and PM subtypes, which progress in a subtype-specific mode, are robustly maintained in paired longitudinal samples. Elevated activities of cell proliferation, genomic instability and microenvironment, rather than subtype switching, mark recurrent gliomas. Within individual gliomas, the EM/PM subtype was preserved across regions and single cells. Malignant cells in the EM and PM gliomas were correlated to neural stem cell and oligodendrocyte progenitor cell compartment, respectively. Thus, while genetic makeup may change during progression and/or within different tumor areas, adult gliomas evolve within a neurodevelopmental framework of the EM and PM molecular subtypes. The dysregulated developmental pathways embedded in these molecular subtypes may contain subtype-specific vulnerabilities. | Jing Feng Zheng Zhao Yanfei Wei Zhaoshi Bao Wei Zhang Fan Wu Guanzhang Li Zhiyan Sun Yanli Tan Jiuyi Li Yunqiu Zhang Zejun Duan Xueling Qi Kai Yu Zhengmin Cong Junjie Yang Yaxin Wang Yingyu Sun Fuchou Tang Xiaodong Su Chuan Fang Tao Jiang Xiaolong Fan | 2023 | Frontiers of Medicine2023，17，2： | 0 |
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