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| 1 | Role of ABC transporters in cancer chemotherapy显示文摘Multidrug resistance(MDR) in cancer cells can significantly attenuate the response to chemotherapy and increase the likelihood of mortality.The major mechanism involved in conferring MDR is the overexpression of ATP-binding cassette(ABC) transporters,which can increase efflux of drugs from cancer cells,thereby decreasing intracellular drug concentration.Modulators of ABC transporters have the potential to augment the efficacy of anticancer drugs.This editorial highlights some major findings related to ABC transporters and current strategies to overcome MDR. | Sun, Yue-Li Patel, Atish Kumar, Priyank Chen, Zhe-Sheng | 2012 | Chinese Journal of Cancer2012，31，2： | 10 |
| 2 | 小P值并不能保证可靠结果:以帕金森病的静息态脑功能成像元分析为例显示文摘Thousands of resting state functional magnetic resonance imaging(RS-f MRI)articles have been published on brain disorders.For precise localization of abnormal brain activity,a voxel-level comparison is needed.Because of the large number of voxels in the brain,multiple comparison correction(MCC)must be performed to reduce false positive rates,and a smaller P value(usually including either liberal or stringent MCC)is widely recommended[1]. | 贾熙泽 赵娜 董昊铭 孙家伟 Marek Barton Roxana Burciu Nicolas Carrière Antonio Cerasa 陈博宇 陈俊 Stephen Coombes Luc Defebvre Christine Delmaire Kathy Dujardin Fabrizio Esposito 范国光 Federica Di Nardo 冯怡萱 Brett W.Fling Saurabh Garg Moran Gilat Martin Gorges Shu-Leong Ho Fay B.Horak 胡晓 胡晓飞 黄飚 黄沛钰 贾泽娟 Christina Jones Jan Kassubek Lenka Krajcovicova Ajay Kurani 李静 李晴 刘爱萍 刘波 刘虎 刘卫国 Renaud Lopes 娄毓婷 罗巍 Tara Madhyastha 毛妮妮 Grainne McAlonan Martin J.McKeown Shirley Pang Andrea Quattrone Irena Rektorova Alessia Sarica 商慧芳 James M.Shine Priyank Shukla Tomas Slavicek 宋潇鹏 Gioacchino Tedeschi Alessandro Tessitore David Vaillancourt 王健 王珏 Z.Jane Wang 魏鲁庆 邬霞 徐晓俊 闫磊 杨靓 杨万群 姚乃琳 张得龙 张久权 张敏鸣 张艳玲 周彩红 严超赣 左西年 Mark Hallett 吴涛 臧玉峰 | 2021 | Science Bulletin2021，66，21： | 3 |
| 3 | Comparison of in-hospital outcomes between octogenarians and nonagenarians undergoing transcatheter aortic valve replacement: a propensity matched analysis显示文摘BackgroundAortic 阀门狭窄(作为) 在在 80 年上面的老病人是很普通的。在如此的病人的 Transcatheter 大动脉的阀门代替(TAVR ) 逐渐地正在被执行。寻求在与严重 AS.MethodThe 学习人口经历 TAVR 的九十至九十九岁的人估计死亡的 octogenarians 和九十至九十九岁的人和预言者之间的在里面医院结果差别的这研究从国家住院病人样品(网络信息服务) 被导出 2012-2014 使用 ICD-9 厘米过程为 TAVR 编码 35.05 和 35.06 的年。低于 80 岁的住院被排除。在执行倾向 20 以后匹配(1:2 ) ,在里面医院结果在匹配的队被比较。然后, multivariate 模型被开发在 nonagenarians.ResultsThere 分析在里面医院死亡的预言者是 11,630 个住院在八十至八十九岁并且在九十至九十九岁的人组的 5815 个住院。在里面医院死亡的主要结果(6% 对 4.1% , P 0.001 ) 在与 octogenarians 相比的九十至九十九岁的人是更高的。第二等的结果包括击(3.4%对2.8%, P 0.001 ),肾的失败(18.9%对17.3%, P 0.001 ),输血(35%对32.6%, P 0.001 ),脉管的复杂并发症(4.5%对3.5%, P 0.001 ),并且心律调整器培植(27.8%对24.8%, P 0.001 )在九十至九十九岁的人是更高的。在他们停留的长度没有差别。中部的费用(70,374 $ 对 65,381 $ , P 0.001 ) 与 nonagenarian.ConclusionsAlthough 在里面医院是稍微更高的死亡在九十至九十九岁的人是稍微更高的,它是可接受的。在死亡的这差别被更高的复杂并发症部分至少在九十至九十九岁的人解释。努力应该被成为能进一步在在这些组之间的在里面医院死亡缩小差别的复杂并发症到减少。 | Rajkumar Doshi Vaibhav Patel Priyank Shah | 2018 | Journal of Geriatric Cardiology2018，15，2： | 2 |
| 4 | Giant Dissecting Aortic Aneurysm in an Asymptomatic Young Male显示文摘 | Priyank Shah Nishant Gupta Irvin Goldfarb Fayez Shamoon Atila Iyisoy | 2015 | Case Reports in Vascular Medicine2015，，： | 1 |
| 5 | The changes in flexural properties and microstructures of carbon fiber bismaleimide composite after exposure to a high temperature显示文摘 | MOHAMMAD H H PRIYANK U SAMIT R | 2014 | Composite Structures2014，108，： | 1 |
| 6 | Testing a small detailed chemical-kinetic mechanism for the combustion of hydrogen and carbon monoxide显示文摘 | PRIYANK S WILLIAMAS F A | 2006 | Combustion and Flame2006，145，1： | 1 |
| 7 | Seismic characterization of a gas hydrate system in the Gulf of Mexico using wide-aperture data显示文摘 | Jaiswal Priyank Zelt | 2006 | Geophysical Journal International2006，165，1： | 1 |
| 8 | Testing a small detailed chemical-kinetic mechanism for the combustion of hydrogen and carbon monoxide显示文摘 | Priyank S Williams F A | 2006 | Combustion and Flame2006，145，1： | 1 |
| 9 | Hydromorphone efficacy and treatment protocol impact on tolerance and μ-opioid receptor regulation显示文摘 | Priyank Kumar Soujanya Sunkaraneni Sunil Sirohi Shveta V. Dighe Ellen A. Walker Byron C. Yoburn | 2008 | European Journal of Pharmacology2008，，1： | 1 |
| 10 | Sublingual route for the systemic de- livery of Ondansetrun 显示文摘 | Priyank P Sandip M Urvish J | 2011 | Int J Drug Dev Res2011，4，3： | 1 |
| 11 | Collaborative Spectrum Sensing in the Presence of Byzantine Attacks in Cognitive Radio Networks显示文摘 | Ankit Singh Rawat Priyank Anand Hao Chen | 2011 | IEEE Transactions on Signal Processing2011，59，2： | 1 |
| 12 | Seismic characterization of a gas hydrate system in the Gulf of Mexico using wide-aperture data显示文摘 | Jaiswal Priyank Zelt Colin A Pecher Ingo A | 2006 | Geophysical Journal International2006，165，1： | 1 |
| 13 | Effect of SARS-CoV-2 infection on the liver显示文摘There have been numerous concerns about the disease and how it affects the human body since the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)pandemic began in December 2019.The impact of SARS-CoV-2 on the liver is being carefully investigated due to an increase in individuals with hepatitis and other liver illnesses,such as alcoholic liver disease.Additionally,the liver is involved in the metabolism of numerous drugs used to treat comorbidities and coronavirus disease 2019(COVID-19).Determining how SARS-CoV-2 affects the liver and what factors place individuals with COVID-19 at a higher risk of developing liver problems are the two main objectives of this study.This evaluation of the literature included research from three major scientific databases.To provide an update on the current impact of COVID-19 on the liver,data was collected and relevant information was incorporated into the review.With more knowledge about the effect of the disease on the liver,better management and therapeutics can be developed,and education can ultimately save lives and reduce the long-term impact of the pandemic on our population. | Adekunle Sanyaolu Aleksandra Marinkovic Abu Fahad Abbasi Stephanie Prakash Risha Patidar Priyank Desai Martina Williams Abdul Jan Kareem Hamdy Rachael Solomon Vyshnavy Balendra Maaz Ansari Omar Shazley Nasar Khan Rochelle Annan Yashika Dixon Chuku Okorie Afolabi Antonio | 2023 | World Journal of Virology2023，12，2： | 0 |
| 14 | Long term outcomes of Cohen’s cross trigonal reimplantation for primary vesicoureteral reflux in poorly functioning kidney显示文摘BACKGROUND Open ureteric reimplantation by cross trigonal technique described by Cohen is considered a common surgical option for correction of vesicoureteral reflux(VUR). There is a lack of evidence in literature though for what happens to such kidneys, in the long run, particularly those which are poorly functioning.AIM To assess the long-term outcomes of ureteric reimplantation in poorly functioning kidneys in children with unilateral primary VUR.METHODS Children with unilateral primary VUR and a relative renal function of less than 35% who underwent open or laparoscopic ureteric reimplantation between January 2005 and January 2017 were included in the study. Patients who had a follow up of less than five years were excluded. Preoperative evaluation consisted of a voiding cystourethrogram and Dimercaptosuccinic acid(DMSA) scan. In the follow-up period, patients underwent a diuretic scan at 6 weeks and 6 months.Follow up ultrasound was done for change in grade of hydronephrosis and retrovesical ureteric diameter. Subsequent follow up was done at 6 monthly intervals with evaluation for proteinuria and hypertension and any recurrent urinary tract infection(UTI). For assessment of cortical function, DMSA was repeated annually for 5 years after surgery. A paired-samples t-test was used to test the mean difference of DMSA between pre-post observations.RESULTS During this period, 36 children underwent ureteric reimplantation for unilateral primary VUR. After excluding those with insufficient follow-up, 31 were included in the analysis. Most of the patients were males(n = 26/31, 83.8%). Patient’s age(mean ± SD, range) was 5.21 ± 3.71, 1-18 years. The grades of VUR were grade Ⅱ(1patient), grade Ⅲ(8 patients), grade Ⅳ(10 patients), and grade Ⅴ(12 patients). The pre and postoperative DMSA was 24.064 ± 12.02 and 24.06 ± 10.93, which was almost the same(statistically equal, paired-samples t-test: P = 0.873). The median(range) follow-up duration was 82(60-120)mo. One patient had persistent reflux after surgery(preoperative: grade Ⅳ, postoperative: grade Ⅲ), and the very same patient developed recurrent UTI. The difference in the preoperative and postoperative DRF was less than 10% in 29 patients. In one patient, the DRF decreased by 17%(22% to 05%) while in another patient, the DRF increased by 12%(25% to 37%) after surgery. None of the patients had an increase in scarring after surgery. 15% of patients were hypertensive before surgery and all of them continued to be hypertensive after surgery while none developed hypertension after surgery. None of the patients had significant proteinuria(> 150 mg/d) during the follow-up period.CONCLUSION Children with unilateral primary VUR and poorly functioning kidney maintain the renal function over the long term in most cases. Hypertension and proteinuria do not progress over time in these patients. | Mohd Sualeh Ansari Ravi Banthia Shrey Jain Vinay N Kaushik Nayab Danish Priyank Yadav | 2023 | World Journal of Clinical Cases2023，11，16： | 0 |
| 15 | Effect of multiple rings on side force over an ogive-cylinder body at subsonic speed显示文摘Experiments and computations were performed over an ogive-cylinder body having an lift-to-drag ratio of 16 at a diameter Reynolds number of 29000. The side force on the slender body augments with increasing angles of attack for the case without a ring. This increase was mainly due to the increase in the asymmetry of the existing vortex pair in the wake of the body. Attempts were made to completely reduce the existing side force at the angle of attack ranging from 35° to 45°.Three rectangular cross-sectioned circumferential rings having a height of 3% of the local diameter were placed at axial distances of 2.5, 3.5 and 4.5 times the base diameter from the tip of the body so as to reduce the side force. The results obtained indicate that inclusion of three rings completely alleviated the side force on the slender body at the angle of attack ranging from 0° to 45°. The presence of rings was found to alter the growth of the vortices that helped in the reduction of the side force. Computations performed were in reasonable agreement with the experiments. | Priyank KUMAR J.K.PRASAD | 2018 | Chinese Journal of Aeronautics2018，31，6： | 0 |
| 16 | Stroke in COVID-19: a single-centre initial experience in a hotspot of the pandemic显示文摘Background COVID-19,caused by SARS-CoV-2,is a global pandemic that has been an immense burden on healthcare systems all over the world.These patients may be at higher risk for acute ischaemic stroke(AIS).We present our experience with AIS in patients with COVID-19.Methods We reviewed all patients admitted to our hospital during a 6-week period with a positive nasopharyngeal swab test for SARS-CoV-2.Among these patients,we identified AIS.We reviewed the demographics,clinical,laboratory,imaging characteristics,treatments received and outcomes of AIS in patients with COVID-19.Results We identified 683 patients admitted with COVID-19 during the study period,of which 20 patients had AIS.Large-vessel occlusion(LVO)was noted in 11 patients(55%).Intravenous alteplase was administered in four patients(20%)and mechanical thrombectomy was performed in five patients(25%).Respiratory symptoms preceded the onset of AIS in most of the patients(70%)by 1 to 21 days.Mortality in patients with AIS was 50%compared with 26%of all COVID-19 admissions.Most of these patients died due to non-neurological causes(70%).Three patients with AIS had clinical and imaging findings consistent with COVID-19,but were negative for multiple nasopharyngeal swab tests.Interpretation LVO was more common in patients with AIS and COVID-19.They had more severe disease and higher mortality rates.Most of the patients had respiratory symptoms preceding AIS by days to weeks.This could explain certain patients with clinical picture of COVID-19 but negative nasopharyngeal swab tests. | Ivo Bach Pratibha Surathi Nora Montealegre Osama Abu-Hadid Sara Rubenstein Sviatoslav Redko Siddharth Gupta Machteld Hillen Pratit Patel Priyank Khandelwal Adham Kamel | 2020 | Stroke & Vascular Neurology2020，5，4： | 0 |
| 17 | Thermophysical properties of iridium at finite temperature显示文摘The bulk properties of materials in an extreme environment such as high temperature and high pressure can be understood by studying anharmonic effects due to the vibration of lattice ions and thermally excited electrons.In this spirit,in the present paper,anharmonic effects are studied by using the recently proposed mean-field potential(MFP) approach and Mermin functional which arise due to the vibration of lattice ions and thermally excited electrons,respectively.The MFP experienced by a wanderer atom in the presence of surrounding atoms is constructed in terms of cold energy using the local form of the pseudopotential.We have calculated the temperature variation of several thermophysical properties in an extreme environment up to melting temperature.The results of our calculations are in excellent agreement with the experimental findings as well as the theoretical results obtained by using first principle methods.We conclude that presently used conjunction scheme(MFP+pseudo potential) is simple computationally,transparent physically,and accurate in the sense that the results generated are comparable and sometimes better than the results obtained by first principle methods.Local pseudopotential used is transferable to extreme environment without adjusting its parameters. | Priyank Kumar N K Bhatt P R Vyas V B Gohel | 2016 | Chinese Physics B2016，25，11： | 0 |
| 18 | Neurology:生物标志物突破可能改进帕金森病的治疗显示文摘在最近发表于《Neurology)期刊的研究中。佛罗里达大学(University of Florida)研究人员使用功能性磁共振成像(fMRI)来揭示帕金森病和相关疾病导致大脑活动进行性衰退的区域。这种追踪疾病进展的新型无创方法,可能有助于评估实验性疗法,从而延缓或停止疾病的发展。 | Roxana G. Burciu, PhD Jae Woo Chung, MSc Priyank Shukla, PhD Edward Ofori, PhD Hong Li, PhD Nikolaus R. McFarland, MD, PhD Michael S. Okun, MD David E. Vaillancourt, PhD | 2016 | 现代生物医学进展2016，16，32： | 0 |
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