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| 1 | Stroke mechanisms and outcomes of isolated symptomatic basilar artery stenosis显示文摘background While diffuse atherosclerotic disease affecting the posterior circulation has been described extensively,the prevalence,natural history and angiographic characteristics of isolated symptomatic basilar artery stenosis(ISBAS)remain unknown.Methods We reviewed our prospective institutional database to identify patients with≥50% symptomatic basilar artery(BA)stenosis without significant atherosclerotic burden in the vertebral or posterior cerebral arteries.Stroke mechanism,collateral circulation,and degree and length of stenosis were analysed.The primary outcome was time from index event to new transient ischaemic attack(TIA),acute ischaemic stroke(AIS)or death.Other outcome variables included modified Rankin Scale(mRS)score on discharge and last follow-up.results Of 6369 patients with AIS/TIA,91(1.43%)had ISBAS.Seventy-three(80.2%)patients presented with AIS and 18(19.8%)with TIA.Twenty-nine(31.9%)were women and the median age was 66.8±13.6 years.The mean follow-up time was 2.7 years.The most common stroke mechanism was artery-to artery thromboembolism(45.2%),followed by perforator occlusion(28.7%)and flow-dependent/hypoperfusion(15.1%).The percentage of stenosis was lower in patients who had favourable outcome compared with those with mRS 3-6 on discharge(78.3±14.3 vs 86.9±14.5,p=0.007).Kaplan-Meier curves showed higher recurrence/death rates in patients with≥80% stenosis,mid-basilar location and poor collateral circulation.Approximately 13% of patients with ISBAS presented with complete BA occlusion.Conclusion ISBAS is an uncommon(1.43%)cause of TIA and AIS.Men in their 60s are mostly affected,and artery-to artery embolism is the most common stroke mechanism.Mid-basilar location,≥80% stenosis and poor collateral circulation are important factors associated with worse prognosis. | Edgar A Samaniego Amir Shaban Santiago Ortega-Gutierrez Jorge A Roa David M Hasan Colin Derdeyn Biyue Dai Harold Adams Enrique Leira | 2019 | Stroke & Vascular Neurology2019，4，4： | 10 |
| 2 | 导致儿童期肥胖的生命早期危险因素:队列研究显示文摘目的确定早年(3岁以内)导致英国儿童肥胖的危险因素。设计前瞻性队列研究。方法Avon英国父母及儿童纵向调查研究。参与者参与队列研究的8234名年龄为7岁的儿童以及亚组的909名重点儿童,后者需额外提供与早期发育有关并涉及可能导致肥胖的各种资料。诊断标准7岁儿童体重指数≥95百分位确定为肥胖,参考1990年英国人口调查的诊断标准。结果经过最终验证,在假设的25项危险因素中有8项与肥胖有关:父母肥胖(父母双方校正后的相对危险度10.44,95%可信区间5.11~21.32);最早期(43个月内)的体重指数或体重反弹升高(校正后的相对危险度15.00,95%可信区间5.32~42.30);3岁时每周看电视的时间超过8小时(校正后的相对危险度1.55,95%可信区间1.13~2.12);追赶性生长(校正后的相对危险度2.60,95%可信区间1.09~6.16);8个月(校正后的相对危险度3.13,95%可信区间1.43~6.85)和18个月(校正后的相对危险度2.65,95%可信区间1.25~5.59)时体重的标准差值;1岁时体重增加值(校正后的相对危险度1.06,95%可信区间1.02~1.10,体重每增加100g);出生体重,每100g(校正后的相对危险度1.05,95%可信区间1.03~1.07);3岁时睡眠不足(<10.5小时,校正后的相对危险度1.45,95%可信区间1.10~1.89)。结论儿童期肥胖可能与8项危险因素有关。 | John J Reilly Julie Amstrong Ahmad R Dorosty Pauline M Emmett A Ness I Rogers Colin Steer Andrea Sherriff Children Study Team 冯凯 | 2005 | 英国医学杂志中文版2005，8，5： | 8 |
| 3 | Cardiotrophin 1 stimulates beneficial myogenic and vascular remodeling of the heart显示文摘出生后的心通过 hypertrophic 生长适应应力和超载,可能病理学或有益的一个过程(生理的肥大) 。生理的肥大改进心脏的性能在健康并且 diseased 个人,然而,宣传这有利改编的机制仍然保持糟糕定义。我们识别 cytokine cardiotrophin (CT1 ) 1 作为能够包括导致的导出 cardiomyocyte 的 angiogenic 信号的心肌层,和刺激的短暂、可逆的肥大概括心的生理的生长的特色的一个因素增加了由脉管形成。CT1 的能力从 caspase 激活的调停 CK2 的制止发源导致生理的肥大,阻止到无限制的病理学的生长的转变。外长的 CT1 蛋白质交货稀释了病理并且在正确的心失败的一个严格的模型恢复了可收缩的功能,建议为这难处理的心脏病的一种新奇处理选择。 | Mohammad Abdul-Ghani Colin Suen Baohua Jiang Yupu Deng Jonathan J Weldrick Charis Putinski Steve Brunette Pasan Femando Tom T Lee Peter Flynn Frans H H Leenen Patrick G Burgon Duncan J Stewar Lynn A Megeney | 2017 | Cell Research2017，27，10： | 8 |
| 4 | PrP^C-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site显示文摘铜绑定,抛锚膜的、细胞的 prion 蛋白质(PrPC ) 有二个组成的劈开地点生产不同 N 终端和 C 终端碎片(N1/C1 和 N2/C2 ) 。用表示也人的 PrPC,鼠标 PrPC 或鼠标 PrPC 的 RK13 房间带 3F4 epitope,这研究在 endoproteolytic 劈开和一个通常认为的 PrPC 函数上探索了 PrPC 主要顺序的影响,地图 kinase 信号 transduction,响应外长的铜与或没有使不安的膜环境。PrPC 主要顺序,特别在 N1/C1 劈开地点附近,看起来在这个地点和细胞外的调整信号的 kinase 1/2 (ERK1/2 ) phosphorylation 影响解朊作用的基础层次,与处理激活增加与基础 ERK1/2 表明一种反的关系。人的 PrPC 独自响应铜显示出增加的 N1/C1 劈开,由特定的 p38 和 JNK/SAPK phosphorylation 伴随了。到加扣押胆固醇的抗菌素 filipin 的铜的联合暴露导致了一只老鼠信号蛋白质 phosphorylation 的 PrPC 特定的实质的增加,由 N1/C1 劈开的增加伴随了。怀有人的 N1/C1 劈开地点的老鼠 PrPC 基础地并且响应铜假定更似人类的侧面并且改变了膜环境。我们的结果证明在 N1/C1 劈开地点附近的 PrPC 主要顺序影响在这个地点处理的 endoproteolytic,它显得连接了基础地并且响应铜印射 kinase 信号 transduction。进一步,主要顺序看起来响应外长的刺激在 PrPC 相关的信号 transduction 的忠实上授与 N1/C1 劈开和膜完整的相互的依赖。 | Cathryn L Haigh | 2009 | Cell Research2009，19，9： | 4 |
| 5 | Colonoscopy quality with Entonox? vs intravenous conscious sedation:18608 colonoscopy retrospective study显示文摘AIM To compare colonoscopy quality with nitrous oxide gas(Entonox?) against intravenous conscious sedation using midazolam plus opioid.METHODS A retrospective analysis was performed on a prospectively held database of 18608 colonoscopies carried out in Lothian health board hospitals between July 2013 and January 2016.The quality of colonoscopies performed with Entonox was compared to intravenous conscious sedation(abbreviated in this article as IVM).Furthermore,the quality of colonoscopies performed with an unmedicated group was compared to IVM.The study used the following key markers of colonoscopy quality:(1) patient comfort scores;(2) caecal intubation rates(CIRs); and (3) polyp detection rates (PDRs).We used binary logistic regression to model the data.RESULTS There was no difference in the rate of moderate-toextreme discomfort between the Entonox and IVM groups (17.9% vs 18.8%; OR = 1.06,95%CI: 0.95-1.18,P = 0.27).Patients in the unmedicated group were less likely to experience moderate-to-extreme discomfort than those in the IVM group(11.4% vs 18.8%; OR = 0.71,95%CI: 0.60-0.83,P < 0.001).There was no difference in caecal intubation between the Entonox and IVM groups(94.4% vs 93.7%; OR = 1.08,95%CI: 0.92-1.28,P = 0.34).There was no difference in caecal intubation between the unmedicated and IVM groups (94.2% vs 93.7%; OR = 0.98,95%CI: 0.79-1.22,P = 0.87).Polyp detection in the Entonox group was not different from IVM group (35.0% vs 33.1%; OR = 1.01,95%CI: 0.93-1.10,P = 0.79).Polyp detection in the unmedicated group was not significantly different from the IVM group (37.4% vs 33.1%; OR = 0.97,95%CI: 0.87-1.08,P = 0.60).CONCLUSION The use of Entonox was not associated with lower colonoscopy quality when compared to intravenous conscious sedation using midazolam plus opioid. | Alexander R Robertson Nicholas A Kennedy James A Robertson Nicholas I Church Colin L Noble | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，9： | 3 |
| 6 | Histological and molecular classification of gliomas显示文摘Rev Neurol (Paris). 2008 June-July;164(6-7):505-515. Epub 2008 Jun 10.Gliomas are the most frequent tumors of the central nervous system. The WHO classification, based on the presumed cell origin,distinguishes astrocytic,oligodendrocytic and mixed gliomas. A grading system is based on the presence of the following criteria: in- | Figarella-Branger D Colin C Coulibaly B Quilichini B Maues De Paula A Fernandez C Bouvier C | 2008 | 中国神经肿瘤杂志2008，6，2： | 3 |
| 7 | Long-term doxycycline-controlled expression of human tyrosine hydroxylase after direct adenovirus-mediated gene transfer to a rat model of Parkinson's disease显示文摘 | Corti O Sanchez-Capelo A Colin P | 1999 | Proc Natl Acad Sci USA1999，96，12： | 2 |
| 8 | Buckling and post-buckling of stressed straight-sided wrinkles: experimental AFM observations of bubbles formation and finite element simulations显示文摘 | G Parry C Coupeau J Colin A Cimetière J Grilhé | 2004 | Acta Materialia2004，，13： | 2 |
| 9 | 分离体验量表中文版信度和效度的初步研究显示文摘目的:探讨对住院精神障碍患者分离体验量表第二版(DES-II)中文版评定的信度和效度。方法:404例住院精神障碍患者进行分离体验量表的评定。6周后在初筛病例中随机抽取样本数20%进行量表重测。将DES-II量表初筛评定结果按得分高低随机排序并分组抽样:0~10分第一组抽取样本数的10%;10~20分第二组抽取30%;20~40分第三组抽取50%;40分以上第四组抽取100%。抽取99例样本进行DDIS量表评定,其中完成量表并符合分析要求量表80例,验证DES-II中文版和DDIS分量表的相关效度。结果:DES量表各项目与总分间的相关系数在0.566~0.728之间;DES-II中文版评定量表的Cronbach's的α系数为0.957;量表奇偶分半系数分别是0.843、0.883。6周后重测量表相关系数为0.617;DES得分分组的一致性Kappa值为0.549。DES量表因子分析结果表明,量表为单一因子的一维量表。对DDIS量表除外躯体性主诉和物质滥用之外所有的13个分量表和DES量表进行关联效度分析,DDIS分量表和DES得分相关系数在0.306~0.720之间,DDIS分量表得分相加的和DES因子分的相关系数为0.994。结论:分离体验量表DES-II中文版信度和效度较好,DES和DDIS各分量表的相关性较高。DES量表可以作为临床筛查的有效工具,具有临床和科研应用价值。 | 张璇 俞峻瀚 张叶文 Colin A Ross Benjamin Keyes 肖泽萍 | 2011 | 临床精神医学杂志2011，21，5： | 2 |
| 10 | Immunity:研究开发出最优的HIV疫苗递送模式显示文摘HIV已不再占据头条新闻。这主要是因为抗逆转录病毒药物的成功开发已将HIV病毒感染导致的艾滋病(AIDS)转化为一种慢性的可控制的疾病。然而。当前在全世界大约0.367亿名HIV感染者中,仅约一半的人能够获得控制这种病毒所需的药物。与此同时。新的HIV感染率持续保持在非常高的水平,这突出强调了需要开发一种预防性疫苗。然而,几十年来。 | Matthias Pauthner Colin Havenar-Daughton Devin Sok Joseph P. Nkolola Raiza Bastidas Archana V. Boopathy Diane G. Carnathan Abishek Chandrashekar Kimberly M. Cirelli Christopher A. Cottrell Alexey M. Eroshkin Javier Guenaga Kirti Kaushik Daniel W. Kulp Jinyan Liu Laura E. McCoy Aaron L. Oom Gabriel Ozorowski Kai W. Post Shailendra K. Sharma Jon M. Steichen Steven W. de Taeye Talar Tokatlian Alba Torrents de la Peña Salvatore T. Butera Celia C. LaBranche David C. Montefiori Guido Silvestri Ian A. Wilson Darrell J. Irvine Rogier W. Sanders William R. Schief Andrew B. Ward Richard T. Wyatt Dan H. Barouch Shane Crotty Dennis R. Burton | 2017 | 现代生物医学进展2017，17，27： | 2 |
| 11 | The 3-zones extended coherent flame model (ECFM3Z) for computing premixed/dif- fusion combustion 显示文摘 | Colin O Benkenida A | 2004 | Oil and Gas Science and Technol- ogy-Review IFP2004，59，6： | 1 |
| 12 | Ureteral and muhifocal tumours have worse prognosis than renal pelvic tumours in urothelial carcinoma of the upper urinary tract treated by nephroureterectomy 显示文摘 | OUZZANE A COLIN P XYLINAS E | 2011 | Eur Urol2011，60，6： | 1 |
| 13 | Mineralogy and Sedimentology of Pleistocene Sediment in the South China Sea (ODP Site 1144)显示文摘 | Boulay S Colin C Trentesaux A | 2003 | Proceedings of Ocean Program Scientific Results2003，184，： | 1 |
| 14 | Survey of background levels of PCDDs and PCDFs in UK soils显示文摘 | Colin S C Alwyn R F Ameera A H | 1989 | Chemosphere1989，18，16： | 1 |
| 15 | Erosional history of the eastern Tibetan Plateau since 190 kyr ago:clay mineralogical and geochemical investigations from the southwestern South China Sea显示文摘 | Liu Z Colin C Trentesaux A | 2004 | Marine Geology2004，209，： | 1 |
| 16 | The Effect of a Worksite Based Walking Program on Cardiovascular Risk in Previously Sedentary Civil Servants显示文摘 | Marie H M Elaine M M Colin A G B | 2006 | BM C Public Health2006，6，： | 1 |
| 17 | Confrontation of immunohistochemistry and fluores- cent in situ hybridization for the assessment of HER-2 /neu (c-erbb-2) status in urothelial carcinoma显示文摘 | De Pinieux G Colin D Vincent-Salomon A | 2004 | Virchows Arch2004，444，5： | 1 |
| 18 | Mineralogy and sedimentology of Pleistocene sediment in the South China Sea( ODP Site 1144) 显示文摘 | Boulay S Colin C Trentesanx A | 2004 | Proceedings of Ocean Program Scientific Results2004，211，： | 1 |
| 19 | Application of carbohydrases in extracting protein from rice bran显示文摘 | Anshamllah James A Hourigan Colin F Chesterman | | 0，，： | 1 |
| 20 | Cmeias color segmentation= an improved computing technology to process color images for quantitative microbial ecology studies at single cell res olution显示文摘 | Gross Colin A Reddy Chandan K Dazzo Frank B | 2010 | Microbial Ecology2010，59，40： | 1 |
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