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| 1 | Disease activity and cancer risk in inflammatory bowel disease associated with primary sclerosing cholangitis显示文摘AIM: To investigate the phenotype of inflammatory bowel disease associated with primary sclerosing cholangitis (PSC-IBD). METHODS: Data from 75 PSC-IBD patients evaluated in our tertiary center between 1963 and 2006 were collected and compared to 150 IBD patients without PSC, matched for sex, birth date, IBD diagnosis date and initial disease location regarding ileal, different colonic segments, and rectum, respectively. RESULTS: While PSC-IBD patients received more 5-aminosalicylates (8.7 years/patient vs 2.9 years/ patient, P < 0.001), they required less immuno-suppressors (24% vs 46% at 10 years; P < 0.001) and less intestinal resection (10% vs 44% at 10 years, P < 0.001). The 25-year cumulative rate of colectomy was 25.1% in PSC-IBD and 37.3% in controls (P = 0.004). The 25-year cumulative rate of colorectal cancer was 23.4% in PSC-IBD vs 0% in controls (P = 0.002). PSC was the only independent risk factor for the development of colorectal cancer (OR = 10.8; 95% CI, 3.7-31.3). Overall survival rate without liver transplantation was reduced in PSC-IBD patients (67% vs 91% in controls at 25 years, P = 0.001).CONCLUSION: This study confirms that patients with PSC-IBD have a particular disease phenotype independent of the initial disease location. Although their disease is less active and they use more 5-aminosalicylates, they present a higher risk of colorectal cancer. | Harry Sokol Jacques Cosnes Olivier Chazouilleres Laurent Beaugerie Emmanuel Tiret Raoul Poupon Philippe Seksik | 2008 | World Journal of Gastroenterology2008，14，22： | 10 |
| 2 | Controlled Attenuation Parameter (CAP): A Novel VCTE? Guided Ultrasonic Attenuation Measurement for the Evaluation of Hepatic Steatosis: Preliminary Study and Validation in a Cohort of Patients with Chronic Liver Disease from Various Causes显示文摘 | Magali Sasso Michel Beaugrand Victor de Ledinghen Catherine Douvin Patrick Marcellin Raoul Poupon Laurent Sandrin Véronique Miette | 2010 | Ultrasound in Medicine & Biology2010，，11： | 3 |
| 3 | Primary biliary cirrhosis显示文摘 | Lindor KD Gershwin ME Poupon R | | Hepatology0，，： | 2 |
| 4 | Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis显示文摘 | Christophe Corpechot Veronique Barbu Dominique Wendum Nils Kinnman Colette Rey Raoul Poupon Chantal Housset Olivier Rosmorduc | 2002 | Hepatology2002，，5： | 2 |
| 5 | Primary biliary cirrhosis: A 2010 update显示文摘 | Raoul Poupon | 2010 | Journal of Hepatology2010，，5： | 2 |
| 6 | Primary biliary cirrhosis显示文摘 | Keith D. Lindor M. Eric Gershwin Raoul Poupon Marshall Kaplan Nora V. Bergasa E. Jenny Heathcote | 2009 | Hepatology2009，，1： | 2 |
| 7 | Features associated with success rate and performance of fibroscan measurements for the diagnosis of cirrhosis in HCV patients: A prospective study of 935 patients显示文摘 | Adrien Kettaneh Patrick Marcellin Catherine Douvin Raoul Poupon Marianne Ziol Michel Beaugrand Victor de Lédinghen | 2006 | Journal of Hepatology2006，，4： | 2 |
| 8 | Chronic Hepatitis B Virus Carriers in the Immunotolerant Phase of Infection: Histologic Findings and Outcome显示文摘 | Tony Andreani Lawrence Serfaty Djamila Mohand Salem Dernaika Dominique Wendum Olivier Chazouillères Raoul Poupon | 2007 | Clinical Gastroenterology and Hepatology2007，，5： | 2 |
| 9 | Diffusion tensor imaging: concepts and applicatior显示文摘 | Le Brhan D Mangin JF Poupon C | 2001 | Magn Reson Imaging2001，13，4： | 1 |
| 10 | Diffusion tensor imaging:concepts and applications 显示文摘 | Le Bihan D Mangin J F Poupon C | 2001 | J Magn Reson Imaging2001，13，4： | 1 |
| 11 | Primary biliary cirrhosis 显示文摘 | LINDOR KD GERSHWIN ME POUPON R | 2009 | Hepatology2009，50，： | 1 |
| 12 | Diffusion tensor imaging: concepts and applications显示文摘 | Le Bihan D Mangin JF Poupon C | 2001 | J Magn Reson Imaging2001，13，4： | 1 |
| 13 | A contribution to electrical log interpretation in Shaly Sands显示文摘 | Poupon A Loy M E Tixier M P | 1963 | Journal of Petroleum Technology1963，6，6： | 1 |
| 14 | MDR3 gene defect in adults with symptomatic intrahepatic and gallbladder cholesterol cholelithiasis显示文摘 | Rosmorduc O Hermelin B Poupon R | 2001 | Gastroenterology2001，120，6： | 1 |
| 15 | Specificity and sensitivity of gp210 autoantibodies detected using an enzymelinked immunosorbent assay and a synthetic polypeptide in the diagnosis of primary biliary cirrhosis显示文摘 | Bandin O Courvalin JC Poupon R | 1996 | Hepatology1996，23，5： | 1 |
| 16 | MDR3 gene defect in adults with symptomatic intrahepatic and gallbladder cholesterol cholelithiasis显示文摘 | Rosmorduc O Hermelin B Poupon R | 2001 | Gastroenterology2001，120，6： | 1 |
| 17 | Genetic factors of susceptibility and of severity in primary biliary cirrhosis显示文摘 | Poupon R Ping C Chretien Y | 2008 | J Heoatolo2008，39，： | 1 |
| 18 | Primary biliary cirrhosis 显示文摘 | Lindor KD Gershwin ME Poupon R | 2009 | Hepatology2009，50，1： | 1 |
| 19 | Diffusion tensor imaging:concepts and applications显示文摘 | Le Bihan D Mangin JF Poupon C | | 0，，： | 1 |
| 20 | Combined treatment with arsenic trioxide and all trans retinoic acid in patients with relapsed acute promyelocytic leukemia 显示文摘 | Rousselot P Poupon J | 2003 | J Clin Oncol2003，21，12： | 1 |
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