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	题名	作者	年代	出处	被引量
1	原发性胆汁性肝硬化:自身免疫性肝炎重叠综合征的长期预后和疗效显示文摘Background/Aims: Whether primary biliary cirrhosis (PBC) autoimmune hepatitis (AIH) overlap syndrome requires immunosuppressive therapy in addition to ursodeoxycholic acid (UDCA) is a controversial issue. Methods: Seventeen patients with simultaneous form of strictly defined overlap were followed for 7.5 years. First-line treatment was UDCA alone (UDCA) in 11 and combination of immunosuppressors and UDCA (UDCA+ IS) in 6. Results: Characteristics at presentation were not significantly different between the 2 groups. In the UDCA+ IS group (f-up 7.3 years), biochemical response in terms of AIH features (ALT< 2ULN and IgG< 16 g/L) was achieved in 4/6 and fibrosis did not progress. In the UDCA group, biochemical response was observed in three patients together with stable or decreased fibrosis (f-up 4.5 years) whereas the eight others were non-responders with increased fibrosis in four (f-up 1.6 years). Seven of these eight patients subsequently received combined therapy for 3 years. Biochemical response was obtained in 6/7 and no further increase of fibrosis was demonstrated. Overall, fibrosis progression in non-cirrhotic patients occurred more frequently under UDCA monotherapy (4/8) than under combined therapy (0/6) (P=0.04). Conclusions: Combination of UDCA and immunosuppressors appears to be the best therapeutic option for strictly defined PBC-AIH overlap syndrome.	Chazouillères O. Wendum D. Serfaty L. 赵菊辉(译) 尹勇(校)	2006	世界核心医学期刊文摘(胃肠病学分册)2006，2，5：	3
2	Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis显示文摘	Christophe Corpechot Veronique Barbu Dominique Wendum Nils Kinnman Colette Rey Raoul Poupon Chantal Housset Olivier Rosmorduc	2002	Hepatology2002，，5：	2
3	Hepatocellular hypoxia-induced vascular endothelial growth factor expression and angiogenesis in experimental biliary cirrhosis 显示文摘	Rosmorduc O Wendum D Corpechot C	1999	Am J Pathol1999，155，4：	2
4	Chronic Hepatitis B Virus Carriers in the Immunotolerant Phase of Infection: Histologic Findings and Outcome显示文摘	Tony Andreani Lawrence Serfaty Djamila Mohand Salem Dernaika Dominique Wendum Olivier Chazouillères Raoul Poupon	2007	Clinical Gastroenterology and Hepatology2007，，5：	2
5	Primary biliary cirrhosis-autoimmune hepatitis overlap syndrome:clinical features and response to therapy显示文摘	CHAZOUILLERES O WENDUM D SEFFATY L	1998	Hepatology1998，2，2：	1
6	Retrorectal developmental cysts in adults:clinical and radiologic histopathologic review,differential diagnosis,and treatment显示文摘	Dahan H Arrive L Wendum D	2001	Radiographics2001，21，3：	1
7	Long tern outcome and response to therapy of primary biliary cirrhosis-autoimmune hepatitis overlap syndrome显示文摘	Chazouilleres O Wendum D Serfaty L	2006	J Heparol2006，44，2：	1
8	Hypoxia-induced VEGF and collagen 1 expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis显示文摘	Corpechot C Barbu V Wendum D	2002	Hepatology2002，35，：	1
9	Cyclooxygenase-2 and its role in colorectal cancer development显示文摘	Wendum D Masliah J Trugnan G	2004	Virchows Arch2004，445，4：	1
10	Hypoxia-induced VEGF and collagen Ⅰ expressions are associated with angiogenesis and fibrogenesis in experimentalcirrhosis显示文摘	Coristophe C Barbu V Wendum D	2002	Hepatology2002，35，：	1
11	Primary biliary cirrhosis-autoimmune hepatitis overlap syndrome:clinical features and response to therapy显示文摘	Wendum D Serfaty L	1998	Hepatology1998，28，2：	1
12	Long term outcome and response to therapy of primary biliary cirrhosis-autoimmune hepatitis overlap syndrome显示文摘	Chazouilleres O Wendum D Senfaty L	2006	J Hepatol2006，44，2：	1
13	Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis显示文摘	ORPECHOT C BARBU V WENDUM D	2002	Hepatology2002，35，：	1
14	Hepatocellular hypoxia-induced vascular endothelial growth factor expression and angiogenesis in experimental biliary cirrhosis显示文摘	Rosmorduc O Wendum D Corpechot C	1999	Am-J-Patbol1999，155，4：	1
15	Primary biliary cirrhosis-autoimmune hepatitisoverlap syndrome:clinical features and response totherapy显示文摘	Chazouilleres 0 Wendum D Serfaty L	1998	Hepatology1998，28，2：	1
16	Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis 显示文摘	Corpechot C Barbu V Wendum D	2002	Hepatology2002，35，5：	1
17	Long term outcome and response to therapy of primary biliary cirrbosisautoimmune hepatitis overlap syndrome显示文摘	Chazouilleres O Wendum D Serfaty L	2006	J Hepatol2006，44，：	1
18	Hepatocellular hypoxia- induced vascular endothelial growth factor expression and angiogenesis in experimental biliary cirrhosis 显示文摘	Rosmorduc O Wendum D Corpechot C	1999	Am J Pathol1999，155，4：	1
19	P- rimary hiliary cirrhosis-autoimmune hepatitis overlap syndrome: clinical features and response to therapy 显示文摘	CHAZOUILLRSE O WENDUM D SERFATY L	1998	Hepatology1998，28，2：	1
20	Hypoxia - in- duced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrho- sis显示文摘	Corpechot C Barbu V Wendum D	2002	Hepatology2002，35，：	1

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