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| 1 | Severe acute pancreatitis: pathogenesis, diagnosis and surgical management显示文摘BACKGROUND: Severe acute pancreatitis is a subtype of acute pancreatitis, associated with multiple organ failure and systemic inflammatory response syndrome. In this qualitative review we looked at the principles of pathogenesis, classification and surgical management of severe acute pancreatitis. We also looked at the current shift in paradigm in the management of severe acute pancreatitis since the guideline developed by the British Society of Gastroenterology.DATA SOURCES: Studies published between 1st January 1991 and 31st December 2015 were identified with Pub Med, MEDLINE, EMBASE and Google Scholar online search engines using the following Medical Subject Headings: 'acute pancreatitis, necrosis, mortality, pathogenesis, incidence' and the terms 'open necrosectomy and minimally invasive necrosectomy'.The National Institute of Clinical Excellence(NICE) Guidelines were also included in our study. Inclusion criteria for our clinical review included established guidelines, randomized controlled trials and non-randomized controlled trials with a follow-up duration of more than 6 weeks.RESULTS: The incidence of severe acute pancreatitis within the UK is significantly rising and pathogenetic theories are still controversial. In developed countries, the most common cause is biliary calculi. The British Society of Gastroenterology,acknowledges the Revised Atlanta criteria for prediction of severity. A newer Determinant-based system has been developed.The principle of surgical management of acute necrotizing pancreatitis requires intensive care management, identifying infection and if indicated, debridement of any infected necrotic area. The current procedures opted for include standard surgical open necrosectomy, endoscopic necrosectomy and minimally invasive necrosectomy. The current paradigm is shifting towards a step-up approach.CONCLUSIONS: Severe acute pancreatitis is still a subject of grey areas in its surgical management even though new studies have been recorded since the origin of the latest UK guidelines for management of severe acute pancreatitis. | Mark Portelli Christopher David Jones | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，2： | 201 |
| 2 | Serum vitamin D levels are lower in Australian children and adolescents with type 1 diabetes than in children without diabetes显示文摘 | GREER R M PORTELLI S L HUNG B S | 2013 | Pediatr Diabetes2013，，： | 1 |
| 3 | Molecular links between endometriosis and cancer显示文摘 | Joel Pollacco Keith Sacco Mark Portelli Pierre Schembri-Wismayer Jean Calleja-Agius | 2012 | Gynecological Endocrinology2012，，8： | 1 |
| 4 | Organization-based incident management: developing a disaster volunteer role on a university campus 显示文摘 | Fulmer T portelli L Fohin GL | 2007 | Disaster Management & Response2007，5，3： | 1 |
| 5 | Organization-based incident management:developing a disaster volunteer role on a university campus 显示文摘 | Fulmer T Portelli I Fohin GL | 2007 | Disaster Manag Response2007，5，3： | 1 |
| 6 | Are vesicular neurotrans- mitter transporters potential treatment targets for temporal lobe epilep- sy显示文摘 | Van Liefferinge J Massie A Portelli J | 2013 | Front Cell Neurosci2013，7，： | 1 |
| 7 | Pilot study on the effect of ramelteon on sleep disturbance after traumatic brain injury (TBl): preliminary evidence from a clinical trial显示文摘 | Lequerica A ]asey N Portelli T]N | 2015 | Arch Phys Med Rehabil2015，，： | 1 |
| 8 | Current practice of chronic hepatitis B treatment in Southern Italy显示文摘 | T. Stroffolini A. Spadaro V. Di Marco G. Scifo M. Russello G. Montalto G. Bertino L. Surace B. Caroleo G. Foti V. Portelli S. Madonia M. Sapienza L. Cosco P. Frugiuele A. Galdieri N. Brandolino R. Siciliano S. Bruno P.L. Almasio | 2012 | European Journal of Internal Medicine2012，，5： | 1 |
| 9 | MolecuLar links belween endometriosis and cancer 显示文摘 | POLI ACCO J SACCO K PORTELLI M | 2012 | Gynecol Endocrinol2012，28，8： | 1 |
| 10 | Krull Rings with Krull divisors显示文摘 | PORTELLI D SPANGHER W | 1983 | Comm Algebra1983，，16： | 1 |
| 11 | Genetic basis for personalized medicine in asthma显示文摘 | Portelli M Sayers I | | 0，，02： | 1 |
| 12 | Enhancement of in vitro and in vivo microdialysis recovery of SB-265123 using Intralipid and Encapsin as perfusates显示文摘 | Ward KW Medina SJ Portelli ST | 2003 | Biopharm Drug Dispos2003，24，1： | 1 |
| 13 | Effect of compounds withantibacterial activities in human milk on respiratory syncytialvirus and cytomegalovirus in vitro显示文摘 | Portelli J Gordon A May JT | 1998 | J Med Microbiol1998，47，11： | 1 |
| 14 | Endometrial seedlings : A survival instinct? Immunomodulation and its role in the pathophysiology of endometriosis 显示文摘 | Portelli M Pollacco J Sacco K | 2011 | Minerva Ginecol2011，63，6： | 1 |
| 15 | Attack Rates Assess- ment of the 2009 Pandemic H1N1 Influenza A in Children and Their Contacts: A Systematic Review and Meta-Analysis 显示文摘 | Glatman-Freedman A Portelli I Jacobs SK | 2012 | PLoS One2012，7，50： | 1 |
| 16 | Serum vitamin D levels are lower in Australian children and adolescents with type 1 diabetes than in children without diabetes显示文摘 | Ristan M Greer Sharon L Portelli Betsy Shin‐Min Hung Geoffrey J Cleghorn Sarah K McMahon Jennifer A Batch Louise S Conwell | 2012 | Pediatr Diabetes2012，，1： | 1 |
| 17 | Enhancement of in vitro and in vivo microdialysis recovery of SB-265123 using intralipid and encapsin as perfusates显示文摘 | Medina SJ Portelli ST | 2003 | Biopharm Drug Dispos2003，24，1： | 1 |
| 18 | Measuring the quality of hospital in the home care: a clinical indica- tor approach显示文摘 | Montalto M Portelli R Collopy B | 1999 | Int J Qual Health Care1999，1，5： | 1 |
| 19 | Organization based incident management:developing a disaster volunteer role on a university campus显示文摘 | Fulmer F Portelli I Foltin GF | 2008 | Disaster Manage Response2008，5，3： | 1 |
| 20 | A fialal iatrgenic right vertebral injury after transoral odontoidectomy and posterior cervical stabilization for a type Ⅱ odontoid fracture显示文摘 | SCALICI E INDORATO F PORTELLI F | 2014 | J Forensic Leg Med2014，22，： | 1 |
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