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| 1 | Laparoscopic versus open appendectomy: Which way to go?显示文摘AIM: To compare the outcome of laparoscopic versus open appendectomy. METHODS: Prospectively collected data from 293 consecutive patients with acute appendicitis were studied. These comprised of 165 patients who underwent conventional appendectomy and 128 patients treated laparoscopically. The two groups were compared with respect to operative time, length of hospital stay, postoperative pain, complication rate and cost. RESULTS: There were no statistical differences regarding patient characteristics between the two groups. Conversion to laparotomy was necessary in 2 patients (1.5%). Laparoscopic appendectomy was associated with a shorter hospital stay (2.2 d vs 3.1 d, P = 0.04), and lower incidence of wound infection (5.3% vs 12.8%, P = 0.03). However, in patients with complicated disease, intra-abdominal abscess formation was more common after laparoscopic appendectomy (5.3% vs 2.1%, P = 0.002). The operative time and analgesia requirements were similar in the two groups. The cost of treatment was higher by 370 € in the laparoscopic group. CONCLUSION: Laparoscopic appendectomy is as safe and effi cient as open appendectomy, provided surgical experience and equipment are available. | Ioannis Kehagias Stavros Nikolaos Karamanakos Spyros Panagiotopoulos Konstantinos Panagopoulos Fotis Kalfarentzos | 2008 | World Journal of Gastroenterology2008，14，31： | 25 |
| 2 | Recent advances in the molecular genetics of type 2 diabetes mellitus显示文摘Type 2 diabetes mellitus(T2DM) is a complex disease in which both genetic and environmental factors interact in determining impaired β-cell insulin secretion and peripheral insulin resistance. Insulin resistance in muscle, liver and fat is a prominent feature of most patients with T2DM and obesity, resulting in a reduced response of these tissues to insulin. Considerable evidence has been accumulated to indicate that heredity is a major determinant of insulin resistance and T2DM. It is believed that, among individuals destined to develop T2DM, hyperinsulinemia is the mechanism by which the pancreatic β-cell initially compensates for deteriorating peripheral insulin sensitivity, thus ensuring normal glucose tolerance. Most of these people will develop T2DM when β-cells fail to compensate. Despite the progress achieved in this field in recent years, the genetic causes of insulin resistance and T2DM remain elusive.Candidate gene association, linkage and genome-wide association studies have highlighted the role of genetic factors in the development of T2DM. Using these strategies, a large number of variants have been identified in many of these genes, most of which may influence both hepatic and peripheral insulin resistance, adipogenesis and β-cell mass and function. Recently, a new gene has been identified by our research group, the HMGA1 gene, whose loss of function can greatly raise the risk of developing T2DM in humans and mice. Functional genetic variants of the HMGA1 gene have been associated with insulin resistance syndromes among white Europeans, Chinese individuals and Americans of Hispanic ancestry. These findings may represent new ways to improve or even prevent T2DM. | Antonio Brunetti Eusebio Chiefari Daniela Foti | 2014 | World Journal of Diabetes2014，5，2： | 20 |
| 3 | PTEN in liver diseases and cancer显示文摘The phosphoinositide 3-kinase (PI3K)/phosphatase and tensin homolog (PTEN)/Akt axis is a key signal transduction node that regulates crucial cellular functions, including insulin and other growth factors signaling, lipid and glucose metabolism, as well as cell survival and apoptosis. In this pathway, PTEN acts as a phosphoinositide phosphatase, which terminates PI3Kpropagated signaling by dephosphorylating PtdIns(3,4)P2 and PtdIns(3,4,5)P3. However, the role of PTEN does not appear to be restricted only to PI3K signaling antagonism, and new functions have been recently discovered for this protein. In addition to the well-established role of PTEN as a tumor suppressor, increasing evidence now suggests that a dysregulated PTEN expression and/or activity is also linked to the development of several hepatic pathologies. Dysregulated PTEN expression/activity is observed with obesity, insulin resistance, diabetes, hepatitis B virus/hepatitis C virus infections, and abusive alcohol consumption, whereas mutations/deletions have also been associated with the occurrence of hepatocellular carcinoma. Thus, it appears that alterations of PTEN expression and activity in hepatocytes are common and recurrent molecular events associated with liver disorders of various etiologies. These recent f indings suggest that PTEN might represent a potential common therapeutic target for a number of liver pathologies. | Marion Peyrou Lucie Bourgoin Michelangelo Foti | 2010 | World Journal of Gastroenterology2010，16，37： | 16 |
| 4 | Genetic and epigenetic risks of intracytoplasmic sperm injection method显示文摘怀孕由帮助繁殖技术完成了,特别地由胞质内精子注射(ICSI ) 过程,产生对与 ICSI 对待的男人口固有的基因风险和对这个创新过程固有的另外的风险。记录,以及理论,风险在现在的评论学习被讨论。这些风险主要表示位于男性下面的基因畸形的后果代替生育力(或不孕) 并且可能在不孕的治疗为新奇途径和应用的发展成为激发器。另外,冒的风险,当先天的异例和另外的理论或随机的风险被讨论,一个复合基因背景出现在出生。最近的数据建议那种帮助繁殖技术可能也影响雄配子,雌配子,或力量的渐成说特征影响早胚胎开始。它可能也为印畸形的 genomic 与增加的风险被联系。 | Ioannis Georgiou Maria Syrrou Nicolaos Pardalidis Konstantinos Karakitsios Themis Mantzavinos Nikolaos Giotitsas Dimitrios Loutradis Fotis Dimitriadis Motoaki Saito Ikuo Miyagawa Pavlos Tzoumis Anastasios Sylakos Nikolaos Kanakas Theodoros Moustakareas Dimitrios Baltogiannis Stavros Touloupides Dimitrios Giannakis Michael Fatouros Nikolaos Sofikitis | 2006 | Asian Journal of Andrology2006，8，6： | 9 |
| 5 | Hemobilia as the initial manifestation of cholangiocarcinoma in a hemophilia B patient显示文摘Hemobilia is a rare manifestation of hemophilia and is usually iatrogenic following liver biopsy. There are only few reports of spontaneous hemobilia in hemophilia patients. Cholangiocarcinoma is a well-established cause of hemobilia. We describe a case of a 70-year-old male, with known haemophilia B and a past history of papillotomy, who presented with classical symptoms of hemobilia. The initial diagnostic work-up failed to demonstrate a potential cause of bleeding other than the coagulopathy. Three months later, he was readmitted to our hospital with a second episode of hemobilia. During the second work-up, a cholangiocarcinoma was diagnosed both by imaging studies and by a significant elevation of cancer antigen 19-9. Although hemobilia could be attributed to hemophilia, especially in a patient with previous papillotomy, an underlying malignancy of the biliary tree should be suspected. | Anastassios C Manolakis Andreas N Kapsoritakis Antonis D Tsikouras Fotis D Tsiopoulos Athanassios K Psychos Spyros P Potamianos | 2008 | World Journal of Gastroenterology2008，14，26： | 5 |
| 6 | phosphatase and tensin homolog is a differential diagnostic marker between nonalcoholic and alcoholic fatty liver disease显示文摘AIM: To investigate the protein expression of phosphatase and tensin homolog(PTEN) in human liver biopsies of patients with alcoholic and non-alcoholic liver disease.METHODS: PTEN protein expression was assessed by immunohistochemistry in formalin-fixed, paraffinembedded liver sections of patients with non-alcoholic fatty liver disease(NAFLD)(n = 44) or alcoholic liver disease(ALD)(n = 25). Liver resections obtained from 3 healthy subjects candidate for partial liver donation served as controls. Histological evaluations were performed by two experienced pathologists, and diagnoses established based on international criteria. The intensity of the PTEN staining in nuclei was compared between steatotic and non-steatotic areas of each liver fragment analyzed. For each liver specimen, the antibody-stained sections were examined and scored blindly by three independent observers, who were unaware of the patients' clinical history.RESULTS: In healthy individuals, PTEN immunostaining was intense in both the cytoplasm and nuclei of all hepatocytes. However, PTEN was strongly downregulated in both the nucleus and the cytoplasm of hepatocytes from steatotic areas in patients with NAFLD, independently of the disease stage. In contrast, no changes in PTEN protein expression were observed in patients with ALD, regardless of the presence of steatosis or the stage of the disease. The degree of PTEN downregulation in hepatocytes of patients with NAFLD correlated with the percentage of steatosis(r = 0.3061, P = 0.0459) and the BMI(r = 0.4268, P = 0.0043). Hovewer, in patients with ALD, PTEN expression was not correlated with the percentage of steatosis with or without obesity as a confounding factor(P = 0.5574). Finally, PTEN expression level in steatotic areas of ALD patients was significantly different from that seen in steatotic areas of NAFLD patients(P < 0.0001).CONCLUSION: PTEN protein expression is downregulated early in NAFLD, but not in ALD. PTEN immunohistochemical detection could help in the differential diagnosis of NAFLD and ALD. | Andrea Sanchez-Pareja Sophie Clément Marion Peyrou Laurent Spahr Francesco Negro Laura Rubbia-Brandt Michelangelo Foti | 2016 | World Journal of Gastroenterology2016，22，14： | 2 |
| 7 | Coherent vorticity dynamics and dissipation in a utility-scale wind turbine wake with uniform inflow显示文摘The vorticity dynamics and its relationship to dissipation in the wake of a utility-scale wind turbine are investigated through large-eddy simulation.The vorticity dynamics is assessed through the enstrophy,which is related to the turbulent dissipation.The averaged enstrophy and turbulent dissipation are shown to be quantitatively similar in the wake.Using temporal phase averaging,the vorticity fluctuations are decomposed into coherent and random fluctuations with respect to the frequency of the tip vortices.The enstrophy in the tip vortices is dominated by coherent fluctuations,while the coherent fluctuations of root vortices are immediately saturated by the random vorticity fluctuations of the unstable hub vortex.The coherent strain rate has significant differences com pared to the coherent enstrophy within one diameter downwind of blade tip,but the random enstrophy and strain rate are relatively similar.Differences in coherent enstrophy and strain rate decrease further from the rotor. | Daniel Foti | 2021 | Theoretical & Applied Mechanics Letters2021，11，5： | 2 |
| 8 | A genome-wide scan for pleiotropy between bone mineral density and nonbone phenotypes显示文摘Osteoporosis is the most common metabolic bone disorder globally and is characterized by skeletal fragility and microarchitectural deterioration.Genetic pleiotropy occurs when a single genetic element is associated with more than one phenotype.We aimed to identify pleiotropic loci associated with bone mineral density(BMD)and nonbone phenotypes in genome-wide association studies.In the discovery stage,the NHGRI-EBI Catalog was searched for genome-wide significant associations(P value<5 x 108),excluding bone-related phenotypes.SNiPA was used to identify proxies of the significantly associated single nucleotide polymorphisms(SNPs)(r2=1).We then assessed putative genetic associations of this set of SNPs with femoral neck(FN)and lumbar spine(LS)BMD data from the GEFOS Consortium.Pleiotropic variants were claimed at a false discovery rate<1.4x 103 for FN-BMD and<1.5 x 10-3 for LS-BMD.Replication of these genetic markers was performed among more than 400000 UK Biobank participants of European ancestry with available genetic and heel bone ultrasound data.In the discovery stage,72 BMD-related pleiotropic SNPs were identified,and 12 SNPs located in 11 loci on 8 chromosomes were replicated in the UK Biobank.These SNPs were associated,in addition to BMD,with 14 different phenotypes.Most pleiotropic associations were exhibited by rs479844(AP5B1,O V O L 1 genes),which was associated with dermatological and allergic diseases,and rs4072037(M U C 1 gene),which was associated with magnesium levels and gastroenterological cancer.In conclusion,12 BMD-related genome-wide significant SNPs showed pleiotropy with nonbone phenotypes.Pleiotropic associations can deepen the genetic understanding of bone-related diseases by identifying shared biological mechanisms with other diseases or traits. | Maria A.Christou Georgios Ntritsos Georgios Markozannes Fotis Koskeridis Spyros N.Nikas David Karasik Douglas P.Kiel Evangelos Evangelou Evangelia E.Ntzani | 2020 | Bone Research2020，8，3： | 2 |
| 9 | Global progress against cancer—challenges and opportunities显示文摘The last ten years have seen remarkable progress in cancer research.However,despite significant breakthroughs in the understanding,prevention,and treatment of cancer,the disease continues to affect millions of people worldwide.Cancer’s complexity compounded with financial,policy and regulatory roadblocks has slowed the rate of progress being made against cancer.In this paper,we review a few of the most recent breakthroughs that are fueling medical advances and bringing new hope for patients affected by this devastating disease.We also address the challenges facing us and the opportunities to accelerate future progress against cancer.The efforts of the American Association for Cancer Research(AACR)to address the cancer burden already extend beyond the borders of the United States of America.The AACR is committed to increasing its efforts to stem the tide of cancer worldwide by promoting innovative programs,strategies,and initiatives for cancer researchers and all those engaged in cancer-related biomedical sciences around the world. | Frédéric Biemar Margaret Foti | 2013 | Cancer Biology & Medicine2013，10，4： | 2 |
| 10 | Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog (PTEN) via microRNA‐21 up‐regulation in hepatocytes显示文摘 | Manlio Vinciguerra Antonino Sgroi Christelle Veyrat‐Durebex Laura Rubbia‐Brandt Leo H. Buhler Michelangelo Foti | 2009 | Hepatology2009，，4： | 2 |
| 11 | Hydrogen effect on atomic configuration of keV-ion-irradiated carbon显示文摘 | Compagnini G Calcagno L Foti G | 1992 | Phys Rev Lett1992，69，3： | 2 |
| 12 | Mechanism of thermal degradation of polyurethanes investigated by direct pyrolysis in the mass spectrometer显示文摘 | Ballistreri A Foti S Maravigna P | 1980 | Polymer Science:PolymerChemistry Edition1980，18，6： | 1 |
| 13 | Venieris, Cennaro Marino, Mobile agent standards and available platforms 显示文摘 | Menelaos K Perdikeas Fotis G Chatzipapadopoulos lakovos S | 1993 | Computer Networks1993，31，： | 1 |
| 14 | The dynamic allocation of attention to emotion:simultaneous and independent evidence from the late positive potential and steady state visual evoked potentials显示文摘 | Hajcak G MacNamara A Foti D | 2013 | Biol Psychol2013，92，3： | 1 |
| 15 | A prospective observational study of the clinical efficacy and safety of intra-articular sodium hyaluronate in synovial joints with osteoarthritis显示文摘 | Foti C Cisari C Carda S ct 81 | 2011 | Eur J Phys Rehabil Med2011，47，3： | 1 |
| 16 | The heart and pediatric rheumatology显示文摘 | Vogel T Kitcharoensakkul M Fotis L | 2014 | Rheum Dis Clin Noah Am2014，40，1： | 1 |
| 17 | Comparison between daidzeinand genistein antioxidant acrivity in primary and cancerlymphocytes显示文摘 | Foti P Erba D Riso Pe t al | 2005 | Arch Biochem Biophys2005，433，2： | 1 |
| 18 | Thyroid-intestinal motility interactions summary显示文摘 | Pustorino S Foti M Calipari G | 2004 | Minerva Gastroenterol Dietol2004，50，4： | 1 |
| 19 | Exogenous polyamines elicit herbivore-induced volatiles in lima bean leaves: involvement of calcium, H202 jasmonic acid 显示文摘 | Ozawa R Bertea C M Foti M | 2009 | Plant Cell Physiol2009，50，12： | 1 |
| 20 | Kinetics of the oxidation of quercetin by 2,2-Diphenyl-1-picryl-hydrazyl(dpph @)显示文摘 | Foti M C Daquino C DiLabio G A | | 0，，18： | 1 |
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