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| 1 | Adjusting CA19-9 values to predict malignancy in obstructive jaundice:Influence of bilirubin and C-reactive protein显示文摘AIM:To find a possible relationship between inflammation and CA19-9 tumor marker by analyzing data from patients with benign jaundice(BJ) and malignant jaundice(MJ).METHODS:All patients admitted for obstructive jaundice,in the period 2005-2009,were prospectively enrolled in the study,obtaining a total of 102 patients.On admission,all patients underwent complete standard blood test examinations including C-reactive protein(CRP),bilirubin,CA19-9.Patients were considered eligible for the study when they presented obstructive jaundice confirmed by instrumental examinations and increased serum bilirubin levels(total bilirubin > 2.0 mg/dL).The standard cut-off level for CA19-9 was 32 U/mL,whereas for CRP this was 1.5 mg/L.The CA19-9 level was adjusted by dividing it by the value of serum bilirubin or by the CRP value.The patients were divided into 2 groups,MJ and BJ,and after the adjustment a comparison between the 2 groups of patients was performed.Sensitivity,specificity and positive predictive values were calculated before and after the adjustment.RESULTS:Of the 102 patients,51 were affected by BJ and 51 by MJ.Pathologic CA19-9 levels were found in 71.7% of the patients.In the group of 51 BJ patients there were 29(56.9%) males and 22(43.1%) females with a median age of 66 years(range 24-96 years),whereas in the MJ group there were 24(47%) males and 27(53%) females,with a mean age of 70 years(range 30-92 years).Pathologic CA19-9 serum level was found in 82.3% of MJ.CRP levels were pathologic in 66.6% of the patients with BJ and in 49% with MJ.Bilirubin and CA19-9 average levels were significantly higher in MJ compared with BJ(P = 0.000 and P = 0.02),while the CRP level was significantly higher in BJ(P = 0.000).Considering a CA19-9 cut-off level of 32 U/mL,82.3% in the MJ group and 54.9% in the BJ group were positive for CA19-9(P = 0.002).A CA19-9 cut-off of 100 U/mL increases the difference between the two groups:35.3% in BJ and 68.6% in MJ(P = 0.0007).Adjusting the CA19-9 value by dividing it by serum bilirubin level meant that 21.5% in the BJ and 49% in the MJ group remained with a positive CA19-9 value(P = 0.003),while adjusting the CA19-9 value by dividing it by serum CRP value meant that 31.4% in the BJ group and 76.5% in the MJ group still had a positive CA19-9 value(P = 0.000004).Sensitivity,specificity,positive predictive values of CA19-9 > 32 U/mL were 82.3%,45% and 59.1%;when the cutoff was CA19-9 > 100 U/mL they were,respectively,68.6%,64.7% and 66%.When the CA19-9 value was adjusted by dividing it by the bilirubin or CRP values,these became 49%,78.4%,69.4% and 76.5%,68.6%,70.9%,respectively.CONCLUSION:The present study proposes CRP as a new and useful correction factor to improve the diag-nostic value of the CA19-9 tumor marker in patients with cholestatic jaundice. | Gaetano La Greca Maria Sofia Rosario Lombardo Saverio Latteri Agostino Ricotta Stefano Puleo Domenico Russello | 2012 | World Journal of Gastroenterology2012，18，31： | 20 |
| 2 | Laparo-endoscopic “Rendezvous” to treat cholecysto-choledocolithiasis: Effective,safe and simplifies the endoscopist’s work显示文摘AIM: To investigate our clinical experience with combined laparo-endoscopic Rendezvous (RV) for the treatment of patients affected by gallstones and common bile duct (CBD) stones and especially to study the never evaluated opinion of the endoscopist concerning the difficulty of the intraoperative endoscopic procedure during the RV in comparison with standard endoscopic retrograde cholangio-pancreatography (ERCP). METHODS: Eighty consecutive patients affected by cholecystolithiasis and diagnosed or suspected CBD stones were treated with a standardized 'tailored' RV. The relevant technical features, the feasibility, the effectiveness in stone clearance, the safety but also the simple evaluation of difficulty and agreement of the endoscopist were analyzed with a questionnaire. RESULTS: The feasibility was 97.5% and the effectiveness 100% concerning CBD clearance and solution of coexisting problems at the papilla. Minor morbidity was 3.3%, the operating time was prolonged by a mean of 14 min, the mean hospital stay was 3.8 d and only one stone’s recurrence occurred. The endoscopist evaluated the procedure to be simpler than standard ERCP-ES in 81.2% of the cases.CONCLUSION: Simultaneous RV carries higheffectiveness and safety at least comparable to those reported for other options. The endoscopist is very often satisfied with this approach because of the minimization of some steps of the endoscopic procedure and avoidance of relevant iatrogenic risk factors. If the mandatory collaboration between surgeons and endoscopists is guaranteed, this approach can often be preferable for the patient, the surgeon, the endoscopist and the hospital. | Gaetano La Greca Francesco Barbagallo Michele Di Blasi Andrea Chisari Rosario Lombardo Rosario Bonaccorso Saverio Latteri Andrea Di Stefano Domenico Russello | 2008 | World Journal of Gastroenterology2008，14，18： | 15 |
| 3 | Recombinant interferon alpha therapy in elderly patients with chronic hepatitis C without cirrhosis显示文摘 | Russello M | 1996 | Arch Gerontol Geriatr1996，5，： | 1 |
| 4 | Immunotherapeutic strategies in neuroblastoma:antitumoral activity of deglycosylated Ricin A conjugated anti-GD2 antibodies and anti-CD3xanti-GD2 bispecific antibodies显示文摘 | Manzke O Russello O Leenen C | 2001 | Medical and pediatric oncology2001，36，1： | 1 |
| 5 | Novel pyrrolo pyrimidine antifolate TNP-351 : Cytotoxic effect on methotrexate-resistant CCRF-CEM eeUs and inhibition of transformylases of de novo purine biosynthesis 显示文摘 | Itoh F Russello O Akimoto H | 1994 | Cancer Chemotherapy and Pharmacolog1994，34，4： | 1 |
| 6 | Recombinant interferon alpha therapy in elderly patients with chronic hepatitis C without cirrhosis 显示文摘 | Russello M Vasquez E | 1996 | Arch Gerontol Geriatr1996，22，1： | 1 |
| 7 | Sharedand searchable encrypted data for untrusted servers 显示文摘 | Dong Changyu Russello Giovanni Dulay Naranker | 2008 | Journal of computer security2008，19，3： | 1 |
| 8 | Comparison of efficacy, safety and immunologic effects of subcutaneous and sublingual immunotherapy in birch pollinosis: a randomized study显示文摘 | MAURO M RUSSELLO M INCORVAIA C | 2007 | Eur Ann Allergy Clin Immunol2007，39，： | 1 |
| 9 | Evaluation of carbapenem-resistane Enterobacteriaceae in an Italian setting:Report from the trench显示文摘 | Barbarini D Russello G Brovarone F | 2015 | Infect Genet Evol2015，30，： | 1 |
| 10 | Oxiracetam treatment of exogenous post-concussion syndrome:statistical evaluation of results 显示文摘 | Russello D Randazzo G Favetta A | 1990 | Minerva Chir1990，45，20： | 1 |
| 11 | Gallstone disease is associated with more severe liver damage in patients with non - alcoholic fatty liver dis- ease显示文摘 | Fracanzani AL Valenti L Russello M | 2012 | PLoS One2012，7，7： | 1 |
| 12 | Shared and searchable encrypted data for untrusted servers显示文摘 | Dong C Russello G Dulay N | 2011 | Journal of Computer Security2011，19，3： | 1 |
| 13 | Current practice of chronic hepatitis B treatment in Southern Italy显示文摘 | T. Stroffolini A. Spadaro V. Di Marco G. Scifo M. Russello G. Montalto G. Bertino L. Surace B. Caroleo G. Foti V. Portelli S. Madonia M. Sapienza L. Cosco P. Frugiuele A. Galdieri N. Brandolino R. Siciliano S. Bruno P.L. Almasio | 2012 | European Journal of Internal Medicine2012，，5： | 1 |
| 14 | Comparison of the Staphy- lococcus QnickFISH BC test with the tube coagulase test performed on positive blood cultures for evaluation and application in a clinical rou- tine setting显示文摘 | Carrctto E Bardaro M Russello G | 2013 | J Clin Microbiol2013，51，1： | 1 |
| 15 | Gallstone disease is associated with more severe liver damage in patients with non-alcoholic fatty liver disease显示文摘 | Fracanzani AL Valenti L Russello M | 2012 | PLoS One2012，7，41： | 1 |
| 16 | Liberal Ends and Republican Means显示文摘 | Russello Gerald J | 1997 | Seton Hall Law Review1997，，28： | 1 |
| 17 | Liberal Ends and Republican Means 显示文摘 | Russello Gerald J | 1997 | Seton Hall Law Review1997，，28： | 1 |
| 18 | Numerical and experimental study of a rectangular slot antenna for UWB communications 显示文摘 | SORBELLO G PAVONE M RUSSELLO L | 2005 | Microwave and Optical Technology Letters2005，46，4： | 1 |
| 19 | Shared and searchable encrypted data for untrusted servers显示文摘 | Dong Chang-yu Russello G and Dulay N | 2011 | Journal of Computer Security2011，19，21： | 1 |
| 20 | Oxiracetam treatemet of exogenous postconcussion syndrome statisticale valuation of results显示文摘 | Russello D Randazzo G Favetta A | 1990 | Minerva Chir1990，45，20： | 1 |
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