|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Systematic review of modulators of benzodiazepine receptors in irritable bowel syndrome:Is there hope?显示文摘Several drugs are used in the treatment of irritable bowel syndrome(IBS) but all have side effects and variable efficacy.Considering the role of the gut-brain axis,immune,neural,and endocrine pathways in the pathogenesis of IBS and possible beneficial effects of benzodiazepines(BZD) in this axis,the present systematic review focuses on the efficacy of BZD receptor modulators in human IBS.For the years 1966 to February 2011,all literature was searched for any articles on the use of BZD receptor modulators and IBS.After thorough evaluation and omission of duplicate data,10 out of 69 articles were included.BZD receptor modulators can be helpful,especially in the diarrhea-dominant form of IBS,by affecting the in? ammatory,neural,and psychologic pathways,however,controversies still exist.Recently,a new BZD receptor modulator,dextof isopam was synthesized and studied in human subjects,but the studies are limited to phase □b of BZDs in IBS,but bearing in mind the concentrationdependent effect of BZDs on cytokines and cell proliferation,future studies using pharmacodynamic and pharmacokinetic approaches are highly recommended. | Pooneh Salari Mohammad Abdollahi | 2011 | World Journal of Gastroenterology2011，17，38： | 9 |
| 2 | Methylenetetrahydrofolate reductase C677T genotype affects promoter methylation of tumor-specific genes in sporadic colorectal cancer through an interaction with folate/vitamin B_(12) status显示文摘AIM:To evaluate joint effects of Methylentetra-hydrofolate reductase(MTHFR) C677T genotypes,and serum folate/vitamin B12 concentrations on promoter methylation of tumor-associated genes among Iranian colorectal cancer patients. METHODS:We examined the associations between MTHFR C677T genotype,and promoter methylation of P16,hMLH1,and hMSH2 tumor-related genes among151 sporadic colorectal cancer patients. The promoter methylation of tumor-related genes was determined by methylation-specific PCR. Eighty six patients from whom fresh tumor samples were obtained and 81 controls were also examined for serum folate and vitamin B12 concentrations by a commercial radioimmunoassay kit. RESULTS:We found 29.1% of cases had tumors with at least one methylated gene promoter. In case-case comparison,we did not find a significant association between methylation in tumors and any single genotype. However,in comparison to controls with the CC genotype,an increased risk of tumor methylation was associated with the CT genotype(OR = 2.5;95% CI,1.1-5.6) . In case-case comparisons,folate/vitamin B12 levels were positively associated with tumor methylation. Adjusted odds ratios for tumor methylation in cases with high(above median) versus low(below median) serum folate/vitamin B12 levels were 4.9(95% CI,1.4-17.7) ,and 3.9(95% CI,1.1-13.9) ,respectively. The frequency of methylated tumors was significantly higher in high methyl donor than low methyl donor group,especially in those with MTHFR CT(P = 0.01) ,and CT/TT(P = 0.002) genotypes,but not in those with the CC genotype(P = 1.0) . CONCLUSION:We conclude that high concentrations of serum folate/vitamin B12 levels are associated with the risk of promoter methylation in tumor-specific genes,and this relationship is modified by MTHFR C677T genotypes. | Pooneh Mokarram Fakhraddin Naghibalhossaini Mehdi Saberi Firoozi Seyed Vahid Hosseini Ahmad Izadpanah Heshmetalah Salahi Seyed Ali Malek-Hosseini Abdoulrasool Talei Mehra Mojallal | 2008 | World Journal of Gastroenterology2008，14，23： | 5 |
| 3 | A Meta-Analysis and Systematic Review on the Effect of Probiotics in Acute Diarrhea显示文摘 | Pooneh Salari Shekoufeh Nikfar Mohammad Abdollahi | 2012 | InflammationandAllergy-Drug Targets (Formerly Current Drug Targets - InflammationandAllergy)2012，，1： | 3 |
| 4 | 精准医学伦理问题综述显示文摘精准医学是针对每个个体的遗传特性和生活方式,而制定预防和治疗方案的新方法。欧美发达国家早在20世纪初就着眼于精准医学的研发,将基因测序技术与靶向药物研发及其相关的监管政策为发展重点,积极推动基于药物基因组学的新药创制与上市。我国精准医学起步晚,研发和应用相对落后,成功研发上市的相关药物仅占世界的0. 7%;相关伦理和法规建设也存在一定的滞后. | Pooneh Salari Bagher Larijani 郑君 | 2018 | 中国医学伦理学2018，31，9： | 2 |
| 5 | Isolation of bacteria able to metabolize high concentrations of formaldehyde显示文摘 | SAEED M AFSANEH R POONEH K | | 0，，： | 1 |
| 6 | Direct identification of non-polio enteroviruses in residual paralysis cases by analysis of VP 1 sequences显示文摘 | Pooneh Rahimi H. Tabatabaie Mohammad M. Gouya M. Mahmudi T. Musavi K. Samimi Rad T. Mokhtari Azad R. Nategh | 2009 | Journal of Clinical Virology2009，，： | 1 |
| 7 | Emergence of African Swine Fever Virus, North- western Ira n 显示文摘 | Pooneh Rahimi Amir Sohrabi Javad Ashrafihelan et al | 2010 | Emerging infectious diseases2010，12，： | 1 |
| 8 | Dry-Weight Reduction in Hypertensive Hemodialysis Patients (DRIP): A Randomized, Controlled Trial显示文摘 | Rajiv Agarwal Pooneh Alborzi Sangeetha Satyan Robert P. Light | 2009 | Hypertension2009，，3： | 1 |
| 9 | Isolation of bacteria able to metabolize high concentrations of formaldehyde显示文摘 | Saeed M Afsaneh R Pooneh K | 2005 | Microbiology &Biotechnology2005，，21： | 1 |
| 10 | A new optimized uncertainty e-valuation applied to the Monte-Carlo simulation in platinum resistance thermometer calibration显示文摘 | KAMRAN S POONEH N | 2010 | Measurement2010，43，7： | 1 |
| 11 | Dry-Weight Reduction in Hypertensive Hemodialysis Patients (DRIP): A Randomized, Controlled Trial显示文摘 | Rajiv Agarwal Pooneh Alborzi Sangeetha Satyan Robert P. Light | 2009 | Hypertension2009，，3： | 1 |
| 12 | Home Blood Pressure Measurements for Managing Hypertension in Hemodialysis Patients显示文摘 | Agarwal Rajiv Satyan Sangeetha Alborzi Pooneh Light Robert P Tegegne Getachew G Mazengia Helmneh S Yigazu Paulos M | 2009 | American Journal of Nephrology2009，，2： | 1 |
| 13 | Dry-Weight Reduction in Hypertensive Hemodialysis Patients (DRIP): A Randomized, Controlled Trial显示文摘 | Rajiv Agarwal Pooneh Alborzi Sangeetha Satyan Robert P. Light | 2009 | Hypertension2009，，3： | 1 |
| 14 | Isolation of bacteria able to metabolize high concentrations of formaldehyde显示文摘 | SAEED M AFSANEH R POONEH K | 2005 | Microbiology & Biotechnology2005，，21： | 1 |
| 15 | Isolation of bacteria able to metabolize high concentrations of formaldehyde显示文摘 | SAEED M AFSANEH R POONEH K | 2005 | Microbiology & Biotechnology2005，21，： | 1 |
| 16 | A new optimized uncertainty evaluation applied to Monte - Carlo simulation in platinum resistance thermometer cali- bration 显示文摘 | Kamran S Pooneh N | 2010 | Measurement2010，43，： | 1 |
| 17 | Paricalcitol Reduces Albuminuria and Inflammation in Chronic Kidney Disease: A Randomized Double-Blind Pilot Trial显示文摘 | Pooneh Alborzi Nina A. Patel Carla Peterson Jennifer E. Bills Dagim M. Bekele Zerihun Bunaye Robert P. Light Rajiv Agarwal | 2008 | Hypertension2008，，2： | 1 |
| 18 | Defects and solarization in YAG transparent ceramics显示文摘Transparent ceramics are emerging as future materials for lasers, scintillation, and illumination. In this paper, an interesting and surprising phenomenon in YAG transparent ceramics is reported. UV light leads to significant changes in the microstructure of open volume defects and nano clusters as well as in the optical properties. Lightinduced lattice relaxation is suggested as the mechanism behind this intriguing behavior. The complex F-type color center with broad absorption bands is caused by the aliovalent sintering additives(Ca^2+∕Mg^2+) and Fe ion impurities. Two individual peaks in the thermoluminescence spectra illustrate both shallow and deep level traps.From positron annihilation lifetime data, vacancy clusters and nanovoids are detected and characterized, although these free-volume defects could not be observed by high-resolution transmission electron microscopy. The solarization induced by UV irradiation is associated with a change in the structure and size of defect clusters due to lattice relaxation. Therefore, this work shows how UV irradiation leads not only to a change in the charge state of defects, but also to a permanent change in defect structure and size. It significantly affects the optical properties of YAG ceramics and their performance in lasers and other optical applications. These results are crucial for advancing transparent ceramics technology. | Le Zhang Jiadong Wu Petr Stepanov Micah Haseman Tianyuan Zhou David Winarski Pooneh Saadatkia Sahil Agarwal Farida A. Selim Hao Yang Qitu Zhang Yun Wang Chingping Wong Hao Chen | 2019 | Photonics Research2019，7，5： | 0 |
| 19 | 特殊医学状态的伊朗患者肌肉注射纯化Vero细胞狂犬病疫苗(PVRV)后的中和抗体反应显示文摘使用WHO批准的的疫苗之一进行暴露后预防处置是预防狂犬病可以选择的方法。某些特殊医学状态(诸如怀孕、慢性乙型肝炎病毒感染、淋巴瘤等不同类型的癌症、Ⅰ型和Ⅱ型糖尿病、类风湿性关节炎和红斑狼疮患者使用皮质类固醇激素)患者不正常的免疫学功能会损害各种疫苗的免疫应答。处于上述医学状态的患者接种狂犬病疫苗后的免疫学反应从未被检测过。 | Pooneh Rahimi RouhAllah Vahabpour Mohammad Reza Aghasadeghi 吕新军(编译) | 2018 | 中华实验和临床病毒学杂志2018，32，5： | 0 |
| 20 | Clinical characteristics,gastrointestinal manifestations and outcomes of COVID-19 patients in Iran;does the location matters?显示文摘BACKGROUND Coronavirus disease 2019(COVID-19)started in Asia,and Iran was one of its first epicenters.AIM To study the gastrointestinal(GI)symptoms and comorbidities associated with this pandemic in four different regions of Iran.METHODS We analyzed data from severe acute respiratory syndrome coronavirus 2 positive patients evaluated at four hospitals of Iran(n=91),including South(Shiraz),Southeast(Dezful),Rasht(North),and Northwest(Mashhad)between April and September 2020.Demographics,comorbidities and clinical findings including GI symptoms were collected.Statistical descriptive analysis and correlation analyses of symptoms,comorbidities,and mortality were performed.RESULTS The average age of COVID-19 patients was 51.1 years,and 56%were male.Mortality rate was 17%.Cough with 84.6%,shortness of breath with 71.4%,fever with 52.7%,and loss of appetite with 43.9%were the main symptoms.Overall cardiac disease was the most common comorbidity with an average of 28.5%followed by hypertension(28.5%)and diabetes(25.2%).The highest comorbidity in North(Rasht)was diabetes(30%)and in South(Dezful)hypertension(37%).Shiraz leads cardiac disease with 43.4%.The most reported GI symptoms included nausea,diarrhea,vomiting,and abdominal pain,with 42.8%,31.8%,26.8%,and 12%prevalence,respectively.In addition,albumin,alkaline phosphatase,aspartate aminotransferase,and alanine aminotransferase were elevated in 26.3%.CONCLUSION Our results show hypertension and diabetes as the most common comorbidities,but their distribution was different in COVID-19 patients in the four studied regions of Iran.Nausea,diarrhea,and elevated liver enzymes were the most common GI symptoms.There was also a high mortality rate that was associated with high infection rates in Iran at the beginning of the pandemic. | Pooneh Mokarram Maryam Mehdipour Dalivand Antonio Pizuorno Farnaz Aligolighasemabadi Mohammadamin Sadeghdoust Ebtesam Sadeghdoust Farshad Aduli Gholamreza Oskrochi Hassan Brim Hassan Ashktorab | 2021 | World Journal of Clinical Cases2021，9，18： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员